{ "uniprot_canonical_ac": "A0A0G2K929-1", "sequence": { "header": "tr|A0A0G2K929-1|A0A0G2K929_RAT Isoform 1 of Centrosomal protein 290 OS=Rattus norvegicus OX=10116 GN=Cep290 PE=4 SV=1 CANONICAL=A0A0G2K929-1", "length": 2756, "sequence": "MPPNIKWKELIKVDPDELPRQEELADKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDTVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELRKDKGTSNIYQQTHYMKIHSKVQILEEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNYKAQIKIRDGEIEVLTKEINKLEMKINDVLDENEALRERAGLEPKTMIDLTEFRNSKRVKQQQYRAENQILLKEIESLEEERLDLKRKIRQMAQERGKRSAASGLTIDDLNLTETFSHGDKIGERKLNFISFNNMNETQSKITSSANTELLHRRPSFSVVQSDRSETEENLTTRSLSRMLSGIHHSVDSAVEPVVSLTRCSSFMQLKDSNTTPEAITIREIFKAPCLRSLRNLESLVSTFSKDSSEELSEYLCSLSDDCVKRGSGNHRALEKTRFLQKRSSSFPASPIAAELMQRYSHRQSSAVFPQQSYAHEVHKVTSEGDQAHSQIKYADLSLKDNKRQSESSSQTEMSRSKSQINLSGLVPVIAQSRASLVHPREKLLGQLQRELVLLRSQNETIAQDLSIQEEQSRNAHLDLDHQRSQEEQNEFLSRELIEKEKDLERSRTVITKFQNKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGSETSLIIPSLERLVNAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAVNYSQQLVKANLKIDHLEKETDLLRQSSGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDVWKADSEMIKEEKRKLEDQAQQDAVKVKEYNNLLNALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEIERQLRKENGKHKNDVISMEAEVTEKIGNLQRFKEMATFRIAALQKVVDNSVSLSELELANKQYSELTAKYRDVLQKDNMLVQRASNLEHLACENASLKEQMEGLSKELEITKEKLHTIEQAWEQETKLGNESNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKHMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVNKAVSDADRQRILELEKREVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRMQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEACNLRLEQKLDEKEQALYYARLEGRNRANHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTISSLEEDIVQQSKFHEERQMAWDQREVELERQLDIFDRQQNEILSAAQKFEDATGSMPDPSLPLPNQLEIALRKIKENIQIILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLQLPATADREKLIAELNRTELEPKSHHTMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLSKFKQTAQDLIKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKRVSRDLERQKEVTEFKVREFETTKLRLQETHANEVKKVKAEVEDLRHALAQAQKDSQNLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTKELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNDLNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERQVDDVDIKPIKEKSGKEELIRWEEGKKWQTKVEGMRNKLKEKEGEVHSLTKQLSTLKELFAKADKEKLTLQKKLKTTGMTVDQVLGVRALESEKELEELKRRNLDLENDIVYMRTHQALPRDSVVEDLHLQNRYLQEKLHTLENKLSKDAYSQSLTSEIESDDHCQKEQELQRENLKLSSENIELKFQLEQAKKDLPRLKNQVRDLKEMCEILKKGKMELERKLGQVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGLLTSEKMATLEEENGKLKAELEKLKAHFGRQLSMQFESKSKGTERIMAENERLRKELKKEMQASEKLRIAKNNLELVNDKMAGQLEETGKRLQFAESRGPQLEGADSQSWKSIVVSRIYDTKIKDLESDIAKKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKNVPEGAETEQELIQQLQLLRLANNQLDKEKAELIHQIEVIKDQTGAESSTPDSDQLKKKINDLETHLRKSEPEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKLNKLSEQFGFELPSPLAASEQREDGESPNGVPIY" }, "uniprot_id": "A0A0G2K929_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "centrosomal protein of 290 kDa isoform X2" ], "uniprotkb": [ "Centrosomal protein 290" ] }, "gene": { "refseq": [ "Cep290", "RGD1311640" ], "uniprotkb": [ "Cep290", "RGD1311640" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Centrosomal protein 290." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929#A0A0G2K715-1", "isoform_ac": "A0A0G2K715-1", "locus": { "end_pos": 40218018, "start_pos": 40305728, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000082090", "id": "ENSRNOT00000082090", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074021", "id": "ENSRNOP00000074021", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K715-1|A0A0G2K929_RAT Computationally mapped isoform of Centrosomal protein 290 OS=Rattus norvegicus OX=10116 GN=Cep290 PE=4 SV=1 CANONICAL=A0A0G2K929-1", "length": 