{
    "uniprot_canonical_ac": "A0A0N4SVR5-1", 
    "sequence": {
        "header": "tr|A0A0N4SVR5-1|A0A0N4SVR5_MOUSE Isoform 1 of RasGEF domain family, member 1A  OS=Mus musculus OX=10090 GN=Rasgef1a PE=1 SV=1 CANONICAL=A0A0N4SVR5-1", 
        "length": 498, 
        "sequence": "MFLEPQEAMPQTSVVFSSILGPNCNRQVQPGMGERGGGASSGSKDLIFQDGRLTSGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFSTKIVQLLKEWTEAFPYDFQDEKVMAELKAIAHRVTQCDEYLMQPRPSQENGTVKKAIAQMIQSLLLSLAARSQLQELREKLRSPVVDKGPVLKAKPPAAQKDILGVCSDPLVLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNHRCRGDMTKTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQTANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYVLTAPIYSEEALFIASFESEGPENHMEKDSWKALRTTLLNRA"
    }, 
    "uniprot_id": "A0A0N4SVR5_MOUSE", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "RasGEF domain family, member 1A"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "Rasgef1a"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0N4SVR5", 
                    "id": "A0A0N4SVR5", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "RasGEF domain family, member 1A."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0N4SVR5#A0A0N4SVF2-1", 
            "isoform_ac": "A0A0N4SVF2-1", 
            "locus": {
                "end_pos": 118066445, 
                "start_pos": 118089837, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000203482", 
                        "id": "ENSMUST00000203482", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000145077", 
                        "id": "ENSMUSP00000145077", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0N4SVF2-1|A0A0N4SVR5_MOUSE Computationally mapped isoform of RasGEF domain family, member 1A  OS=Mus musculus OX=10090 GN=Rasgef1a PE=1 SV=1 CANONICAL=A0A0N4SVR5-1", 
                "length": 489, 
                "sequence": "MFLEPQEAMPQTSVVFSSILGPNCNRQVQPGMGERGGGASSGSKDLIFQDGRLTSGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFSTKIVQLLKEWTEAFPYDFQDEKVMAELKAIAHRVTQCDEENGTVKKAIAQMIQSLLLSLAARSQLQELREKLRSPVVDKGPVLKAKPPAAQKDILGVCSDPLVLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNHRCRGDMTKTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQTANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYVLTAPIYSEEALFIASFESEGPENHMEKDSWKALRTTLLNRA"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0N4SVR5#A0A0N4SVR5-1", 
            "isoform_ac": "A0A0N4SVR5-1", 
            "locus": {
                "end_pos": 118066445, 
                "start_pos": 118089837, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000203804", 
                        "id": "ENSMUST00000203804", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000145214", 
                        "id": "ENSMUSP00000145214", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0N4SVR5-1|A0A0N4SVR5_MOUSE Isoform 1 of RasGEF domain family, member 1A  OS=Mus musculus OX=10090 GN=Rasgef1a PE=1 SV=1 CANONICAL=A0A0N4SVR5-1", 
                "length": 498, 
                "sequence": "MFLEPQEAMPQTSVVFSSILGPNCNRQVQPGMGERGGGASSGSKDLIFQDGRLTSGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFSTKIVQLLKEWTEAFPYDFQDEKVMAELKAIAHRVTQCDEYLMQPRPSQENGTVKKAIAQMIQSLLLSLAARSQLQELREKLRSPVVDKGPVLKAKPPAAQKDILGVCSDPLVLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNHRCRGDMTKTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQTANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYVLTAPIYSEEALFIASFESEGPENHMEKDSWKALRTTLLNRA"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0N4SVR5#A6H650-1", 
            "isoform_ac": "A6H650-1", 
            "locus": {
                "end_pos": 118080364, 
                "start_pos": 118089837, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000164960", 
                        "id": "ENSMUST00000164960", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000132244", 
                        "id": "ENSMUSP00000132244", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A6H650-1|A0A0N4SVR5_MOUSE Computationally mapped isoform of RasGEF domain family, member 1A  OS=Mus musculus OX=10090 GN=Rasgef1a PE=1 SV=1 CANONICAL=A0A0N4SVR5-1", 
                "length": 481, 
                "sequence": "MPQTSVVFSSILGPNCNRQVQPGMGERGGGASSGSKDLIFQDGRLTSGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFSTKIVQLLKEWTEAFPYDFQDEKVMAELKAIAHRVTQCDEENGTVKKAIAQMIQSLLLSLAARSQLQELREKLRSPVVDKGPVLKAKPPAAQKDILGVCSDPLVLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNHRCRGDMTKTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQTANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYVLTAPIYSEEALFIASFESEGPENHMEKDSWKALRTTLLNRA"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5673001", 
            "resource": "Reactome", 
            "id": "R-MMU-5673001", 
            "name": "RAF/MAP kinase cascade"
        }
    ], 
    "function": [], 
    "orthologs": [], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005088", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0N4SVR5", 
                                "id": "A0A0N4SVR5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Ras guanyl-nucleotide exchange factor activity", 
                        "id": "GO:0005088"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046579", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0N4SVR5", 
                                "id": "A0A0N4SVR5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of Ras protein signal transduction", 
                        "id": "GO:0046579"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0N4SVR5", 
                                "id": "A0A0N4SVR5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell migration", 
                        "id": "GO:0016477"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0N4SVR5", 
                                "id": "A0A0N4SVR5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "small GTPase mediated signal transduction", 
                        "id": "GO:0007264"
                    }
                ], 
                "total": 3, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 174, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 172
        }, 
        {
            "end_pos": 340, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 338
        }, 
        {
            "end_pos": 390, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 388
        }
    ], 
    "crossref": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5673001", 
            "id": "R-MMU-5673001", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000030134", 
            "id": "ENSMUSG00000030134", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06224", 
            "id": "cd06224", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00155", 
            "id": "cd00155", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000651", 
            "id": "IPR000651", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008937", 
            "id": "IPR008937", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001895", 
            "id": "IPR001895", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023578", 
            "id": "IPR023578", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036964", 
            "id": "IPR036964", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00618", 
            "id": "PF00618", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00617", 
            "id": "PF00617", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113", 
            "id": "PTHR23113", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1917977", 
            "id": "1917977", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0N4SVR5", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 56925.0, 
        "chemical_mass": 56925.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0N4SVR5", 
            "name": "Rasgef1a.", 
            "locus": {
                "end_pos": 118091546, 
                "start_pos": 118011438, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000030134", 
                        "id": "ENSMUSG00000030134", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}