{ "uniprot_canonical_ac": "A0A0G2K677-1", "sequence": { "header": "tr|A0A0G2K677-1|A0A0G2K677_RAT Isoform 1 of Spectrin beta chain OS=Rattus norvegicus OX=10116 GN=Sptbn4 PE=1 SV=1 CANONICAL=A0A0G2K677-1", "length": 2561, "sequence": "MAQVPGEVDNMEGPAASNNNNPAARWESPDRGWDREPPAAANAAASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYADLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDLSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVDKIIERYEELAAELLAWIHRTVDLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRAHNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDARRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQTQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLSELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEATSGSGGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRRGEELAAAGGSVGPGAEPLHLAGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVGGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLAMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNQTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQATRLHQGAEELGAEWGALAGAAQACGEAVAAAGRLQRFLRDLDTFLDWLVRAQEAAGAVEGPLPRSLEEADGLLARHAALKEEVDQREEDYARIVAASEALLASDGAELGPGLALDEWLPHLEVGWHKLLGLWEERREALVQAHVYQLFLRDLCQALAVLRNQEVALSGAELPCTVESVEEAMKRHRDFLTTMELNQQKMQVAVQAAEGLLRQGNAYGEQAQEAVARLLEKSQENQLRAQQWMQKLLDQLVLQHFLRDCHELDGWIHEKMLMARDGTREDSHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKRLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWCREVGELQAQTAALPLEQASKELVGERQSAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMLTERGTGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGVLASLRSPEAEAVRRGQEQLQSAWTGLREATERRQQTLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVSLEQQYWLYQLSRQVDELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGTAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTAPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLAACEDARLHVSSTADALRFHSQARDLLSWMDGIAGQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTACQELGRSLLLNKSAMADEIQAQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYDRGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPETSGKVEPAAPTAAALDTTDTPGTPAVTEQVRPRPERQELADRAEELPRRRRSERQESTDQPEEAARRRRPERQESADHEGPHSLTLGRYEQMERRRERRERRIERQESSEQETPTRGELVKGKATLADIVEQLQEKEAGPGLPAAVPSLPQPRELPPGRLPNGLEPPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKRELDANRKSSNRSWVNLYCVLSKGELGFYKDSKGPASGGTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVANSVAEHAEIARWGQTLPTTSSTDEGNPKREGGERRASGRRK" }, "uniprot_id": "A0A0G2K677_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "spectrin beta chain, non-erythrocytic 4", "spectrin beta 4; spectrin beta chain, brain 3" ], "uniprotkb": [ "Spectrin beta chain" ] }, "gene": { "refseq": [ "Sptbn4", "Spnb4" ], "uniprotkb": [ "Sptbn4", "Spnb4" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Spectrin beta chain." }, "publication": [ { "title": "Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27356871", "journal": "Molecular neurodegeneration", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094315.2", "id": "NP_001094315.2", "database": "RefSeq" } ], "authors": "Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L", "date": "2016", "pmid": "27356871" }, { "title": "TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26671463", "journal": "Neuron", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094315.2", "id": "NP_001094315.2", "database": "RefSeq" } ], "authors": "van Beuningen SFB, Will L, Harterink M, Chazeau A, van Battum EY, Frias CP, Franker MAM, Katrukha EA, Stucchi R, Vocking K, Antunes AT, Slenders L, Doulkeridou S, Sillevis Smitt P, Altelaar AFM, Post JA, Akhmanova A, Pasterkamp RJ, Kapitein LC, de Graaff E, Hoogenraad CC", "date": "2015", "pmid": "26671463" }, { "title": "Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23239625", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094315.2", "id": "NP_001094315.2", "database": "RefSeq" } ], "authors": "Xu K, Zhong G, Zhuang X", "date": "2013", "pmid": "23239625" }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677/publications", "id": "A0A0G2K677", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11294830", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094315.2", "id": "NP_001094315.2", "database": "RefSeq" } ], "authors": "Tse WT, Tang J, Jin O, Korsgren C, John KM, Kung AL, Gwynn B, Peters LL, Lux SE", "date": "2001", "pmid": "11294830" }, { "title": "Genetic and age related models of neurodegeneration in mice: dystrophic axons.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/1634998", "journal": "Journal of neurogenetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094315.2", "id": "NP_001094315.2", "database": "RefSeq" } ], "authors": "Bronson RT, Sweet HO, Spencer CA, Davisson MT", "date": "1992", "pmid": "1634998" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677#A0A0G2K677-1", "isoform_ac": "A0A0G2K677-1", "locus": { "end_pos": 84169414, "start_pos": 84250947, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000077651", "id": "ENSRNOT00000077651", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073706", "id": "ENSRNOP00000073706", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K677-1|A0A0G2K677_RAT Isoform 1 of Spectrin beta chain OS=Rattus norvegicus OX=10116 GN=Sptbn4 PE=1 SV=1 CANONICAL=A0A0G2K677-1", "length": 2561, "sequence": "MAQVPGEVDNMEGPAASNNNNPAARWESPDRGWDREPPAAANAAASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYADLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDLSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVDKIIERYEELAAELLAWIHRTVDLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRAHNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDARRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQTQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLSELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEATSGSGGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRRGEELAAAGGSVGPGAEPLHLAGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVGGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLAMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNQTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQATRLHQGAEELGAEWGALAGAAQACGEAVAAAGRLQRFLRDLDTFLDWLVRAQEAAGAVEGPLPRSLEEADGLLARHAALKEEVDQREEDYARIVAASEALLASDGAELGPGLALDEWLPHLEVGWHKLLGLWEERREALVQAHVYQLFLRDLCQALAVLRNQEVALSGAELPCTVESVEEAMKRHRDFLTTMELNQQKMQVAVQAAEGLLRQGNAYGEQAQEAVARLLEKSQENQLRAQQWMQKLLDQLVLQHFLRDCHELDGWIHEKMLMARDGTREDSHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKRLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWCREVGELQAQTAALPLEQASKELVGERQSAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMLTERGTGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGVLASLRSPEAEAVRRGQEQLQSAWTGLREATERRQQTLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVSLEQQYWLYQLSRQVDELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGTAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTAPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLAACEDARLHVSSTADALRFHSQARDLLSWMDGIAGQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTACQELGRSLLLNKSAMADEIQAQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYDRGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPETSGKVEPAAPTAAALDTTDTPGTPAVTEQVRPRPERQELADRAEELPRRRRSERQESTDQPEEAARRRRPERQESADHEGPHSLTLGRYEQMERRRERRERRIERQESSEQETPTRGELVKGKATLADIVEQLQEKEAGPGLPAAVPSLPQPRELPPGRLPNGLEPPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKRELDANRKSSNRSWVNLYCVLSKGELGFYKDSKGPASGGTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVANSVAEHAEIARWGQTLPTTSSTDEGNPKREGGERRASGRRK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:308458", "resource": "KEGG Pathway", "id": "rno:308458", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-375165", "resource": "Reactome", "id": "R-RNO-375165", "name": "NCAM signaling for neurite out-growth" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-445095", "resource": "Reactome", "id": "R-RNO-445095", "name": "Interaction between L1 and Ankyrins" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807878", "resource": "Reactome", "id": "R-RNO-6807878", "name": "COPI-mediated anterograde transport" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5673001", "resource": "Reactome", "id": "R-RNO-5673001", "name": "RAF/MAP kinase cascade" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094315.2", "annotation": "Study of the organization of actin, spectrin and associated proteins in neurons; spectrin exhibited periodic structures alternating with those of actin and adducin; the distance between adjacent actin-adducin rings was comparable to the length of a spectrin tetramer", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094315.2", "id": "NP_001094315.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "E9PX29-1", "protein_name": "Spectrin beta chain.", "sequence": { "length": 2561, "sequence": "MAQVPGEVDNMEGPAVSNNNNPSARWESPDRGWDREPPAAANAAASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYADLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDLSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVDKIIERYEELAAELLAWIHRTVDLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRAHNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDARRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQTQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLSELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEATSGSGGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRRGEELAAAGGSVGPGAEPLHLAGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVGGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLAMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNQTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQATRLHQGAEELGAEWGALAGAAQACGEAVAAAGRLQRFLRDLDTFLDWLVRAQEAAGAVEGPLPRSLEEADGLLARHAALKEEVDQREEDYARIVAASEALLASEGAELGPGLALDEWLPHLEVGWHKLLGLWEERREALVQAHVYQLFLRDLCQALAVLRNQEVALSGAELPCTVESVEEAMKRHRDFLTTMELNQQKMQVAVQAAESLLRQGNAYGEQAQEAVARLLEKSQENQLRAQQWMQKLLDQLVLQHFLRDCHELDGWIHEKMLMARDGTREDSHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKRLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWCREVGELQAQTAALPLEQASKELVGERQSAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGTGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGVLASLRSPEAEAVRRGQEQLQSAWTGLREAAERRQQTLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVSLEQQYWLYQLSRQVDELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGTAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTAPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLAACEDARLHVSSTADALRFHSQARDLLSWMDGIAGQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELATCQELGRSLLLNKSAMADEIQAQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYDRGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPETSGKVEPAAPTAAALDTTDTPGTPAATELVRPRSERQELADRAEELPRRRRSERQESVDQPEETARRRRPERQESADHEGPHSLTLGRYEQMERRRERRERRIERQESSEQETPTRGELVKGKATLADIVEQLQEKEAGPGIPAGVPSLPQPRELPPGRLPNGLEPPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKRELDANRKSSNRSWVSLYCVLSKGELGFYKDSKGPASGGTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVANSVAEHAEIARWGQTLPTTSSTDEGNPKREGGERRASGRRK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11879", "id": "11879", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2K677/", "id": "A0A0G2K677", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9H254-1", "protein_name": "Spectrin beta chain, non-erythrocytic 4; Spectrin, non-erythroid beta chain 3; Beta-IV spectrin.", "sequence": { "length": 2564, "sequence": "MAQVPGEVDNMEGLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKRELDANRKSSNRSWVSLYCVLSKGELGFYKDSKGPASGSTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVASSVAEHAEIARWGQTLPTTSSTDEGNPKREGGDRRASGRRK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11879", "id": "11879", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2K677/", "id": "A0A0G2K677", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094315.2", "ac": "NP_001094315.2", "name": "spectrin beta chain, non-erythrocytic 4; spectrin beta 4; spectrin beta chain, brain 3.