{ "uniprot_canonical_ac": "A0A140LIF8-1", "sequence": { "header": "tr|A0A140LIF8-1|A0A140LIF8_MOUSE Isoform 1 of Immunity-related GTPase family M member 2 OS=Mus musculus OX=10090 GN=Irgm2 PE=1 SV=1 CANONICAL=A0A140LIF8-1", "length": 407, "sequence": "MPTSRVAPLLDNMEEAVESPEVKEFEYFSDAVFIPKDGNTLSVGVIKRIETAVKEGEVVKVVSIVKEIIQNVSRNKIKIAVTGDSGNGMSSFINALRLIGHEEKDSAPTGVVRTTQKPTCYFSSHFPYVELWDLPGLGATAQSVESYLEEMQISIYDLIIIVASEQFSLNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRDSLQKEKVKEHPMFLVSVFKPESHDFPKLRETLQKDLPVIKYHGLVETLYQVCEKTVNERVESIKKSIDEDNLHTEFGISDPGNAIEIRKAFQKTFGLDDISLHLVALEMKNKHFNTSMESQETQRYQQDDWVLARLYRTGTRVGSIGFDYMKCCFTSHHSRCKQQKDILDETAAKAKEVLLKILRLSIPHP" }, "uniprot_id": "A0A140LIF8_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Immunity-related GTPase family M member 2" ] }, "gene": { "refseq": [], "uniprotkb": [ "Irgm2" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Immunity-related GTPase family M member 2." }, "publication": [ { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144319", "journal": "Immunity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8/publications", "id": "A0A140LIF8", "database": "UniProtKB" } ], "authors": "Thibault P., Trost M., Desjardins M., Courcelles M., English L., Lemieux S.", "date": "2009", "pmid": "19144319" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8#A0A140LIF8-1", "isoform_ac": "A0A140LIF8-1", "locus": { "end_pos": 58216987, "start_pos": 58220669, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000209079", "id": "ENSMUST00000209079", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000146805", "id": "ENSMUSP00000146805", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A140LIF8-1|A0A140LIF8_MOUSE Isoform 1 of Immunity-related GTPase family M member 2 OS=Mus musculus OX=10090 GN=Irgm2 PE=1 SV=1 CANONICAL=A0A140LIF8-1", "length": 407, "sequence": "MPTSRVAPLLDNMEEAVESPEVKEFEYFSDAVFIPKDGNTLSVGVIKRIETAVKEGEVVKVVSIVKEIIQNVSRNKIKIAVTGDSGNGMSSFINALRLIGHEEKDSAPTGVVRTTQKPTCYFSSHFPYVELWDLPGLGATAQSVESYLEEMQISIYDLIIIVASEQFSLNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRDSLQKEKVKEHPMFLVSVFKPESHDFPKLRETLQKDLPVIKYHGLVETLYQVCEKTVNERVESIKKSIDEDNLHTEFGISDPGNAIEIRKAFQKTFGLDDISLHLVALEMKNKHFNTSMESQETQRYQQDDWVLARLYRTGTRVGSIGFDYMKCCFTSHHSRCKQQKDILDETAAKAKEVLLKILRLSIPHP" } }, { "url": "https://www.uniprot.org/uniprot/A0A140LIF8#Q9Z1M2-1", "isoform_ac": "Q9Z1M2-1", "locus": { "end_pos": 58219485, "start_pos": 58220669, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000058704", "id": "ENSMUST00000058704", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000056001", "id": "ENSMUSP00000056001", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q9Z1M2-1|A0A140LIF8_MOUSE Computationally mapped isoform of Immunity-related GTPase family M member 2 OS=Mus musculus OX=10090 GN=Irgm2 PE=1 SV=1 CANONICAL=A0A140LIF8-1", "length": 395, "sequence": "MEEAVESPEVKEFEYFSDAVFIPKDGNTLSVGVIKRIETAVKEGEVVKVVSIVKEIIQNVSRNKIKIAVTGDSGNGMSSFINALRLIGHEEKDSAPTGVVRTTQKPTCYFSSHFPYVELWDLPGLGATAQSVESYLEEMQISIYDLIIIVASEQFSLNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRDSLQKEKVKEHPMFLVSVFKPESHDFPKLRETLQKDLPVIKYHGLVETLYQVCEKTVNERVESIKKSIDEDNLHTEFGISDPGNAIEIRKAFQKTFGLDDISLHLVALEMKNKHFNTSMESQETQRYQQDDWVLARLYRTGTRVGSIGFDYMKCCFTSHHSRCKQQKDILDETAAKAKEVLLKILRLSIPHP" } } ], "pathway": [], "function": [], "orthologs": [], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "GTPase activity", "id": "GO:0003924" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "GTP binding", "id": "GO:0005525" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043539", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "protein serine/threonine kinase activator activity", "id": "GO:0043539" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051434", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "BH3 domain binding", "id": "GO:0051434" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050700", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "CARD domain binding", "id": "GO:0050700" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "Golgi membrane", "id": "GO:0000139" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "mitochondrion", "id": "GO:0005739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "defense response", "id": "GO:0006952" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009617", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "response to bacterium", "id": "GO:0009617" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035458", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "cellular response to interferon-beta", "id": "GO:0035458" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070431", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "nucleotide-binding oligomerization domain containing 2 signaling pathway", "id": "GO:0070431" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "autophagosome assembly", "id": "GO:0000045" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "positive regulation of protein phosphorylation", "id": "GO:0001934" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010800", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "positive regulation of peptidyl-threonine phosphorylation", "id": "GO:0010800" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033138", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "positive regulation of peptidyl-serine phosphorylation", "id": "GO:0033138" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "innate immune response", "id": "GO:0045087" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "defense response to Gram-negative bacterium", "id": "GO:0050829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "cellular response to lipopolysaccharide", "id": "GO:0071222" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "protein stabilization", "id": "GO:0050821" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "positive regulation of autophagy", "id": "GO:0010508" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061762", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "CAMKK-AMPK signaling cascade", "id": "GO:0061762" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901098", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "positive regulation of autophagosome maturation", "id": "GO:1901098" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071902", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "positive regulation of protein serine/threonine kinase activity", "id": "GO:0071902" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061739", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "protein lipidation involved in autophagosome assembly", "id": "GO:0061739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "defense response to bacterium", "id": "GO:0042742" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043254", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "regulation of protein complex assembly", "id": "GO:0043254" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098586", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "cellular response to virus", "id": "GO:0098586" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031648", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "protein destabilization", "id": "GO:0031648" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0075044", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "positive regulation by symbiont of host autophagy", "id": "GO:0075044" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "regulation of protein complex stability", "id": "GO:0061635" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060335", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "id": "A0A140LIF8", "database": "UniProtKB" } ], "name": "positive regulation of interferon-gamma-mediated signaling pathway", "id": "GO:0060335" } ], "total": 24, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 73, "annotation": "n_glycosylation_sequon", "start_pos": 71 }, { "end_pos": 333, "annotation": "n_glycosylation_sequon", "start_pos": 331 } ], "crossref": [ { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007743", "id": "IPR007743", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030385", "id": "IPR030385", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF05049", "id": "PF05049", "database": "Pfam" }, { "url": "http://www.informatics.jax.org/marker/MGI:1926262", "id": "1926262", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A0A140LIF8", "disease": [], "mass": { "monoisotopic_mass": 46500.0, "chemical_mass": 46500.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A140LIF8", "name": "Irgm2.", "locus": { "end_pos": 58222782, "start_pos": 58199618, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000069874", "id": "ENSMUSG00000069874", "database": "Ensembl Gene" } ] } } ] }