{ "uniprot_canonical_ac": "A0A0G2K6P4-1", "sequence": { "header": "tr|A0A0G2K6P4-1|A0A0G2K6P4_RAT Isoform 1 of High-mobility group (nonhistone chromosomal) protein 1-like 1 OS=Rattus norvegicus OX=10116 GN=Hmg1l1 PE=4 SV=1 CANONICAL=A0A0G2K6P4-1", "length": 214, "sequence": "MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIPAYRAKGKPDAAKKGVVKAEKSKKKKEEEDNEEDEEDEEEEEEEEDEDEEDDDDE" }, "uniprot_id": "A0A0G2K6P4_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "high mobility group box 1 like" ], "uniprotkb": [ "High-mobility group (nonhistone chromosomal) protein 1-like 1", "RCG50935" ] }, "gene": { "refseq": [ "Hmg1l1", "amphoterin" ], "uniprotkb": [ "Hmg1l1", "rCG_50935", "amphoterin" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "High-mobility group (nonhistone chromosomal) protein 1-like 1; RCG50935." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4#A0A0G2K6P4-1", "isoform_ac": "A0A0G2K6P4-1", "locus": { "end_pos": 59984748, "start_pos": 59985389, "chromosome": "19", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000086591", "id": "ENSRNOT00000086591", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073890", "id": "ENSRNOP00000073890", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K6P4-1|A0A0G2K6P4_RAT Isoform 1 of High-mobility group (nonhistone chromosomal) protein 1-like 1 OS=Rattus norvegicus OX=10116 GN=Hmg1l1 PE=4 SV=1 CANONICAL=A0A0G2K6P4-1", "length": 214, "sequence": "MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIPAYRAKGKPDAAKKGVVKAEKSKKKKEEEDNEEDEEDEEEEEEEEDEDEEDDDDE" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:679571", "resource": "KEGG Pathway", "id": "rno:679571", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "P63158-1", "protein_name": "High mobility group protein B1; High mobility group protein 1; HMG-1.", "sequence": { "length": 215, "sequence": "MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/135819", "id": "135819", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102843.1", "ac": "NP_001102843.1", "name": "high mobility group box 1 like.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008301", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "DNA binding, bending", "id": "GO:0008301" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "transcription factor binding", "id": "GO:0008134" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "nuclear chromatin", "id": "GO:0000790" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "DNA recombination", "id": "GO:0006310" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "positive regulation of NIK/NF-kappaB signaling", "id": "GO:1901224" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-6 production", "id": "GO:0032755" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010469", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "regulation of signaling receptor activity", "id": "GO:0010469" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032502", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "developmental process", "id": "GO:0032502" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050716", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-1 secretion", "id": "GO:0050716" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050718", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-1 beta secretion", "id": "GO:0050718" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060326", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "cell chemotaxis", "id": "GO:0060326" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "positive regulation of autophagy", "id": "GO:0010508" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002218", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "activation of innate immune response", "id": "GO:0002218" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902741", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "positive regulation of interferon-alpha secretion", "id": "GO:1902741" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045089", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "id": "A0A0G2K6P4", "database": "UniProtKB" } ], "name": "positive regulation of innate immune response", "id": "GO:0045089" } ], "total": 16, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 39, "annotation": "n_glycosylation_sequon", "start_pos": 37 }, { "end_pos": 136, "annotation": "n_glycosylation_sequon", "start_pos": 134 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102843.1", "id": "NP_001102843.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:679571", "id": "rno:679571", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000051482", "id": "ENSRNOG00000051482", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/YADEMAS/", "id": "YADEMAS", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017967", "id": "IPR017967", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "id": "IPR036910", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "id": "IPR009071", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00505", "id": "PF00505", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09011", "id": "PF09011", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/679571", "id": "679571", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1587112", "id": "1587112", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K6P4", "disease": [], "mass": { "monoisotopic_mass": 24790.0, "chemical_mass": 24790.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6P4", "name": "Hmg1l1; rCG_50935; amphoterin.", "locus": { "end_pos": 59984234, "start_pos": 59985494, "chromosome": "19", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000051482", "id": "ENSRNOG00000051482", "database": "Ensembl Gene" } ] } } ] }