{ "uniprot_canonical_ac": "A0A0G2K735-1", "sequence": { "header": "tr|A0A0G2K735-1|A0A0G2K735_RAT Isoform 1 of Ubiquitin-like modifier-activating enzyme 7 OS=Rattus norvegicus OX=10116 GN=Uba7 PE=1 SV=1 CANONICAL=A0A0G2K735-1", "length": 989, "sequence": "MDEELYSRQLYVLGLPAMQRIREAKVLLCGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWADLAAQFFLSEESLGRSRAEASQPQLAQLNEAVQISVHRGDITEDLVRGFQVVVLTDSKLEDQLNMGALCHKNRVYFLMAETRGLVGRLFCDFGEDFTVVDPTEVEPTSAAIQDISQGSPGIVTLRGGSKRPSFYDGDLVMFSDIEGMVELNSHSPQPVRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVKHKPLDIALLQPCMVVQNTQEIQRAHCLHQTFHALHKFQQLHGRLPKPWDPDDAETVVWLAQDLEPLKGAKEESLDEALLRTIALSSAGSLSPMAAILGGVAAQEVLKAVSGKFMPLDQWLYFDALECLPEDETLLPSPEDCHPRNCRYDGQIAVFGTGFQEKLSYKHYLLVGAGAIGCEMLKGFALVGLGVRDNGGVTIADMDHVERSNLSRQFLFRPKDTGRPKAEVAAEAAHRLNPDLQVTSHTCPLDPTTEDIYDDDFFSRVDGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTRGSASVFVPYVTEVYKGPTSAEEAPYPVCTLRHFPSTVEHSLQWAQDEFEGLFRLSAETINDYQQTCTSSLLGTDGTGILALLQQVMGVLRTRPQTWQDCVVWALGHWQLCFRDNIVELLRKFPSDKVLEDGTLFWSGSKKCPHPLQFDPNQDTHFLYVLAAANLYARMHGLPGSQSQTALRELLTLTLLQEPDSMPQNLFSAEFGQEQLKELQETLDDWNKGPPLKPVLFGKDDSSNFHEDFVVAATDLRCQNYGILPVNRARIKQTIGRIIPAIATSTAVVAGLLGLELYKVVSGPRPLGTFRHSYLHLAENHFIRSAPSAPAMQSFHHLEWTCWHRLTVPAGQPERTLESLLAHLQEEHGLTVRMLLHDQALLYSSGWPFEKQAQHLGLRVTELVQQVTGQKPKPGLRVLVFELSCEGEDDEMAFPPLHYEL" }, "uniprot_id": "A0A0G2K735_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "ubiquitin-like modifier-activating enzyme 7 isoform X1" ], "uniprotkb": [ "Ubiquitin-like modifier-activating enzyme 7" ] }, "gene": { "refseq": [ "Uba7", "Ube1l" ], "uniprotkb": [ "Uba7", "Ube1l" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K735", "id": "A0A0G2K735", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Ubiquitin-like modifier-activating enzyme 7." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K735#D3ZEU5-1", "isoform_ac": "D3ZEU5-1", "locus": { "end_pos": 116754347, "start_pos": 116758804, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000068295", "id": "ENSRNOT00000068295", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000062984", "id": "ENSRNOP00000062984", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZEU5-1|A0A0G2K735_RAT Computationally mapped isoform of Ubiquitin-like modifier-activating enzyme 7 OS=Rattus norvegicus OX=10116 GN=Uba7 PE=1 SV=1 CANONICAL=A0A0G2K735-1", "length": 676, "sequence": "MDEELYSRQLYVLGLPAMQRIREAKVLLCGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWADLAAQFFLSEESLGRSRAEASQPQLAQLNEAVQISVHRGDITEDLVRGFQVVVLTDSKLEDQLNMGALCHKNRVYFLMAETRGLVGRLFCDFGEDFTVVDPTEVEPTSAAIQDISQGSPGIVTLRGGSKRPSFYDGDLVMFSDIEGMVELNSHSPQPVRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVKHKPLDIALLQPCMVVQNTQEIQRAHCLHQTFHALHKFQQLHGRLPKPWDPDDAETVVWLAQDLEPLKGAKEESLDEALLRTIALSSAGSLSPMAAILGGVAAQEVLKAVSGKFMPLDQWLYFDALECLPEDETLLPSPEDCHPRNCRYDGQIAVFGTGFQEKLSYKHYLLVGAGAIGCEMLKGFALVGLGVRDNGGVTIADMDHVERSNLSRQFLFRPKDTGRPKAEVAAEAAHRLNPDLQVTSHTCPLDPTTEDIYDDDFFSRVDGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTRGSASVFVPYVTEVYKGPTSAEEAPYPVCTLRHFPSTVEHSLQWAQDEFEGLFRLSAETINDYQQCLRTELCSGQDPKSAHIPCNLIPTKTRISSMYWQLPTCMHGCMGCRAHKVRLHSGNC" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K735#A0A0G2K735-1", "isoform_ac": "A0A0G2K735-1", "locus": { "end_pos": 116754347, "start_pos": 116762871, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000084429", "id": "ENSRNOT00000084429", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074046", "id": "ENSRNOP00000074046", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K735-1|A0A0G2K735_RAT Isoform 1 of Ubiquitin-like modifier-activating enzyme 7 OS=Rattus norvegicus OX=10116 GN=Uba7 PE=1 SV=1 CANONICAL=A0A0G2K735-1", "length": 