{
    "uniprot_canonical_ac": "A0A0G2K4P8-1", 
    "sequence": {
        "header": "tr|A0A0G2K4P8-1|A0A0G2K4P8_RAT Isoform 1 of Ring finger protein 41  OS=Rattus norvegicus OX=10116 GN=Rnf41 PE=4 SV=1 CANONICAL=A0A0G2K4P8-1", 
        "length": 317, 
        "sequence": "MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDSLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI"
    }, 
    "uniprot_id": "A0A0G2K4P8_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "E3 ubiquitin-protein ligase NRDP1 isoform X1"
            ], 
            "uniprotkb": [
                "Ring finger protein 41", 
                "RCG42493"
            ]
        }, 
        "gene": {
            "refseq": [
                "Rnf41"
            ], 
            "uniprotkb": [
                "Rnf41", 
                "rCG_42493"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                    "id": "A0A0G2K4P8", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Ring finger protein 41; RCG42493."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8#A0A0G2K4P8-1", 
            "isoform_ac": "A0A0G2K4P8-1", 
            "locus": {
                "end_pos": 2842633, 
                "start_pos": 2851713, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000090689", 
                        "id": "ENSRNOT00000090689", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000073126", 
                        "id": "ENSRNOP00000073126", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2K4P8-1|A0A0G2K4P8_RAT Isoform 1 of Ring finger protein 41  OS=Rattus norvegicus OX=10116 GN=Rnf41 PE=4 SV=1 CANONICAL=A0A0G2K4P8-1", 
                "length": 317, 
                "sequence": "MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDSLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8#G3V930-1", 
            "isoform_ac": "G3V930-1", 
            "locus": {
                "end_pos": 2842633, 
                "start_pos": 2851713, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000029778", 
                        "id": "ENSRNOT00000029778", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000034376", 
                        "id": "ENSRNOP00000034376", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|G3V930-1|A0A0G2K4P8_RAT Computationally mapped isoform of Ring finger protein 41  OS=Rattus norvegicus OX=10116 GN=Rnf41 PE=4 SV=2 CANONICAL=A0A0G2K4P8-1", 
                "length": 297, 
                "sequence": "MGYDVTRFQGDVDEDLICPICSGVLEEPVQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDSLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", 
            "resource": "Reactome", 
            "id": "R-RNO-983168", 
            "name": "Antigen processing: Ubiquitination & Proteasome degradation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1358803", 
            "resource": "Reactome", 
            "id": "R-RNO-1358803", 
            "name": "Downregulation of ERBB2:ERBB3 signaling"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9H4P4-1", 
            "protein_name": "E3 ubiquitin-protein ligase NRDP1; 2.3.2.27; RING finger protein 41; RING-type E3 ubiquitin transferase NRDP1.", 
            "sequence": {
                "length": 317, 
                "sequence": "MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/4226", 
                    "id": "4226", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q8BH75-1", 
            "protein_name": "E3 ubiquitin-protein ligase NRDP1; 2.3.2.27; RING finger protein 41; RING-type E3 ubiquitin transferase NRDP1.", 
            "sequence": {
                "length": 317, 
                "sequence": "MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/4226", 
                    "id": "4226", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2K4P8/", 
                    "id": "A0A0G2K4P8", 
                    "database": "OMA"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006240834.1", 
        "ac": "XP_006240834.1", 
        "name": "E3 ubiquitin-protein ligase NRDP1 isoform X1.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005135", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "interleukin-3 receptor binding", 
                        "id": "GO:0005135"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein domain specific binding", 
                        "id": "GO:0019904"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "metal ion binding", 
                        "id": "GO:0046872"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin protein ligase activity", 
                        "id": "GO:0061630"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "receptor tyrosine kinase binding", 
                        "id": "GO:0030971"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005128", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "erythropoietin receptor binding", 
                        "id": "GO:0005128"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017160", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Ral GTPase binding", 
                        "id": "GO:0017160"
                    }
                ], 
                "total": 7, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "perinuclear region of cytoplasm", 
                        "id": "GO:0048471"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071782", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum tubular network", 
                        "id": "GO:0071782"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051896", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of protein kinase B signaling", 
                        "id": "GO:0051896"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901525", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of mitophagy", 
                        "id": "GO:1901525"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cell population proliferation", 
                        "id": "GO:0008285"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051091", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of DNA-binding transcription factor activity", 
                        "id": "GO:0051091"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cell migration", 
                        "id": "GO:0030336"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000379", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of reactive oxygen species metabolic process", 
                        "id": "GO:2000379"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097191", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extrinsic apoptotic signaling pathway", 
                        "id": "GO:0097191"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of protein catabolic process", 
                        "id": "GO:0045732"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010498", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "proteasomal protein catabolic process", 
                        "id": "GO:0010498"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein polyubiquitination", 
                        "id": "GO:0000209"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein autoubiquitination", 
                        "id": "GO:0051865"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045637", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of myeloid cell differentiation", 
                        "id": "GO:0045637"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000114", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of establishment of cell polarity", 
                        "id": "GO:2000114"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043408", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of MAPK cascade", 
                        "id": "GO:0043408"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045619", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
                                "id": "A0A0G2K4P8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of lymphocyte differentiation", 
                        "id": "GO:0045619"
                    }
                ], 
                "total": 15, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006240834.1", 
            "id": "XP_006240834.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", 
            "id": "R-RNO-983168", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1358803", 
            "id": "R-RNO-1358803", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000023456", 
            "id": "ENSRNOG00000023456", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/SRQPTCP/", 
            "id": "SRQPTCP", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015036", 
            "id": "IPR015036", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037255", 
            "id": "IPR037255", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", 
            "id": "IPR001841", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", 
            "id": "IPR013083", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", 
            "id": "IPR017907", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008974", 
            "id": "IPR008974", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF08941", 
            "id": "PF08941", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/362814", 
            "id": "362814", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309557", 
            "id": "1309557", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0G2K4P8", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 35878.0, 
        "chemical_mass": 35878.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", 
            "name": "Rnf41; rCG_42493.", 
            "locus": {
                "end_pos": 2852681, 
                "start_pos": 2827247, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000023456", 
                        "id": "ENSRNOG00000023456", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}