{ "uniprot_canonical_ac": "A0A0G2KB61-1", "sequence": { "header": "tr|A0A0G2KB61-1|A0A0G2KB61_RAT Isoform 1 of Protein phosphatase 1, regulatory subunit 13B OS=Rattus norvegicus OX=10116 GN=Ppp1r13b PE=1 SV=1 CANONICAL=A0A0G2KB61-1", "length": 1085, "sequence": "MILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGGCHLAEVWRGSERPIPCDHMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGARQSQEQRTQRNVMNVPGEKHTENGVGNPRVELTLSELQDMAARQQQQIESQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQSYNGRLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSTGGFPLPGDPVKPQSLTIASSAAHGRSKSANDGNWPTLKQNSASVKSTQMAGGDWKDSGMEGTLKQGAISSQPLPLSALGATDKLGIEIGKGPPPIPGVGKPLPPSYGTYPSPGPLGPGSTSSLERRKEGSLPRPAAGPPSRQKPAPLPPAGSAPQPSSSQQIQQRISVPPSPTYPPAGPPAFPAGDGKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPPAHGTLNKSVKAVYGKPVLPSGSASPSPLPFLHGSLGTGTTQPQPPSECAEKEAEPEGPSVPGEGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFVGTLADVDNGNTNANGNLDESFPPRPTAPLPDELAPSSDANDNELPSPEPEELICPQTTHQTAEPTEDNNNNVATVPSTEQIPSPVAEAPSEEDQVPPAPLSPVVHPPTASASKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGIVYALWDYEAQNNDELSFHEGDAITILRRKDENETEWWWARLGDREGYVPKNLLGLYPRIKPRQRTLA" }, "uniprot_id": "A0A0G2KB61_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Protein phosphatase 1, regulatory subunit 13B" ] }, "gene": { "refseq": [], "uniprotkb": [ "Ppp1r13b" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Protein phosphatase 1, regulatory subunit 13B." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61/publications", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61#A0A0G2KB61-1", "isoform_ac": "A0A0G2KB61-1", "locus": { "end_pos": 136398719, "start_pos": 136436620, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000082600", "id": "ENSRNOT00000082600", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075666", "id": "ENSRNOP00000075666", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KB61-1|A0A0G2KB61_RAT Isoform 1 of Protein phosphatase 1, regulatory subunit 13B OS=Rattus norvegicus OX=10116 GN=Ppp1r13b PE=1 SV=1 CANONICAL=A0A0G2KB61-1", "length": 1085, "sequence": "MILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGGCHLAEVWRGSERPIPCDHMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGARQSQEQRTQRNVMNVPGEKHTENGVGNPRVELTLSELQDMAARQQQQIESQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQSYNGRLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSTGGFPLPGDPVKPQSLTIASSAAHGRSKSANDGNWPTLKQNSASVKSTQMAGGDWKDSGMEGTLKQGAISSQPLPLSALGATDKLGIEIGKGPPPIPGVGKPLPPSYGTYPSPGPLGPGSTSSLERRKEGSLPRPAAGPPSRQKPAPLPPAGSAPQPSSSQQIQQRISVPPSPTYPPAGPPAFPAGDGKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPPAHGTLNKSVKAVYGKPVLPSGSASPSPLPFLHGSLGTGTTQPQPPSECAEKEAEPEGPSVPGEGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFVGTLADVDNGNTNANGNLDESFPPRPTAPLPDELAPSSDANDNELPSPEPEELICPQTTHQTAEPTEDNNNNVATVPSTEQIPSPVAEAPSEEDQVPPAPLSPVVHPPTASASKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGIVYALWDYEAQNNDELSFHEGDAITILRRKDENETEWWWARLGDREGYVPKNLLGLYPRIKPRQRTLA" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61#D4A6A8-1", "isoform_ac": "D4A6A8-1", "locus": { "end_pos": 136398719, "start_pos": 136436620, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000067118", "id": "ENSRNOT00000067118", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000059338", "id": "ENSRNOP00000059338", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4A6A8-1|A0A0G2KB61_RAT Computationally mapped isoform of Protein phosphatase 1, regulatory subunit 13B OS=Rattus norvegicus OX=10116 GN=Ppp1r13b PE=1 SV=1 CANONICAL=A0A0G2KB61-1", "length": 