{ "uniprot_canonical_ac": "A0A0G2KAU4-1", "sequence": { "header": "tr|A0A0G2KAU4-1|A0A0G2KAU4_RAT Isoform 1 of RAS guanyl-releasing protein 3 OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=4 SV=1 CANONICAL=A0A0G2KAU4-1", "length": 691, "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG" }, "uniprot_id": "A0A0G2KAU4_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "ras guanyl-releasing protein 3 isoform X1" ], "uniprotkb": [ "RAS guanyl-releasing protein 3" ] }, "gene": { "refseq": [ "Rasgrp3" ], "uniprotkb": [ "Rasgrp3" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "RAS guanyl-releasing protein 3." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4#A0A0G2KAU4-1", "isoform_ac": "A0A0G2KAU4-1", "locus": { "end_pos": 21074806, "start_pos": 21109640, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000079819", "id": "ENSRNOT00000079819", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075529", "id": "ENSRNOP00000075529", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KAU4-1|A0A0G2KAU4_RAT Isoform 1 of RAS guanyl-releasing protein 3 OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=4 SV=1 CANONICAL=A0A0G2KAU4-1", "length": 691, "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4#D3ZZN2-1", "isoform_ac": "D3ZZN2-1", "locus": { "end_pos": 21074806, "start_pos": 21109640, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000051239", "id": "ENSRNOT00000051239", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000051116", "id": "ENSRNOP00000051116", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZZN2-1|A0A0G2KAU4_RAT Computationally mapped isoform of RAS guanyl-releasing protein 3 OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=4 SV=1 CANONICAL=A0A0G2KAU4-1", "length": 603, "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVELWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5673001", "resource": "Reactome", "id": "R-RNO-5673001", "name": "RAF/MAP kinase cascade" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169092", "resource": "Reactome", "id": "R-RNO-1169092", "name": "Activation of RAS in B cells" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q6NZH9-1", "protein_name": "RAS, guanyl-releasing protein 3.", "sequence": { "length": 691, "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGDLNDSYLPRIVLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGHEKHISLMDISSVPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPGSLPGSPALPPVQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPTVQAGVDVVDRGTAFEPDQDDGQDEAKQGGEDG" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2KAU4/", "id": "A0A0G2KAU4", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/15019", "id": "15019", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q8IV61-1", "protein_name": "Ras guanyl-releasing protein 3; Calcium and DAG-regulated guanine nucleotide exchange factor III; Guanine nucleotide exchange factor for Rap1.", "sequence": { "length": 690, "sequence": "MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVHAGVDVVDRGTEFELDQDEGEETRQDGEDG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/15019", "id": "15019", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006239819.1", "ac": "XP_006239819.1", "name": "ras guanyl-releasing protein 3 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "GTPase activator activity", "id": "GO:0005096" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "kinase binding", "id": "GO:0019900" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005088", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "Ras guanyl-nucleotide exchange factor activity", "id": "GO:0005088" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032045", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "guanyl-nucleotide exchange factor complex", "id": "GO:0032045" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "Ras protein signal transduction", "id": "GO:0007265" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 32, "annotation": "n_glycosylation_sequon", "start_pos": 30 }, { "end_pos": 63, "annotation": "n_glycosylation_sequon", "start_pos": 61 }, { "end_pos": 347, "annotation": "n_glycosylation_sequon", "start_pos": 345 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006239819.1", "id": "XP_006239819.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5673001", "id": "R-RNO-5673001", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169092", "id": "R-RNO-1169092", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000032703", "id": "ENSRNOG00000032703", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/WENEKPS/", "id": "WENEKPS", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06224", "id": "cd06224", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "id": "cd00051", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00029", "id": "cd00029", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00155", "id": "cd00155", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029645", "id": "IPR029645", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000651", "id": "IPR000651", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "id": "IPR002048", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "id": "IPR011992", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "id": "IPR018247", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002219", "id": "IPR002219", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020454", "id": "IPR020454", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008937", "id": "IPR008937", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001895", "id": "IPR001895", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023578", "id": "IPR023578", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036964", "id": "IPR036964", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00130", "id": "PF00130", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00617", "id": "PF00617", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13202", "id": "PF13202", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113:SF178", "id": "PTHR23113:SF178", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113", "id": "PTHR23113", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/313874", "id": "313874", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304612", "id": "1304612", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2KAU4", "disease": [], "mass": { "monoisotopic_mass": 78529.0, "chemical_mass": 78529.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "name": "Rasgrp3.", "locus": { "end_pos": 21072634, "start_pos": 21135880, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000032703", "id": "ENSRNOG00000032703", "database": "Ensembl Gene" } ] } } ] }