{ "uniprot_canonical_ac": "A0A0G2K9X2-1", "sequence": { "header": "tr|A0A0G2K9X2-1|A0A0G2K9X2_RAT Isoform 1 of Receptor-associated protein of the synapse OS=Rattus norvegicus OX=10116 GN=Rapsn PE=4 SV=1 CANONICAL=A0A0G2K9X2-1", "length": 412, "sequence": "MGQDQTKQQIEKGLQLYQSNQTEKALQVWMKVLEKGSDLVGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSLFQKALESFEKALRYAHNNDDTMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNDYGKGWSLKYRAMSQYHMAVAYRLLGHLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVHVLLGVAKCWIARKVLDKALDAIEKAQDLAEEVGNKLSQLKLHCLSEGICRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV" }, "uniprot_id": "A0A0G2K9X2_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "43 kDa receptor-associated protein of the synapse isoform X1" ], "uniprotkb": [ "Receptor-associated protein of the synapse", "Receptor-associated protein of the synapse (Predicted), isoform CRA_a" ] }, "gene": { "refseq": [ "Rapsn", "rapsyn" ], "uniprotkb": [ "Rapsn", "Rapsn_predicted", "rCG_26649", "rapsyn" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Receptor-associated protein of the synapse; Receptor-associated protein of the synapse (Predicted), isoform CRA_a." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2#D3ZPG2-1", "isoform_ac": "D3ZPG2-1", "locus": { "end_pos": 79860369, "start_pos": 79869295, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000068444", "id": "ENSRNOT00000068444", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000060958", "id": "ENSRNOP00000060958", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZPG2-1|A0A0G2K9X2_RAT Computationally mapped isoform of Receptor-associated protein of the synapse OS=Rattus norvegicus OX=10116 GN=Rapsn PE=4 SV=1 CANONICAL=A0A0G2K9X2-1", "length": 359, "sequence": "MGQDQTKQQIEKGLQLYQSNQTEKALQVWMKVLEKGSDLVGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSLFQKALESFEKALRYAHNNDDTMLECRVCCSLGSFYAQVKESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVHVLLGVAKCWIARKVLDKALDAIEKAQDLAEEVGNKLSQLKLHCLSEGICRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2#A0A0G2K9X2-1", "isoform_ac": "A0A0G2K9X2-1", "locus": { "end_pos": 79860369, "start_pos": 79869295, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000081160", "id": "ENSRNOT00000081160", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075166", "id": "ENSRNOP00000075166", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K9X2-1|A0A0G2K9X2_RAT Isoform 1 of Receptor-associated protein of the synapse OS=Rattus norvegicus OX=10116 GN=Rapsn PE=4 SV=1 CANONICAL=A0A0G2K9X2-1", "length": 412, "sequence": "MGQDQTKQQIEKGLQLYQSNQTEKALQVWMKVLEKGSDLVGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSLFQKALESFEKALRYAHNNDDTMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNDYGKGWSLKYRAMSQYHMAVAYRLLGHLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVHVLLGVAKCWIARKVLDKALDAIEKAQDLAEEVGNKLSQLKLHCLSEGICRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "P12672-1", "protein_name": "43 kDa receptor-associated protein of the synapse; RAPsyn; Acetylcholine receptor-associated 43 kDa protein; 43 kDa postsynaptic protein.", "sequence": { "length": 412, "sequence": "MGQDQTKQQIEKGLQLYQSNQTEKALQVWMKVLEKGSDLVGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARGLEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSLFQKALESFEKALRYAHNNDDTMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNDYGKGWSLKYRAMSQYHMAVAYRLLGHLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVHVLLGVAKCWMARKVQDKALDAIEKAQDLAEEVGNKLSQLKLHCLSESIYRSKGLQRELRTHVVRFHECVEETELYCGLCGESIGERNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K9X2/", "id": "A0A0G2K9X2", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/3708", "id": "3708", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q13702-1", "protein_name": "43 kDa receptor-associated protein of the synapse; RAPsyn; RING finger protein 205; Acetylcholine receptor-associated 43 kDa protein; 43 kDa postsynaptic protein.", "sequence": { "length": 412, "sequence": "MGQDQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVGNKLSQLKLHCLSESIYRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K9X2/", "id": "A0A0G2K9X2", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/3708", "id": "3708", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006234590.1", "ac": "XP_006234590.1", "name": "43 kDa receptor-associated protein of the synapse isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035255", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "ionotropic glutamate receptor binding", "id": "GO:0035255" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033130", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "acetylcholine receptor binding", "id": "GO:0033130" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043495", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "protein membrane anchor", "id": "GO:0043495" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "neuromuscular junction", "id": "GO:0031594" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "centrosome", "id": "GO:0005813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "postsynaptic specialization membrane", "id": "GO:0099634" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900075", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "positive regulation of neuromuscular synaptic transmission", "id": "GO:1900075" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901626", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "regulation of postsynaptic membrane organization", "id": "GO:1901626" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903540", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "establishment of protein localization to postsynaptic membrane", "id": "GO:1903540" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007271", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "synaptic transmission, cholinergic", "id": "GO:0007271" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043525", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "id": "A0A0G2K9X2", "database": "UniProtKB" } ], "name": "positive regulation of neuron apoptotic process", "id": "GO:0043525" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 22, "annotation": "n_glycosylation_sequon", "start_pos": 20 }, { "end_pos": 396, "annotation": "n_glycosylation_sequon", "start_pos": 394 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006234590.1", "id": "XP_006234590.1", "database": "RefSeq" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011208", "id": "ENSRNOG00000011208", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/MCGESIG/", "id": "MCGESIG", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "id": "IPR011990", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013026", "id": "IPR013026", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "id": "IPR019734", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "id": "IPR001841", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "id": "IPR013083", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001237", "id": "IPR001237", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018293", "id": "IPR018293", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019568", "id": "IPR019568", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041617", "id": "IPR041617", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF13639", "id": "PF13639", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF10579", "id": "PF10579", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17874", "id": "PF17874", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/362161", "id": "362161", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311592", "id": "1311592", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K9X2", "disease": [], "mass": { "monoisotopic_mass": 46284.0, "chemical_mass": 46284.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9X2", "name": "Rapsn; Rapsn_predicted; rCG_26649; rapsyn.", "locus": { "end_pos": 79869524, "start_pos": 79860179, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000011208", "id": "ENSRNOG00000011208", "database": "Ensembl Gene" } ] } } ] }