{ "uniprot_canonical_ac": "A0A0G2K2Y2-1", "sequence": { "header": "tr|A0A0G2K2Y2-1|A0A0G2K2Y2_RAT Isoform 1 of WNK lysine deficient protein kinase 3 OS=Rattus norvegicus OX=10116 GN=Wnk3 PE=4 SV=1 CANONICAL=A0A0G2K2Y2-1", "length": 1698, "sequence": "MATDSGEPASTEDSEKPDGVSFQSRVARAVAPLTVEARIKEKYSTFSASGETIERKRFFRKSVEMTEDDKVAQSSRRDERKVATNISRVEKVPTNVLRGGQEVKYEQCSKATSESSKDCFKEKTEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLEADTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTLIKKIREKKPAGCLEERRDSQCKHARNVNPQQQTATLRPAPGPHNAAECEETEVDQHVRQQLVQGKAQQQPSSVRGDTSSEPAAGPVLHSDTSSHPTVAYSSNQATSSQLQEQPKLTRSPVLPVVQGQSSVMPIYAAGPAVASQSQISPLTIQKVSQIKPVSQPIGAEQQATPPNPDFVRSLNQDVTSVKENTNSPDTPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSVSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLENEKEKFVEELRAIVGQAQEILHVHSAAEKSIGVDSVALESNSNQTGSSEQVLINSASTQTSNESAPQSSPVGRWRFCINQTIKNREAQSPPSLQPSVAMVPGLHPFPNNTSNQEISQDTLFTVPGHHVVFTSKLDGKIGERASVETEQTSVPYQAEDDKLKAPATDTSNYSATLVCPDPAGCEALTSQAGMFIPTYPCQQAAVPADVLMSHPGESVQIGSNAVVTSVLVSSDQKPQSLSVQQPTIDAEFISQEGETTVNSETSSPKAVGATQTPGFEPTVLLPATILESDGERPPKMEFTDNRIKTLDEKLRNLLYQEHSISTICPESQKDTQSIDSPFSSSAEDILSSPMPEVIAISHCGIQDSQAQSPNFQPTGSKILSNVAASQPAHIPVLKRDLNVITSVPSELCLHEMSPDASLPGDPEAYPAAVSSDGTIHLQTGVETEDKRSAIASDPIPLTREFSADTRALSRCKAMSGSFQRGRFQVITVPQQQPVKMMSFGKEHRPPSKKTTAQSNEQALTFTEAAVTQLIEVEPAIPTHKASVSSQKLRTLYETFKEDKGDPEQGDILSLSTARETSVSSVTTEKNVEETSTTGISVQSGSEMLDKEKDESTPGKQTCTNEFSATPAGSGKSVAKAAPKSGQHLPARAQTQSSLFYSPSSPMSSDNESEIEDEDLKAELQRLREKHIQEVVSLQTQQNKELQELYERLRATKDSKAQSSEVPMPPASPRRPRSFKSKLRSRPQSLTHSDNLVVVKDVQRAESNTAPRQQSPASKKGMFTDDLHKLVDDWTRETVGNFPSKPSLNQLKQSQQKSEAENWNKLHESTPSTVGYTSTWISSLSQIRGAAPSSLPHGLPLPSFPGPLASYGMPHACQYNPVGAASYPVQWVGISGAAQQSVVLPTQSGGLFQPGMNLQSFPAPPVQNPPSIPPGPK" }, "uniprot_id": "A0A0G2K2Y2_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "serine/threonine-protein kinase WNK3 isoform X4" ], "uniprotkb": [ "WNK lysine deficient protein kinase 3" ] }, "gene": { "refseq": [ "Wnk3", "RGD1563131" ], "uniprotkb": [ "Wnk3", "RGD1563131" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "WNK lysine deficient protein kinase 3." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2#D4A7Z8-1", "isoform_ac": "D4A7Z8-1", "locus": { "end_pos": 20351548, "start_pos": 20454156, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000047444", "id": "ENSRNOT00000047444", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000042493", "id": "ENSRNOP00000042493", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4A7Z8-1|A0A0G2K2Y2_RAT Computationally mapped isoform of WNK lysine deficient protein kinase 3 OS=Rattus norvegicus OX=10116 GN=Wnk3 PE=4 SV=2 