{ "uniprot_canonical_ac": "A0A0G2K7N9-1", "sequence": { "header": "tr|A0A0G2K7N9-1|A0A0G2K7N9_RAT Isoform 1 of Rho GTPase-activating protein 5 OS=Rattus norvegicus OX=10116 GN=Arhgap5 PE=1 SV=1 CANONICAL=A0A0G2K7N9-1", "length": 1503, "sequence": "MMAKNKEPRPPSYTVSVVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDITQNGEDGVECKIHVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRGKPKIIPYLDAYKTQRQLVVTATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYISTLPRAFNTLLPDLEEIEHLNWLEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRIEMKEKFKKTLEKIQFISPGQPWEEVMCFVMEDEAFKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQYCTDIKVENLLANSLLHSDHNRSRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIYELDLRPVDAKSPYILSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQLANKLQCPFVDVPAGTYPRKFNESQIKQALRGVLESVKHNLDVVSPVPINKDVSEADLRIVMCAMCGDPFSVDIILSPFLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKELMTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPPYSPIGDDVQLLPTPSDRSRYRLDLEGNEYPVHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLAHPEDMDSSDNYAEPLDTIFKQKGYPDEIYVVPDDSQNRIIKIRNSFVNNTQGDEENGFSDRTSKGHGERRPSKYKYKSKTLFSKAKSYYRRTHSDASDDEAFPTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQEVDDKKIKKKPHKVKEDKKQKKKTKTFNPPTRRNWESNYFGMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLASMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQNKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFFYNGEIVETANTVAAPPTSNPGQLVESMVPLQLPPPLQPQLIQPQLQTDPLGII" }, "uniprot_id": "A0A0G2K7N9_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "rho GTPase-activating protein 5 isoform X1" ], "uniprotkb": [ "Rho GTPase-activating protein 5" ] }, "gene": { "refseq": [ "Arhgap5", "LRRGT00098" ], "uniprotkb": [ "Arhgap5", "rCG_61384", "LRRGT00098" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9", "id": "A0A0G2K7N9", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Rho GTPase-activating protein 5." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9/publications", "id": "A0A0G2K7N9", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9#A0A0G2K7N9-1", "isoform_ac": "A0A0G2K7N9-1", "locus": { "end_pos": 73358109, "start_pos": 73405679, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000088378", "id": "ENSRNOT00000088378", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074284", "id": "ENSRNOP00000074284", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K7N9-1|A0A0G2K7N9_RAT Isoform 1 of Rho GTPase-activating protein 5 OS=Rattus norvegicus OX=10116 GN=Arhgap5 PE=1 SV=1 CANONICAL=A0A0G2K7N9-1", "length": 1503, "sequence": "MMAKNKEPRPPSYTVSVVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDITQNGEDGVECKIHVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRGKPKIIPYLDAYKTQRQLVVTATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYISTLPRAFNTLLPDLEEIEHLNWLEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRIEMKEKFKKTLEKIQFISPGQPWEEVMCFVMEDEAFKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQYCTDIKVENLLANSLLHSDHNRSRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIYELDLRPVDAKSPYILSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQLANKLQCPFVDVPAGTYPRKFNESQIKQALRGVLESVKHNLDVVSPVPINKDVSEADLRIVMCAMCGDPFSVDIILSPFLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKELMTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPPYSPIGDDVQLLPTPSDRSRYRLDLEGNEYPVHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLAHPEDMDSSDNYAEPLDTIFKQKGYPDEIYVVPDDSQNRIIKIRNSFVNNTQGDEENGFSDRTSKGHGERRPSKYKYKSKTLFSKAKSYYRRTHSDASDDEAFPTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQEVDDKKIKKKPHKVKEDKKQKKKTKTFNPPTRRNWESNYFGMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLASMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQNKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFFYNGEIVETANTVAAPPTSNPGQLVESMVPLQLPPPLQPQLIQPQLQTDPLGII" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9#Q6TUE6-1", "isoform_ac": "Q6TUE6-1", "locus": { "end_pos": 73358112, "start_pos": 73365930, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000041373", "id": "ENSRNOT00000041373", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000047384", "id": "ENSRNOP00000047384", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q6TUE6-1|A0A0G2K7N9_RAT Computationally mapped isoform of Rho GTPase-activating protein 5 OS=Rattus norvegicus OX=10116 GN=Arhgap5 PE=1 SV=1 CANONICAL=A0A0G2K7N9-1", "length": 1245, "sequence": "MAKNKEPRPPSYTVSVVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDITQNGEDGVECKIHVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRGKPKIIPYLDAYKTQRQLVVTATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYISTLPRAFNTLLPDLEEIEHLNWLEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRIEMKEKFKKTLEKIQFISPGQPWEEVMCFVMEDEAFKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQYCTDIKVENLLANSLLHSDHNRSRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIYELDLRPVDAKSPYILSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQLANKLQCPFVDVPAGTYPRKFNESQIKQALRGVLESVKHNLDVVSPVPINKDVSEADLRIVMCAMCGDPFSVDIILSPFLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKELMTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPPYSPIGDDVQLLPTPSDRSRYRLDLEGNEYPVHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLAHPEDMDSSDNYAEPLDTIFKQKGYPDEIYVVPDDSQNRIIKIRNSFVNNTQGDEENGFSDRTSKGHGERRPSKYKYKSKTLFSKAKSYYRRTHSDASDDEAFPTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQEVDDKKIKKKPHKVKEDKKGFVSKG" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194840", "resource": "Reactome", "id": "R-RNO-194840", "name": "Rho