{ "uniprot_canonical_ac": "A0A0G2K7X2-1", "sequence": { "header": "tr|A0A0G2K7X2-1|A0A0G2K7X2_RAT Isoform 1 of TNF receptor-associated factor OS=Rattus norvegicus OX=10116 GN=Traf3 PE=3 SV=1 CANONICAL=A0A0G2K7X2-1", "length": 610, "sequence": "MKLPLLQPAHRQFLCTSDMLQSKEYHISMETKSINTSEFLLPKMEPSKKMGAAGAAQPNPPLKLQPDRGAASVLVPEQGGYKEKFAKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQESIIKDKVFKDNCCKREILALQIYCRNEGRGCVEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRRDLRDHVEKACKYREATCAHCKSQVPMITLQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP" }, "uniprot_id": "A0A0G2K7X2_RAT", "enzyme_annotation": [ { "ec": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine." }, { "ec": "2.3.2.27", "activity": "" } ], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "TNF receptor-associated factor", "2.3.2.27" ] }, "gene": { "refseq": [], "uniprotkb": [ "Traf3" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2", "id": "A0A0G2K7X2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "TNF receptor-associated factor; 2.3.2.27." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2#A0A0G2K7X2-1", "isoform_ac": "A0A0G2K7X2-1", "locus": { "end_pos": 135680814, "start_pos": 135715072, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000077770", "id": "ENSRNOT00000077770", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074381", "id": "ENSRNOP00000074381", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K7X2-1|A0A0G2K7X2_RAT Isoform 1 of TNF receptor-associated factor OS=Rattus norvegicus OX=10116 GN=Traf3 PE=3 SV=1 CANONICAL=A0A0G2K7X2-1", "length": 610, "sequence": "MKLPLLQPAHRQFLCTSDMLQSKEYHISMETKSINTSEFLLPKMEPSKKMGAAGAAQPNPPLKLQPDRGAASVLVPEQGGYKEKFAKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQESIIKDKVFKDNCCKREILALQIYCRNEGRGCVEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRRDLRDHVEKACKYREATCAHCKSQVPMITLQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2#D3Z9G0-1", "isoform_ac": "D3Z9G0-1", "locus": { "end_pos": 135690468, "start_pos": 135715072, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000010906", "id": "ENSRNOT00000010906", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000010906", "id": "ENSRNOP00000010906", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3Z9G0-1|A0A0G2K7X2_RAT Computationally mapped isoform of TNF receptor-associated factor OS=Rattus norvegicus OX=10116 GN=Traf3 PE=3 SV=1 CANONICAL=A0A0G2K7X2-1", "length": 567, "sequence": "MEPSKKMGAAGAAQPNPPLKLQPDRGAASVLVPEQGGYKEKFAKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQESIIKDKVFKDNCCKREILALQIYCRNEGRGCVEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRRDLRDHVEKACKYREATCAHCKSQVPMITLQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668541", "resource": "Reactome", "id": "R-RNO-5668541", "name": "TNFR2 non-canonical NF-kB pathway" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5676594", "resource": "Reactome", "id": "R-RNO-5676594", "name": "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-936964", "resource": "Reactome", "id": "R-RNO-936964", "name": "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689896", "resource": "Reactome", "id": "R-RNO-5689896", "name": "Ovarian tumor domain proteases" } ], "function": [], "orthologs": [], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2", "id": "A0A0G2K7X2", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase binding", "id": "GO:0031625" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005164", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2", "id": "A0A0G2K7X2", "database": "UniProtKB" } ], "name": "tumor necrosis factor receptor binding", "id": "GO:0005164" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2", "id": "A0A0G2K7X2", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2", "id": "A0A0G2K7X2", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031996", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2", "id": "A0A0G2K7X2", "database": "UniProtKB" } ], "name": "thioesterase binding", "id": "GO:0031996" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019903", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2", "id": "A0A0G2K7X2", "database": "UniProtKB" } ], "name": "protein phosphatase binding", "id": "GO:0019903" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2", "id": "A0A0G2K7X2", "database": "UniProtKB" } ], "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2", "id": "A0A0G2K7X2", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035631", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2", "id": "A0A0G2K7X2", "database": "UniProtKB" } ], "name": "CD40 receptor complex", "id": "GO:0035631" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2", "id": "A0A0G2K7X2", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": 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