{ "uniprot_canonical_ac": "A0A0G2K490-1", "sequence": { "header": "tr|A0A0G2K490-1|A0A0G2K490_RAT Isoform 1 of TRAF2 and NCK-interacting kinase OS=Rattus norvegicus OX=10116 GN=Tnik PE=1 SV=1 CANONICAL=A0A0G2K490-1", "length": 1360, "sequence": "MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHGQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPLEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPQLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPVLESSLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPSKVKPEESRDIPRPSRPASYKKAIDEDLTALAKELRELRIEETNRPLKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGKNEQYNMGMVGTHGLETSHADTFGGSISREGTLMIRETAEEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDTGAEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDDESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW" }, "uniprot_id": "A0A0G2K490_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "TRAF2 and NCK-interacting protein kinase isoform X1" ], "uniprotkb": [ "TRAF2 and NCK-interacting kinase" ] }, "gene": { "refseq": [ "Tnik", "RGD1561817" ], "uniprotkb": [ "Tnik", "RGD1561817" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "TRAF2 and NCK-interacting kinase." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490/publications", "id": "A0A0G2K490", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16641100", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490/publications", "id": "A0A0G2K490", "database": "UniProtKB" } ], "authors": "Wang G., Shen R.F., Knepper M.A., Shen R.-F., Hoffert J.D., Pisitkun T.", "date": "2006", "pmid": "16641100" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490#A0A0G2JTC0-1", "isoform_ac": "A0A0G2JTC0-1", "locus": { "end_pos": 114386019, "start_pos": 114386351, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000082148", "id": "ENSRNOT00000082148", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068648", "id": "ENSRNOP00000068648", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JTC0-1|A0A0G2K490_RAT Computationally mapped isoform of TRAF2 and NCK-interacting kinase OS=Rattus norvegicus OX=10116 GN=Tnik PE=1 SV=1 CANONICAL=A0A0G2K490-1", "length": 111, "sequence": "MFLQTSQHTVNNICAEMCMYLVQVDLCPYRNPYSNDLNLYVTDWDFPQSSKHGRLWYPGVAKWYLCCASCFNLPRFVCFCFSVHHSSVISRRHIESSPGNLSCLEHFQNSS" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K490#A0A0G2K490-1", "isoform_ac": "A0A0G2K490-1", "locus": { "end_pos": 113985013, "start_pos": 114384693, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000086399", "id": "ENSRNOT00000086399", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072950", "id": "ENSRNOP00000072950", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K490-1|A0A0G2K490_RAT Isoform 1 of TRAF2 and NCK-interacting kinase OS=Rattus norvegicus OX=10116 GN=Tnik PE=1 SV=1 CANONICAL=A0A0G2K490-1", "length": 1360, "sequence": "MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHGQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPLEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPQLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPVLESSLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPSKVKPEESRDIPRPSRPASYKKAIDEDLTALAKELRELRIEETNRPLKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGKNEQYNMGMVGTHGLETSHADTFGGSISREGTLMIRETAEEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDTGAEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDDESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K490#D3ZZQ0-1", "isoform_ac": "D3ZZQ0-1", "locus": { "end_pos": 113985013, "start_pos": 114382742, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000016799", "id": "ENSRNOT00000016799", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000016799", "id": "ENSRNOP00000016799", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZZQ0-1|A0A0G2K490_RAT Computationally mapped isoform of TRAF2 and NCK-interacting kinase OS=Rattus norvegicus OX=10116 GN=Tnik PE=1 SV=1 CANONICAL=A0A0G2K490-1", "length": 1354, "sequence": "MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHGQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPLEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPQLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPVLESSLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPSKVKPEESRDIPRPSRPADLTALAKELRELRIEETNRPLKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGKNEQYNMGMVGTHGLETSHADTFGGSISREGTLMIRETAEEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDTGAEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDDESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVNPFQLCFSVCILRDHQVPVKPSFSFILT" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559580", "resource": "Reactome", "id": "R-RNO-2559580", "name": "Oxidative Stress Induced Senescence" } ], "function": [], "orthologs": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017446219.1", "ac": "XP_017446219.1", "name": "TRAF2 and NCK-interacting protein kinase isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "protein serine/threonine kinase activity", "id": "GO:0004674" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "glutamatergic synapse", "id": "GO:0098978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "presynapse", "id": "GO:0098793" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099092", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "postsynaptic density, intracellular component", "id": "GO:0099092" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "apical plasma membrane", "id": "GO:0016324" } ], "total": 8, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0023014", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "signal transduction by protein phosphorylation", "id": "GO:0023014" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048812", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "neuron projection morphogenesis", "id": "GO:0048812" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032147", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "activation of protein kinase activity", "id": "GO:0032147" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007256", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "activation of JNKK activity", "id": "GO:0007256" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030033", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "microvillus assembly", "id": "GO:0030033" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048814", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "regulation of dendrite morphogenesis", "id": "GO:0048814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "protein localization to plasma membrane", "id": "GO:0072659" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "protein autophosphorylation", "id": "GO:0046777" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031532", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "id": "A0A0G2K490", "database": "UniProtKB" } ], "name": "actin cytoskeleton reorganization", "id": "GO:0031532" } ], "total": 9, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 35, "annotation": "n_glycosylation_sequon", "start_pos": 33 }, { "end_pos": 335, "annotation": "n_glycosylation_sequon", "start_pos": 333 }, { "end_pos": 629, "annotation": "n_glycosylation_sequon", "start_pos": 627 }, { "end_pos": 693, "annotation": "n_glycosylation_sequon", "start_pos": 691 }, { "end_pos": 1239, "annotation": "n_glycosylation_sequon", "start_pos": 1237 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017446219.1", "id": "XP_017446219.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559580", "id": "R-RNO-2559580", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012422", "id": "ENSRNOG00000012422", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/FKIVRYE/", "id": "FKIVRYE", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "id": "IPR017441", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "id": "IPR008271", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001180", "id": "IPR001180", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00069", "id": "PF00069", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00780", "id": "PF00780", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/294917", "id": "294917", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1561817", "id": "1561817", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K490", "disease": [], "mass": { "monoisotopic_mass": 154971.0, "chemical_mass": 154971.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K490", "name": "Tnik; RGD1561817.", "locus": { "end_pos": 114384894, "start_pos": 113984646, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000012422", "id": "ENSRNOG00000012422", "database": "Ensembl Gene" } ] } } ] }