2479, "sequence": "MPPNIKWKELIKVDPDELPRQEELADKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDTVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELRKDKGTSNIYQQTHYMKIHSKVQILEEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNYKAQIKIRDGEIEVLTKEINKLEMKINDVLDENEALRERAGLEPKTMIDLTEFRNSKRVKQQQYRAENQILLKEIESLEEERLDLKRKIRQMAQERGKRSAASGLTIDDLNLTETFSHGDKIGERKLNFISFNNMNETQSKNEFLSRELIEKEKDLERSRTVITKFQNKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGSETSLIIPSLERLVNAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAVNYSQQLVKANLKIDHLEKETDLLRQSSGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDVWKADSEMIKEEKRKLEDQAQQDAVKVKEYNNLLNALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEIERQLRKENGKHKNDVISMEAEVTEKIGNLQRFKEMATFRIAALQKVVDNSVSLSELELANKQYSELTAKYRDVLQKDNMLVQRASNLEHLACENASLKEQMEGLSKELEITKEKLHTIEQAWEQETKLGNESNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKHMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVNKAVSDADRQRILELEKREVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRMQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEACNLRLEQKLDEKEQALYYARLEGRNRANHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTISSLEEDIVQQSKFHEERQMAWDQREVELERQLDIFDRQQNEILSAAQKFEDATGSMPDPSLPLPNQLEIALRKIKENIQIILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLQLPATADREKLIAELNRTELEPKSHHTMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLSKFKQTAQDLIKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKRVSRDLERQKEVTEFKVREFETTKLRLQETHANEVKKVKAEVEDLRHALAQAQKDSQNLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTKELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNDLNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERQVDDVDIKPIKEKSGKEELIRWEEGKKWQTKVEGMRNKLKEKEGEVHSLTKQLSTLKELFAKADKEKLTLQKKLKTTGMTVDQVLGVRALESEKELEELKRRNLDLENDIVYMRTHQALPRDSVVEDLHLQNRYLQEKLHTLENKLSKDAYSQSLTSEIESDDHCQKEQELQRENLKLSSENIELKFQLEQAKKDLPRLKNQVRDLKEMCEILKKGKMELERKLGQVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGLLTSEKMATLEEENGKLKAELEKLKAHFGRQLSMQFESKSKGTERIMAENERLRKELKKEMQASEKLRIAKNNLELVNDKMAGQLEETGKRLQFAESRGPQLEGADSQSWKSIVVSRIYDTKIKDLESDIAKKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKNVPEGAETEQELIQQLQLLRLANNQLDKEKAELIHQIEVIKDQTGAESSTPDSDQLKKKINDLETHLRKSEPEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKLNKLSEQFGFELPSPLAASEQREDGESPNGVPIY" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K929#A0A0G2K929-1", "isoform_ac": "A0A0G2K929-1", "locus": { "end_pos": 40218018, "start_pos": 40305728, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000085684", "id": "ENSRNOT00000085684", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074837", "id": "ENSRNOP00000074837", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K929-1|A0A0G2K929_RAT Isoform 1 of Centrosomal protein 290 OS=Rattus norvegicus OX=10116 GN=Cep290 PE=4 SV=1 CANONICAL=A0A0G2K929-1", "length": 2756, "sequence": "MPPNIKWKELIKVDPDELPRQEELADKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDTVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELRKDKGTSNIYQQTHYMKIHSKVQILEEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNYKAQIKIRDGEIEVLTKEINKLEMKINDVLDENEALRERAGLEPKTMIDLTEFRNSKRVKQQQYRAENQILLKEIESLEEERLDLKRKIRQMAQERGKRSAASGLTIDDLNLTETFSHGDKIGERKLNFISFNNMNETQSKITSSANTELLHRRPSFSVVQSDRSETEENLTTRSLSRMLSGIHHSVDSAVEPVVSLTRCSSFMQLKDSNTTPEAITIREIFKAPCLRSLRNLESLVSTFSKDSSEELSEYLCSLSDDCVKRGSGNHRALEKTRFLQKRSSSFPASPIAAELMQRYSHRQSSAVFPQQSYAHEVHKVTSEGDQAHSQIKYADLSLKDNKRQSESSSQTEMSRSKSQINLSGLVPVIAQSRASLVHPREKLLGQLQRELVLLRSQNETIAQDLSIQEEQSRNAHLDLDHQRSQEEQNEFLSRELIEKEKDLERSRTVITKFQNKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGSETSLIIPSLERLVNAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAVNYSQQLVKANLKIDHLEKETDLLRQSSGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDVWKADSEMIKEEKRKLEDQAQQDAVKVKEYNNLLNALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEIERQLRKENGKHKNDVISMEAEVTEKIGNLQRFKEMATFRIAALQKVVDNSVSLSELELANKQYSELTAKYRDVLQKDNMLVQRASNLEHLACENASLKEQMEGLSKELEITKEKLHTIEQAWEQETKLGNESNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKHMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVNKAVSDADRQRILELEKREVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRMQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEACNLRLEQKLDEKEQALYYARLEGRNRANHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTISSLEEDIVQQSKFHEERQMAWDQREVELERQLDIFDRQQNEILSAAQKFEDATGSMPDPSLPLPNQLEIALRKIKENIQIILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLQLPATADREKLIAELNRTELEPKSHHTMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLSKFKQTAQDLIKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKRVSRDLERQKEVTEFKVREFETTKLRLQETHANEVKKVKAEVEDLRHALAQAQKDSQNLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTKELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNDLNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERQVDDVDIKPIKEKSGKEELIRWEEGKKWQTKVEGMRNKLKEKEGEVHSLTKQLSTLKELFAKADKEKLTLQKKLKTTGMTVDQVLGVRALESEKELEELKRRNLDLENDIVYMRTHQALPRDSVVEDLHLQNRYLQEKLHTLENKLSKDAYSQSLTSEIESDDHCQKEQELQRENLKLSSENIELKFQLEQAKKDLPRLKNQVRDLKEMCEILKKGKMELERKLGQVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGLLTSEKMATLEEENGKLKAELEKLKAHFGRQLSMQFESKSKGTERIMAENERLRKELKKEMQASEKLRIAKNNLELVNDKMAGQLEETGKRLQFAESRGPQLEGADSQSWKSIVVSRIYDTKIKDLESDIAKKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKNVPEGAETEQELIQQLQLLRLANNQLDKEKAELIHQIEVIKDQTGAESSTPDSDQLKKKINDLETHLRKSEPEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKLNKLSEQFGFELPSPLAASEQREDGESPNGVPIY" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2565942", "resource": "Reactome", "id": "R-RNO-2565942", "name": "Regulation of PLK1 Activity at G2/M Transition" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380259", "resource": "Reactome", "id": "R-RNO-380259", "name": "Loss of Nlp from mitotic centrosomes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380270", "resource": "Reactome", "id": "R-RNO-380270", "name": "Recruitment of mitotic centrosome proteins and complexes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380284", "resource": "Reactome", "id": "R-RNO-380284", "name": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380320", "resource": "Reactome", "id": "R-RNO-380320", "name": "Recruitment of NuMA to mitotic centrosomes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620912", "resource": "Reactome", "id": "R-RNO-5620912", "name": "Anchoring of the basal body to the plasma membrane" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "resource": "Reactome", "id": "R-RNO-6798695", "name": "Neutrophil degranulation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8854518", "resource": "Reactome", "id": "R-RNO-8854518", "name": "AURKA Activation by TPX2" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O15078-1", "protein_name": "Centrosomal protein of 290 kDa; Cep290; testis antigen 87; CT87; Bardet-Biedl syndrome 14 protein; Nephrocystin-6; Tumor antigen se2-2.", "sequence": { "length": 2479, "sequence": "MPPNINWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEESPVNFPIY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/77213", "id": "77213", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q6A078-1", "protein_name": "Centrosomal protein of 290 kDa; Cep290; Bardet-Biedl syndrome 14 protein homolog; Nephrocystin-6.", "sequence": { "length": 2472, "sequence": "MPPNIKWKELIKVDPDDLPRQEELADKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQTHYMKIHSKVQILEEKTKEAERIAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGLEPKTMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGKRNAASGLTIDDLNLSETFSHENKIEGRKLNFMSLNNMNETQSKNEFLSRELAEKEKDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGGETSLIIPSLERLVNAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEKETDLLRQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDIWKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMERHLRKENGKHRNDVIAMEAEVTEKLGSLQRFKEMAIFKIAALQKVIDNSVSLSELELANKQYNELTTKYRDILQKDNMLVQRTSNLEHLECENASLKEQMEAISKELEITKEKLHTIEQAWEQETKLGNDSNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVTKAVSDADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLELELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELERQLDIFDHQQNEILSAAQKFEDSTGSMPDPSLPLPNQLEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEPKSHHTMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLNKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVKEKSSKEELIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLKTTGMTVDQVLGVRALESEKELEELKKKNLDLENDILYMRTQQALPRDSVVEDLHLQNKYLQEKLHTLEKKLSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERKLGQVRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAHFGRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEGADSKSWKSIVVSRVYETKMKELESDIAKKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKNVPEGAETEQELIRELQLLRLANNQMDKERAELIHQIEINKDQTRADSSIPDSDQLKEKINDLETQLRKLELEKQHSKEEVKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKLKKLSEQFGFELPSPLAASEHSEDGESPHSFPIY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/77213", "id": "77213", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017450332.1", "ac": "XP_017450332.1", "name": "centrosomal