{ "uniprot_canonical_ac": "A0A0G2K654-1", "sequence": { "header": "tr|A0A0G2K654-1|A0A0G2K654_RAT Isoform 1 of RCG45246 OS=Rattus norvegicus OX=10116 GN=Hist1h1c PE=1 SV=1 CANONICAL=A0A0G2K654-1", "length": 212, "sequence": "MSETAPAAPAAAPPAEKAPAKKKAAKKPAGMRRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGILVQTKGTGASGSFKLNKKAASGEAKPKAKKAAAAKAKKPAGAAKKPKKATGAATPKKAAKKTPKKAKKPAAAAVTKKVAKSPKKAKVTKAKKVKSASKAVKPKAAKPKVAKAKKVAAKKK" }, "uniprot_id": "A0A0G2K654_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "histone H1.2" ], "uniprotkb": [ "RCG45246", "Histone cluster 1 H1 family member c" ] }, "gene": { "refseq": [ "Hist1h1c" ], "uniprotkb": [ "Hist1h1c", "LOC684681", "rCG_45246" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "RCG45246; Histone cluster 1 H1 family member c." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654#A0A0G2K654-1", "isoform_ac": "A0A0G2K654-1", "locus": { "end_pos": 43639752, "start_pos": 43640387, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087731", "id": "ENSRNOT00000087731", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073681", "id": "ENSRNOP00000073681", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K654-1|A0A0G2K654_RAT Isoform 1 of RCG45246 OS=Rattus norvegicus OX=10116 GN=Hist1h1c PE=1 SV=1 CANONICAL=A0A0G2K654-1", "length": 212, "sequence": "MSETAPAAPAAAPPAEKAPAKKKAAKKPAGMRRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGILVQTKGTGASGSFKLNKKAASGEAKPKAKKAAAAKAKKPAGAAKKPKKATGAATPKKAAKKTPKKAKKPAAAAVTKKVAKSPKKAKVTKAKKVKSASKAVKPKAAKPKVAKAKKVAAKKK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:684681", "resource": "KEGG Pathway", "id": "rno:684681", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559584", "resource": "Reactome", "id": "R-RNO-2559584", "name": "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-140342", "resource": "Reactome", "id": "R-RNO-140342", "name": "Apoptosis induced DNA fragmentation" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "P15864-1", "protein_name": "Histone H1.2; H1 VAR.1; H1c.", "sequence": { "length": 212, "sequence": "MSEAAPAAPAAAPPAEKAPAKKKAAKKPAGVRRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGILVQTKGTGASGSFKLNKKAASGEAKPQAKKAGAAKAKKPAGAAKKPKKATGAATPKKAAKKTPKKAKKPAAAAVTKKVAKSPKKAKVTKPKKVKSASKAVKPKAAKPKVAKAKKVAAKKK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K654/", "id": "A0A0G2K654", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "P16403-1", "protein_name": "Histone H1.2; Histone H1s-1; Histone H1d; Histone H1c.", "sequence": { "length": 213, "sequence": "MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTPRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKVKKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAKVAKPKKAAKSAAKAVKPKAAKPKVVKPKKAAPKKK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K654/", "id": "A0A0G2K654", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001071565.2", "ac": "XP_001071565.2", "name": "histone H1.2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "double-stranded DNA binding", "id": "GO:0003690" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031492", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "nucleosomal DNA binding", "id": "GO:0031492" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "nuclear chromatin", "id": "GO:0000790" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005719", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "nuclear euchromatin", "id": "GO:0005719" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "nucleosome", "id": "GO:0000786" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035327", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "transcriptionally active chromatin", "id": "GO:0035327" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016584", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "nucleosome positioning", "id": "GO:0016584" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "regulation of transcription, DNA-templated", "id": "GO:0006355" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030261", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "chromosome condensation", "id": "GO:0030261" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "nucleosome assembly", "id": "GO:0006334" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031936", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "negative regulation of chromatin silencing", "id": "GO:0031936" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045910", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "negative regulation of DNA recombination", "id": "GO:0045910" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080182", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "histone H3-K4 trimethylation", "id": "GO:0080182" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098532", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "histone H3-K27 trimethylation", "id": "GO:0098532" } ], "total": 9, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 78, "annotation": "n_glycosylation_sequon", "start_pos": 76 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001071565.2", "id": "XP_001071565.2", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559584", "id": "R-RNO-2559584", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-140342", "id": "R-RNO-140342", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:684681", "id": "rno:684681", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054978", "id": "ENSRNOG00000054978", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/NPTHPPY/", "id": "NPTHPPY", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00073", "id": "cd00073", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "id": "IPR036388", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "id": "IPR036390", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005818", "id": "IPR005818", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005819", "id": "IPR005819", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00538", "id": "PF00538", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0G2K654*", "id": "A0A0G2K654", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/684681", "id": "684681", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1587893", "id": "1587893", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K654", "disease": [], "mass": { "monoisotopic_mass": 21317.0, "chemical_mass": 21317.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "name": "Hist1h1c; LOC684681; rCG_45246.", "locus": { "end_pos": 43639749, "start_pos": 43640387, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000054978", "id": "ENSRNOG00000054978", "database": "Ensembl Gene" } ] } } ] }