{
    "uniprot_canonical_ac": "A0A0M3HER8-1", 
    "sequence": {
        "header": "tr|A0A0M3HER8-1|A0A0M3HER8_HUMAN Isoform 1 of Golgin subfamily A member 6-like protein 10  OS=Homo sapiens OX=9606 GN=GOLGA6L10 PE=4 SV=1 CANONICAL=A0A0M3HER8-1", 
        "length": 536, 
        "sequence": "MWPQPRLPPHPAMSEKTQQGKLAAAKKKLKAYWQRKSPGIPAGANRKKKVNGSSPDTATSGGYHSPGDSATGIYGEGRASSTTLQDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLREQEERLREQEERLHEQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLCEQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLRELERLRELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELEKSGGAEEPRGSESAAAARPVPGAPVPQGAWMCGQAGWTPQEHPGLSGEAVGTGEAAGGAEEAACHSFRAAENRELNITII"
    }, 
    "uniprot_id": "A0A0M3HER8_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "golgin subfamily A member 6-like protein 10 isoform 2", 
                "golgi autoantigen, golgin subfamily a, 6-like 10; putative golgin subfamily A member 6-like protein 10; golgin A6 family-like 18"
            ], 
            "uniprotkb": [
                "Golgin subfamily A member 6-like protein 10"
            ]
        }, 
        "gene": {
            "refseq": [
                "GOLGA6L10", 
                "GOLGA6L18"
            ], 
            "uniprotkb": [
                "GOLGA6L10", 
                "GOLGA6L18"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Golgin subfamily A member 6-like protein 10."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 251, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (2/5): patient freq. (1.5%); num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "H", 
            "subjects_tested": "66", 
            "end_pos": 251, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 265, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "66", 
            "end_pos": 265, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 269, 
            "subjects_positive": "3", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "4.5", 
            "annotation": "Filters passed (1/5): patient freq. (4.5%).", 
            "sequence_org": "E", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "G", 
            "subjects_tested": "66", 
            "end_pos": 269, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 481, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "V", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "F", 
            "subjects_tested": "66", 
            "end_pos": 481, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 258, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "P", 
            "subjects_tested": "66", 
            "end_pos": 258, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 272, 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "3.0", 
            "annotation": "Filters passed (1/5): patient freq. (3.0%).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "66", 
            "end_pos": 272, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 151, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "E", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "66", 
            "end_pos": 151, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 516, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "E", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "G", 
            "subjects_tested": "66", 
            "end_pos": 516, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 520, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "C", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "G", 
            "subjects_tested": "66", 
            "end_pos": 520, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 259, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "E", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "V", 
            "subjects_tested": "66", 
            "end_pos": 259, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 251, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.3", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "4362", 
                "url": "http://disease-ontology.org/term/DOID:4362", 
                "icd10": "", 
                "name": "Cervical cancer"
            }, 
            "sequence_mut": "H", 
            "subjects_tested": "350", 
            "end_pos": 251, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 314, 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "3.0", 
            "annotation": "Filters passed (1/5): patient freq. (3.0%).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "H", 
            "subjects_tested": "66", 
            "end_pos": 314, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 251, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0M3HER8", 
                    "id": "A0A0M3HER8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1612", 
                "url": "http://disease-ontology.org/term/DOID:1612", 
                "icd10": "", 
                "name": "Breast cancer"
            }, 
            "sequence_mut": "H", 
            "subjects_tested": "1144", 
            "end_pos": 251, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0M3HER8#A0A0G2JNH6-1", 
            "isoform_ac": "A0A0G2JNH6-1", 
            "locus": {
                "end_pos": 82342795, 
                "start_pos": 82349435, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000618409", 
                        "id": "ENST00000618409", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000481389", 