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "actin binding", "id": "GO:0003779" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "structural constituent of cytoskeleton", "id": "GO:0005200" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "phospholipid binding", "id": "GO:0005543" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030507", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "spectrin binding", "id": "GO:0030507" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030506", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "ankyrin binding", "id": "GO:0030506" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019902", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "phosphatase binding", "id": "GO:0019902" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "axon", "id": "GO:0030424" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033268", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "node of Ranvier", "id": "GO:0033268" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043194", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "axon initial segment", "id": "GO:0043194" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014704", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "intercalated disc", "id": "GO:0014704" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016363", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "nuclear matrix", "id": "GO:0016363" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070852", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "cell body fiber", "id": "GO:0070852" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "PML body", "id": "GO:0016605" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043203", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "axon hillock", "id": "GO:0043203" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033270", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "paranode region of axon", "id": "GO:0033270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008091", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "spectrin", "id": "GO:0008091" } ], "total": 12, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "fertilization", "id": "GO:0009566" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002028", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "regulation of sodium ion transport", "id": "GO:0002028" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007628", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "adult walking behavior", "id": "GO:0007628" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010459", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "negative regulation of heart rate", "id": "GO:0010459" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033135", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "regulation of peptidyl-serine phosphorylation", "id": "GO:0033135" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "sensory perception of sound", "id": "GO:0007605" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019226", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "transmission of nerve impulse", "id": "GO:0019226" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021952", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "central nervous system projection neuron axonogenesis", "id": "GO:0021952" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034613", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "cellular protein localization", "id": "GO:0034613" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061337", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "cardiac conduction", "id": "GO:0061337" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045162", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "clustering of voltage-gated sodium channels", "id": "GO:0045162" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051693", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "actin filament capping", "id": "GO:0051693" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040018", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "id": "A0A0G2K677", "database": "UniProtKB" } ], "name": "positive regulation of multicellular organism growth", "id": "GO:0040018" } ], "total": 13, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 207, "annotation": "n_glycosylation_sequon", "start_pos": 205 }, { "end_pos": 939, "annotation": "n_glycosylation_sequon", "start_pos": 937 }, { "end_pos": 2009, "annotation": "n_glycosylation_sequon", "start_pos": 2007 }, { "end_pos": 2438, "annotation": "n_glycosylation_sequon", "start_pos": 2436 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094315.2", "id": "NP_001094315.2", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-375165", "id": "R-RNO-375165", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-445095", "id": "R-RNO-445095", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807878", "id": "R-RNO-6807878", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5673001", "id": "R-RNO-5673001", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:308458", "id": "rno:308458", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000055371", "id": "ENSRNOG00000055371", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/TRWESPD/", "id": "TRWESPD", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00014", "id": "cd00014", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "id": "IPR001849", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001589", "id": "IPR001589", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "id": "IPR001715", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002017", "id": "IPR002017", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018159", "id": "IPR018159", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "id": "IPR036872", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001605", "id": "IPR001605", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016343", "id": "IPR016343", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041681", "id": "IPR041681", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00307", "id": "PF00307", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00435", "id": "PF00435", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF15410", "id": "PF15410", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/308458", "id": "308458", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304682", "id": "1304682", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K677", "disease": [], "mass": { "monoisotopic_mass": 288817.0, "chemical_mass": 288817.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K677", "name": "Sptbn4; Spnb4.", "locus": { "end_pos": 84168495, "start_pos": 84254645, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000055371", "id": "ENSRNOG00000055371", "database": "Ensembl Gene" } ] } } ] }