{ "uniprot_canonical_ac": "A0A0G2KB52-1", "sequence": { "header": "tr|A0A0G2KB52-1|A0A0G2KB52_RAT Isoform 1 of Microtubule-associated protein 7 OS=Rattus norvegicus OX=10116 GN=Map7 PE=1 SV=1 CANONICAL=A0A0G2KB52-1", "length": 751, "sequence": "MPGSATAIRQERLKTTHSRTIPLVLFTINEEDELQKNGNSRRPKASDGYKIQGKRPAPSRPTSTLSGQTSNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAARETVWLEREERARQHYERHLEARKKKLEDQRLKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKYNRWSWGSPLHGSSSIHSGDPDRRSVSTMNLSKHVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVSRLLTPTHSFLARSKSTAALSGDTASCSPITTPFKTAHSRNPVDRPKLFITPPEGSARRRTIHGISSYKREREHIPFHVSPGVRRTLSPSNLKARSPAPARLWPPSKSMPHLPGTPRPASSLTPGPVRAAASSSSPGNIRPVKREVKVEPEKKDPEKKVTNDPTIKGRVPLVKVEEGTVEEGTPVKPPDPGKNGPAAVPAPTPATDPAPAPPSPSSVSVGVIPKTSAGTTDPEEATRLLAEKRRLAREQREKEERERKEKEELERQKIEELARRVAEERSRREEEARRLEAEQARKREELALRLAEEERERWEREEVERAQKQKEEEARAREEAEKARQEREKHFQKEEQERLERKKRLEEIMRRTRRTETADKKTTGQSNGDMVKGVLAGETEVSALPGVNSPGHVESAGSTHGVALQQSKVTIESSPDLEKQPNENGMSTQNENFEEIINLPVGSKASRLDVSNENPEIPLKPILAFNDEGTLGPLPQVDGVQTQQTTEVI" }, "uniprot_id": "A0A0G2KB52_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "ensconsin isoform 1", "ensconsin" ], "uniprotkb": [ "Microtubule-associated protein 7" ] }, "gene": { "refseq": [ "Map7", "Mtap7" ], "uniprotkb": [ "Map7", "Mtap7" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB52", "id": "A0A0G2KB52", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Microtubule-associated protein 7." }, "publication": [ { "title": "MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30132755", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099740.2", "id": "NP_001099740.2", "database": "RefSeq" } ], "authors": "Tymanskyj SR, Yang BH, Verhey KJ, Ma L", "date": "2018", "pmid": "30132755" }, { "title": "MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglion Neurons.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28069923", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099740.2", "id": "NP_001099740.2", "database": "RefSeq" } ], "authors": "Tymanskyj SR, Yang B, Falnikar A, Lepore AC, Ma L", "date": "2017", "pmid": "28069923" }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB52/publications", "id": "A0A0G2KB52", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18308723", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099740.2", "id": "NP_001099740.2", "database": "RefSeq" } ], "authors": "Rabionet M, van der Spoel AC, Chuang CC, von Tumpling-Radosta B, Litjens M, Bouwmeester D, Hellbusch CC, Korner C, Wiegandt H, Gorgas K, Platt FM, Grone HJ, Sandhoff R", "date": "2008", "pmid": "18308723" }, { "title": "Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4).", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14517216", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099740.2", "id": "NP_001099740.2", "database": "RefSeq" } ], "authors": "Suzuki M, Hirao A, Mizuno A", "date": "2003", "pmid": "14517216" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB52#F1MA82-1", "isoform_ac": "F1MA82-1", "locus": { "end_pos": 15620667, "start_pos": 15746589, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000017401", "id": "ENSRNOT00000017401", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000017401", "id": "ENSRNOP00000017401", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F1MA82-1|A0A0G2KB52_RAT Computationally mapped isoform of Microtubule-associated protein 7 OS=Rattus norvegicus OX=10116 GN=Map7 PE=1 SV=3 CANONICAL=A0A0G2KB52-1", "length": 648, "sequence": "MAEQGAGGDGHRGGDGATQSDPASDGYKIQGKRPAPSRPTSTLSGQTSNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAARETVWLEREERARQHYERHLEARKKKLEDQRLKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKYNRWSWGSPLHGSSSIHSGASCSPITTPFKTAHSRNPVDRPKLFITPPEGSARRRTIHGISSYKREREHIPFHVSPGVRRTLSPSNLKARSPAPARLWPPSKSMPHLPGTPRPASSLTPGPVRAAASSSSPGNIRPVKREVKVEPEKKDPEKKVTNDPTIKGRVPLVKVEEGTVEEGTPVKPPDPAVPAPTPATDPAPAPPSPSSVSVGVIPKTSAGTTDPEEATRLLAEKRRLAREQREKEERERKEKEELERQKIEELARRVAEERSRREEEARRLEAEQARKREELALRLAEEERERWEREEVERAQKQKEEEARAREEAEKARQEREKHFQKEEQERLERKKRLEEIMRRTRRTETADKKTTGQSNGDMVKGVLAGETEVSALPGVNSPGHVESAGSTHGVALQQSKVTIESSPDLEKQPNENGMSTQNENFEEIINLPVGSKASRLDVSNENPEIPLKPILAFNDEGTLGPLPQVDGVQTQQTTEVI" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB52#A0A0G2KB52-1", "isoform_ac": "A0A0G2KB52-1", "locus": { "end_pos": 15642324, "start_pos": 15746589, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000079845", "id": "ENSRNOT00000079845", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075655", "id": "ENSRNOP00000075655", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KB52-1|A0A0G2KB52_RAT Isoform 1 of Microtubule-associated protein 7 OS=Rattus norvegicus OX=10116 GN=Map7 PE=1 SV=1 CANONICAL=A0A0G2KB52-1", "length": 