{ "uniprot_canonical_ac": "A0A0G2K7L4-1", "sequence": { "header": "tr|A0A0G2K7L4-1|A0A0G2K7L4_RAT Isoform 1 of Inositol-tetrakisphosphate 1-kinase OS=Rattus norvegicus OX=10116 GN=Itpk1 PE=1 SV=1 CANONICAL=A0A0G2K7L4-1", "length": 463, "sequence": "MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGDDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLSAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSGSSPGPSLMPPVWTGSGRSSGRTVGHTGVARGLCAPLAGRMPDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCSSMKGQDTPWKTEAEAGNMGAGGGGSAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ" }, "uniprot_id": "A0A0G2K7L4_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "inositol-tetrakisphosphate 1-kinase isoform X1" ], "uniprotkb": [ "Inositol-tetrakisphosphate 1-kinase" ] }, "gene": { "refseq": [ "Itpk1" ], "uniprotkb": [ "Itpk1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Inositol-tetrakisphosphate 1-kinase." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4#A0A0G2K7L4-1", "isoform_ac": "A0A0G2K7L4-1", "locus": { "end_pos": 126450511, "start_pos": 126582034, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000080829", "id": "ENSRNOT00000080829", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074255", "id": "ENSRNOP00000074255", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K7L4-1|A0A0G2K7L4_RAT Isoform 1 of Inositol-tetrakisphosphate 1-kinase OS=Rattus norvegicus OX=10116 GN=Itpk1 PE=1 SV=1 CANONICAL=A0A0G2K7L4-1", "length": 463, "sequence": "MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGDDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLSAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSGSSPGPSLMPPVWTGSGRSSGRTVGHTGVARGLCAPLAGRMPDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCSSMKGQDTPWKTEAEAGNMGAGGGGSAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4#D3ZQM7-1", "isoform_ac": "D3ZQM7-1", "locus": { "end_pos": 126450511, "start_pos": 126582034, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000010656", "id": "ENSRNOT00000010656", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000010656", "id": "ENSRNOP00000010656", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZQM7-1|A0A0G2K7L4_RAT Computationally mapped isoform of Inositol-tetrakisphosphate 1-kinase OS=Rattus norvegicus OX=10116 GN=Itpk1 PE=1 SV=3 CANONICAL=A0A0G2K7L4-1", "length": 421, "sequence": "MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGDDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLSAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCSSMKGQDTPWKTEAEAGNMGAGGGGSAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855167", "resource": "Reactome", "id": "R-RNO-1855167", "name": "Synthesis of pyrophosphates in the cytosol" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855204", "resource": "Reactome", "id": "R-RNO-1855204", "name": "Synthesis of IP3 and IP4 in the cytosol" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983231", "resource": "Reactome", "id": "R-RNO-983231", "name": "Factors involved in megakaryocyte development and platelet production" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8BYN3-1", "protein_name": "Inositol-tetrakisphosphate 1-kinase; 2.7.1.134; 6-kinase; 2.7.1.159.", "sequence": { "length": 419, "sequence": "MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGEDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCGSMKGQDTPWKTETEAGNMGAGASAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K7L4/", "id": "A0A0G2K7L4", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8588", "id": "8588", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q13572-1", "protein_name": "Inositol-tetrakisphosphate 1-kinase; 2.7.1.134; 6-kinase; 2.7.1.159.", "sequence": { "length": 414, "sequence": "MQTFLKGKRVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLATKASSQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8588", "id": "8588", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017449793.1", "ac": "XP_017449793.1", "name": "inositol-tetrakisphosphate 1-kinase isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047325", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "inositol tetrakisphosphate 1-kinase activity", "id": "GO:0047325" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052725", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "inositol-1,3,4-trisphosphate 6-kinase activity", "id": "GO:0052725" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052726", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "inositol-1,3,4-trisphosphate 5-kinase activity", "id": "GO:0052726" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "magnesium ion binding", "id": "GO:0000287" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000825", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "inositol tetrakisphosphate 6-kinase activity", "id": "GO:0000825" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "apical plasma membrane", "id": "GO:0016324" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052746", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "inositol phosphorylation", "id": "GO:0052746" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021915", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "neural tube development", "id": "GO:0021915" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070266", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "necroptotic process", "id": "GO:0070266" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032957", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4", "database": "UniProtKB" } ], "name": "inositol trisphosphate metabolic process", "id": "GO:0032957" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 44, "annotation": "n_glycosylation_sequon", "start_pos": 42 }, { "end_pos": 72, "annotation": "n_glycosylation_sequon", "start_pos": 70 }, { "end_pos": 219, "annotation": "n_glycosylation_sequon", "start_pos": 217 }, { "end_pos": 278, "annotation": "n_glycosylation_sequon", "start_pos": 276 }, { "end_pos": 330, "annotation": "n_glycosylation_sequon", "start_pos": 328 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017449793.1", "id": "XP_017449793.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855167", "id": "R-RNO-1855167", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855204", "id": "R-RNO-1855204", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983231", "id": "R-RNO-983231", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000008051", "id": "ENSRNOG00000008051", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/YMQDERI/", "id": "YMQDERI", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008656", "id": "IPR008656", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR040464", "id": "IPR040464", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041429", "id": "IPR041429", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF05770", "id": "PF05770", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17927", "id": "PF17927", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14217", "id": "PTHR14217", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/500709", "id": "500709", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1595691", "id": "1595691", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K7L4", "disease": [], "mass": { "monoisotopic_mass": 50290.0, "chemical_mass": 50290.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "name": "Itpk1.", "locus": { "end_pos": 126450139, "start_pos": 126582134, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000008051", "id": "ENSRNOG00000008051", "database": "Ensembl Gene" } ] } } ] }