{ "uniprot_canonical_ac": "A0A0G2QC28-1", "sequence": { "header": "tr|A0A0G2QC28-1|A0A0G2QC28_RAT Isoform 1 of NLR family, pyrin domain-containing 1A OS=Rattus norvegicus OX=10116 GN=Nlrp1a PE=4 SV=1 CANONICAL=A0A0G2QC28-1", "length": 1229, "sequence": "MEESQSKEESNTEGAQHAVESNTRVAQHGSQQDVDPTFQTKRALEKERSKPRPRPLPRVQLQSLPGWSSTSNDVPLSQLIREMDHESRRCIHRSKKKLDRSEHISQGTIPEIYEKRKETISHTQSMEQKYLFQNFTKLLLLQKCCPGGSEKLVRESWHPCVPEEGGHMIEIQDLFDPNLDTEKKPQLVIIEGAAGIGKSTLARQVKRAWDEGQLYRDRFQHVFFFSCRELAQCKQLSLAELIAQGQEVPTAPTRQILSRPEKLLFILDGIDEPAWVLEDQNPELCVHWSQAQPVHTLLGSLLGKSILPEASLMLTARTTALQKLVPSLGQPHRVEVLGFSEFERKDYFYKYFAKERNTIIDFNLIGSIPVLLTLCEVPWVCWLLCTCLEKQMQQGEVLSLTSQTTTALCLKYLSLTIPGQHLSTQLRTLCSLAAEGICQRRTLFSKSDLCKQGLAEDAIATFLKIGVLQRQPSSLSYSFAHLCLQEFFAAMSYILEDSEEAHGDMGNDRTVETLVERYGRQNLFEAPTVRFLLGLLNTREMREMENIFACKFPWETKLKLLQSIIGEPFCQPCHLGLFHCLYENQEEELLTETMLCFPLTASGPNHMEATVFQTNVKRLVIQTDMELMVVTFCITFSHVRSLRLKGKGQQEYKLTAPAMVLYRWTPISEASWKVLFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALRQPGCRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAELDLRLNDLGDNGVRQLCEGLRNPACNLSILRLDQASLSEQVITELRALETKNPKLFISSTWMSHMTMPTENTDGEESLTSSKQQQQQSGDKHMEPLGTDDDFWGPSGPVSTEVVDRERNLYRVRLPMAGSYHCPSTGLHFVVTRAVTIEIGFCAWSQFLHETPLQHSHMVAGPLFDIKAEHGAVTAVCLPHFVSLQEGKVDSSLFHVAHFQDHGMVLETPARVEPHFAVLENPSFSPMGVLLRMIPAVGHFIPITSITLIYYRLYLEDITFHLYLVPNDCTIRKAIDEEELKFQFVRINKPPPVDALYVGSRYIVSSSKEVEILPKELELCYRSPRESQLFSEIYVGNIGSGINLQLTDKKYMNLIWEALLKPGDLRPALPRMASAPKDAPALLHFVDQHREQLVARVTSVDPLLDKLHGLVLSEEDYETVRAEATNQDKMRKLFRGSRSWSWDCKDHFYQALKETHPHLIMDLLEKSGGVSVRL" }, "uniprot_id": "A0A0G2QC28_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "NLR family, pyrin domain-containing 1A" ] }, "gene": { "refseq": [], "uniprotkb": [ "Nlrp1a" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "id": "A0A0G2QC28", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "NLR family, pyrin domain-containing 1A." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28#D9I2F9-1", "isoform_ac": "D9I2F9-1", "locus": { "end_pos": 57695802, "start_pos": 57739067, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000082171", "id": "ENSRNOT00000082171", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073609", "id": "ENSRNOP00000073609", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D9I2F9-1|A0A0G2QC28_RAT Computationally mapped isoform of NLR family, pyrin domain-containing 1A OS=Rattus norvegicus OX=10116 GN=Nlrp1a PE=4 SV=1 CANONICAL=A0A0G2QC28-1", "length": 1218, "sequence": "MEESQSKQESNTRVAQHGSQQDVDPTFQTKRALEKERSKPRPRPLPRVQLQSLPGWSSTSNDVPLSQLIREMDHESRRCIHRSKKKLDRSEHISQGTIPEIYEKRKETISHTQSMEQKYLFQNFTKLLLLQKCCPGGSEKLVRESWHPCVPEEGGHMIEIQDLFDPNLDTEKKPQLVIIEGAAGIGKSTLARQVKRAWDEGQLYRDRFQHVFFFSCRELAQCKQLSLAELIAQGQEVPTAPTRQILSRPEKLLFILDGIDEPAWVLEDQNPELCVHWSQAQPVHTLLGSLLGKSILPEASLMLTARTTALQKLVPSLGQPHRVEVLGFSEFERKDYFYKYFAKERNTIIDFNLIGSIPVLLTLCEVPWVCWLLCTCLEKQMQQGEVLSLTSQTTTALCLKYLSLTIPGQHLSTQLRTLCSLAAEGICQRRTLFSKSDLCKQGLAEDAIATFLKIGVLQRQPSSLSYSFAHLCLQEFFAAMSYILEDSEEAHGDMGNDRTVETLVERYGRQNLFEAPTVRFLLGLLNTREMREMENIFACKFPWETKLKLLQSIIGEPFCQPCHLGLFHCLYENQEEELLTETMLCFPLTASGPNHMEATVFQTNVKRLVIQTDMELMVVTFCITFSHVRSLRLKGKGQQEYKLTAPAMVLYRWTPISEASWKVLFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALRQPGCRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAELDLRLNDLGDNGVRQLCEGLRNPACNLSILRLDQASLSEQVITELRALETKNPKLFISSTWMSHMTMPTENTDGEESLTSSKQQQQQSGDKHMEPLGTDDDFWGPSGPVSTEVVDRERNLYRVRLPMAGSYHCPSTGLHFVVTRAVTIEIGFCAWSQFLHETPLQHSHMVAGPLFDIKAEHGAVTAVCLPHFVSLQEGKVDSSLFHVAHFQDHGMVLETPARVEPHFAVLENPSFSPMGVLLRMIPAVGHFIPITSITLIYYRLYLEDITFHLYLVPNDCTIRKAIDEEELKFQFVRINKPPPVDALYVGSRYIVSSSKEVEILPKELELCYRSPRESQLFSEIYVGNIGSGINLQLTDKKYMNLIWEALLKPGDLRPALPRMASAPKDAPALLHFVDQHREQLVARVTSVDPLLDKLHGLVLSEEDYETVRAEATNQDKMRKLFRGSRSWSWDCKDHFYQALKETHPHLIMDLLEKSGGVSVRL" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28#A0A0G2QC28-1", "isoform_ac": "A0A0G2QC28-1", "locus": { "end_pos": 57695802, "start_pos": 57822498, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000037546", "id": "ENSRNOT00000037546", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000034130", "id": "ENSRNOP00000034130", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2QC28-1|A0A0G2QC28_RAT Isoform 1 of NLR family, pyrin domain-containing 1A OS=Rattus norvegicus OX=10116 GN=Nlrp1a PE=4 SV=1 CANONICAL=A0A0G2QC28-1", "length": 1229, "sequence": "MEESQSKEESNTEGAQHAVESNTRVAQHGSQQDVDPTFQTKRALEKERSKPRPRPLPRVQLQSLPGWSSTSNDVPLSQLIREMDHESRRCIHRSKKKLDRSEHISQGTIPEIYEKRKETISHTQSMEQKYLFQNFTKLLLLQKCCPGGSEKLVRESWHPCVPEEGGHMIEIQDLFDPNLDTEKKPQLVIIEGAAGIGKSTLARQVKRAWDEGQLYRDRFQHVFFFSCRELAQCKQLSLAELIAQGQEVPTAPTRQILSRPEKLLFILDGIDEPAWVLEDQNPELCVHWSQAQPVHTLLGSLLGKSILPEASLMLTARTTALQKLVPSLGQPHRVEVLGFSEFERKDYFYKYFAKERNTIIDFNLIGSIPVLLTLCEVPWVCWLLCTCLEKQMQQGEVLSLTSQTTTALCLKYLSLTIPGQHLSTQLRTLCSLAAEGICQRRTLFSKSDLCKQGLAEDAIATFLKIGVLQRQPSSLSYSFAHLCLQEFFAAMSYILEDSEEAHGDMGNDRTVETLVERYGRQNLFEAPTVRFLLGLLNTREMREMENIFACKFPWETKLKLLQSIIGEPFCQPCHLGLFHCLYENQEEELLTETMLCFPLTASGPNHMEATVFQTNVKRLVIQTDMELMVVTFCITFSHVRSLRLKGKGQQEYKLTAPAMVLYRWTPISEASWKVLFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALRQPGCRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAELDLRLNDLGDNGVRQLCEGLRNPACNLSILRLDQASLSEQVITELRALETKNPKLFISSTWMSHMTMPTENTDGEESLTSSKQQQQQSGDKHMEPLGTDDDFWGPSGPVSTEVVDRERNLYRVRLPMAGSYHCPSTGLHFVVTRAVTIEIGFCAWSQFLHETPLQHSHMVAGPLFDIKAEHGAVTAVCLPHFVSLQEGKVDSSLFHVAHFQDHGMVLETPARVEPHFAVLENPSFSPMGVLLRMIPAVGHFIPITSITLIYYRLYLEDITFHLYLVPNDCTIRKAIDEEELKFQFVRINKPPPVDALYVGSRYIVSSSKEVEILPKELELCYRSPRESQLFSEIYVGNIGSGINLQLTDKKYMNLIWEALLKPGDLRPALPRMASAPKDAPALLHFVDQHREQLVARVTSVDPLLDKLHGLVLSEEDYETVRAEATNQDKMRKLFRGSRSWSWDCKDHFYQALKETHPHLIMDLLEKSGGVSVRL" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-844455", "resource": "Reactome", "id": "R-RNO-844455", "name": "The NLRP1 inflammasome" } ], "function": [], "orthologs": [], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097110", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "id": "A0A0G2QC28", "database": "UniProtKB" } ], "name": "scaffold protein binding", "id": "GO:0097110" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "id": "A0A0G2QC28", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "id": "A0A0G2QC28", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "id": "A0A0G2QC28", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061702", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "id": "A0A0G2QC28", "database": "UniProtKB" } ], "name": "inflammasome