{ "uniprot_canonical_ac": "A0A0U1RPR8-1", "sequence": { "header": "tr|A0A0U1RPR8-1|A0A0U1RPR8_MOUSE Isoform 1 of Guanylate cyclase OS=Mus musculus OX=10090 GN=Gucy2d PE=3 SV=1 CANONICAL=A0A0U1RPR8-1", "length": 1117, "sequence": "MAGLQQGCHFEGQNWTAPHWKTCLPCQGPWRLTVSHLKTVSSISVLSVVFWSVLLWADSLSLLAWARETFTLGVLGPWDCDPIFAQALPSIATQLAVDQVNQDASLLPGSQLDFKVLPTGCDTPHALATFVAHKNIVAAFVGPVNPGFCSAAALLAQGWGKSLFSWACEAPEGGGDLVPTLPSAADVLLSVMRHFGWARWAIVSSHQDIWVTTAQQLATAFRTHGLPIGLVTSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTTLLHCAWEEGLTDGRLVFLPYDTLLFALPYGNRSYLVLDDHGPLQEAYDAVLTVSLESSPESHAFTATEMSGGATANLEPEQVSPLFGTIYDAVILLAHALNRSETHGAGLSGAHLGDHVRALDVAGFSQRIRTDGKGRRLAQYVILDTDGEGSQLVPTHILDTSTWQVQPLGKPIHFPGGSPPAHDASCWFDPNTLCIRGVQPLGSLLTLTIACVLALVGGFLAYFIRLGLQQLRLLRGPHRILLTSQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPRSVTQGSARSLPAFLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSSRPQPAPEELLWTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRPLPTPLSIKPGDPWQDRINQEIRTGFAKARQGLAEPRKSGEAGPGP" }, "uniprot_id": "A0A0U1RPR8_MOUSE", "enzyme_annotation": [ { "ec": "4.6.1.2", "activity": "GTP = 3',5'-cyclic GMP + diphosphate." }, { "ec": "4.6.1.2", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "olfactory guanylyl cyclase GC-D", "guanylyl cyclase 2d; guanylyl cyclase D" ], "uniprotkb": [ "Guanylate cyclase", "4.6.1.2" ] }, "gene": { "refseq": [ "Gucy2d" ], "uniprotkb": [ "Gucy2d" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Guanylate cyclase; 4.6.1.2." }, "publication": [ { "title": "The R838S Mutation in Retinal Guanylyl Cyclase 1 (RetGC1) Alters Calcium Sensitivity of cGMP Synthesis in the Retina and Causes Blindness in Transgenic Mice.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27703005", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ], "authors": "Dizhoor AM, Olshevskaya EV, Peshenko IV", "date": "2016", "pmid": "27703005" }, { "title": "Functional study of two biochemically unusual mutations in GUCY2D Leber congenital amaurosis expressed via adenoassociated virus vector in mouse retinas.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27881908", "journal": "Molecular vision", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ], "authors": "Boye SL, Olshevskaya EV, Peshenko IV, McCullough KT, Boye SE, Dizhoor AM", "date": "2016", "pmid": "27881908" }, { "title": "Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22623665", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ], "authors": "Olshevskaya EV, Peshenko IV, Savchenko AB, Dizhoor AM", "date": "2012", "pmid": "22623665" }, { "title": "Guanylyl cyclase-activating proteins (GCAPs) are Ca2+/Mg2+ sensors: implications for photoreceptor guanylyl cyclase (RetGC) regulation in mammalian photoreceptors.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14993224", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ], "authors": "Peshenko IV, Dizhoor AM", "date": "2004", "pmid": "14993224" }, { "title": "Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8838319", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ], "authors": "Yang RB, Fulle HJ, Garbers DL", "date": "1996", "pmid": "8838319" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8#A0A0U1RPB5-1", "isoform_ac": "A0A0U1RPB5-1", "locus": { "end_pos": 98467694, "start_pos": 98474743, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000205350", "id": "ENSMUST00000205350", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000145913", "id": "ENSMUSP00000145913", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0U1RPB5-1|A0A0U1RPR8_MOUSE Computationally mapped isoform of Guanylate cyclase OS=Mus musculus OX=10090 GN=Gucy2d PE=3 SV=1 CANONICAL=A0A0U1RPR8-1", "length": 178, "sequence": "PIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRPLPTPLSIKPG" } }, { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8#A0A0U1RPR8-1", "isoform_ac": "A0A0U1RPR8-1", "locus": { "end_pos": 98440509, "start_pos": 