{ "uniprot_canonical_ac": "A0A0G2K5M1-1", "sequence": { "header": "tr|A0A0G2K5M1-1|A0A0G2K5M1_RAT Isoform 1 of Sp3 transcription factor OS=Rattus norvegicus OX=10116 GN=Sp3 PE=1 SV=1 CANONICAL=A0A0G2K5M1-1", "length": 714, "sequence": "GPPPPADDDEEEAAAAAGVPAAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPGAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQSTDAQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPPANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDVNETNADTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTTSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKVIHSSSTVLASVEAGRDDALITAGGTTLILANIQQGSVSGIGTVNASATSNQDILTNTEIPLQLVTVSGNETME" }, "uniprot_id": "A0A0G2K5M1_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Sp3 transcription factor" ] }, "gene": { "refseq": [], "uniprotkb": [ "Sp3" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Sp3 transcription factor." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1#A0A0G2K5M1-1", "isoform_ac": "A0A0G2K5M1-1", "locus": { "end_pos": 59646018, "start_pos": 59688692, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000078752", "id": "ENSRNOT00000078752", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073478", "id": "ENSRNOP00000073478", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K5M1-1|A0A0G2K5M1_RAT Isoform 1 of Sp3 transcription factor OS=Rattus norvegicus OX=10116 GN=Sp3 PE=1 SV=1 CANONICAL=A0A0G2K5M1-1", "length": 714, "sequence": "GPPPPADDDEEEAAAAAGVPAAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPGAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQSTDAQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPPANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDVNETNADTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTTSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKVIHSSSTVLASVEAGRDDALITAGGTTLILANIQQGSVSGIGTVNASATSNQDILTNTEIPLQLVTVSGNETME" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3232118", "resource": "Reactome", "id": "R-RNO-3232118", "name": "SUMOylation of transcription factors" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q02447-1", "protein_name": "Transcription factor Sp3; SPR-2.", "sequence": { "length": 781, "sequence": "MTAPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGAVAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K5M1/", "id": "A0A0G2K5M1", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "O70494-1", "protein_name": "Transcription factor Sp3.", "sequence": { "length": 783, "sequence": "MTAPEKPVKQEEMAALDVDGGGGGGGHGEYLQQQQQQQQQHGNGAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDDEEAAVAAAAGVPAAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPGAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQSTDAQQVQIGFTGSSDNGGINQENSQIQIIPGSNQTLLASGTPPANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDVNETNADTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTTSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKVIHSSSTVLASVEAGRDDALITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K5M1/", "id": "A0A0G2K5M1", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "RNA polymerase II regulatory region sequence-specific DNA binding", "id": "GO:0000977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "proximal promoter sequence-specific DNA binding", "id": "GO:0000987" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", "id": "GO:0000978" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017053", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "transcriptional repressor complex", "id": "GO:0017053" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032993", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "protein-DNA complex", "id": "GO:0032993" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030219", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "megakaryocyte differentiation", "id": "GO:0030219" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001779", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "natural killer cell differentiation", "id": "GO:0001779" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030851", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "granulocyte differentiation", "id": "GO:0030851" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043353", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "enucleate erythrocyte differentiation", "id": "GO:0043353" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001889", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "liver development", "id": "GO:0001889" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030324", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "lung development", "id": "GO:0030324" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "trophectodermal cell differentiation", "id": "GO:0001829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060136", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "embryonic process involved in female pregnancy", "id": "GO:0060136" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030183", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "B cell differentiation", "id": "GO:0030183" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001503", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "ossification", "id": "GO:0001503" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001892", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "embryonic placenta development", "id": "GO:0001892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060216", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "definitive hemopoiesis", "id": "GO:0060216" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030217", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "T cell differentiation", "id": "GO:0030217" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048596", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "embryonic camera-type eye morphogenesis", "id": "GO:0048596" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030224", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "monocyte differentiation", "id": "GO:0030224" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048706", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "id": "A0A0G2K5M1", "database": "UniProtKB" } ], "name": "embryonic skeletal system development", "id": "GO:0048706" } ], "total": 19, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 97, "annotation": "n_glycosylation_sequon", "start_pos": 95 }, { "end_pos": 146, "annotation": "n_glycosylation_sequon", "start_pos": 144 }, { "end_pos": 198, "annotation": "n_glycosylation_sequon", "start_pos": 196 }, { "end_pos": 256, "annotation": "n_glycosylation_sequon", "start_pos": 254 }, { "end_pos": 365, "annotation": "n_glycosylation_sequon", "start_pos": 363 }, { "end_pos": 687, "annotation": "n_glycosylation_sequon", "start_pos": 685 }, { "end_pos": 712, "annotation": "n_glycosylation_sequon", "start_pos": 710 } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3232118", "id": "R-RNO-3232118", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000060479", "id": "ENSRNOG00000060479", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/HQGENAG/", "id": "HQGENAG", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "id": "IPR013087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "id": "IPR036236", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030452", "id": "IPR030452", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00096", "id": "PF00096", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF3", "id": "PTHR23235:SF3", "database": "PANTHER" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1583765", "id": "1583765", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K5M1", "disease": [], "mass": { "monoisotopic_mass": 75420.0, "chemical_mass": 75420.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5M1", "name": "Sp3.", "locus": { "end_pos": 59646015, "start_pos": 59688692, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000060479", "id": "ENSRNOG00000060479", "database": "Ensembl Gene" } ] } } ] }