{ "uniprot_canonical_ac": "A0A0G2KB67-1", "sequence": { "header": "tr|A0A0G2KB67-1|A0A0G2KB67_RAT Isoform 1 of Acid phosphatase 4 OS=Rattus norvegicus OX=10116 GN=Acp4 PE=3 SV=1 CANONICAL=A0A0G2KB67-1", "length": 378, "sequence": "MHHWRSPVLCSVLRLETQGTYMVFRHGDRAPLASYPTDPHKEAASTLWPRGLGQLTKEGIRQQLELGRFLRRRYKAFLSPEYRREEVYIRSTDFDRTLESAQANLAGLFPEAAPGSPEADWKPIPVHTVPVSEDKLLRFPMRSCPRYHELLRESTEAADYQEALEGWTDFLTRLGNFTGLSLVGEPLRRAWKVLDTLICQRAHGLALPSWASPDVLRTLSQISALDIRAHVGPPRAAEKAQLTGGILLDAILSNFSRAQRLGLPLKMVMYSAHDSTLLALQGALGLYDGNTPPYAACMAFEFRGSSREPEEEDGENVTVSLIYRNDTSRPPLPLRVPGCPAPCPLGRFQQLTAPARPPAHGAPCHGSYEPASPPGGNL" }, "uniprot_id": "A0A0G2KB67_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "testicular acid phosphatase isoform X4" ], "uniprotkb": [ "Acid phosphatase 4" ] }, "gene": { "refseq": [ "Acpt" ], "uniprotkb": [ "Acp4", "Acpt" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67", "id": "A0A0G2KB67", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Acid phosphatase 4." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67#D4AD24-1", "isoform_ac": "D4AD24-1", "locus": { "end_pos": 100227581, "start_pos": 100229707, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000032200", "id": "ENSRNOT00000032200", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000038370", "id": "ENSRNOP00000038370", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4AD24-1|A0A0G2KB67_RAT Computationally mapped isoform of Acid phosphatase 4 OS=Rattus norvegicus OX=10116 GN=Acp4 PE=3 SV=1 CANONICAL=A0A0G2KB67-1", "length": 271, "sequence": "MRSCPRYHELLRESTEAADYQEALEGWTDFLTRLGNFTGLSLVGEPLRRAWKVLDTLICQRAHGLALPSWASPDVLRTLSQISALDIRAHVGPPRAAEKAQLTGGILLDAILSNFSRAQRLGLPLKMVMYSAHDSTLLALQGALGLYDGNTPPYAACMAFEFRGSSREPEEEDGENVTVSLIYRNDTSRPPLPLRVPGCPAPCPLGRFQQLTAPARPPAHGAPCHGSYEPASPPATVPLLAGAVAVLAVLSLGLGLLAWRPSCLRALGGVV" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67#A0A0G2KB67-1", "isoform_ac": "A0A0G2KB67-1", "locus": { "end_pos": 100227359, "start_pos": 100233952, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000079199", "id": "ENSRNOT00000079199", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075674", "id": "ENSRNOP00000075674", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KB67-1|A0A0G2KB67_RAT Isoform 1 of Acid phosphatase 4 OS=Rattus norvegicus OX=10116 GN=Acp4 PE=3 SV=1 CANONICAL=A0A0G2KB67-1", "length": 378, "sequence": "MHHWRSPVLCSVLRLETQGTYMVFRHGDRAPLASYPTDPHKEAASTLWPRGLGQLTKEGIRQQLELGRFLRRRYKAFLSPEYRREEVYIRSTDFDRTLESAQANLAGLFPEAAPGSPEADWKPIPVHTVPVSEDKLLRFPMRSCPRYHELLRESTEAADYQEALEGWTDFLTRLGNFTGLSLVGEPLRRAWKVLDTLICQRAHGLALPSWASPDVLRTLSQISALDIRAHVGPPRAAEKAQLTGGILLDAILSNFSRAQRLGLPLKMVMYSAHDSTLLALQGALGLYDGNTPPYAACMAFEFRGSSREPEEEDGENVTVSLIYRNDTSRPPLPLRVPGCPAPCPLGRFQQLTAPARPPAHGAPCHGSYEPASPPGGNL" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "D3YTS9-1", "protein_name": "Testicular acid phosphatase; 3.1.3.2; Acid phosphatase 4.", "sequence": { "length": 425, "sequence": "MAEPGSQGHTVGPLLLLLLLLLPRALPEGPLLFVALVFRHGDRAPLASYPTDPHKEAASTLWPRGLGQLTKEGIRQQLELGRFLRRRYKAFLSPEYKREEVYIRSTDFDRTLESAQANLAGLFPEAAPGSPETDWKPIPVHTVPVSEDKLLRFPMRSCPRYHELLRESTEAADYQEALEGWTDFLTRLGNFTGLSLVGEPLRRAWKVLDTLICQRAHGLDLPSWASPDVLRTLSQISALDIRAHVGPPRAAEKAQLTGGILLDAILSNFSRTQRLGLPLKMVMYSAHDSTLLALQGALGLYDGNTPPYAACMAFEFRGSSREPEEEDGENVTVSLIYRNDTSRPPLPLRVPGCPAPCPLGRFQQLTAPARPPAHGAPCHGSYEPASPPATVPLLAGAVAVLAVLSLGLGLLAWRPRCLRALGGTV" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2KB67/", "id": "A0A0G2KB67", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/57200", "id": "57200", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9BZG2-1", "protein_name": "Testicular acid phosphatase; 3.1.3.2; Acid phosphatase 4.", "sequence": { "length": 426, "sequence": "MAGLGFWGHPAGPLLLLLLLVLPPRALPEGPLVFVALVFRHGDRAPLASYPMDPHKEVASTLWPRGLGQLTTEGVRQQLELGRFLRSRYEAFLSPEYRREEVYIRSTDFDRTLESAQANLAGLFPEAAPGSPEARWRPIPVHTVPVAEDKLLRFPMRSCPRYHELLREATEAAEYQEALEGWTGFLSRLENFTGLSLVGEPLRRAWKVLDTLMCQQAHGLPLPAWASPDVLRTLAQISALDIGAHVGPPRAAEKAQLTGGILLNAILANFSRVQRLGLPLKMVMYSAHDSTLLALQGALGLYDGHTPPYAACLGFEFRKHLGNPAKDGGNVTVSLFYRNDSAHLPLPLSLPGCPAPCPLGRFYQLTAPARPPAHGVSCHGPYEAAIPPAPVVPLLAGAVAVLVALSLGLGLLAWRPGCLRALGGPV" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2KB67/", "id": "A0A0G2KB67", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/57200", "id": "57200", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008757590.1", "ac": "XP_008757590.1", "name": "testicular acid phosphatase isoform X4.