{ "uniprot_canonical_ac": "A0A0G2K7K3-1", "sequence": { "header": "tr|A0A0G2K7K3-1|A0A0G2K7K3_RAT Isoform 1 of SIX homeobox 5 OS=Rattus norvegicus OX=10116 GN=Six5 PE=4 SV=1 CANONICAL=A0A0G2K7K3-1", "length": 720, "sequence": "MATSPAEPSAGPAAQGEAAAATEEEEEEARQLLQTLQAAEGEAAAAGAGEGAAADSGSPSGPGSPRETGTEAPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCKSESDGNPTTEDESSRSPEDLERGVASVAAEAPTQSSIFLAGATPSATCPASSSILVNGSFLAASSPPAVLLNGSPVIINSLTLGEGSSLGPLLLTGGGGTPQPQPSPQGVSETKTSLVLDPQTGEVRLDEAQSEAPEAKGVHGTTPGEEIPGTLPQVVPGPPPASTFPLTPGAVPSVAAPQVVPLSPSSGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAATAGPTNVHLINSSVGVTALQLPSSATPGNLLLANPVSGSPIVTGVAVQQGRILLTATFPTRMLVSQVLPPAPSLALPLKQEPAITVPEGALPVGPSPTLPEGHTLGPVSTQPLPPAPAVTSATSLPFSPDSSGLLSSFSAPLPEGLMLSPAAVPVWPAGLELSTGVEGLGTQATHTVLRLPDPDHQGLLLGATAGTEVDEGLEAEAKVLTQLQSVPVEEPLEL" }, "uniprot_id": "A0A0G2K7K3_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "SIX homeobox 5" ] }, "gene": { "refseq": [], "uniprotkb": [ "Six5" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "SIX homeobox 5." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3#A0A0G2K7K3-1", "isoform_ac": "A0A0G2K7K3-1", "locus": { "end_pos": 80000165, "start_pos": 80003229, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000084912", "id": "ENSRNOT00000084912", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074243", "id": "ENSRNOP00000074243", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K7K3-1|A0A0G2K7K3_RAT Isoform 1 of SIX homeobox 5 OS=Rattus norvegicus OX=10116 GN=Six5 PE=4 SV=1 CANONICAL=A0A0G2K7K3-1", "length": 720, "sequence": "MATSPAEPSAGPAAQGEAAAATEEEEEEARQLLQTLQAAEGEAAAAGAGEGAAADSGSPSGPGSPRETGTEAPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCKSESDGNPTTEDESSRSPEDLERGVASVAAEAPTQSSIFLAGATPSATCPASSSILVNGSFLAASSPPAVLLNGSPVIINSLTLGEGSSLGPLLLTGGGGTPQPQPSPQGVSETKTSLVLDPQTGEVRLDEAQSEAPEAKGVHGTTPGEEIPGTLPQVVPGPPPASTFPLTPGAVPSVAAPQVVPLSPSSGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAATAGPTNVHLINSSVGVTALQLPSSATPGNLLLANPVSGSPIVTGVAVQQGRILLTATFPTRMLVSQVLPPAPSLALPLKQEPAITVPEGALPVGPSPTLPEGHTLGPVSTQPLPPAPAVTSATSLPFSPDSSGLLSSFSAPLPEGLMLSPAAVPVWPAGLELSTGVEGLGTQATHTVLRLPDPDHQGLLLGATAGTEVDEGLEAEAKVLTQLQSVPVEEPLEL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:308406", "resource": "KEGG Pathway", "id": "rno:308406", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "P70178-1", "protein_name": "Homeobox protein SIX5; Sine oculis homeobox homolog 5; DM locus-associated homeodomain protein homolog.", "sequence": { "length": 719, "sequence": "MATSPAEPSAGPAARGEAAAATEEQEEEARQLLQTLQAAEGEAAAAGAGDAAAAADSGSPSGPGSPRETVTEVPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCKSESDGNPTTEDESSRSPEDLERGVASMAAEAPAQSSIFLAGATSPATCPASSSILVNGSFLAASSPPAVLLNGSPVIINSLALGENSSLGPLLLTGGSAPQPQPSLQGVSEAKNSLVLDPQTGEVRLDEAQSEAPETKGVHGTTGEEIPGALPQVVPGPPPASTFPLTPGAVPAVAAPQVVPLSPSSGYPTGLSPTSPRLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPTNVHLINSSVGVTALQLPSSTAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPSLALPLKQEPAITVPEGALPVGPSPTLPEGHTLGPISTQPLPPASVVTSGTSLPFSPDSSGLLSSFSAPLPEGLMLSPAAVPVWPAGLELSTGVEGLGTQATHTVLRLPDPDPQGLLLGATTGTEVDEGLEAEAKVLTQLQSVPVEEPLEL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/72248", "id": "72248", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2K7K3/", "id": "A0A0G2K7K3", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q8N196-1", "protein_name": "Homeobox protein SIX5; Sine oculis homeobox homolog 5; DM locus-associated homeodomain protein.", "sequence": { "length": 739, "sequence": "MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVALQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEAEAKVLTQLQSVPVEEPLEL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/72248", "id": "72248", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2K7K3/", "id": "A0A0G2K7K3", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "transcription regulatory region sequence-specific DNA binding", "id": "GO:0000976" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", "id": "GO:0000978" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "transcription factor complex", "id": "GO:0005667" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048856", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "anatomical structure development", "id": "GO:0048856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "spermatid development", "id": "GO:0007286" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002088", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "lens development in camera-type eye", "id": "GO:0002088" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "id": "A0A0G2K7K3", "database": "UniProtKB" } ], "name": "negative regulation of skeletal muscle satellite cell proliferation", "id": "GO:1902723" } ], "total": 6, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 318, "annotation": "n_glycosylation_sequon", "start_pos": 316 }, { "end_pos": 333, "annotation": "n_glycosylation_sequon", "start_pos": 331 }, { "end_pos": 510, "annotation": "n_glycosylation_sequon", "start_pos": 508 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003748828.2", "id": "XP_003748828.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:308406", "id": "rno:308406", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000060146", "id": "ENSRNOG00000060146", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/EAHTLGT/", "id": "EAHTLGT", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "id": "cd00086", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "id": "IPR001356", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "id": "IPR009057", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "id": "IPR017970", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031701", "id": "IPR031701", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00046", "id": "PF00046", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF16878", "id": "PF16878", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/308406", "id": "308406", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305040", "id": "1305040", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K7K3", "disease": [], "mass": { "monoisotopic_mass": 73733.0, "chemical_mass": 73733.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K7K3", "name": "Six5.", "locus": { "end_pos": 80003232, "start_pos": 80000165, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000060146", "id": "ENSRNOG00000060146", "database": "Ensembl Gene" } ] } } ] }