{ "uniprot_canonical_ac": "A0A0J9YV76-1", "sequence": { "header": "tr|A0A0J9YV76-1|A0A0J9YV76_MOUSE Isoform 1 of MCG142506, isoform CRA_b OS=Mus musculus OX=10090 GN=Oas1e PE=4 SV=1 CANONICAL=A0A0J9YV76-1", "length": 386, "sequence": "MARELFRTPIWRLDNFIEDQLLPDTTFLTELRADIDSISAFLKERCFQGATHPMRVARVVMGGSYDEHNALKGRSEANMVVFFNDLTSFEDQLKWQQVFIEEIRKHLLQLQQEKPCKLKFEVQSSEEPNTRSLTFKLCSPERQQEVEFDVQPAYDALYEGGYCKSFESINYNKVYAQLIHECTTLEKEGEFSICFTDLHQSFLRYRAPKLWNLIRLVKHWYQLCKEKLRGPLPPQYALELLTVYVWEFGVQDSFGLHAAQCFRTVLELVTKYKCLLIYWTWFYDFRPEISDYLHGQIKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWIHSNFFRNCDMSLVNGWEVSLPTVFSGSQAVMDREERKLDFHLSTCWEVLSNSG" }, "uniprot_id": "A0A0J9YV76_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "2'-5' oligoadenylate synthetase 1E isoform 1", "2'-5'olygoadenylate synthetase 1E; 2'-5' oligoadenylate synthetase-like 7; 2,5-oligoadenylate synthetase-like 7" ], "uniprotkb": [ "MCG142506, isoform CRA_b", "2'-5' oligoadenylate synthetase 1E" ] }, "gene": { "refseq": [ "Oas1e", "C87484", "oasl7" ], "uniprotkb": [ "Oas1e", "mCG_142506", "C87484", "oasl7" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "MCG142506, isoform CRA_b; 2'-5' oligoadenylate synthetase 1E." }, "publication": [ { "title": "The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21142819", "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" } ], "authors": "Kristiansen H, Gad HH, Eskildsen-Larsen S, Despres P, Hartmann R", "date": "2011", "pmid": "21142819" }, { "title": "Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17015433", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" } ], "authors": "Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P, Eppig JJ, Solter D, Knowles BB", "date": "2006", "pmid": "17015433" }, { "title": "Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14559211", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" } ], "authors": "Mashimo T, Glaser P, Lucas M, Simon-Chazottes D, Ceccaldi PE, Montagutelli X, Despres P, Guenet JL", "date": "2003", "pmid": "14559211" }, { "title": "Positional cloning of the murine flavivirus resistance gene.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12080145", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" } ], "authors": "Perelygin AA, Scherbik SV, Zhulin IB, Stockman BM, Li Y, Brinton MA", "date": "2002", "pmid": "12080145" }, { "title": "Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12396720", "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" } ], "authors": "Kakuta S, Shibata S, Iwakura Y", "date": "2002", "pmid": "12396720" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76#A0A0J9YV17-1", "isoform_ac": "A0A0J9YV17-1", "locus": { "end_pos": 120791845, "start_pos": 120795498, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000200786", "id": "ENSMUST00000200786", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000144442", "id": "ENSMUSP00000144442", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0J9YV17-1|A0A0J9YV76_MOUSE Computationally mapped isoform of MCG142506, isoform CRA_b OS=Mus musculus OX=10090 GN=Oas1e PE=4 SV=1 CANONICAL=A0A0J9YV76-1", "length": 106, "sequence": "MARELFRTPIWRLDNFIEDQLLPDTTFLTELRADIDSISAFLKERCFQGATHPMRVARVVMMKGDTASPLNPLTTTKSTPNSSMSAPPWRRRASSPSASPTFIRAS" } }, { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76#A0A0J9YV76-1", "isoform_ac": "A0A0J9YV76-1", "locus": { "end_pos": 120786614, "start_pos": 120795498, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000201172", "id": "ENSMUST00000201172", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000144529", "id": "ENSMUSP00000144529", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0J9YV76-1|A0A0J9YV76_MOUSE Isoform 1 of MCG142506, isoform CRA_b OS=Mus musculus OX=10090 GN=Oas1e PE=4 SV=1 CANONICAL=A0A0J9YV76-1", "length": 386, "sequence": "MARELFRTPIWRLDNFIEDQLLPDTTFLTELRADIDSISAFLKERCFQGATHPMRVARVVMGGSYDEHNALKGRSEANMVVFFNDLTSFEDQLKWQQVFIEEIRKHLLQLQQEKPCKLKFEVQSSEEPNTRSLTFKLCSPERQQEVEFDVQPAYDALYEGGYCKSFESINYNKVYAQLIHECTTLEKEGEFSICFTDLHQSFLRYRAPKLWNLIRLVKHWYQLCKEKLRGPLPPQYALELLTVYVWEFGVQDSFGLHAAQCFRTVLELVTKYKCLLIYWTWFYDFRPEISDYLHGQIKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWIHSNFFRNCDMSLVNGWEVSLPTVFSGSQAVMDREERKLDFHLSTCWEVLSNSG" } }, { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76#Q8C2W3-1", "isoform_ac": "Q8C2W3-1", "locus": { "end_pos": 120786927, "start_pos": 