{
    "uniprot_canonical_ac": "A0A183-1", 
    "sequence": {
        "header": "sp|A0A183-1|LCE6A_HUMAN Isoform 1 of Late cornified envelope protein 6A  OS=Homo sapiens OX=9606 GN=LCE6A PE=3 SV=1 CANONICAL=A0A183-1", 
        "length": 80, 
        "sequence": "MSQQKQQSWKPPNVPKCSPPQRSNPCLAPYSTPCGAPHSEGCHSSSQRPEVQKPRRARQKLRCLSRGTTYHCKEEECEGD"
    }, 
    "uniprot_id": "LCE6A_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "late cornified envelope protein 6A"
            ], 
            "uniprotkb": [
                "Late cornified envelope protein 6A"
            ]
        }, 
        "gene": {
            "refseq": [
                "LCE6A", 
                "C1orf44"
            ], 
            "uniprotkb": [
                "LCE6A", 
                "C1orf44"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A183", 
                    "id": "A0A183", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Late cornified envelope protein 6A."
    }, 
    "publication": [
        {
            "title": "Large-scale identification of human genes implicated in epidermal barrier function.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/17562024", 
            "journal": "Genome Biol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A183/publications", 
                    "id": "A0A183", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Guerrin M., Jonca N., Serre G., Toulza E., Wincker P., Galliano M.F., Dossat C., Jacob D., Mattiuzzo N.R., de Daruvar A.", 
            "date": "2007", 
            "pmid": "17562024"
        }, 
        {
            "title": "Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/15854049", 
            "journal": "The Journal of investigative dermatology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122072.1", 
                    "id": "NP_001122072.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Jackson B, Tilli CM, Hardman MJ, Avilion AA, MacLeod MC, Ashcroft GS, Byrne C", 
            "date": "2005", 
            "pmid": "15854049"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A183#A0A183-1", 
            "isoform_ac": "A0A183-1", 
            "locus": {
                "end_pos": 152843521, 
                "start_pos": 152843760, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000431011", 
                        "id": "ENST00000431011", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000411070", 
                        "id": "ENSP00000411070", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0A183-1|LCE6A_HUMAN Isoform 1 of Late cornified envelope protein 6A  OS=Homo sapiens OX=9606 GN=LCE6A PE=3 SV=1 CANONICAL=A0A183-1", 
                "length": 80, 
                "sequence": "MSQQKQQSWKPPNVPKCSPPQRSNPCLAPYSTPCGAPHSEGCHSSSQRPEVQKPRRARQKLRCLSRGTTYHCKEEECEGD"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:448835", 
            "resource": "KEGG Pathway", 
            "id": "hsa:448835", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6809371", 
            "resource": "Reactome", 
            "id": "R-HSA-6809371", 
            "name": "Formation of the cornified envelope"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A183#function", 
            "annotation": "Precursors of the cornified envelope of the stratum corneum.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A183#function", 
                    "id": "A0A183", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122072.1", 
            "annotation": "Describes neighboring LCE family members that are present in the same cluster on chromosome 1q21.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122072.1", 
                    "id": "NP_001122072.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3YV94-1", 
            "protein_name": "Late cornified envelope 6A; MCG1042765.", 
            "sequence": {
                "length": 81, 
                "sequence": "MSQQKPQLSELPNAPIYSPPKGPNLSLSTCSTSCGTSCSAGCSSYSKRLRLQNTVSHKEIHHPQPRCLRGSTTYHCKEEEC"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A183/", 
                    "id": "A0A183", 
                    "database": "OMA"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "A0A0G2JTC4-1", 
            "protein_name": "Late cornified envelope 6A; RCG40941.", 
            "sequence": {
                "length": 81, 
                "sequence": "MSQQKQQPSELPNAPKCSPPKGPNFCLTSCSSSCGTSCSAGYSSQLRRLGLRNTANRKKIHHPQPRCLRGGTTYHCKEEEC"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A183/", 
                    "id": "A0A183", 
                    "database": "OMA"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122072.1", 
        "ac": "NP_001122072.1", 
        "name": "late cornified envelope protein 6A.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031424", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A183", 
                                "id": "A0A183", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "keratinization", 
                        "id": "GO:0031424"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122072.1", 
            "id": "NP_001122072.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=31824", 
            "id": "31824", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A0A183", 
            "id": "A0A183", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A0A183", 
            "id": "NX_A0A183", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=LCE6A", 
            "id": "LCE6A", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6809371", 
            "id": "R-HSA-6809371", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:448835", 
            "id": "hsa:448835", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
            "id": "ENSG00000235942", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/HSEGCHS/", 
            "id": "HSEGCHS", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR031716", 
            "id": "IPR031716", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15858", 
            "id": "PF15858", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0A183", 
            "id": "PR_A0A183", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/448835", 
            "id": "448835", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Down", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A183", 
                    "id": "A0A183", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A183", 
                    "id": "A0A183", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A183", 
                    "id": "A0A183", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A183", 
                    "id": "A0A183", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A183", 
                    "id": "A0A183", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A0A183", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 9022.0, 
        "chemical_mass": 9022.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155", 
                "uberon": "0001155", 
                "name": "Colon"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001987", 
                "uberon": "0001987", 
                "name": "Placenta"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000955", 
                "uberon": "0000955", 
                "name": "Brain"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001160", 
                "uberon": "0001160", 
                "name": "Fundus of stomach"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001150", 
                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048", 
                "uberon": "0002048", 
                "name": "Lung"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107", 
                "uberon": "0002107", 
                "name": "Liver"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046", 
                "uberon": "0002046", 
                "name": "Thyroid gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043", 
                "uberon": "0001043", 
                "name": "Esophagus"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367", 
                "uberon": "0002367", 
                "name": "Prostate gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
                "uberon": "0001161", 
                "name": "Body of stomach"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255", 
                "uberon": "0001255", 
                "name": "Urinary bladder"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000235942", 
                    "id": "ENSG00000235942", 
                    "database": "Bgee"
                }
            ]
        }
    ], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A183", 
            "name": "LCE6A; C1orf44.", 
            "locus": {
                "end_pos": 152843983, 
                "start_pos": 152842868, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000235942", 
                        "id": "ENSG00000235942", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}