98477289, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000206435", "id": "ENSMUST00000206435", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000146093", "id": "ENSMUSP00000146093", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0U1RPR8-1|A0A0U1RPR8_MOUSE Isoform 1 of Guanylate cyclase OS=Mus musculus OX=10090 GN=Gucy2d PE=3 SV=1 CANONICAL=A0A0U1RPR8-1", "length": 1117, "sequence": "MAGLQQGCHFEGQNWTAPHWKTCLPCQGPWRLTVSHLKTVSSISVLSVVFWSVLLWADSLSLLAWARETFTLGVLGPWDCDPIFAQALPSIATQLAVDQVNQDASLLPGSQLDFKVLPTGCDTPHALATFVAHKNIVAAFVGPVNPGFCSAAALLAQGWGKSLFSWACEAPEGGGDLVPTLPSAADVLLSVMRHFGWARWAIVSSHQDIWVTTAQQLATAFRTHGLPIGLVTSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTTLLHCAWEEGLTDGRLVFLPYDTLLFALPYGNRSYLVLDDHGPLQEAYDAVLTVSLESSPESHAFTATEMSGGATANLEPEQVSPLFGTIYDAVILLAHALNRSETHGAGLSGAHLGDHVRALDVAGFSQRIRTDGKGRRLAQYVILDTDGEGSQLVPTHILDTSTWQVQPLGKPIHFPGGSPPAHDASCWFDPNTLCIRGVQPLGSLLTLTIACVLALVGGFLAYFIRLGLQQLRLLRGPHRILLTSQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPRSVTQGSARSLPAFLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSSRPQPAPEELLWTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRPLPTPLSIKPGDPWQDRINQEIRTGFAKARQGLAEPRKSGEAGPGP" } }, { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8#F6VFS9-1", "isoform_ac": "F6VFS9-1", "locus": { "end_pos": 98443421, "start_pos": 98477289, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000098274", "id": "ENSMUST00000098274", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000095875", "id": "ENSMUSP00000095875", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6VFS9-1|A0A0U1RPR8_MOUSE Computationally mapped isoform of Guanylate cyclase OS=Mus musculus OX=10090 GN=Gucy2d PE=3 SV=1 CANONICAL=A0A0U1RPR8-1", "length": 1116, "sequence": "SGLQQGCHFEGQNWTAPHWKTCLPCQGPWRLTVSHLKTVSSISVLSVVFWSVLLWADSLSLLAWARETFTLGVLGPWDCDPIFAQALPSIATQLAVDQVNQDASLLPGSQLDFKVLPTGCDTPHALATFVAHKNIVAAFVGPVNPGFCSAAALLAQGWGKSLFSWACEAPEGGGDLVPTLPSAADVLLSVMRHFGWARWAIVSSHQDIWVTTAQQLATAFRTHGLPIGLVTSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTTLLHCAWEEGLTDGRLVFLPYDTLLFALPYGNRSYLVLDDHGPLQEAYDAVLTVSLESSPESHAFTATEMSGGATANLEPEQVSPLFGTIYDAVILLAHALNRSETHGAGLSGAHLGDHVRALDVAGFSQRIRTDGKGRRLAQYVILDTDGEGSQLVPTHILDTSTWQVQPLGKPIHFPGGSPPAHDASCWFDPNTLCIRGVQPLGSLLTLTIACVLALVGGFLAYFIRLGLQQLRLLRGPHRILLTSQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPRSVTQGSARSLPAFLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSSRPQPAPEELLWTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRPLPTPLSIKPGDPWQDRINQEIRTGFAKARQGLAEPRKSGEAGPGP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:14918", "resource": "KEGG Pathway", "id": "mmu:14918", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "annotation": "This mouse model provides the first direct biochemical and physiological in vivo evidence for the Arg(838) substitutions in RetGC1 being the culprit behind the pathogenesis of the CORD6 congenital blindness.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "annotation": "The S248W mutation contributes to Leber congenital amaurosis 1 by hampering the expression, processing, and/or cellular transport of GUCY2D, rather than its enzymatic properties. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "annotation": "Mg(2+) binding to GCAPs is critical for setting the actual dynamic range of RetGC regulation by GCAPs at physiological levels of free Ca(2+)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P51839-1", "protein_name": "Olfactory guanylyl cyclase GC-D; 4.6.1.2; Guanylate cyclase, olfactory.", "sequence": { "length": 1110, "sequence": "MAGLQQGCHPEGQDWTAPHWKTCRALPGPRGLTVRHLRTVSSISVFSVVFWGVLLWADSLSLPAWARETFTLGVLGPWDCDPIFAQALPSMATQLAVDRVNQDASLLLGSQLDFKILPTGCDTPHALATFVAHRNTVAAFIGPVNPGYCPAAALLAQGWGKSLFSWACGAPEGGGALVPTLPSMADVLLSVMRHFGWARLAIVSSHQDIWVTTAQQLATAFRAHGLPIGLITSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTVLLRCAREEGLTDGRLVFLPYDTLLFALPYRNRSYLVLDDDGPLQEAYDAVLTISLDTSPESHAFTATKMRGGAAANLGPEQVSPLFGTIYDAVILLAHALNHSETHGTGLSGAHLGNHIRALDVAGFSQRIRIDGKGRRLPQYVILDTNGEGSQLVPTHILDVSTQQVQPLGTAVHFPGGSPPAHDASCWFDPNTLCIRGVQPLGSLLTLTITCVLALVGGFLAYFIRLGLQQLRLLRGPHRILLTPQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPQSVIQGSTRSVPAFLEHTNVALYQGEWVWLKKFEAGTAPDLRPSSLSLLRKMREMRHENVTAFLGLFVGPEVSAMVLEHCARGSLEDLLRNEDLRLDWTFKASLLLDLIRGLRYLHHRHFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSFRPQPAPEELLWTAPELLRGPRGPWGPGKATFKGDVFSLGIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVADSMLRMLEKYSQSLEGLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANMALEILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKTGFCRSLPTPLSIQPGDPWQDHINQEIRTGFAKLARVC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/71540", "id": "71540", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "ac": "NP_001124165.1", "name": "olfactory