complex", "id": "GO:0061702" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043280", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "id": "A0A0G2QC28", "database": "UniProtKB" } ], "name": "positive regulation of cysteine-type endopeptidase activity involved in apoptotic process", "id": "GO:0043280" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006919", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "id": "A0A0G2QC28", "database": "UniProtKB" } ], "name": "activation of cysteine-type endopeptidase activity involved in apoptotic process", "id": "GO:0006919" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050718", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "id": "A0A0G2QC28", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-1 beta secretion", "id": "GO:0050718" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "id": "A0A0G2QC28", "database": "UniProtKB" } ], "name": "inflammatory response", "id": "GO:0006954" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "id": "A0A0G2QC28", "database": "UniProtKB" } ], "name": "innate immune response", "id": "GO:0045087" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 136, "annotation": "n_glycosylation_sequon", "start_pos": 134 }, { "end_pos": 772, "annotation": "n_glycosylation_sequon", "start_pos": 770 } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-844455", "id": "R-RNO-844455", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000023143", "id": "ENSRNOG00000023143", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/YFTEESQ/", "id": "YFTEESQ", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08330", "id": "cd08330", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "id": "IPR011029", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "id": "IPR001611", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "id": "IPR032675", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001315", "id": "IPR001315", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033516", "id": "IPR033516", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007111", "id": "IPR007111", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR025307", "id": "IPR025307", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041075", "id": "IPR041075", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041267", "id": "IPR041267", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF13516", "id": "PF13516", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00619", "id": "PF00619", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13553", "id": "PF13553", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF05729", "id": "PF05729", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17776", "id": "PF17776", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17779", "id": "PF17779", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310963", "id": "1310963", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2QC28", "disease": [], "mass": { "monoisotopic_mass": 139517.0, "chemical_mass": 139517.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC28", "name": "Nlrp1a.", "locus": { "end_pos": 57692474, "start_pos": 57822498, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000023143", "id": "ENSRNOG00000023143", "database": "Ensembl Gene" } ] } } ] }