CANONICAL=A0A0G2K2Y2-1", "length": 1691, "sequence": "MATDSGEPASTEDSEKPDGVSFQSRVARAVAPLTVEARIKEKYSTFSASGETIERKRFFRKSVEMTEDDKVAQSSRRDERKVATNISRVEKVPTNVLRGGQEVKYEQCSKATSESSKDCFKEKTEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLEADTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTLIKKIREKKPAGCLEERRDSQCKHARNVNPQQQTATLRPAPGPHNAAECEETEVDQHVRQQLVQGKAQQQPSSVRGDTSSEPAAGPVLHSDTSSHPTVAYSSNQATSSQEQPKLTRSPVLPVVQGQSSVMPIYAAGPAVASQSQISPLTIQKVSQIKPVSQPIGAEQQATPPNPDFVRSLNQDVTSVKENTNSPDTPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSVSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMTGSSEQVLINSASTQTSNESAPQSSPVGRWRFCINQTIKNREAQSPPSLQPSVAMVPGLHPFPNNTSNQEISQDTLFTVPGHHVVFTSKLDGKIGERASVETEQTSVPYQAEDDKLKAPATDTSNYSATLVCPDPAGCEALTSQAGMFIPTYPCQQAAVPADVLMSHPGESVQIGSNAVVTSVLVSSDQKPQSLSVQQPTIDAEFISQEGETTVNSETSSPKAVGATQTPGFEPTVLLPATILESDGERPPKMEFTDNRIKTLDEKLRNLLYQEHSISTICPESQKDTQSIDSPFSSSAEDILSSPMPEVIAISHCGIQDSQAQSPNFQPTGSKILSNVAASQPAHIPVLKRDLNVITSVPSELCLHEMSPDASLPGDPEAYPAAVSSDGTIHLQTGGGYFGLSFTCPSLKNPISRKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEDKRSAIASDPIPLTREFSADTRALSRCKAMSGSFQRGRFQVITVPQQQPVKMMSFGKEHRPPSKKTTAQSNEQALTFTEAAVTQLIEVEPAIPTHKASVSSQKLRTLYETFKEDKGDPEQGDILSLSTARETSVSSVTTEKNVEETSTTGISVQSGSEMLDKEKDESTPGKQTCTNEFSATPAGSGKSVAKAAPKSGQHLPARAQTQSSLFYSPSSPMSSDNESEIEDEDLKAELQRLREKHIQEVVSLQTQQNKELQELYERLRATKDSKAQSSEVPMPPASPRRPRSFKSKLRSRPQSLTHSDNLVVVKDVQRAESNTAPRQQSPASKKGMFTDDLHKLVDDWTRETVGNFPSKPSLNQLKQSQQKSEAENWNKLHESTPSTVGYTSTWISSLSQIRGAAPSSLPHGLPLPSFPGPLASYGMPHACQYNPVGAASYPVQWVGISGAAQQSVVLPTQSGGLFQPGMNLQSFPAPPVQNPPSIPPGPK" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2#A0A0G2K2Y2-1", "isoform_ac": "A0A0G2K2Y2-1", "locus": { "end_pos": 20351548, "start_pos": 20454156, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000082177", "id": "ENSRNOT00000082177", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072423", "id": "ENSRNOP00000072423", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K2Y2-1|A0A0G2K2Y2_RAT Isoform 1 of WNK lysine deficient protein kinase 3 OS=Rattus norvegicus OX=10116 GN=Wnk3 PE=4 SV=1 CANONICAL=A0A0G2K2Y2-1", "length": 1698, "sequence": "MATDSGEPASTEDSEKPDGVSFQSRVARAVAPLTVEARIKEKYSTFSASGETIERKRFFRKSVEMTEDDKVAQSSRRDERKVATNISRVEKVPTNVLRGGQEVKYEQCSKATSESSKDCFKEKTEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLEADTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTLIKKIREKKPAGCLEERRDSQCKHARNVNPQQQTATLRPAPGPHNAAECEETEVDQHVRQQLVQGKAQQQPSSVRGDTSSEPAAGPVLHSDTSSHPTVAYSSNQATSSQLQEQPKLTRSPVLPVVQGQSSVMPIYAAGPAVASQSQISPLTIQKVSQIKPVSQPIGAEQQATPPNPDFVRSLNQDVTSVKENTNSPDTPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSVSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLENEKEKFVEELRAIVGQAQEILHVHSAAEKSIGVDSVALESNSNQTGSSEQVLINSASTQTSNESAPQSSPVGRWRFCINQTIKNREAQSPPSLQPSVAMVPGLHPFPNNTSNQEISQDTLFTVPGHHVVFTSKLDGKIGERASVETEQTSVPYQAEDDKLKAPATDTSNYSATLVCPDPAGCEALTSQAGMFIPTYPCQQAAVPADVLMSHPGESVQIGSNAVVTSVLVSSDQKPQSLSVQQPTIDAEFISQEGETTVNSETSSPKAVGATQTPGFEPTVLLPATILESDGERPPKMEFTDNRIKTLDEKLRNLLYQEHSISTICPESQKDTQSIDSPFSSSAEDILSSPMPEVIAISHCGIQDSQAQSPNFQPTGSKILSNVAASQPAHIPVLKRDLNVITSVPSELCLHEMSPDASLPGDPEAYPAAVSSDGTIHLQTGVETEDKRSAIASDPIPLTREFSADTRALSRCKAMSGSFQRGRFQVITVPQQQPVKMMSFGKEHRPPSKKTTAQSNEQALTFTEAAVTQLIEVEPAIPTHKASVSSQKLRTLYETFKEDKGDPEQGDILSLSTARETSVSSVTTEKNVEETSTTGISVQSGSEMLDKEKDESTPGKQTCTNEFSATPAGSGKSVAKAAPKSGQHLPARAQTQSSLFYSPSSPMSSDNESEIEDEDLKAELQRLREKHIQEVVSLQTQQNKELQELYERLRATKDSKAQSSEVPMPPASPRRPRSFKSKLRSRPQSLTHSDNLVVVKDVQRAESNTAPRQQSPASKKGMFTDDLHKLVDDWTRETVGNFPSKPSLNQLKQSQQKSEAENWNKLHESTPSTVGYTSTWISSLSQIRGAAPSSLPHGLPLPSFPGPLASYGMPHACQYNPVGAASYPVQWVGISGAAQQSVVLPTQSGGLFQPGMNLQSFPAPPVQNPPSIPPGPK" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2#A0A1W2Q671-1", "isoform_ac": "A0A1W2Q671-1", "locus": { "end_pos": 20351548, "start_pos": 20422982, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000093675", "id": "ENSRNOT00000093675", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000076151", "id": "ENSRNOP00000076151", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1W2Q671-1|A0A0G2K2Y2_RAT Computationally mapped isoform of WNK lysine deficient protein kinase 3 OS=Rattus norvegicus OX=10116 GN=Wnk3 PE=4 SV=1 CANONICAL=A0A0G2K2Y2-1", "length": 870, "sequence": "MATDSGEPASTEDSEKPDGVSFQSRVARAVAPLTVEARIKEKYSTFSASGETIERKRFFRKSVEMTEDDKVAQSSRRDERKVATNISRVEKVPTNVLRGGQEVKYEQCSKATSESSKDCFKEKTEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLEADTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTLIKKIREKKPAGCLEERRDSQCKHARNVNPQQQTATLRPAPGPHNAAECEETEVDQHVRQQLVQGKAQQQPSSVRGDTSSEPAAGPVLHSDTSSHPTVAYSSNQATSSQEQPKLTRSPVLPVVQGQSSVMPIYAAGPAVASQSQISPLTIQKVSQIKPVSQPIGAEQQATPPNPDFVRSLNQDVTSVKENTNSPDTPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSVSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLENEKEKFVEELRAIVGQAQEILHVHSAAEKSIGVDSVALESNSNQTGSSEQVLINSASTQTSNESAPQSSPVGRWRFCINQTIKNREAQSPPSLQPSVAMVPGLHPFP" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2#A0A1W2Q6C5-1", "isoform_ac": "A0A1W2Q6C5-1", "locus": { "end_pos": 20423401, "start_pos": 20454157, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000093162", "id": "ENSRNOT00000093162", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000076217", "id": "ENSRNOP00000076217", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1W2Q6C5-1|A0A0G2K2Y2_RAT Computationally mapped isoform of WNK lysine