989, "sequence": "MDEELYSRQLYVLGLPAMQRIREAKVLLCGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWADLAAQFFLSEESLGRSRAEASQPQLAQLNEAVQISVHRGDITEDLVRGFQVVVLTDSKLEDQLNMGALCHKNRVYFLMAETRGLVGRLFCDFGEDFTVVDPTEVEPTSAAIQDISQGSPGIVTLRGGSKRPSFYDGDLVMFSDIEGMVELNSHSPQPVRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVKHKPLDIALLQPCMVVQNTQEIQRAHCLHQTFHALHKFQQLHGRLPKPWDPDDAETVVWLAQDLEPLKGAKEESLDEALLRTIALSSAGSLSPMAAILGGVAAQEVLKAVSGKFMPLDQWLYFDALECLPEDETLLPSPEDCHPRNCRYDGQIAVFGTGFQEKLSYKHYLLVGAGAIGCEMLKGFALVGLGVRDNGGVTIADMDHVERSNLSRQFLFRPKDTGRPKAEVAAEAAHRLNPDLQVTSHTCPLDPTTEDIYDDDFFSRVDGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTRGSASVFVPYVTEVYKGPTSAEEAPYPVCTLRHFPSTVEHSLQWAQDEFEGLFRLSAETINDYQQTCTSSLLGTDGTGILALLQQVMGVLRTRPQTWQDCVVWALGHWQLCFRDNIVELLRKFPSDKVLEDGTLFWSGSKKCPHPLQFDPNQDTHFLYVLAAANLYARMHGLPGSQSQTALRELLTLTLLQEPDSMPQNLFSAEFGQEQLKELQETLDDWNKGPPLKPVLFGKDDSSNFHEDFVVAATDLRCQNYGILPVNRARIKQTIGRIIPAIATSTAVVAGLLGLELYKVVSGPRPLGTFRHSYLHLAENHFIRSAPSAPAMQSFHHLEWTCWHRLTVPAGQPERTLESLLAHLQEEHGLTVRMLLHDQALLYSSGWPFEKQAQHLGLRVTELVQQVTGQKPKPGLRVLVFELSCEGEDDEMAFPPLHYEL" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "resource": "Reactome", "id": "R-RNO-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169408", "resource": "Reactome", "id": "R-RNO-1169408", "name": "ISG15 antiviral mechanism" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5656169", "resource": "Reactome", "id": "R-RNO-5656169", "name": "Termination of translesion DNA synthesis" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q9DBK7-1", "protein_name": "MCG18845, isoform CRA_d; Ubiquitin-like modifier-activating enzyme 7; Ubiquitin-activating enzyme E1-like.", "sequence": { "length": 977, "sequence": "MDEELYSRQLYVLGLPAMQRIQEAKVLLCGLQGLGAEVAKNLVLTGVGSLTLHDPHPTCWADLAAQCFLSEESLGRNRAEASQAQLAQLNEAVQISVHSGDITEDLLQGFQVVVLTDSKLEDQLKVGPLCHKHGVRFLMAETRGLVGRLFCDFGEDFTVLDPTEVEPMTAAIQDISQGFPGIVTLRGDTKRHSFHDGDLVIFSDIEGMVELNSCSPQSVRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVRHKPLDIALLQPHVVAQNTQEVQRAHCLHQAFHVLHKFQQLHGRLPKPWDPDDAETVVELAQDLEPLKGTEEESLDEALLRTIALSSAGTLSPMAAIMGGVAAQEVLKAISRKFMPLDQWLYFDALECLPEDETLLPSPEDCQPRNCRYDGQIAVFGTDLQEKLSDQHYLLVGAGAIGCEMLKVFALVGLGVRANGGVTVADMDYIERSNLSRQFLFRPKDVRRPKAEVAAAAAHRLNPDLRATPYTCPLDPTTEDIYDDSFFSRVNGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTWGSASVFVPYVTEAYRGPASDAASEDAPYPVCTLRHIPSSMEHSVQWAQDQFEGLFRLSTETINCYQQTCTSLSATDRTETLALLQQVMGVLRTRPQTWQDCVVWALGHWQLCFHDKVLEGGTQFSSGSNKCPHPLQFDPNHDMHFLYVLAAANLYARMHGLPGSQSQPALRELLTRLLESDSRPQNLFSAEHGQEQLKELQETLDDWRKGPPLKPVLFVKDDDSNFHVDFVVAATDLRCQNYGILPVNHARIKQIVGRIIPAIATSTAVVAGLLGLELYKVVSGLRSHGTFRHSYLHLAENHFIRSAPSAPAVQSFRDLKWTCWDRLKVPAVQPERTLKSLLAHLQEEHGLKVEMLLHHQALLYSSGWSSEKQAQHLCLRVTELVQHVTGWKPKPGLKVLVFELSCEGEEEEMAFPPLHYEL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/2502", "id": "2502", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2K735/", "id": "A0A0G2K735", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "P41226-1", "protein_name": "Ubiquitin-like modifier-activating enzyme 7; Ubiquitin-activating enzyme 7; D8; Ubiquitin-activating enzyme E1 homolog.", "sequence": { "length": 1012, "sequence": "MDALDASKLLDEELYSRQLYVLGSPAMQRIQGARVLVSGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWSDLAAQFLLSEQDLERSRAEASQELLAQLNRAVQVVVHTGDITEDLLLDFQVVVLTAAKLEEQLKVGTLCHKHGVCFLAADTRGLVGQLFCDFGEDFTVQDPTEAEPLTAAIQHISQGSPGILTLRKGANTHYFRDGDLVTFSGIEGMVELNDCDPRSIHVREDGSLEIGDTTTFSRYLRGGAITEVKRPKTVRHKSLDTALLQPHVVAQSSQEVHHAHCLHQAFCALHKFQHLHGRPPQPWDPVDAETVVGLARDLEPLKRTEEEPLEEPLDEALVRTVALSSAGVLSPMVAMLGAVAAQEVLKAISRKFMPLDQWLYFDALDCLPEDGELLPSPEDCALRGSRYDGQIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGLTVVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPTTEHIYGDNFFSRVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTSGTWGSATVFMPHVTEAYRAPASAAASEDAPYPVCTVRYFPSTAEHTLQWARHEFEELFRLSAETINHHQQAHTSLADMDEPQTLTLLKPVLGVLRVRPQNWQDCVAWALGHWKLCFHYGIKQLLRHFPPNKVLEDGTPFWSGPKQCPQPLEFDTNQDTHLLYVLAAANLYAQMHGLPGSQDWTALRELLKLLPQPDPQQMAPIFASNLELASASAEFGPEQQKELNKALEVWSVGPPLKPLMFEKDDDSNFHVDFVVAAASLRCQNYGIPPVNRAQSKRIVGQIIPAIATTTAAVAGLLGLELYKVVSGPRPRSAFRHSYLHLAENYLIRYMPFAPAIQTFHHLKWTSWDRLKVPAGQPERTLESLLAHLQEQHGLRVRILLHGSALLYAAGWSPEKQAQHLPLRVTELVQQLTGQAPAPGQRVLVLELSCEGDDEDTAFPPLHYEL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/2502", "id": "2502", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2K735/", "id": "A0A0G2K735", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006243803.1", "ac": "XP_006243803.1", "name": "ubiquitin-like