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2." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4#A0A0G2K7Q4-1", "isoform_ac": "A0A0G2K7Q4-1", "locus": { "end_pos": 36371492, "start_pos": 36373546, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000079552", "id": "ENSRNOT00000079552", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074299", "id": "ENSRNOP00000074299", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K7Q4-1|A0A0G2K7Q4_RAT Isoform 1 of Heart- and neural crest derivatives-expressed protein 2 OS=Rattus norvegicus OX=10116 GN=Hand2 PE=4 SV=1 CANONICAL=A0A0G2K7Q4-1", "length": 214, "sequence": "MSLVGAFPTPVVHHEGYPFAAAAAAAAAAAASPDHEENPYFPRLGSIGHPEMSPPTAWALSTVPEYASGARLDHSHYGEECRPGAGPPGLGGRRPVEASGHRQRKERRQTQSNSALAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVWALELKQ" } } ], "pathway": [], "function": [], "orthologs": [], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003680", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "AT DNA binding", "id": "GO:0003680" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "protein homodimerization activity", "id": "GO:0042803" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "protein heterodimerization activity", "id": "GO:0046982" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "transcription factor binding", "id": "GO:0008134" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070888", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "E-box binding", "id": "GO:0070888" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "nuclear chromatin", "id": "GO:0000790" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "transcription factor complex", "id": "GO:0005667" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "in utero embryonic development", "id": "GO:0001701" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001967", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "suckling behavior", "id": "GO:0001967" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "negative regulation of gene expression", "id": "GO:0010629" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "url": 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"https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "heart looping", "id": "GO:0001947" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042733", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "embryonic digit morphogenesis", "id": "GO:0042733" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007512", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "adult heart development", "id": "GO:0007512" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045668", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "negative regulation of osteoblast differentiation", "id": "GO:0045668" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048485", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "sympathetic nervous system development", "id": "GO:0048485" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010613", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "positive regulation of cardiac muscle hypertrophy", "id": "GO:0010613" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010667", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "negative regulation of cardiac muscle cell apoptotic process", "id": "GO:0010667" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060982", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "coronary artery morphogenesis", "id": "GO:0060982" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043586", "evidence": [ { "url": 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"evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "regulation of secondary heart field cardioblast proliferation", "id": "GO:0003266" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043392", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "negative regulation of DNA binding", "id": "GO:0043392" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003253", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "cardiac neural crest cell migration involved in outflow tract morphogenesis", "id": "GO:0003253" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010463", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "mesenchymal cell proliferation", "id": "GO:0010463" }, { "url": 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"UniProtKB" } ], "name": "positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis", "id": "GO:2000764" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903929", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7Q4", "id": "A0A0G2K7Q4", "database": "UniProtKB" } ], "name": "primary palate development", "id": "GO:1903929" } ], "total": 32, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000060448", "id": "ENSRNOG00000060448", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00083", "id": "cd00083", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "id": "IPR011598", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "id": "IPR036638", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00010", "id": "PF00010", "database": "Pfam" } 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