guanylyl cyclase GC-D; guanylyl cyclase 2d; guanylyl cyclase D.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017046", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "peptide hormone binding", "id": "GO:0017046" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016941", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "natriuretic peptide receptor activity", "id": "GO:0016941" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001653", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "peptide receptor activity", "id": "GO:0001653" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004383", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "guanylate cyclase activity", "id": "GO:0004383" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "protein kinase activity", "id": "GO:0004672" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120199", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "cone photoreceptor outer segment", "id": "GO:0120199" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120200", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "rod photoreceptor outer segment", "id": "GO:0120200" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006182", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "cGMP biosynthetic process", "id": "GO:0006182" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "signal transduction", "id": "GO:0007165" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007168", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "receptor guanylyl cyclase signaling pathway", "id": "GO:0007168" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "intracellular signal transduction", "id": "GO:0035556" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 16, "annotation": "n_glycosylation_sequon", "start_pos": 14 }, { "end_pos": 306, "annotation": "n_glycosylation_sequon", "start_pos": 304 }, { "end_pos": 376, "annotation": "n_glycosylation_sequon", "start_pos": 374 }, { "end_pos": 613, "annotation": "n_glycosylation_sequon", "start_pos": 611 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:14918", "id": "mmu:14918", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/QRIRTDE/", "id": "QRIRTDE", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001054", "id": "IPR001054", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "id": "IPR001245", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018297", "id": "IPR018297", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029787", "id": "IPR029787", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001828", "id": "IPR001828", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028082", "id": "IPR028082", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00211", "id": "PF00211", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF07714", "id": "PF07714", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01094", "id": "PF01094", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/14918", "id": "14918", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:106030", "id": "106030", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A0A0U1RPR8", "disease": [], "mass": { "monoisotopic_mass": 122528.0, "chemical_mass": 122528.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "name": "Gucy2d.", "locus": { "end_pos": 98477479, "start_pos": 98440416, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000074003", "id": "ENSMUSG00000074003", "database": "Ensembl Gene" } ] } } ] }