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67", "id": "A0A0G2KB67", "database": "UniProtKB" } ], "name": "receptor tyrosine kinase binding", "id": "GO:0030971" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67", "id": "A0A0G2KB67", "database": "UniProtKB" } ], "name": "protein tyrosine phosphatase activity", "id": "GO:0004725" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67", "id": "A0A0G2KB67", "database": "UniProtKB" } ], "name": "postsynaptic membrane", "id": "GO:0045211" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010977", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67", "id": "A0A0G2KB67", "database": "UniProtKB" } ], "name": "negative regulation of neuron projection development", "id": "GO:0010977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042476", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67", "id": "A0A0G2KB67", "database": "UniProtKB" } ], "name": "odontogenesis", "id": "GO:0042476" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048168", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67", "id": "A0A0G2KB67", "database": "UniProtKB" } ], "name": "regulation of neuronal synaptic plasticity", "id": "GO:0048168" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990264", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67", "id": "A0A0G2KB67", "database": "UniProtKB" } ], "name": "peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity", "id": "GO:1990264" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010955", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67", "id": "A0A0G2KB67", "database": "UniProtKB" } ], "name": "negative regulation of protein processing", "id": "GO:0010955" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120154", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67", "id": "A0A0G2KB67", "database": "UniProtKB" } ], "name": "negative regulation of ERBB4 signaling pathway", "id": "GO:0120154" } ], "total": 6, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 178, "annotation": "n_glycosylation_sequon", "start_pos": 176 }, { "end_pos": 256, "annotation": "n_glycosylation_sequon", "start_pos": 254 }, { "end_pos": 318, "annotation": "n_glycosylation_sequon", "start_pos": 316 }, { "end_pos": 327, "annotation": "n_glycosylation_sequon", "start_pos": 325 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008757590.1", "id": "XP_008757590.1", "database": "RefSeq" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000021659", "id": "ENSRNOG00000021659", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/ADWKPIP/", "id": "ADWKPIP", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07061", "id": "cd07061", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029033", "id": "IPR029033", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000560", "id": "IPR000560", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033379", "id": "IPR033379", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00328", "id": "PF00328", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/308569", "id": "308569", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308270", "id": "1308270", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2KB67", "disease": [], "mass": { "monoisotopic_mass": 41904.0, "chemical_mass": 41904.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB67", "name": "Acp4; Acpt.", "locus": { "end_pos": 100227157, "start_pos": 100234040, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000021659", "id": "ENSRNOG00000021659", "database": "Ensembl Gene" } ] } } ] }