{ "uniprot_canonical_ac": "A0A0G2QC56-1", "sequence": { "header": "tr|A0A0G2QC56-1|A0A0G2QC56_RAT Isoform 1 of Coronin OS=Rattus norvegicus OX=10116 GN=Coro2a PE=1 SV=1 CANONICAL=A0A0G2QC56-1", "length": 543, "sequence": "MWNGNSKLRPSPPLLKPNQMSWHPQYRSSKFRHVYGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKLDPHYPKVCGHRGNVLDIKWNPFDDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELMGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDSVISGPVRTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQEASYKGHRANKVLFLGNLKKLLSTGTSRWNNRQMALWDQDNLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSTEKPHLTYLTEYRSYNPQKGIGIMPKRGLDVSSCEIFRFYKLITTKSLIEPVSMIVPRRSESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRPGSELLDPQALPPERLLSNSVVQVSPQPLEPVKQPAEDGDQAPFSLLEEKVTKWTTEHQLEEKSWLTNGFDIFECPPPKTENELLQMFYRQQEEIRRLRELLIQREVQTKQLELEIKNLRMVLGQF" }, "uniprot_id": "A0A0G2QC56_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "coronin-2A", "coronin, actin binding protein 2A" ], "uniprotkb": [ "Coronin" ] }, "gene": { "refseq": [ "Coro2a" ], "uniprotkb": [ "Coro2a" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC56", "id": "A0A0G2QC56", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Coronin." }, "publication": [ { "title": "A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22114352", "journal": "Molecular biology of the cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012101.2", "id": "NP_001012101.2", "database": "RefSeq" } ], "authors": "Revenu C, Ubelmann F, Hurbain I, El-Marjou F, Dingli F, Loew D, Delacour D, Gilet J, Brot-Laroche E, Rivero F, Louvard D, Robine S", "date": "2012", "pmid": "22114352" }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC56/publications", "id": "A0A0G2QC56", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19654210", "journal": "Journal of cell science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012101.2", "id": "NP_001012101.2", "database": "RefSeq" } ], "authors": "Marshall TW, Aloor HL, Bear JE", "date": "2009", "pmid": "19654210" }, { "title": "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12628926", "journal": "The EMBO journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012101.2", "id": "NP_001012101.2", "database": "RefSeq" } ], "authors": "Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J", "date": "2003", "pmid": "12628926" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC56#A0A0G2QC56-1", "isoform_ac": "A0A0G2QC56-1", "locus": { "end_pos": 62157291, "start_pos": 62186257, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000089789", "id": "ENSRNOT00000089789", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072816", "id": "ENSRNOP00000072816", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2QC56-1|A0A0G2QC56_RAT Isoform 1 of Coronin OS=Rattus norvegicus OX=10116 GN=Coro2a PE=1 SV=1 CANONICAL=A0A0G2QC56-1", "length": 543, "sequence": "MWNGNSKLRPSPPLLKPNQMSWHPQYRSSKFRHVYGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKLDPHYPKVCGHRGNVLDIKWNPFDDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELMGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDSVISGPVRTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQEASYKGHRANKVLFLGNLKKLLSTGTSRWNNRQMALWDQDNLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSTEKPHLTYLTEYRSYNPQKGIGIMPKRGLDVSSCEIFRFYKLITTKSLIEPVSMIVPRRSESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRPGSELLDPQALPPERLLSNSVVQVSPQPLEPVKQPAEDGDQAPFSLLEEKVTKWTTEHQLEEKSWLTNGFDIFECPPPKTENELLQMFYRQQEEIRRLRELLIQREVQTKQLELEIKNLRMVLGQF" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:313235", "resource": "KEGG Pathway", "id": "rno:313235", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012101.2", "annotation": "Coronin 2A and cofilin regulate a subset of focal-adhesion-turnover events.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012101.2", "id": "NP_001012101.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q92828-1", "protein_name": "Coronin-2A; IR10; WD repeat-containing protein 2.", "sequence": { "length": 525, "sequence": "MSWHPQYRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRNLTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEASYKGHRASKVLFLGNLKKLMSTGTSRWNNRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSADKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVPRRSESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLRPGSELLRPHPLPAERPIFNSMAPASPRLLNQTEKLAAEDGWRSSSLLEEKMPRWAAEHRLEEKKTWLTNGFDVFECPPPKTENELLQMFYRQQEEIRRLRELLTQREVQAKQLELEIKNLRMGSEQL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2QC56/", "id": "A0A0G2QC56", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/2546", "id": "2546", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8C0P5-1", "protein_name": "Coronin-2A.", "sequence": { "length": 524, "sequence": "MSWHPQYRSSKFRHVYGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKLDPHYPKVCGHRGNVLDIKWNPFNDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELIGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDSVIAGPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQEASYKGHRANKVLFLGSLKKLLSTGTSRWNNRQMALWDQENLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSMEKPHLTYLTEYRSYNPQKGIGIMPKRGLDVSSCEIFRFYKLITTKSLIEPVSMIVPRRSESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRPGSELLDSQTLPPERPLSNSMVQVSPQPLEPMKQPAEDGDQAPFSLLEEKLAKWTAEHHLGEKSCLTNGFDVFECSPPKTENELLQMFYRQQEEIRRLRELLIQREVQTKQLELEIKNLRMALGQL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/2546", "id": "2546", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012101.2", "ac": "NP_001012101.2", "name": "coronin-2A; coronin, actin binding protein 2A.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC56", "id": "A0A0G2QC56", "database": "UniProtKB" } ], "name": "actin filament binding", "id": "GO:0051015" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017053", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC56", "id": "A0A0G2QC56", "database": "UniProtKB" } ], "name": "transcriptional repressor complex", "id": "GO:0017053" } ], "total": 1, "name": "Cellular Component" } ] }, "site_annotation": [ { "end_pos": 141, "annotation": "n_glycosylation_sequon", "start_pos": 139 }, { "end_pos": 212, "annotation": "n_glycosylation_sequon", "start_pos": 210 }, { "end_pos": 278, "annotation": "n_glycosylation_sequon", "start_pos": 276 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012101.2", "id": "NP_001012101.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:313235", "id": "rno:313235", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000008901", "id": "ENSRNOG00000008901", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/FDIFECP/", "id": "FDIFECP", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027335", "id": "IPR027335", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "id": "IPR019775", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015048", "id": "IPR015048", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015505", "id": "IPR015505", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00400", "id": "PF00400", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08953", "id": "PF08953", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10856:SF2", "id": "PTHR10856:SF2", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10856", "id": "PTHR10856", "database": "PANTHER" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0G2QC56*", "id": "A0A0G2QC56", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/313235", "id": "313235", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309719", "id": "1309719", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2QC56", "disease": [], "mass": { "monoisotopic_mass": 61989.0, "chemical_mass": 61989.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC56", "name": "Coro2a.", "locus": { "end_pos": 62156839, "start_pos": 62187930, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000008901", "id": "ENSRNOG00000008901", "database": "Ensembl Gene" } ] } } ] }