{ "uniprot_canonical_ac": "A0A0G2K889-1", "sequence": { "header": "tr|A0A0G2K889-1|A0A0G2K889_RAT Isoform 1 of Euchromatic histone lysine methyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Ehmt1 PE=1 SV=1 CANONICAL=A0A0G2K889-1", "length": 1289, "sequence": "MAAADAEQAVLAKQETKQDCCMKTELLREDTLMAADEGSTEKQAGETPMAADGETNGSCEKSGDISHPNAPKHTQENTRASPQEGTNRVSRVAENGVSERDTEVGKQNHVTADDFMQTSVIGSNGYFLNKPALQGQPLRTPNTLNSSLPGHAAKTLPGGASKCRTPSALPQTPTTAPTVPGEGSADTEDRKPTASGTDVRVHRARKTMPKSILGLHAASKDHREVQDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYMATTKSQTAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKVLDDSALHVNGESLEMDSEEEDSEELEDEEDRGAEQAAAFPTEDSRTSKESMSETDRAAKMDGDSEEEQESPDTGEDEDGGDESDLSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEACKSSPGSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLANGPDVLETDGLHEVPLCSCRMETPKSREISTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEETSKAKEVTIAKADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPEDEKSQSTVTQAPECFDPAGPAGFVRPTSGFSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGFDYGERFWDVKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQENGLPDTSSAAAADPL" }, "uniprot_id": "A0A0G2K889_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Euchromatic histone lysine methyltransferase 1" ] }, "gene": { "refseq": [], "uniprotkb": [ "Ehmt1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Euchromatic histone lysine methyltransferase 1." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889#A0A0G2K889-1", "isoform_ac": "A0A0G2K889-1", "locus": { "end_pos": 1962148, "start_pos": 2123796, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000086843", "id": "ENSRNOT00000086843", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074513", "id": "ENSRNOP00000074513", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K889-1|A0A0G2K889_RAT Isoform 1 of Euchromatic histone lysine methyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Ehmt1 PE=1 SV=1 CANONICAL=A0A0G2K889-1", "length": 1289, "sequence": "MAAADAEQAVLAKQETKQDCCMKTELLREDTLMAADEGSTEKQAGETPMAADGETNGSCEKSGDISHPNAPKHTQENTRASPQEGTNRVSRVAENGVSERDTEVGKQNHVTADDFMQTSVIGSNGYFLNKPALQGQPLRTPNTLNSSLPGHAAKTLPGGASKCRTPSALPQTPTTAPTVPGEGSADTEDRKPTASGTDVRVHRARKTMPKSILGLHAASKDHREVQDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYMATTKSQTAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKVLDDSALHVNGESLEMDSEEEDSEELEDEEDRGAEQAAAFPTEDSRTSKESMSETDRAAKMDGDSEEEQESPDTGEDEDGGDESDLSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEACKSSPGSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLANGPDVLETDGLHEVPLCSCRMETPKSREISTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEETSKAKEVTIAKADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPEDEKSQSTVTQAPECFDPAGPAGFVRPTSGFSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGFDYGERFWDVKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQENGLPDTSSAAAADPL" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K889#D4A005-1", "isoform_ac": "D4A005-1", "locus": { "end_pos": 1968086, "start_pos": 2060167, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000066777", "id": "ENSRNOT00000066777", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000063511", "id": "ENSRNOP00000063511", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4A005-1|A0A0G2K889_RAT Computationally mapped isoform of Euchromatic histone lysine methyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Ehmt1 PE=1 SV=3 CANONICAL=A0A0G2K889-1", "length": 1264, "sequence": "QQAVLAKQETKQDCCMKTELLREDTLMAADEGSTEKQAGETPMAADGETNGSCEKSGDISHPNAPKHTQENTRASPQEGTNRVSRVAENGVSERDTEVGKQNHVTADDFMQTSVIGSNGYFLNKPALQGQPLRTPNTLNSSLPGHAAKTLPGGASKCRTPSALPQTPTTAPTVPGEGSADTEDRKPTASGTDVRVHRARKTMPKSILGLHAASKDHREVQDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKVLDDSALHVNGESLEMDSEEEDSEELEDEEDRGAEQAAAFPTEDSRTSKESMSETDRAAKSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEACKSSPGSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLANGPDVLETDGLHEVPLCSCRMETPKSREISTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEETSKAKEVTIAKADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPEDEKSQSTVTQAPECFDPAGPAGFVRPTSGFSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGFDYGERFWDVKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQENGLPDTSSAAAADPL" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559582", "resource": "Reactome", "id": "R-RNO-2559582", "name": "Senescence-Associated Secretory Phenotype (SASP)" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804760", "resource": "Reactome", "id": "R-RNO-6804760", "name": "Regulation of TP53 Activity through Methylation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8953750", "resource": "Reactome", "id": "R-RNO-8953750", "name": "Transcriptional Regulation by E2F6" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3214841", "resource": "Reactome", "id": "R-RNO-3214841", "name": "PKMTs methylate histone lysines" } ], "function": [], "orthologs": [], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "p53 binding", "id": "GO:0002039" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046974", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "histone methyltransferase activity (H3-K9 specific)", "id": "GO:0046974" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046976", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "histone methyltransferase activity (H3-K27 specific)", "id": "GO:0046976" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070742", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "C2H2 zinc finger domain binding", "id": "GO:0070742" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "nuclear body", "id": "GO:0016604" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "chromosome", "id": "GO:0005694" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060992", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "response to fungicide", "id": "GO:0060992" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006306", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "DNA methylation", "id": "GO:0006306" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018026", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "peptidyl-lysine monomethylation", "id": "GO:0018026" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018027", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "peptidyl-lysine dimethylation", "id": "GO:0018027" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045995", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "id": "A0A0G2K889", "database": "UniProtKB" } ], "name": "regulation of embryonic development", "id": "GO:0045995" } ], "total": 7, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 58, "annotation": "n_glycosylation_sequon", "start_pos": 56 }, { "end_pos": 147, "annotation": "n_glycosylation_sequon", "start_pos": 145 }, { "end_pos": 240, "annotation": "n_glycosylation_sequon", "start_pos": 238 }, { "end_pos": 618, "annotation": "n_glycosylation_sequon", "start_pos": 616 }, { "end_pos": 1048, "annotation": "n_glycosylation_sequon", "start_pos": 1046 }, { "end_pos": 1187, "annotation": "n_glycosylation_sequon", "start_pos": 1185 } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559582", "id": "R-RNO-2559582", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804760", "id": "R-RNO-6804760", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8953750", "id": "R-RNO-8953750", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3214841", "id": "R-RNO-3214841", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000007242", "id": "ENSRNOG00000007242", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/TNGSCEH/", "id": "TNGSCEH", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007728", "id": "IPR007728", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "id": "IPR002110", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020683", "id": "IPR020683", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "id": "IPR036770", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "id": "IPR001214", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR038035", "id": "IPR038035", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF05033", "id": "PF05033", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12796", "id": "PF12796", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00856", "id": "PF00856", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46307:SF2", "id": "PTHR46307:SF2", "database": "PANTHER" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307588", "id": "1307588", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K889", "disease": [], "mass": { "monoisotopic_mass": 141466.0, "chemical_mass": 141466.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K889", "name": "Ehmt1.", "locus": { "end_pos": 1960957, "start_pos": 2123820, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000007242", "id": "ENSRNOG00000007242", "database": "Ensembl Gene" } ] } } ] }