120795498, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000100785", "id": "ENSMUST00000100785", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000098348", "id": "ENSMUSP00000098348", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q8C2W3-1|A0A0J9YV76_MOUSE Computationally mapped isoform of MCG142506, isoform CRA_b OS=Mus musculus OX=10090 GN=Oas1e PE=4 SV=1 CANONICAL=A0A0J9YV76-1", "length": 356, "sequence": "MARELFRTPIWRLDNFIEDQLLPDTTFLTELRADIDSISAFLKERCFQGATHPMRVARVVMGGSYDEHNALKGRSEANMVVFFNDLTSFEDQLKWQQVFIEEIRKHLLQLQQEKPCKLKFEVQSSEEPNTRSLTFKLCSPERQQEVEFDVQPAYDALYEGGYCKSFESINYNKVYAQLIHECTTLEKEGEFSICFTDLHQSFLRYRAPKLWNLIRLVKHWYQLCKEKLRGPLPPQYALELLTVYVWEFGVQDSFGLHAAQCFRTVLELVTKYKCLLIYWTWFYDFRPEISDYLHGQIKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWIHSNFFRNCDMSLVNGWEVSPEKQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:231699", "resource": "KEGG Pathway", "id": "mmu:231699", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8VI95-1", "protein_name": "Inactive 2'-5'-oligoadenylate synthase 1D.", "sequence": { "length": 361, "sequence": "MARELFRTPIWRLDKFIEDQLLPDTTFLTELRADIDSISAFLMERCFQGAAHPVRVSRVVMGGCYNEYTVLKGRSEANMVVFLINLTSFEDQFNGQVVFIEEIWRHLLQLQQEKLCKLKFEVQSPKEPNSRFLSFKLSCPERQHELEFDVQPAYDALYEVRHFKPFDSSNYNKVYAQLTHECTTLEKEGEFSICFTDLHQSFLRYRAPKLWNLIRLVKHWYQLCKEKLRGPLPPQYALELLTVYVWEYGIHENPGLHTAQCFRTVLELVTKYKRLRIYWTWCYDFQHEISDYLQGQIKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQIWIDSTFFTNHDMSIVEAWEVMPERQECVFL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/110815", "id": "110815", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q924S2-1", "protein_name": "Inactive 2'-5' oligoadenylate synthetase 1C; 2',5'-oligoadenylate synthetase-like 5.", "sequence": { "length": 362, "sequence": "MENGLCSIQARELDEFICDYLFPDTTFLTELRADIDSISAFLKERCFQGAAHPVRVSRVVMGGSYDEHTALKGKSEAKMVLFFNNLTSFEEQLKRRGEFVEEIQKHLCQLQQEKPFKVKFEVQSSEEPNSRSLSFKLSSPELQQEVEFDVQPAYDVLYELRNNTYAEPQFYNKVYAQLIHECTTLEKEGDFSICFTDLHQNFMRYRAPKLWNLIRLVKHWYQLCKEKLREPLPPQYALELLTVYVWEHSNKNQEKVTTAKNFRTFLELVAYYKNLRIYWTWYYDFRHQEVCAYLCRQLKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWMQSSCFRNCDMSFVPTWDLSPERQECAFQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/110815", "id": "110815", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "ac": "NP_001334379.1", "name": "2'-5' oligoadenylate synthetase 1E isoform 1; 2'-5'olygoadenylate synthetase 1E; 2'-5' oligoadenylate synthetase-like 7; 2,5-oligoadenylate synthetase-like 7.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "double-stranded RNA binding", "id": "GO:0003725" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "transferase activity", "id": "GO:0016740" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "defense response to virus", "id": "GO:0051607" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045071", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "negative regulation of viral genome replication", "id": "GO:0045071" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060700", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "regulation of ribonuclease activity", "id": "GO:0060700" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "immune response", "id": "GO:0006955" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:231699", "id": "mmu:231699", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000066867", "id": "ENSMUSG00000066867", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR038121", "id": "IPR038121", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006116", "id": "IPR006116", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026774", "id": "IPR026774", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018952", "id": "IPR018952", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF10421", "id": "PF10421", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11258", "id": "PTHR11258", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/231699", "id": "231699", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2180856", "id": "2180856", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A0A0J9YV76", "disease": [], "mass": { "monoisotopic_mass": 45299.0, "chemical_mass": 45299.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "name": "Oas1e; mCG_142506; C87484; oasl7.", "locus": { "end_pos": 120786226, "start_pos": 120795530, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000066867", "id": "ENSMUSG00000066867", "database": "Ensembl Gene" } ] } } ] }