{ "uniprot_canonical_ac": "A0A0G2K7Z8-1", "sequence": { "header": "tr|A0A0G2K7Z8-1|A0A0G2K7Z8_RAT Isoform 1 of Cadherin 26 OS=Rattus norvegicus OX=10116 GN=Cdh26 PE=4 SV=1 CANONICAL=A0A0G2K7Z8-1", "length": 761, "sequence": "MDTSVCAWLLLLLSLPQGQSHQPLHRSKRRWVLTTLELQEEDPGPFPKLVGELFNNMSKNVSLMYLIRGPGVDEFPEIGLFSIEDRQSGKIYVHRPVDREMTPSFMVYFDAVDRSTGKVVDESLIFNIRIRDVNDHAPQFPEKEFSITVKESQAAGQPIFQLLTVDLDQENTPNSQVLYFLVSQTPLLRESGFRIDLISGEVRLSGCLHYETAPRFTLIIRASDCGEPSLSSTATIHISVEDSNNHMPTFTDDHYTIQISEGQVERDVLYLPVHDGDSPFTPAWRTQFNIWDGNEEGHFDITTDPETNQGLLSIIKPLDYETQVAHSLLIVVENQEQLFNCQEGQLQPLRKAMASTTVSVQVLDTNDPPAFHPRSFIVSEEDGAWPAIQLGYFNATDPDRADSQIRYELVRDPENWVTVDEKSGEVTTKRQIDRESPHVNGSFYTIVVHAIDNGLPPLTGTGTLMLFLYDVNDNAPILQPHSRHLEICESAGNKALLLEAEDADLDPYAGPFTFDLDSDQGDVREIWMLRIKQEEGHSAELIMRRSLPPGDYLVPLFIGDRQGLAQKQTVHVRICSCPSGSDCEEHSDPGLLWWALSPVCAAVMALSASLLGLLRCYCVFGPKRLRGFIPSDSGHQTLIVSNEETKALSAQGCGMFFEPRGAKNLTSTPIYLERMVPRRPLQLTEGRVVEMWSQKLQGVDVLEGDTGDLPHVYREEGECEGAETLSSLTFLEQDLSSELLDSSGSKSTPPEAMCFTSRVPS" }, "uniprot_id": "A0A0G2K7Z8_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "cadherin-like protein 26 precursor", "cadherin-like protein 26; cadherin-like 26" ], "uniprotkb": [ "Cadherin 26" ] }, "gene": { "refseq": [ "Cdh26" ], "uniprotkb": [ "Cdh26" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Cadherin 26." }, "publication": [ { "title": "Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28051089", "journal": "Mucosal immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178674.1", "id": "NP_001178674.1", "database": "RefSeq" } ], "authors": "Caldwell JM, Collins MH, Kemme KA, Sherrill JD, Wen T, Rochman M, Stucke EM, Amin L, Tai H, Putnam PE, Jimenez-Dalmaroni MJ, Wormald MR, Porollo A, Abonia JP, Rothenberg ME", "date": "2017", "pmid": "28051089" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8#A0A0G2K7Z8-1", "isoform_ac": "A0A0G2K7Z8-1", "locus": { "end_pos": 173969273, "start_pos": 174019763, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000083970", "id": "ENSRNOT00000083970", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074411", "id": "ENSRNOP00000074411", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K7Z8-1|A0A0G2K7Z8_RAT Isoform 1 of Cadherin 26 OS=Rattus norvegicus OX=10116 GN=Cdh26 PE=4 SV=1 CANONICAL=A0A0G2K7Z8-1", "length": 761, "sequence": "MDTSVCAWLLLLLSLPQGQSHQPLHRSKRRWVLTTLELQEEDPGPFPKLVGELFNNMSKNVSLMYLIRGPGVDEFPEIGLFSIEDRQSGKIYVHRPVDREMTPSFMVYFDAVDRSTGKVVDESLIFNIRIRDVNDHAPQFPEKEFSITVKESQAAGQPIFQLLTVDLDQENTPNSQVLYFLVSQTPLLRESGFRIDLISGEVRLSGCLHYETAPRFTLIIRASDCGEPSLSSTATIHISVEDSNNHMPTFTDDHYTIQISEGQVERDVLYLPVHDGDSPFTPAWRTQFNIWDGNEEGHFDITTDPETNQGLLSIIKPLDYETQVAHSLLIVVENQEQLFNCQEGQLQPLRKAMASTTVSVQVLDTNDPPAFHPRSFIVSEEDGAWPAIQLGYFNATDPDRADSQIRYELVRDPENWVTVDEKSGEVTTKRQIDRESPHVNGSFYTIVVHAIDNGLPPLTGTGTLMLFLYDVNDNAPILQPHSRHLEICESAGNKALLLEAEDADLDPYAGPFTFDLDSDQGDVREIWMLRIKQEEGHSAELIMRRSLPPGDYLVPLFIGDRQGLAQKQTVHVRICSCPSGSDCEEHSDPGLLWWALSPVCAAVMALSASLLGLLRCYCVFGPKRLRGFIPSDSGHQTLIVSNEETKALSAQGCGMFFEPRGAKNLTSTPIYLERMVPRRPLQLTEGRVVEMWSQKLQGVDVLEGDTGDLPHVYREEGECEGAETLSSLTFLEQDLSSELLDSSGSKSTPPEAMCFTSRVPS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:311693", "resource": "KEGG Pathway", "id": "rno:311693", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "P59862-1", "protein_name": "Cadherin-like protein 26.", "sequence": { "length": 763, "sequence": "MDTRGCAWLLLLLSLPQGQSHQPLHRSKRRWVLTTLELQEEDPGPFPKLVGELFNNMSNNVSLIYLIRGPGVDEFPEIGLFSIEDHQSGKIYVHRPVDREVTPSFMVHFDAVDRSTGKVVDESLIFNIRIRDVNDHAPQFPEKEFNISVKESQAAGQPIFQLLTVDLDQENTPNSQVLYFLVSQTPLLRESGFRIDLISGEVRLSGCLHYETAPLFTLIVRASDCGEPSLTSTATIHVSVEDSNNHMPTFMEDRYEIRISEGQVEQGVLYLPVQDGDSPFTPAWRTQFNIWDGNEEGHFDIVTDPETNQGLLSIIKPLDYESQVAHSLVVVVENQEQLFVCTEGQLQPLRKAMASTMVSVQVLDTNDPPAFHPQSFIVSEEDGAWPAIQLGYFNATDPDRADSQIRYKLVHDPENWVTVDEKSGVVTTKKQIDRESPHVNDSFYTIIVHAVDNGLPPLTGTGTLMLFLSDVNDNAPTLRPHSRHLEVCESAGSQPLLIEAEDADLDPYADPFTFDLDNAQGDVEETWMLRTKQGEGHSAELTMLRSVPPGDYLVPLFIADRQGLAQKQTVHVRICSCRSGSECEEPSDTWLLWWALSPVGAALMVLSAALLCLLRCSCTFGPKRLRGFIPSDSGHQTLIVYNEESKVPSAQGCDTFFEPRGVKTLLSSTPVYLDRMVPRQQPLQLLEGRVVEAWSQKLQSIDVLEGDTGYLPHVYREEGECEGAETLSSLTFLEQDLSPKLLGCSGSKSTPSEAMCFTSRVPS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18643", "id": "18643", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q8IXH8-4", "protein_name": "Cadherin-like protein 26; Cadherin-like protein VR20.", "sequence": { "length": 832, "sequence": "MAMRSGRHPSLLLLLVLLLWLLQVSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPFPKLIGELFNNMSYNMSLMYLISGPGVDEYPEIGLFSLEDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKESGFRVDRLSGEIRLSGCLDYETAPQFTLLIRARDCGEPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIPEGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSFIVNKEEGARPGTLLGTFNAMDPDSQIRYELVHDPANWVSVDKNSGVVITVEPIDRESPHVNNSFYVIIIHAVDDGFPPQTATGTLMLFLSDINDNVPTLRPRSRYMEVCESAVHEPLHIEAEDPDLEPFSDPFTFELDNTWGNAEDTWKLGRNWGQSVELLTLRSLPRGNYLVPLFIGDKQGLSQKQTVHVRICPCASGLTCVELADAEVGLHVGALFPVCAAFVALAVALLFLLRCYFVLEPKRHGCSVSNDEGHQTLVMYNAESKGTSAQTWSDVEGQRPALLICTAAAGPTQGVKDLEEVPPSAASQSAQARCALGSWGYGKPFEPRSVKNIHSTPAYPDATMHRQLLAPVEGRMAETLNQKLHVANVLEDDPGYLPHVYSEEGECGGAPSLSSLASLEQELQPDLLDSLGSKATPFEEIYSESGVPS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K7Z8/", "id": "A0A0G2K7Z8", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/18643", "id": "18643", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178674.1", "ac": "NP_001178674.1", "name": "cadherin-like protein 26 precursor; cadherin-like protein 26; cadherin-like 26.