protein of 290 kDa isoform X2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "ciliary basal body", "id": "GO:0036064" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "ciliary basal body", "id": "GO:0036064" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "centriolar satellite", "id": "GO:0034451" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "ciliary transition zone", "id": "GO:0035869" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000930", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "gamma-tubulin complex", "id": "GO:0000930" } ], "total": 8, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090316", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "positive regulation of intracellular protein transport", "id": "GO:0090316" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "id": "A0A0G2K929", "database": "UniProtKB" } ], "name": "cilium assembly", "id": "GO:0060271" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 574, "annotation": "n_glycosylation_sequon", "start_pos": 572 }, { "end_pos": 599, "annotation": "n_glycosylation_sequon", "start_pos": 597 }, { "end_pos": 633, "annotation": "n_glycosylation_sequon", "start_pos": 631 }, { "end_pos": 673, "annotation": "n_glycosylation_sequon", "start_pos": 671 }, { "end_pos": 821, "annotation": "n_glycosylation_sequon", "start_pos": 819 }, { "end_pos": 858, "annotation": "n_glycosylation_sequon", "start_pos": 856 }, { "end_pos": 1008, "annotation": "n_glycosylation_sequon", "start_pos": 1006 }, { "end_pos": 1280, "annotation": "n_glycosylation_sequon", "start_pos": 1278 }, { "end_pos": 1316, "annotation": "n_glycosylation_sequon", "start_pos": 1314 }, { "end_pos": 1596, "annotation": "n_glycosylation_sequon", "start_pos": 1594 }, { "end_pos": 1803, "annotation": "n_glycosylation_sequon", "start_pos": 1801 }, { "end_pos": 2570, "annotation": "n_glycosylation_sequon", "start_pos": 2568 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017450332.1", "id": "XP_017450332.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2565942", "id": "R-RNO-2565942", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380259", "id": "R-RNO-380259", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380270", "id": "R-RNO-380270", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380284", "id": "R-RNO-380284", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380320", "id": "R-RNO-380320", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620912", "id": "R-RNO-5620912", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "id": "R-RNO-6798695", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8854518", "id": "R-RNO-8854518", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000056458", "id": "ENSRNOG00000056458", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/FHDDQQR/", "id": "FHDDQQR", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026201", "id": "IPR026201", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032321", "id": "IPR032321", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF16574", "id": "PF16574", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18879", "id": "PTHR18879", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/314787", "id": "314787", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311640", "id": "1311640", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K929", "disease": [], "mass": { "monoisotopic_mass": 320733.0, "chemical_mass": 320733.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K929", "name": "Cep290; RGD1311640.", "locus": { "end_pos": 40306327, "start_pos": 40217269, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000056458", "id": "ENSRNOG00000056458", "database": "Ensembl Gene" } ] } } ] }