{ "uniprot_canonical_ac": "A0A0G2K6D0-1", "sequence": { "header": "tr|A0A0G2K6D0-1|A0A0G2K6D0_RAT Isoform 1 of Lysine demethylase 6A OS=Rattus norvegicus OX=10116 GN=Kdm6a PE=1 SV=1 CANONICAL=A0A0G2K6D0-1", "length": 1366, "sequence": "MKSCGVSLATAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARMKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEEYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQLENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKNCSNTSGLAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGNAVPHPPVQQQTHSWCLTPQKLQMRQTGVAQVRPTGIPNGPTADSSLPTNSASGQQPQLPLTRMPSVSQPGVQPACPRQALANGPFSAGHVPCSTSRTLGSTDTILIGNNHVTGSGSNGNVPYLQRNAPTLPHNRTNLTSSTEEPWKNQLSNSTQGLHKGQSSHLAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNTLTLPETNRQTGETPNSTASVEGLPNHVHQVMADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGPGTCDIVNNIHPTVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPIKTDLLLVSHRPSPQIIPSVSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGKGEAGPFKTISFGTNINLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMVKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCAWKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSASS" }, "uniprot_id": "A0A0G2K6D0_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Lysine demethylase 6A" ] }, "gene": { "refseq": [], "uniprotkb": [ "Kdm6a", "NEWGENE_1565481" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Lysine demethylase 6A." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0/publications", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0#A0A0G2K6D0-1", "isoform_ac": "A0A0G2K6D0-1", "locus": { "end_pos": 4806964, "start_pos": 4945388, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000077238", "id": "ENSRNOT00000077238", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073763", "id": "ENSRNOP00000073763", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K6D0-1|A0A0G2K6D0_RAT Isoform 1 of Lysine demethylase 6A OS=Rattus norvegicus OX=10116 GN=Kdm6a PE=1 SV=1 CANONICAL=A0A0G2K6D0-1", "length": 1366, "sequence": "MKSCGVSLATAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARMKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEEYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQLENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKNCSNTSGLAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGNAVPHPPVQQQTHSWCLTPQKLQMRQTGVAQVRPTGIPNGPTADSSLPTNSASGQQPQLPLTRMPSVSQPGVQPACPRQALANGPFSAGHVPCSTSRTLGSTDTILIGNNHVTGSGSNGNVPYLQRNAPTLPHNRTNLTSSTEEPWKNQLSNSTQGLHKGQSSHLAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNTLTLPETNRQTGETPNSTASVEGLPNHVHQVMADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGPGTCDIVNNIHPTVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPIKTDLLLVSHRPSPQIIPSVSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGKGEAGPFKTISFGTNINLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMVKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCAWKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSASS" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3214842", "resource": "Reactome", "id": "R-RNO-3214842", "name": "HDMs demethylate histones" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O70546-1", "protein_name": "Lysine-specific demethylase 6A; 1.14.11.-; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein; Ubiquitously transcribed TPR protein on the X chromosome; Histone demethylase UTX.", "sequence": { "length": 1401, "sequence": "MKSCGVSLATAAAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARMKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATILQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKNCSNTSGLAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGNAPPPVEQQTHSWCLTPQKLQHLEQLRANRNNLNPAQKLMLEQLESQFVLMQQHQMRQTGVAQVRPTGILNGPTVDSSLPTNSVSGQQPQLPLTRMPSVSQPGVHTACPRQTLANGPFSAGHVPCSTSRTLGSTDTVLIGNNHVTGSGSNGNVPYLQRNAPTLPHNRTNLTSSTEEPWKNQLSNSTQGLHKGPSSHLAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNTLTVPETSRQTGETPNSTASVEGLPNHVHQVMADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGPGTCDKVNNIHPTVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPIKTDLLLVSHRPSPQIIPSMSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGKRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQNVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSASS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K6D0/", "id": "A0A0G2K6D0", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "chromatin DNA binding", "id": "GO:0031490" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071558", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "histone demethylase activity (H3-K27 specific)", "id": "GO:0071558" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "nuclear chromatin", "id": "GO:0000790" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044666", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "MLL3/4 complex", "id": "GO:0044666" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048570", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "notochord morphogenesis", "id": "GO:0048570" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "in utero embryonic development", "id": "GO:0001701" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003016", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "respiratory system process", "id": "GO:0003016" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "chromatin remodeling", "id": "GO:0006338" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "positive regulation of gene expression", "id": "GO:0010628" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035264", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "multicellular organism growth", "id": "GO:0035264" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "neural tube closure", "id": "GO:0001843" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003007", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "heart morphogenesis", "id": "GO:0003007" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072358", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "cardiovascular system development", "id": "GO:0072358" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "canonical Wnt signaling pathway", "id": "GO:0060070" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032525", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "somite rostral/caudal axis specification", "id": "GO:0032525" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048333", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "id": "A0A0G2K6D0", "database": "UniProtKB" } ], "name": "mesodermal cell differentiation", "id": "GO:0048333" } ], "total": 12, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 237, "annotation": "n_glycosylation_sequon", "start_pos": 235 }, { "end_pos": 378, "annotation": "n_glycosylation_sequon", "start_pos": 376 }, { "end_pos": 384, "annotation": "n_glycosylation_sequon", "start_pos": 382 }, { "end_pos": 387, "annotation": "n_glycosylation_sequon", "start_pos": 385 }, { "end_pos": 412, "annotation": "n_glycosylation_sequon", "start_pos": 410 }, { "end_pos": 445, "annotation": "n_glycosylation_sequon", "start_pos": 443 }, { "end_pos": 449, "annotation": "n_glycosylation_sequon", "start_pos": 447 }, { "end_pos": 587, "annotation": "n_glycosylation_sequon", "start_pos": 585 }, { "end_pos": 590, "annotation": "n_glycosylation_sequon", "start_pos": 588 }, { "end_pos": 605, "annotation": "n_glycosylation_sequon", "start_pos": 603 }, { "end_pos": 706, "annotation": "n_glycosylation_sequon", "start_pos": 704 }, { "end_pos": 877, "annotation": "n_glycosylation_sequon", "start_pos": 875 }, { "end_pos": 993, "annotation": "n_glycosylation_sequon", "start_pos": 991 }, { "end_pos": 1056, "annotation": "n_glycosylation_sequon", "start_pos": 1054 }, { "end_pos": 1313, "annotation": "n_glycosylation_sequon", "start_pos": 1311 } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3214842", "id": "R-RNO-3214842", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000052721", "id": "ENSRNOG00000052721", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/PMANGPF/", "id": "PMANGPF", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "id": "IPR011990", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013026", "id": "IPR013026", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "id": "IPR019734", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347", "id": "IPR003347", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF13181", "id": "PF13181", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF02373", "id": "PF02373", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=9275041", "id": "9275041", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K6D0", "disease": [], "mass": { "monoisotopic_mass": 149994.0, "chemical_mass": 149994.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K6D0", "name": "Kdm6a; NEWGENE_1565481.", "locus": { "end_pos": 4806277, "start_pos": 4945944, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000052721", "id": "ENSRNOG00000052721", "database": "Ensembl Gene" } ] } } ] }