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "protein homodimerization activity", "id": "GO:0042803" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "cadherin binding", "id": "GO:0045296" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008092", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "cytoskeletal protein binding", "id": "GO:0008092" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "integrin binding", "id": "GO:0005178" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "beta-catenin binding", "id": "GO:0008013" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045294", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "alpha-catenin binding", "id": "GO:0045294" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070097", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "delta-catenin binding", "id": "GO:0070097" } ], "total": 8, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "cell surface", "id": "GO:0009986" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005913", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "cell-cell adherens junction", "id": "GO:0005913" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016342", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "catenin complex", "id": "GO:0016342" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000902", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "cell morphogenesis", "id": "GO:0000902" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "cell-cell adhesion", "id": "GO:0098609" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007043", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "cell-cell junction assembly", "id": "GO:0007043" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034332", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "adherens junction organization", "id": "GO:0034332" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016339", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0016339" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044331", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "cell-cell adhesion mediated by cadherin", "id": "GO:0044331" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035710", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "id": "A0A0G2K7Z8", "database": "UniProtKB" } ], "name": "CD4-positive, alpha-beta T cell activation", "id": "GO:0035710" } ], "total": 8, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 58, "annotation": "n_glycosylation_sequon", "start_pos": 56 }, { "end_pos": 62, "annotation": "n_glycosylation_sequon", "start_pos": 60 }, { "end_pos": 396, "annotation": "n_glycosylation_sequon", "start_pos": 394 }, { "end_pos": 442, "annotation": "n_glycosylation_sequon", "start_pos": 440 }, { "end_pos": 666, "annotation": "n_glycosylation_sequon", "start_pos": 664 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178674.1", "id": "NP_001178674.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:311693", "id": "rno:311693", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000053332", "id": "ENSRNOG00000053332", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/WRAKFNI/", "id": "WRAKFNI", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039808", "id": "IPR039808", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "id": "IPR002126", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "id": "IPR015919", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "id": "IPR020894", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00028", "id": "PF00028", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027", "id": "PTHR24027", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/311693", "id": "311693", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311632", "id": "1311632", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K7Z8", "disease": [], "mass": { "monoisotopic_mass": 85095.0, "chemical_mass": 85095.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z8", "name": "Cdh26.", "locus": { "end_pos": 174019766, "start_pos": 173969273, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000053332", "id": "ENSRNOG00000053332", "database": "Ensembl Gene" } ] } } ] }