                        "id": "ENSP00000481389", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2JNH6-1|A0A0M3HER8_HUMAN Computationally mapped isoform of Golgin subfamily A member 6-like protein 10  OS=Homo sapiens OX=9606 GN=GOLGA6L10 PE=4 SV=1 CANONICAL=A0A0M3HER8-1", 
                "length": 474, 
                "sequence": "MWPQPRLPPHPAMSEKTQQGKLAAAKKKLKAYWQRKSPGIPAGANRKKKVNGSSPDTATSGGYHSPGDSATGIYGEGRASSTTLQDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQEERLLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLCEQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLRELERLRELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELEKSGGAEEPRGSESAAAARPVPGAPVPQGAWMCGQAGWTPQEHPGLSGEAVGTGEAAGGAEEAACHSFRAAENRELNITII"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0M3HER8#A0A0M3HER8-1", 
            "isoform_ac": "A0A0M3HER8-1", 
            "locus": {
                "end_pos": 82342795, 
                "start_pos": 82349435, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000632596", 
                        "id": "ENST00000632596", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000488730", 
                        "id": "ENSP00000488730", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0M3HER8-1|A0A0M3HER8_HUMAN Isoform 1 of Golgin subfamily A member 6-like protein 10  OS=Homo sapiens OX=9606 GN=GOLGA6L10 PE=4 SV=1 CANONICAL=A0A0M3HER8-1", 
                "length": 536, 
                "sequence": "MWPQPRLPPHPAMSEKTQQGKLAAAKKKLKAYWQRKSPGIPAGANRKKKVNGSSPDTATSGGYHSPGDSATGIYGEGRASSTTLQDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLREQEERLREQEERLHEQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLCEQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLRELERLRELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELEKSGGAEEPRGSESAAAARPVPGAPVPQGAWMCGQAGWTPQEHPGLSGEAVGTGEAAGGAEEAACHSFRAAENRELNITII"
            }
        }
    ], 
    "pathway": [], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A6NEF3-1", 
            "protein_name": "Golgin subfamily A member 6-like protein 4.", 
            "sequence": {
                "length": 574, 
                "sequence": "MWPQPRFPPHPAMSEKTQQGKLAAAKKKLKAYWQRKSPGIPAGANRKKKINGSSPDTATSGGYHSPGDSATGIYGEGRASSTTLEDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEDRLHEQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEKLLEQERQQEEQERLLERERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLDEVEELLEQERLRQQDERLWQQETLQELERLRELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEEPRGSESAAAARPVAGAPVPQGAWMCGQAGWTPQEHPGLSGEAVGTGEAAGGAGEAACHSFRAAENRELNITII"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/109368", 
                    "id": "109368", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "A6NEM1-1", 
            "protein_name": "Golgin subfamily A member 6-like protein 9.", 
            "sequence": {
                "length": 432, 
                "sequence": "MWPQPRLPPHPAMSEKTQQGKLAAAKKKLKAYWQRKSPGIPAGANRKKKINGSSPDTFTSGGYHSPGDSATGIYGEGRASSTTLQDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPQPPAGPSKMEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLCEQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLRELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELEKSGGAEEPRGSESAAAARPVAGAPVPQGAWMCGQAGWTPQEHPGLSGEAVGTGEAAGGAGEAACHSFRAAENRELNITII"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/109368", 
                    "id": "109368", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309329.1", 
        "ac": "NP_001309329.1", 
        "name": "golgin subfamily A member 6-like protein 10 isoform 2; golgi autoantigen, golgin subfamily a, 6-like 10; putative golgin subfamily A member 6-like protein 10; golgin A6 family-like 18.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0M3HER8", 
                                "id": "A0A0M3HER8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Golgi apparatus", 
                        "id": "GO:0005794"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 53, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 51
        }, 
        {
            "end_pos": 144, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 142
        }, 
        {
            "end_pos": 444, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 442
        }, 
        {
            "end_pos": 534, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 532
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309329.1", 
            "id": "NP_001309329.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026737", 
            "id": "IPR026737", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024858", 
            "id": "IPR024858", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15070", 
            "id": "PF15070", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23143", 
            "id": "PTHR23143", 
            "database": "PANTHER"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/647042", 
            "id": "647042", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0M3HER8", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 62799.0, 
        "chemical_mass": 62799.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0M3HER8", 
            "name": "GOLGA6L10; GOLGA6L18.", 
            "locus": {
                "end_pos": 82339998, 
                "start_pos": 82349475, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000278662", 
                        "id": "ENSG00000278662", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}