{ "uniprot_canonical_ac": "A0A0G2QC02-1", "sequence": { "header": "tr|A0A0G2QC02-1|A0A0G2QC02_RAT Isoform 1 of Ski2-like RNA helicase OS=Rattus norvegicus OX=10116 GN=Skiv2l PE=1 SV=1 CANONICAL=A0A0G2QC02-1", "length": 1244, "sequence": "MMETERLVLPPPDPLNLPLRALEVGCTGRWELLNVPGPPESTLPHGLPPCAPDLCQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAALGTPVPSDLQAQRHPTTGHILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPSITDLSTREEAEEEIDFEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLSLSRLLEPLDLSGGDEGEGEAAGGPRGDAASASPSSTPLIRASSLEDLVLKEASTVVSTLEPLKPPPQEQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLEQHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLALLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLRRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALADLTKRLGALEEPDVTGQLADLPEYYSWAEELTETRNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVILQVSSNSTSRVFTTLVLCDKPAVSENPRDKGPATPDVPHPDDLVGFKLFLPEGPCEHTVAKLQPGDVAAISTKVLRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQAYPAGPPTLDPINDLQLKDVAVVEGGLRARKLEELIRGAQCVHSPRFPAQYVKLQERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSALRPEEIAALLSGLVCQSPGDPGDQLPSTLKQGVERVKAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ" }, "uniprot_id": "A0A0G2QC02_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "helicase SKI2W isoform X1" ], "uniprotkb": [ "Ski2-like RNA helicase" ] }, "gene": { "refseq": [ "Skiv2l" ], "uniprotkb": [ "Skiv2l" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC02", "id": "A0A0G2QC02", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Ski2-like RNA helicase." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC02/publications", "id": "A0A0G2QC02", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC02#A0A0G2QC02-1", "isoform_ac": "A0A0G2QC02-1", "locus": { "end_pos": 4519616, "start_pos": 4530088, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000000481", "id": "ENSRNOT00000000481", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000000481", "id": "ENSRNOP00000000481", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2QC02-1|A0A0G2QC02_RAT Isoform 1 of Ski2-like RNA helicase OS=Rattus norvegicus OX=10116 GN=Skiv2l PE=1 SV=1 CANONICAL=A0A0G2QC02-1", "length": 1244, "sequence": "MMETERLVLPPPDPLNLPLRALEVGCTGRWELLNVPGPPESTLPHGLPPCAPDLCQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAALGTPVPSDLQAQRHPTTGHILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPSITDLSTREEAEEEIDFEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLSLSRLLEPLDLSGGDEGEGEAAGGPRGDAASASPSSTPLIRASSLEDLVLKEASTVVSTLEPLKPPPQEQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLEQHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLALLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLRRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALADLTKRLGALEEPDVTGQLADLPEYYSWAEELTETRNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVILQVSSNSTSRVFTTLVLCDKPAVSENPRDKGPATPDVPHPDDLVGFKLFLPEGPCEHTVAKLQPGDVAAISTKVLRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQAYPAGPPTLDPINDLQLKDVAVVEGGLRARKLEELIRGAQCVHSPRFPAQYVKLQERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSALRPEEIAALLSGLVCQSPGDPGDQLPSTLKQGVERVKAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-429958", "resource": "Reactome", "id": "R-RNO-429958", "name": "mRNA decay by 3' to 5' exoribonuclease" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q15477-1", "protein_name": "Helicase SKI2W; Ski2; 3.6.4.-; Helicase-like protein; HLP.", "sequence": { "length": 1246, "sequence": "MMETERLVLPPPDPLDLPLRAVELGCTGHWELLNLPGAPESSLPHGLPPCAPDLQQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAVLGAPVPSDLQAQRHPTTGQILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPTITDLNTREEAEEEIDFEKDLLTIPPGFKKGMDFAPKDCPTPAPGLLSLSCMLEPLDLGGGDEDENEAVGQPGGPRGDTVSASPCSAPLARASSLEDLVLKEASTAVSTPEAPEPPSQEQWAIPVDATSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDVERGVVWEEVLIMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALAELTKRLGALEEPDMTGQLVDLPEYYSWGEELTETQHMIQRRIMESVNGLKSLSAGRVVVVKNQEHHNALGVILQVSSNSTSRVFTTLVLCDKPLSQDPQDRGPATAEVPYPDDLVGFKLFLPEGPCDHTVVKLQPGDMAAITTKVLRVNGEKILEDFSKRQQPKFKKDPPLAAVTTAVQELLRLAQAHPAGPPTLDPVNDLQLKDMSVVEGGLRARKLEELIQGAQCVHSPRFPAQYLKLRERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSTLRPEEIAALLSGLVCQSPGDAGDQLPNTLKQGIERVRAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/123971", "id": "123971", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q6NZR5-1", "protein_name": "Superkiller