751, "sequence": "MPGSATAIRQERLKTTHSRTIPLVLFTINEEDELQKNGNSRRPKASDGYKIQGKRPAPSRPTSTLSGQTSNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAARETVWLEREERARQHYERHLEARKKKLEDQRLKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKYNRWSWGSPLHGSSSIHSGDPDRRSVSTMNLSKHVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVSRLLTPTHSFLARSKSTAALSGDTASCSPITTPFKTAHSRNPVDRPKLFITPPEGSARRRTIHGISSYKREREHIPFHVSPGVRRTLSPSNLKARSPAPARLWPPSKSMPHLPGTPRPASSLTPGPVRAAASSSSPGNIRPVKREVKVEPEKKDPEKKVTNDPTIKGRVPLVKVEEGTVEEGTPVKPPDPGKNGPAAVPAPTPATDPAPAPPSPSSVSVGVIPKTSAGTTDPEEATRLLAEKRRLAREQREKEERERKEKEELERQKIEELARRVAEERSRREEEARRLEAEQARKREELALRLAEEERERWEREEVERAQKQKEEEARAREEAEKARQEREKHFQKEEQERLERKKRLEEIMRRTRRTETADKKTTGQSNGDMVKGVLAGETEVSALPGVNSPGHVESAGSTHGVALQQSKVTIESSPDLEKQPNENGMSTQNENFEEIINLPVGSKASRLDVSNENPEIPLKPILAFNDEGTLGPLPQVDGVQTQQTTEVI" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:293016", "resource": "KEGG Pathway", "id": "rno:293016", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099740.2", "annotation": "MAP7 recruits kinesin-1 dynamically to microtubules, leading to alterations in organelle transport behaviors, particularly pause/speed switching. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099740.2", "id": "NP_001099740.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099740.2", "annotation": "MAP7 promotes axon collateral branch morphogenesis and neural circuit function in dorsal root ganglion neurons.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099740.2", "id": "NP_001099740.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "O88735-1", "protein_name": "Ensconsin; Epithelial microtubule-associated protein of 115 kDa; E-MAP-115; Microtubule-associated protein 7; MAP-7.", "sequence": { "length": 730, "sequence": "MAEQGAGGDGHRGGDGATHSDPASDGYKVQEKRTAPSRPTSTVSGQTSNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAARETVWLEREERARQHYERHLEARKKKLEDQRLKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPRQKSNRWSWGSPLHGSSSIHSGDPDRRSVSTMNLSKHVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVSRLLTPTHSFLARSKSTAALSGDTASCSPIIMPFKAAHSRNPVDRPKLFVTPPEGSARRRTIHGLASHKREREREHVPFHVSPGARRTLSPSNLKARSPAPARLWLPSKSMPHLPGTPRPASSLPPGSVRAASAQAPSSSPGNIRPFKREVKVEPEKKDPLPAVKSRVPLVKVEEVTVEEGTPVKPPEPAAPASAPIATPAPAPATDPAPVPAPSSTVTVGVVPKTSAGTTDPEEATRLLAEKRRLAREQREKEERERKEKEELERQKIEELARRVAEERSRREEEARRLEEEQAREKEELALRLAEEERERWEREEVERVQKQKEEEARAREEAERARQEREKHFQKEEQERLERKKRLEEIMRRTRRTETADKKTTEQRNGDIAKGVLTGEPEVPALPCMASSGNGESAESPHGVALQQSEVTTESSPDLEKQPNENGMSIQNENFEEVINLPVGSKASRLDVTNENPEIPLKPILAFNDEGTLGPLPQVDGVQTQQTAEVI" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20851", "id": "20851", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q14244-1", "protein_name": "Ensconsin; Epithelial microtubule-associated protein of 115 kDa; E-MAP-115; Microtubule-associated protein 7; MAP-7.", "sequence": { "length": 749, "sequence": "MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20851", "id": "20851", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099740.2", "ac": "NP_001099740.2", "name": "ensconsin isoform 1; ensconsin.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB52", "id": "A0A0G2KB52", "database": "UniProtKB" } ], "name": "axon", "id": "GO:0030424" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB52", "id": "A0A0G2KB52", "database": "UniProtKB" } ], "name": "microtubule cytoskeleton", "id": "GO:0015630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB52", "id": "A0A0G2KB52", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB52", "id": "A0A0G2KB52", "database": "UniProtKB" } ], "name": "microtubule cytoskeleton organization", "id": "GO:0000226" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 73, "annotation": "n_glycosylation_sequon", "start_pos": 71 }, { "end_pos": 210, "annotation": "n_glycosylation_sequon", "start_pos": 208 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099740.2", "id": "NP_001099740.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:293016", "id": "rno:293016", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012701", "id": "ENSRNOG00000012701", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/GNIRPGK/", "id": "GNIRPGK", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030707", "id": "IPR030707", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008604", "id": "IPR008604", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF05672", "id": "PF05672", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15073:SF4", "id": "PTHR15073:SF4", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/293016", "id": "293016", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308866", "id": "1308866", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2KB52", "disease": [], "mass": { "monoisotopic_mass": 84731.0, "chemical_mass": 84731.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB52", "name": "Map7; Mtap7.", "locus": { "end_pos": 15748203, "start_pos": 15620653, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000012701", "id": "ENSRNOG00000012701", "database": "Ensembl Gene" } ] } } ] }