{ "uniprot_canonical_ac": "A0A0G2K5K7-1", "sequence": { "header": "tr|A0A0G2K5K7-1|A0A0G2K5K7_RAT Isoform 1 of Inositol polyphosphate-5-phosphatase K OS=Rattus norvegicus OX=10116 GN=Inpp5k PE=1 SV=1 CANONICAL=A0A0G2K5K7-1", "length": 451, "sequence": "MTTASLRKPSAPKELMLSIHVVTWNVASAAPTVDLSDLLQLNNEDLNLDIYIIGLQEMNYXXXYGIISLLSDAAFEDPWSSFFMDMLSPLNLVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSIPTGLYGYWGNKGGINICLKLYGYYVSIVNCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQECITKKRYKELWEKDQLFIAKKQDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPAKANPSGFLLTQKDYVSHMTYSISDHKPVTGTFDLELNPLMAVPLITMMPEYLVEPRERPFLINYTSTPEFLSTPWDWIGLYKVGMRHINDYVSYVWVGDNQVSRGNNPNQVYINISAIPDTEEQFLLCYYSNNLHSIVGISQPFKIPSGFFLREDTLSELEPQL" }, "uniprot_id": "A0A0G2K5K7_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Inositol polyphosphate-5-phosphatase K" ] }, "gene": { "refseq": [], "uniprotkb": [ "Inpp5k" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Inositol polyphosphate-5-phosphatase K." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7#A0A0G2K5K7-1", "isoform_ac": "A0A0G2K5K7-1", "locus": { "end_pos": 63776378, "start_pos": 63795688, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000084496", "id": "ENSRNOT00000084496", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073462", "id": "ENSRNOP00000073462", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K5K7-1|A0A0G2K5K7_RAT Isoform 1 of Inositol polyphosphate-5-phosphatase K OS=Rattus norvegicus OX=10116 GN=Inpp5k PE=1 SV=1 CANONICAL=A0A0G2K5K7-1", "length": 451, "sequence": "MTTASLRKPSAPKELMLSIHVVTWNVASAAPTVDLSDLLQLNNEDLNLDIYIIGLQEMNYXXXYGIISLLSDAAFEDPWSSFFMDMLSPLNLVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSIPTGLYGYWGNKGGINICLKLYGYYVSIVNCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQECITKKRYKELWEKDQLFIAKKQDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPAKANPSGFLLTQKDYVSHMTYSISDHKPVTGTFDLELNPLMAVPLITMMPEYLVEPRERPFLINYTSTPEFLSTPWDWIGLYKVGMRHINDYVSYVWVGDNQVSRGNNPNQVYINISAIPDTEEQFLLCYYSNNLHSIVGISQPFKIPSGFFLREDTLSELEPQL" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7#A0A0G2K2Z2-1", "isoform_ac": "A0A0G2K2Z2-1", "locus": { "end_pos": 63778755, "start_pos": 63795688, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000090481", "id": "ENSRNOT00000090481", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072437", "id": "ENSRNOP00000072437", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K2Z2-1|A0A0G2K5K7_RAT Computationally mapped isoform of Inositol polyphosphate-5-phosphatase K OS=Rattus norvegicus OX=10116 GN=Inpp5k PE=1 SV=1 CANONICAL=A0A0G2K5K7-1", "length": 388, "sequence": "YGIISLLSDAAFEDPWSSFFMDMLSPLNLVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSIPTGLYGYWGNKGGINICLKLYGYYVSIVNCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQECITKKRYKELWEKDQLFIAKKQDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPAKANPSGFLLTQKDYVSHMTYSISDHKPVTGTFDLELNPLMAVPLITMMPEYLWSQGENDFLINYTSTPEFLSRPWDWIGLYKVGMRHINDYVSYVWVGDNQVSRGNNPNQVYINISAIPDTEEQFLLCYYSNNLHSIVGISQPFKIPSGFFLREDTLSELEPQL" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1660499", "resource": "Reactome", "id": "R-RNO-1660499", "name": "Synthesis of PIPs at the plasma membrane" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8C5L6-1", "protein_name": "Inositol polyphosphate 5-phosphatase K; 3.1.3.56; Skeletal muscle and kidney-enriched inositol phosphatase; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; 3.1.3.36; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; 3.1.3.86.", "sequence": { "length": 468, "sequence": "MQHGDRNTPGYREGIMSAVSLRRPSAPKGFALSVHVVTWNVASAAPTVDLSDLLQLNNQDLNLDIYIIGLQEMNFGIISLLSDAAFEDPWSSLFMDMLSPLNFVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSTPTGLYGYWGNKGGVNVCLKLYGYYVSIINCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQESITRKYYKELWEKDQLFIAKKNDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPSQASPLASSVPTSYFLLTLKNYVSHMAYSISDHKPVTGTFDLELNPLMSVPLITMMPEHLWTMENDMLISYTSTPEFLSSSWDWIGLYKVGMRHINDYVAYVWVGDNQVSYGNNPNQVYINISAIPDTEDQFLLCYYSNNLHSVVGISQPFKIPIRSFLREDTLYEPEPQI" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K5K7/", "id": "A0A0G2K5K7", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004439", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "id": "GO:0004439" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016312", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "inositol bisphosphate phosphatase activity", "id": "GO:0016312" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034485", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "id": "GO:0034485" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005000", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "vasopressin receptor activity", "id": "GO:0005000" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046030", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "inositol trisphosphate phosphatase activity", "id": "GO:0046030" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "ruffle", "id": "GO:0001726" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "neuron projection", "id": "GO:0043005" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "ruffle