{ "uniprot_canonical_ac": "A0A0G2KB47-1", "sequence": { "header": "tr|A0A0G2KB47-1|A0A0G2KB47_RAT Isoform 1 of EGF-like-domain, multiple 6 OS=Rattus norvegicus OX=10116 GN=Egfl6 PE=1 SV=1 CANONICAL=A0A0G2KB47-1", "length": 551, "sequence": "MQPPWGLALPLLLPWVAGGVGTSPRDYWLPALAHQPGVCHYGTKTACCYGWKRNSKGVCEAVCEPRCKFGECVGPNKCRCFPGYTGKTCSQDVNECAFKPRPCQHRCVNTHGSYKCFCLSGHMLLPDATCSNSRTCARINCQYSCEDTAEGPRCVCPSSGLRLGPNGRVCLDIDECASSKAVCPSNRRCVNTFGSYYCKCHIGFELKYISRRYDCVDINECTLNTRTCSPHANCLNTQGSFKCKCKQGYRGNGLQCSVIPEHSVKEILTAPGTIKDRIKKLLAHKHTMKKKVKLKNVTPRPTSTRAPKVNLPYSSEEGVSRGRNSGGEQKRKEERKRKRLEEEKSEKALRNEVEQERPLRGDVFSPKVNEAEDLDLVYIQRKELNSKQEHKADLNISVDCSFDLGVCDWKQDREDDFDWNPADRDNDVGYYMAVPALAGHKKNIGRLKLLLPNLTPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEETKTEDGKWKTGKVPLYQGIDTTKSVIFEAERGKGKTGEIAVDGVLLVSGLCPDDFLSEEG" }, "uniprot_id": "A0A0G2KB47_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "epidermal growth factor-like protein 6 isoform X1" ], "uniprotkb": [ "EGF-like-domain, multiple 6" ] }, "gene": { "refseq": [ "Egfl6" ], "uniprotkb": [ "Egfl6" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB47", "id": "A0A0G2KB47", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "EGF-like-domain, multiple 6." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB47/publications", "id": "A0A0G2KB47", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB47#A0A0G2KB47-1", "isoform_ac": "A0A0G2KB47-1", "locus": { "end_pos": 29431037, "start_pos": 29487942, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087621", "id": "ENSRNOT00000087621", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075650", "id": "ENSRNOP00000075650", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KB47-1|A0A0G2KB47_RAT Isoform 1 of EGF-like-domain, multiple 6 OS=Rattus norvegicus OX=10116 GN=Egfl6 PE=1 SV=1 CANONICAL=A0A0G2KB47-1", "length": 551, "sequence": "MQPPWGLALPLLLPWVAGGVGTSPRDYWLPALAHQPGVCHYGTKTACCYGWKRNSKGVCEAVCEPRCKFGECVGPNKCRCFPGYTGKTCSQDVNECAFKPRPCQHRCVNTHGSYKCFCLSGHMLLPDATCSNSRTCARINCQYSCEDTAEGPRCVCPSSGLRLGPNGRVCLDIDECASSKAVCPSNRRCVNTFGSYYCKCHIGFELKYISRRYDCVDINECTLNTRTCSPHANCLNTQGSFKCKCKQGYRGNGLQCSVIPEHSVKEILTAPGTIKDRIKKLLAHKHTMKKKVKLKNVTPRPTSTRAPKVNLPYSSEEGVSRGRNSGGEQKRKEERKRKRLEEEKSEKALRNEVEQERPLRGDVFSPKVNEAEDLDLVYIQRKELNSKQEHKADLNISVDCSFDLGVCDWKQDREDDFDWNPADRDNDVGYYMAVPALAGHKKNIGRLKLLLPNLTPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEETKTEDGKWKTGKVPLYQGIDTTKSVIFEAERGKGKTGEIAVDGVLLVSGLCPDDFLSEEG" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB47#D3Z8B8-1", "isoform_ac": "D3Z8B8-1", "locus": { "end_pos": 29431037, "start_pos": 29487942, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000068337", "id": "ENSRNOT00000068337", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000062411", "id": "ENSRNOP00000062411", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3Z8B8-1|A0A0G2KB47_RAT Computationally mapped isoform of EGF-like-domain, multiple 6 OS=Rattus norvegicus OX=10116 GN=Egfl6 PE=1 SV=3 CANONICAL=A0A0G2KB47-1", "length": 516, "sequence": "MQPPWGLALPLLLPWVAGGVGTSPRDYWLPALAHQPGVCHYGTKTACCYGWKRNSKGVCEAVCEPRCKFGECVGPNKCRCFPGYTGKTCSQDVNECAFKPRPCQHRCVNTHGSYKCFCLSGHMLLPDATCSNSRTCARINCQYSCEDTAEGPRCVCPSSGLRLGPNGRVCLDIDECASSKAVCPSNRRCVNTFGSYYCKCHIGFELKYISRRYDCVDINECTLNTRTCSPHANCLNTQGSFKCKCKQGYRGNGLQCSVIPEHSVKEILTAPGTIKDRIKKLLAHKHTMKKKVKLKNVTPRPTSTRAPKVNLPYSSEEGVSRGRNSGGEQKRKEERKRKRLEEEKSEKALRNEVEQERPLRGDVFSPKVNEAEDLDLVYIQRKELNSKQEHKDVGYYMAVPALAGHKKNIGRLKLLLPNLTPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEETKTEDGKWKTGKVPLYQGIDTTKSVIFEAERGKGKTGEIAVDGVLLVSGLCPDDFLSEEG" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8IUX8-1", "protein_name": "Epidermal growth factor-like protein 6; EGF-like protein 6; MAM and EGF domains-containing gene protein.", "sequence": { "length": 553, "sequence": "MPLPWSLALPLLLSWVAGGFGNAASARHHGLLASARQPGVCHYGTKLACCYGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTIKDRIKKLLAHKNSMKKKAKIKNVTPEPTRTPTPKVNLQPFNYEEIVSRGGNSHGGKKGNEEKMKEGLEDEKREEKALKNDIEERSLRGDVFFPKVNEAGEFGLILVQRKALTSKLEHKDLNISVDCSFNHGICDWKQDREDDFDWNPADRDNAIGFYMAVPALAGHKKDIGRLKLLLPDLQPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEKTTSEDEKWKTGKIQLYQGTDATKSIIFEAERGKGKTGEIAVDGVLLVSGLCPDSLLSVDD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/9166", "id": "9166", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9JJZ5-1", "protein_name": "Epidermal