{
    "uniprot_canonical_ac": "A0A0G2QC40-1", 
    "sequence": {
        "header": "tr|A0A0G2QC40-1|A0A0G2QC40_RAT Isoform 1 of Makorin ring finger protein 1  OS=Rattus norvegicus OX=10116 GN=Mkrn1 PE=1 SV=1 CANONICAL=A0A0G2QC40-1", 
        "length": 481, 
        "sequence": "MAEAAAPGTTATTSGAGAAAAAVAAASLTSIPTVAAPSPGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYGVVCKYFQRGYCVYGDRCRYEHSKPLKQEEVTATDLSAKPSPAASSSLPSGVGSLAEMNPGEAESRNPNFPTVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEVPLQGSVTKEESEKEPTTVETEKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRSHFWELIEERENNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLEL"
    }, 
    "uniprot_id": "A0A0G2QC40_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "E3 ubiquitin-protein ligase makorin-1 isoform X1"
            ], 
            "uniprotkb": [
                "Makorin ring finger protein 1", 
                "RCG28025, isoform CRA_a"
            ]
        }, 
        "gene": {
            "refseq": [
                "Mkrn1"
            ], 
            "uniprotkb": [
                "Mkrn1", 
                "rCG_28025"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2QC40", 
                    "id": "A0A0G2QC40", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Makorin ring finger protein 1; RCG28025, isoform CRA_a."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2QC40#A0A0G2QC40-1", 
            "isoform_ac": "A0A0G2QC40-1", 
            "locus": {
                "end_pos": 67186606, 
                "start_pos": 67206270, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000013124", 
                        "id": "ENSRNOT00000013124", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000013124", 
                        "id": "ENSRNOP00000013124", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2QC40-1|A0A0G2QC40_RAT Isoform 1 of Makorin ring finger protein 1  OS=Rattus norvegicus OX=10116 GN=Mkrn1 PE=1 SV=1 CANONICAL=A0A0G2QC40-1", 
                "length": 481, 
                "sequence": "MAEAAAPGTTATTSGAGAAAAAVAAASLTSIPTVAAPSPGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYGVVCKYFQRGYCVYGDRCRYEHSKPLKQEEVTATDLSAKPSPAASSSLPSGVGSLAEMNPGEAESRNPNFPTVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEVPLQGSVTKEESEKEPTTVETEKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRSHFWELIEERENNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLEL"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198323", 
            "resource": "Reactome", 
            "id": "R-RNO-198323", 
            "name": "AKT phosphorylates targets in the cytosol"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948751", 
            "resource": "Reactome", 
            "id": "R-RNO-8948751", 
            "name": "Regulation of PTEN stability and activity"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", 
            "resource": "Reactome", 
            "id": "R-RNO-983168", 
            "name": "Antigen processing: Ubiquitination & Proteasome degradation"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9UHC7-1", 
            "protein_name": "E3 ubiquitin-protein ligase makorin-1; 2.3.2.27; RING finger protein 61; RING-type E3 ubiquitin transferase makorin-1.", 
            "sequence": {
                "length": 482, 
                "sequence": "MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2QC40/", 
                    "id": "A0A0G2QC40", 
                    "database": "OMA"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006236363.1", 
        "ac": "XP_006236363.1", 
        "name": "E3 ubiquitin-protein ligase makorin-1 isoform X1.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2QC40", 
                                "id": "A0A0G2QC40", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "metal ion binding", 
                        "id": "GO:0046872"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2QC40", 
                                "id": "A0A0G2QC40", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin-protein transferase activity", 
                        "id": "GO:0004842"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2QC40", 
                                "id": "A0A0G2QC40", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein polyubiquitination", 
                        "id": "GO:0000209"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 308, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 306
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006236363.1", 
            "id": "XP_006236363.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198323", 
            "id": "R-RNO-198323", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948751", 
            "id": "R-RNO-8948751", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", 
            "id": "R-RNO-983168", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000009280", 
            "id": "ENSRNOG00000009280", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/DPFETDE/", 
            "id": "DPFETDE", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR031644", 
            "id": "IPR031644", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", 
            "id": "IPR001841", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", 
            "id": "IPR013083", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", 
            "id": "IPR017907", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018957", 
            "id": "IPR018957", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571", 
            "id": "IPR000571", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036855", 
            "id": "IPR036855", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041367", 
            "id": "IPR041367", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15815", 
            "id": "PF15815", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00097", 
            "id": "PF00097", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF18044", 
            "id": "PF18044", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/296988", 
            "id": "296988", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1303251", 
            "id": "1303251", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0G2QC40", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 53088.0, 
        "chemical_mass": 53088.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2QC40", 
            "name": "Mkrn1; rCG_28025.", 
            "locus": {
                "end_pos": 67185138, 
                "start_pos": 67206426, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000009280", 
                        "id": "ENSRNOG00000009280", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}