modifier-activating enzyme 7 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019782", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K735", "id": "A0A0G2K735", "database": "UniProtKB" } ], "name": "ISG15 activating enzyme activity", "id": "GO:0019782" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K735", "id": "A0A0G2K735", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K735", "id": "A0A0G2K735", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032446", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K735", "id": "A0A0G2K735", "database": "UniProtKB" } ], "name": "protein modification by small protein conjugation", "id": "GO:0032446" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K735", "id": "A0A0G2K735", "database": "UniProtKB" } ], "name": "ISG15-protein conjugation", "id": "GO:0032020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019941", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K735", "id": "A0A0G2K735", "database": "UniProtKB" } ], "name": "modification-dependent protein catabolic process", "id": "GO:0019941" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 465, "annotation": "n_glycosylation_sequon", "start_pos": 463 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006243803.1", "id": "XP_006243803.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "id": "R-RNO-983168", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169408", "id": "R-RNO-1169408", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5656169", "id": "R-RNO-5656169", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000029195", "id": "ENSRNOG00000029195", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/DTNQDMH/", "id": "DTNQDMH", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000011", "id": "IPR000011", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000594", "id": "IPR000594", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035985", "id": "IPR035985", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018075", "id": "IPR018075", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018965", "id": "IPR018965", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019572", "id": "IPR019572", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032418", "id": "IPR032418", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032420", "id": "IPR032420", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033127", "id": "IPR033127", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR038252", "id": "IPR038252", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042063", "id": "IPR042063", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042302", "id": "IPR042302", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042449", "id": "IPR042449", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00899", "id": "PF00899", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09358", "id": "PF09358", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF10585", "id": "PF10585", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF16190", "id": "PF16190", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF16191", "id": "PF16191", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/301000", "id": "301000", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308323", "id": "1308323", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K735", "disease": [], "mass": { "monoisotopic_mass": 109915.0, "chemical_mass": 109915.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K735", "name": "Uba7; Ube1l.", "locus": { "end_pos": 116764126, "start_pos": 116754178, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000029195", "id": "ENSRNOG00000029195", "database": "Ensembl Gene" } ] } } ] }