growth factor-like protein 6; EGF-like protein 6; MAM and EGF domains-containing gene protein; Protein W80.", "sequence": { "length": 550, "sequence": "MQPPWGLALPLLLPWVTGGVGTSPWDYGLSALAHQPGVCQYGTKMACCYGWKRNNKGVCEAMCEPRCKFGECVGPNKCRCFPGYTGKTCTQDVNECGVKPRPCQHRCVNTHGSYKCFCLSGHMLLPDATCSNSRTCARLNCQYGCEDTEEGPRCVCPSSGLRLGPNGRVCLDIDECASSKAVCPSNRRCVNTFGSYYCKCHIGFELKYIGRRYDCVDINECALNTHPCSPHANCLNTRGSFKCKCKQGYRGNGLQCSVIPEHSVKEILTAPGTIKDRIKKLLAHKRTMKKKVKLKMVTPRPASTRVPKVNLPYSSEEGVSRGRNYDGEQKKKEEGKRERLEEEKGEKTLRNEVEQERTLRGDVFSPKVNEAEDLDLVYVQRKELNSKLKHKDLNISVDCSFDLGVCDWKQDREDDFDWHPADRDNDVGYYMAVPALAGHKKNIGRLKLLLPNLTPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEETKNEDGRWRTGKIQLYQGIDTTKSVIFEAERGKGKTGEIAVDGVLLVSGLCPDDFLSVEG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/9166", "id": "9166", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2KB47/", "id": "A0A0G2KB47", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008771393.1", "ac": "XP_008771393.1", "name": "epidermal growth factor-like protein 6 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB47", "id": "A0A0G2KB47", "database": "UniProtKB" } ], "name": "integrin binding", "id": "GO:0005178" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB47", "id": "A0A0G2KB47", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB47", "id": "A0A0G2KB47", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB47", "id": "A0A0G2KB47", "database": "UniProtKB" } ], "name": "basement membrane", "id": "GO:0005604" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB47", "id": "A0A0G2KB47", "database": "UniProtKB" } ], "name": "extracellular matrix organization", "id": "GO:0030198" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010811", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB47", "id": "A0A0G2KB47", "database": "UniProtKB" } ], "name": "positive regulation of cell-substrate adhesion", "id": "GO:0010811" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 298, "annotation": "n_glycosylation_sequon", "start_pos": 296 }, { "end_pos": 397, "annotation": "n_glycosylation_sequon", "start_pos": 395 }, { "end_pos": 455, "annotation": "n_glycosylation_sequon", "start_pos": 453 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008771393.1", "id": "XP_008771393.1", "database": "RefSeq" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004275", "id": "ENSRNOG00000004275", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/IGFELKY/", "id": "IGFELKY", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06263", "id": "cd06263", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "id": "IPR000742", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "id": "IPR013032", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "id": "IPR000152", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "id": "IPR001881", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "id": "IPR009030", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "id": "IPR018097", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "id": "IPR013320", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000998", "id": "IPR000998", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032930", "id": "IPR032930", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF07645", "id": "PF07645", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00629", "id": "PF00629", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24050:SF24", "id": "PTHR24050:SF24", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/317470", "id": "317470", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1563321", "id": "1563321", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2KB47", "disease": [], "mass": { "monoisotopic_mass": 61542.0, "chemical_mass": 61542.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB47", "name": "Egfl6.", "locus": { "end_pos": 29488739, "start_pos": 29430831, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000004275", "id": "ENSRNOG00000004275", "database": "Ensembl Gene" } ] } } ] }