1042, "sequence": "MILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGGCHLAEVWRGSERPIPCDHMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGARQSQEQRTQRNVMNVPGEKHTENGEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQSYNGRLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKKIQAPEPCEWDIITTVTPEHIRPGRCCGSLYPGDPVKPQSLTIASSAAHGRSKSANDGNWPTLKQNSASVKSTQMAGGDWKDSGMEGTLKQGAISSQPLPLSALGATDKLGIEIGKGPPPIPGVGKPLPPSYGTYPSPGPLGPGSTSSLERRKEGSLPRPAAGPPSRQKPAPLPPAGSAPQPSSSQQIQQRISVPPSPTYPPAGPPAFPAGDGKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPPAHGTLNKSVKAVYGKPVLPSGSASPSPLPFLHGSLGTGTTQPQPPSECAEKEAEPEGPSVPGEGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFVGTLADVDNGNTNANGNLDESFPPRPTAPLPDELAPSSDANDNELPSPEPEELICPQTTHQTAEPTEDNNNNVATVPSTEQIPSPVAEAPSEEDQVPPAPLSPVVHPPTASASKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGIVYALWDYEAQNNDELSFHEGDAITILRRKDENETEWWWARLGDREGYVPKNLLGLYPRIKPRQRTLA" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804759", "resource": "Reactome", "id": "R-RNO-6804759", "name": "Regulation of TP53 Activity through Association with Co-factors" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q96KQ4-1", "protein_name": "Apoptosis-stimulating of p53 protein 1; Protein phosphatase 1 regulatory subunit 13B.", "sequence": { "length": 1090, "sequence": "MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDHMMYEHLQKWGPRREEVKFFLRHEDSPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYVPKNLLGLYPRIKPRQRTLA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2KB61/", "id": "A0A0G2KB61", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "name": "p53 binding", "id": "GO:0002039" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "name": "transcription factor binding", "id": "GO:0008134" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901216", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "name": "positive regulation of neuron death", "id": "GO:1901216" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072332", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "name": "intrinsic apoptotic signaling pathway by p53 class mediator", "id": "GO:0072332" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045786", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "id": "A0A0G2KB61", "database": "UniProtKB" } ], "name": "negative regulation of cell cycle", "id": "GO:0045786" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 208, "annotation": "n_glycosylation_sequon", "start_pos": 206 }, { "end_pos": 327, "annotation": "n_glycosylation_sequon", "start_pos": 325 }, { "end_pos": 573, "annotation": "n_glycosylation_sequon", "start_pos": 571 }, { "end_pos": 600, "annotation": "n_glycosylation_sequon", "start_pos": 598 }, { "end_pos": 1052, "annotation": "n_glycosylation_sequon", "start_pos": 1050 } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804759", "id": "R-RNO-6804759", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012653", "id": "ENSRNOG00000012653", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/VYLQQAT/", "id": "VYLQQAT", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "id": "IPR001452", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "id": "IPR002110", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020683", "id": "IPR020683", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "id": "IPR029071", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "id": "IPR036028", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "id": "IPR036770", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028319", "id": "IPR028319", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00018", "id": "PF00018", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12796", "id": "PF12796", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24131:SF5", "id": "PTHR24131:SF5", "database": "PANTHER" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304651", "id": "1304651", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2KB61", "disease": [], "mass": { "monoisotopic_mass": 118754.0, "chemical_mass": 118754.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB61", "name": "Ppp1r13b.", "locus": { "end_pos": 136398518, "start_pos": 136436818, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000012653", "id": "ENSRNOG00000012653", "database": "Ensembl Gene" } ] } } ] }