membrane", "id": "GO:0032587" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "trans-Golgi network", "id": "GO:0005802" } ], "total": 10, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046627", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of insulin receptor signaling pathway", "id": "GO:0046627" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051898", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of protein kinase B signaling", "id": "GO:0051898" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033137", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of peptidyl-serine phosphorylation", "id": "GO:0033137" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046855", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "inositol phosphate dephosphorylation", "id": "GO:0046855" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046856", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "phosphatidylinositol dephosphorylation", "id": "GO:0046856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045719", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of glycogen biosynthetic process", "id": "GO:0045719" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of glucose transmembrane transport", "id": "GO:0010829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "in utero embryonic development", "id": "GO:0001701" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "cellular response to insulin stimulus", "id": "GO:0032869" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "cellular response to cAMP", "id": "GO:0071320" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "protein localization to plasma membrane", "id": "GO:0072659" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035810", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "positive regulation of urine volume", "id": "GO:0035810" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "glucose homeostasis", "id": "GO:0042593" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051926", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of calcium ion transport", "id": "GO:0051926" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045869", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of single stranded viral RNA replication via double stranded DNA intermediate", "id": "GO:0045869" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043407", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of MAP kinase activity", "id": "GO:0043407" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097178", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "ruffle assembly", "id": "GO:0097178" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "cellular response to tumor necrosis factor", "id": "GO:0071356" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071364", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "cellular response to epidermal growth factor stimulus", "id": "GO:0071364" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051497", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of stress fiber assembly", "id": "GO:0051497" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010801", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of peptidyl-threonine phosphorylation", "id": "GO:0010801" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035305", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of dephosphorylation", "id": "GO:0035305" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043922", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation by host of viral transcription", "id": "GO:0043922" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090315", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of protein targeting to membrane", "id": "GO:0090315" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000466", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "negative regulation of glycogen (starch) synthase activity", "id": "GO:2000466" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001153", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5K7", "id": "A0A0G2K5K7", "database": "UniProtKB" } ], "name": "positive regulation of renal water transport", "id": "GO:2001153" } ], "total": 28, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 352, "annotation": "n_glycosylation_sequon", "start_pos": 350 }, { "end_pos": 403, "annotation": "n_glycosylation_sequon", "start_pos": 401 } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1660499", "id": "R-RNO-1660499", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000056954", "id": "ENSRNOG00000056954", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/PEGLWTM/", "id": "PEGLWTM", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005135", "id": "IPR005135", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "id": "IPR036691", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000300", "id": "IPR000300", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041611", "id": "IPR041611", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF03372", "id": "PF03372", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17751", "id": "PF17751", "database": "Pfam" }, { "url": 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