GTPase cycle" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q13017-1", "protein_name": "Rho GTPase-activating protein 5; Rho-type GTPase-activating protein 5; p190-B.", "sequence": { "length": 1502, "sequence": "MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKIHVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVVTATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLNWSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPWEEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIYELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQLANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKELMTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPPYSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLAHPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHGERRPSKYKYKSKTLFSKAKSYYRRTHSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYFGMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFFYNGEIVETTNIVAPPPPSNPGQLVEPMVPLQLPPPLQPQLIQPQLQTDPLGII" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/907", "id": "907", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008762878.1", "ac": "XP_008762878.1", "name": "rho GTPase-activating protein 5 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042169", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9", "id": "A0A0G2K7N9", "database": "UniProtKB" } ], "name": "SH2 domain binding", "id": "GO:0042169" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9", "id": "A0A0G2K7N9", "database": "UniProtKB" } ], "name": "GTPase activity", "id": "GO:0003924" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9", "id": "A0A0G2K7N9", "database": "UniProtKB" } ], "name": "GTP binding", "id": "GO:0005525" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9", "id": "A0A0G2K7N9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9", "id": "A0A0G2K7N9", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030879", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9", "id": "A0A0G2K7N9", "database": "UniProtKB" } ], "name": "mammary gland development", "id": "GO:0030879" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9", "id": "A0A0G2K7N9", "database": "UniProtKB" } ], "name": "signal transduction", "id": "GO:0007165" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 509, "annotation": "n_glycosylation_sequon", "start_pos": 507 }, { "end_pos": 584, "annotation": "n_glycosylation_sequon", "start_pos": 582 }, { "end_pos": 744, "annotation": "n_glycosylation_sequon", "start_pos": 742 }, { "end_pos": 815, "annotation": "n_glycosylation_sequon", "start_pos": 813 }, { "end_pos": 1130, "annotation": "n_glycosylation_sequon", "start_pos": 1128 }, { "end_pos": 1304, "annotation": "n_glycosylation_sequon", "start_pos": 1302 }, { "end_pos": 1411, "annotation": "n_glycosylation_sequon", "start_pos": 1409 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008762878.1", "id": "XP_008762878.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194840", "id": "R-RNO-194840", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004696", "id": "ENSRNOG00000004696", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/HIDKVND/", "id": "HIDKVND", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "id": "IPR000198", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "id": "IPR001806", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "id": "IPR008936", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002713", "id": "IPR002713", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032835", "id": "IPR032835", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036517", "id": "IPR036517", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039006", "id": "IPR039006", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039007", "id": "IPR039007", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00071", "id": "PF00071", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00620", "id": "PF00620", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01846", "id": "PF01846", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF16512", "id": "PF16512", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/299012", "id": "299012", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308507", "id": "1308507", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K7N9", "disease": [], "mass": { "monoisotopic_mass": 172291.0, "chemical_mass": 172291.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7N9", "name": "Arhgap5; rCG_61384; LRRGT00098.", "locus": { "end_pos": 73405880, "start_pos": 73345392, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000004696", "id": "ENSRNOG00000004696", "database": "Ensembl Gene" } ] } } ] }