{
    "uniprot_canonical_ac": "A0A0U1RNF2-1", 
    "sequence": {
        "header": "tr|A0A0U1RNF2-1|A0A0U1RNF2_MOUSE Isoform 1 of Leucine carboxyl methyltransferase 1  OS=Mus musculus OX=10090 GN=Lcmt1 PE=1 SV=1 CANONICAL=A0A0U1RNF2-1", 
        "length": 332, 
        "sequence": "MASSSRESSFSSCSSSCDLDDEGVRGTCEDASLCKRFAVSIGYWHDPYIEHLVRQSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQILNLGAGMDTTFWKLKDEGLLPNKYFEVDFPMIVTRKLLTIKSKPLLFRPIMELHPEDTLQMGNHMLDSKRYAIIGADLRDLSELEEKLKKCNMNTQLPTLLITECVLVYMTPEQSANLLKWAASSFETAMFINYEQVNMDDRFGQIMIENLRRRSCDLAGVETCKSLESQKERLLLNGWETASAVNMMELYSGLPRAEVNRIESLEFLDEMELLEQLMRHYCLCWATRGGQELGLKEITY"
    }, 
    "uniprot_id": "A0A0U1RNF2_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "2.1.1.233", 
            "activity": "S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester."
        }, 
        {
            "ec": "2.1.1.233", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "Leucine carboxyl methyltransferase 1", 
                "2.1.1.233"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "Lcmt1"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
                    "id": "A0A0U1RNF2", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Leucine carboxyl methyltransferase 1; 2.1.1.233."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2#A0A0U1RNF2-1", 
            "isoform_ac": "A0A0U1RNF2-1", 
            "locus": {
                "end_pos": 123378149, 
                "start_pos": 123430152, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000206574", 
                        "id": "ENSMUST00000206574", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000145539", 
                        "id": "ENSMUSP00000145539", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0U1RNF2-1|A0A0U1RNF2_MOUSE Isoform 1 of Leucine carboxyl methyltransferase 1  OS=Mus musculus OX=10090 GN=Lcmt1 PE=1 SV=1 CANONICAL=A0A0U1RNF2-1", 
                "length": 332, 
                "sequence": "MASSSRESSFSSCSSSCDLDDEGVRGTCEDASLCKRFAVSIGYWHDPYIEHLVRQSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQILNLGAGMDTTFWKLKDEGLLPNKYFEVDFPMIVTRKLLTIKSKPLLFRPIMELHPEDTLQMGNHMLDSKRYAIIGADLRDLSELEEKLKKCNMNTQLPTLLITECVLVYMTPEQSANLLKWAASSFETAMFINYEQVNMDDRFGQIMIENLRRRSCDLAGVETCKSLESQKERLLLNGWETASAVNMMELYSGLPRAEVNRIESLEFLDEMELLEQLMRHYCLCWATRGGQELGLKEITY"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2#A0A0U1RPZ5-1", 
            "isoform_ac": "A0A0U1RPZ5-1", 
            "locus": {
                "end_pos": 123369784, 
                "start_pos": 123401475, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000206721", 
                        "id": "ENSMUST00000206721", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000146184", 
                        "id": "ENSMUSP00000146184", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0U1RPZ5-1|A0A0U1RNF2_MOUSE Computationally mapped isoform of Leucine carboxyl methyltransferase 1  OS=Mus musculus OX=10090 GN=Lcmt1 PE=1 SV=2 CANONICAL=A0A0U1RNF2-1", 
                "length": 121, 
                "sequence": "MRLNCFFMAAAAVAARQAGGGELGTVWRVLPTSLPGPGGGDGGYNSAPPLAASLPASPPAPTTSWAEPSRKRPKPERWNRFAVSIGYWHDPYIEHLVRQSKERKAPEINRGYFARVHGVSQ"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2#A2RTH5-1", 
            "isoform_ac": "A2RTH5-1", 
            "locus": {
                "end_pos": 123378149, 
                "start_pos": 123430152, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000033025", 
                        "id": "ENSMUST00000033025", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000033025", 
                        "id": "ENSMUSP00000033025", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2RTH5-1|A0A0U1RNF2_MOUSE Computationally mapped isoform of Leucine carboxyl methyltransferase 1  OS=Mus musculus OX=10090 GN=Lcmt1 PE=1 SV=1 CANONICAL=A0A0U1RNF2-1", 
                "length": 332, 
                "sequence": "MASSSRESSFSSCSSSCDLDDEGVRGTCEDASLCKRFAVSIGYWHDPYIEHLVRQSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQILNLGAGMDTTFWKLKDEGLLPNKYFEVDFPMIVTRKLLTIKSKPLLFRPIMELHPEDTLQMDSHMLDSKRYAIIGADLRDLSELEEKLKKCNMNTQLPTLLITECVLVYMTPEQSANLLKWAASSFETAMFINYEQVNMDDRFGQIMIENLRRRSCDLAGVETCKSLESQKERLLLNGWETASAVNMMELYSGLPRAEVNRIESLEFLDEMELLEQLMRHYCLCWATRGGQELGLKEITY"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-69273", 
            "resource": "Reactome", 
            "id": "R-MMU-69273", 
            "name": "Cyclin A/B1/B2 associated events during G2/M transition"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2#function", 
            "annotation": "Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2#function", 
                    "id": "A0A0U1RNF2", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008276", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
                                "id": "A0A0U1RNF2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein methyltransferase activity", 
                        "id": "GO:0008276"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003880", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
                                "id": "A0A0U1RNF2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein C-terminal carboxyl O-methyltransferase activity", 
                        "id": "GO:0003880"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018423", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
                                "id": "A0A0U1RNF2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein C-terminal leucine carboxyl O-methyltransferase activity", 
                        "id": "GO:0018423"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
                                "id": "A0A0U1RNF2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010906", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
                                "id": "A0A0U1RNF2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of glucose metabolic process", 
                        "id": "GO:0010906"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006479", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
                                "id": "A0A0U1RNF2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein methylation", 
                        "id": "GO:0006479"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006481", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
                                "id": "A0A0U1RNF2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "C-terminal protein methylation", 
                        "id": "GO:0006481"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031333", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
                                "id": "A0A0U1RNF2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of protein complex assembly", 
                        "id": "GO:0031333"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
                                "id": "A0A0U1RNF2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of apoptotic process", 
                        "id": "GO:0042981"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090266", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
                                "id": "A0A0U1RNF2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of mitotic cell cycle spindle assembly checkpoint", 
                        "id": "GO:0090266"
                    }
                ], 
                "total": 6, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-69273", 
            "id": "R-MMU-69273", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", 
            "id": "IPR029063", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007213", 
            "id": "IPR007213", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016651", 
            "id": "IPR016651", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF04072", 
            "id": "PF04072", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13600", 
            "id": "PTHR13600", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1353593", 
            "id": "1353593", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0U1RNF2", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 38161.0, 
        "chemical_mass": 38161.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0U1RNF2", 
            "name": "Lcmt1.", 
            "locus": {
                "end_pos": 123430358, 
                "start_pos": 123369784, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000030763", 
                        "id": "ENSMUSG00000030763", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}