{
    "uniprot_canonical_ac": "A0A0G2KA94-1", 
    "sequence": {
        "header": "tr|A0A0G2KA94-1|A0A0G2KA94_RAT Isoform 1 of Tyrosine-protein kinase  OS=Rattus norvegicus OX=10116 GN=Tec PE=1 SV=1 CANONICAL=A0A0G2KA94-1", 
        "length": 674, 
        "sequence": "MGLVSACQTPGSAVWPALSPVLCQHALGQESRDLQWQEKEQQKTEMNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLTYYEGRAEKKYRKGFIDISKIKCVEIVKNDDGIIPCQNKFPFQVVHDANTLYIFAPSPQSRDRWVKKLKEEIKNNNNIMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDTHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLPRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEETFGR"
    }, 
    "uniprot_id": "A0A0G2KA94_RAT", 
    "enzyme_annotation": [
        {
            "ec": "2.7.10.2", 
            "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate."
        }, 
        {
            "ec": "2.7.10.2", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "Tyrosine-protein kinase", 
                "2.7.10.2"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "Tec"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                    "id": "A0A0G2KA94", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Tyrosine-protein kinase; 2.7.10.2."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2KA94#A0A0G2KA94-1", 
            "isoform_ac": "A0A0G2KA94-1", 
            "locus": {
                "end_pos": 37919199, 
                "start_pos": 38027371, 
                "chromosome": "14", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000088441", 
                        "id": "ENSRNOT00000088441", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000075313", 
                        "id": "ENSRNOP00000075313", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2KA94-1|A0A0G2KA94_RAT Isoform 1 of Tyrosine-protein kinase  OS=Rattus norvegicus OX=10116 GN=Tec PE=1 SV=1 CANONICAL=A0A0G2KA94-1", 
                "length": 674, 
                "sequence": "MGLVSACQTPGSAVWPALSPVLCQHALGQESRDLQWQEKEQQKTEMNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLTYYEGRAEKKYRKGFIDISKIKCVEIVKNDDGIIPCQNKFPFQVVHDANTLYIFAPSPQSRDRWVKKLKEEIKNNNNIMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDTHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLPRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEETFGR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2KA94#B2RYC7-1", 
            "isoform_ac": "B2RYC7-1", 
            "locus": {
                "end_pos": 37962848, 
                "start_pos": 38027371, 
                "chromosome": "14", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000003125", 
                        "id": "ENSRNOT00000003125", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000003125", 
                        "id": "ENSRNOP00000003125", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|B2RYC7-1|A0A0G2KA94_RAT Computationally mapped isoform of Tyrosine-protein kinase  OS=Rattus norvegicus OX=10116 GN=Tec PE=1 SV=1 CANONICAL=A0A0G2KA94-1", 
                "length": 629, 
                "sequence": "MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLTYYEGRAEKKYRKGFIDISKIKCVEIVKNDDGIIPCQNKFPFQVVHDANTLYIFAPSPQSRDRWVKKLKEEIKNNNNIMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDTHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLPRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEETFGR"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1433557", 
            "resource": "Reactome", 
            "id": "R-RNO-1433557", 
            "name": "Signaling by SCF-KIT"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871809", 
            "resource": "Reactome", 
            "id": "R-RNO-2871809", 
            "name": "FCERI mediated Ca+2 mobilization"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-512988", 
            "resource": "Reactome", 
            "id": "R-RNO-512988", 
            "name": "Interleukin-3, Interleukin-5 and GM-CSF signaling"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "P42680-1", 
            "protein_name": "Tyrosine-protein kinase Tec; 2.7.10.2.", 
            "sequence": {
                "length": 631, 
                "sequence": "MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETFGR"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2KA94/", 
                    "id": "A0A0G2KA94", 
                    "database": "OMA"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004715", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "non-membrane spanning protein tyrosine kinase activity", 
                        "id": "GO:0004715"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ATP binding", 
                        "id": "GO:0005524"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoskeleton", 
                        "id": "GO:0005856"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010543", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of platelet activation", 
                        "id": "GO:0010543"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integrin-mediated signaling pathway", 
                        "id": "GO:0007229"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038083", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "peptidyl-tyrosine autophosphorylation", 
                        "id": "GO:0038083"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "T cell receptor signaling pathway", 
                        "id": "GO:0050852"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "adaptive immune response", 
                        "id": "GO:0002250"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "B cell receptor signaling pathway", 
                        "id": "GO:0050853"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042246", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "tissue regeneration", 
                        "id": "GO:0042246"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intracellular signal transduction", 
                        "id": "GO:0035556"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050731", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
                                "id": "A0A0G2KA94", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of peptidyl-tyrosine phosphorylation", 
                        "id": "GO:0050731"
                    }
                ], 
                "total": 9, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 257, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 255
        }, 
        {
            "end_pos": 298, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 296
        }, 
        {
            "end_pos": 583, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 581
        }
    ], 
    "crossref": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1433557", 
            "id": "R-RNO-1433557", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871809", 
            "id": "R-RNO-2871809", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-512988", 
            "id": "R-RNO-512988", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002278", 
            "id": "ENSRNOG00000002278", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/GIRHYHI/", 
            "id": "GIRHYHI", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11905", 
            "id": "cd11905", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035572", 
            "id": "IPR035572", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", 
            "id": "IPR000719", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", 
            "id": "IPR000980", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", 
            "id": "IPR001245", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", 
            "id": "IPR001452", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", 
            "id": "IPR001849", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008266", 
            "id": "IPR008266", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", 
            "id": "IPR011009", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", 
            "id": "IPR011993", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", 
            "id": "IPR017441", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020635", 
            "id": "IPR020635", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", 
            "id": "IPR036028", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", 
            "id": "IPR036860", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001562", 
            "id": "IPR001562", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00017", 
            "id": "PF00017", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00018", 
            "id": "PF00018", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00169", 
            "id": "PF00169", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07714", 
            "id": "PF07714", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00779", 
            "id": "PF00779", 
            "database": "Pfam"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620973", 
            "id": "620973", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0G2KA94", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 78291.0, 
        "chemical_mass": 78291.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", 
            "name": "Tec.", 
            "locus": {
                "end_pos": 38027925, 
                "start_pos": 37918652, 
                "chromosome": "14", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000002278", 
                        "id": "ENSRNOG00000002278", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}