viralicidic activity 2-like (S. cerevisiae).", "sequence": { "length": 1244, "sequence": "MMETERLVLPPLDPLNLPLRALEVGCTGRWELLNVPGPPESTLPHGLPPCAPDLCQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAAVETPVPSDLQAQRHPTTGHILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPSITDLHTREEAEEEIDFEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLSLSRLLEPLDLSGGDEDEGEAAGGPRGDNASPSPSGTPLVRASSLEDLVLKEAATVVSTPEPPKPPPQEQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLEQHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTQGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLRRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALADLTKRLGALEEPDVTGQLADLPEYYSWAEELTETQNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVILQVSSNSTSRVFTTLVLCDKPVVSDNPRDKGPATPDVPHPDDLIGFKLFLPEGPCEHTVAKLQPGDVAAISTKVLRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQSYPAGPPTLDPINDLQLKDVAVVEGGLRARKLEELIRGAQCVHSPRFPAQYVKLRERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSALRPEEIAALLSGLVCQSPGDPGDQLPSTLKQGVERVKAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/123971", "id": "123971", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2QC02/", "id": "A0A0G2QC02", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255985.1", "ac": "XP_006255985.1", "name": "helicase SKI2W isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC02", "id": "A0A0G2QC02", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC02", "id": "A0A0G2QC02", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC02", "id": "A0A0G2QC02", "database": "UniProtKB" } ], "name": "RNA helicase activity", "id": "GO:0003724" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055087", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC02", "id": "A0A0G2QC02", "database": "UniProtKB" } ], "name": "Ski complex", "id": "GO:0055087" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070478", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC02", "id": "A0A0G2QC02", "database": "UniProtKB" } ], "name": "nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay", "id": "GO:0070478" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006401", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC02", "id": "A0A0G2QC02", "database": "UniProtKB" } ], "name": "RNA catabolic process", "id": "GO:0006401" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 127, "annotation": "n_glycosylation_sequon", "start_pos": 125 }, { "end_pos": 864, "annotation": "n_glycosylation_sequon", "start_pos": 862 }, { "end_pos": 1155, "annotation": "n_glycosylation_sequon", "start_pos": 1153 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255985.1", "id": "XP_006255985.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-429958", "id": "R-RNO-429958", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000000421", "id": "ENSRNOG00000000421", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/FLKHFAM/", "id": "FLKHFAM", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016438", "id": "IPR016438", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR025696", "id": "IPR025696", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "id": "IPR001650", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "id": "IPR011545", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "id": "IPR014001", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012961", "id": "IPR012961", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR040801", "id": "IPR040801", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF13234", "id": "PF13234", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00270", "id": "PF00270", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00271", "id": "PF00271", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08148", "id": "PF08148", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17911", "id": "PF17911", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/294260", "id": "294260", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1303059", "id": "1303059", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2QC02", "disease": [], "mass": { "monoisotopic_mass": 137305.0, "chemical_mass": 137305.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC02", "name": "Skiv2l.", "locus": { "end_pos": 4519474, "start_pos": 4530126, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000000421", "id": "ENSRNOG00000000421", "database": "Ensembl Gene" } ] } } ] }