deficient protein kinase 3 OS=Rattus norvegicus OX=10116 GN=Wnk3 PE=4 SV=1 CANONICAL=A0A0G2K2Y2-1", "length": 799, "sequence": "XGKIGERASVETEQTSVPYQAEDDKLKAPATDTSNYSATLVCPDPAGCEALTSQAGMFIPTYPCQQAAVPADVLMSHPGESVQIGSNAVVTSVLVSSDQKPQSLSVQQPTIDAEFISQEGETTVNSETSSPKAVGATQTPGFEPTVLLPATILESDGERPPKMEFTDNRIKTLDEKLRNLLYQEHSISTICPESQKDTQSIDSPFSSSAEDILSSPMPEVIAISHCGIQDSQAQSPNFQPTGSKILSNVAASQPAHIPVLKRDLNVITSVPSELCLHEMSPDASLPGDPEAYPAAVSSDGTIHLQTGVETEDKRSAIASDPIPLTREFSADTRALSRCKAMSGSFQRGRFQVITVPQQQPVKMMSFGKEHRPPSKKTTAQSNEQALTFTEAAVTQLIEVEPAIPTHKASVSSQKLRTLYETFKEDKGDPEQGDILSLSTARETSVSSVTTEKNVEETSTTGISVQSGSEMLDKEKDESTPGKQTCTNEFSATPAGSGKSVAKAAPKSGQHLPARAQTQSSLFYSPSSPMSSDNESEIEDEDLKAELQRLREKHIQEVVSLQTQQNKELQELYERLRATKDSKAQSSEVPMPPASPRRPRSFKSKLRSRPQSLTHSDNLVVVKDVQRAESNTAPRQQSPASKKGMFTDDLHKLVDDWTRETVGNFPSKPSLNQLKQSQQKSEAENWNKLHESTPSTVGYTSTWISSLSQIRGAAPSSLPHGLPLPSFPGPLASYGMPHACQYNPVGAASYPVQWVGISGAAQQSVVLPTQSGGLFQPGMNLQSFPAPPVQNPPSIPPGPK" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2672351", "resource": "Reactome", "id": "R-RNO-2672351", "name": "Stimuli-sensing channels" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q80XP9-1", "protein_name": "Serine/threonine-protein kinase WNK3; 2.7.11.1; Protein kinase lysine-deficient 3; Protein kinase with no lysine 3.", "sequence": { "length": 1757, "sequence": "MATDSGEPASTEDSEKPDGVSFENRAARAVAPLTVEARIKEKYSTFSASGENIERKRFFRKSVEMTEDDKVAESSRRDERKAATNISRVDKVPTNVLRGGQEVKYEQCSKATSESSKDCFKEKTEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTLKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLEADTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTLIKKIREKKPAGCLEERRDSQCKYVRNVLPQQQTATLQPTPGPHTAAEYEETEVDQHVRQQFLQGKPQQQSSSVRGDTSSEPTAGPVLHSDTSSHPTVAYSSNQTTSSQEQPKLTQSPVLPVVQGQSSVMPIYAAGVGVVSQSQISPLTIQKVSQIKPVSQPIGAEQQATLQNPDFVRSLNQDVTSVKENTNNPDTPSGNGKQDRNKQRRASCPRPEKGTKFQLTVLQVSVSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLENEKEKFVEELRAIVGQAQEILHVHSAVEKSIGVDSVALESNSNQTGSSEQVLINSASTQTSNESAPQSSPVGRWRFCINQTIKNREAQSPPSLQPSMAMVPGLHPFPSSRNTSNQAISQNTVFTIENNPGHRELFTSKLDHKDVVDGKIGEHASIETEQSSISYQVEDDRQIMTPATDNSNYSAALVCPVPGECEALTSQAGMFMPTYPNQQAAVLADVHIAYPGESVPIGGNAALTSVLVSSDQKPQSLSVQQPTIDAEFISKEGETTVNTETSSPKAVIATQTPGFEPAVILPATILESDGERPPKMEFADNRIKTLDEKLRNLLYQEHSISSICPESQKDTQSIDSPFSSSAEDILSYSMPEVIAISHCGIQDSPAQSPNFQQTGSKILSNVAASQPAHISVFKKDLNVITSVPSELCLHEMSPDASLPGDPEAYPAAVSSDGTIHLQTGGGYFGLSFTCPSLKNPISRKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEDKRSAIASDPIPLTREFSSDTRALSRCKAMSGSFQRGRFQVITVPQQQPVKMMSFGKDHRPPFNKTTVQSSEQALTFAEAAVSQLIEVEPAMPTHKASVSSRKLRTLYETFKEDKGDPEQGDIVSYSTACETSVSSVATEKNVTSTTEVSVQSGSEPLDKEKNESTPGKQTCTNEFSATLAGNRKSVTKTRPEGDQYLPLREEQAYAQTQNSLFYSPSSPMSSDNESEIEDEDLKVELQRLREKHIQEVVSLQTQQNKELQELYERLRATKDNKAQSSEVPLSPASPRRPRSFKSKLRSRPQSMTHSDNLVVKDALGVESNTVSCQQSPASKKGMFTDDLHKLVDDWTRETVGHFPSKPSLNQLKQSQQKSEAENWNKSCESTPSTMGYTSNWISSLSQIRGAAPTSLPQGLPLPSFHGPLASYGMPHVCQYNAVGAAGYPVQWVGISGPAQQSVVLPTQSGGLFQPGMNLQSFPAPPVQNPASIPPGPK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32493", "id": "32493", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9BYP7-1", "protein_name": "Serine/threonine-protein kinase WNK3; 2.7.11.1; Protein kinase lysine-deficient 3; Protein kinase with no lysine 3.", "sequence": { "length": 1800, "sequence": "MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLINELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32493", "id": "32493", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008771339.1", "ac": "XP_008771339.1", "name": "serine/threonine-protein kinase WNK3 isoform X4.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019870", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "potassium channel inhibitor activity", "id": "GO:0019870" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019869", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "chloride channel inhibitor activity", "id": "GO:0019869" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "protein serine/threonine kinase activity", "id": "GO:0004674" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "adherens junction", "id": "GO:0005912" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "bicellular tight junction", "id": "GO:0005923" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "protein phosphorylation", "id": "GO:0006468" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "intracellular signal transduction", "id": "GO:0035556" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032414", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "positive regulation of ion transmembrane transporter activity", "id": "GO:0032414" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051928", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "positive regulation of calcium ion transport", "id": "GO:0051928" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000651", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "positive regulation of sodium ion transmembrane transporter activity", "id": "GO:2000651" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903288", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "positive regulation of potassium ion import across plasma membrane", "id": "GO:1903288" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050801", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "ion homeostasis", "id": "GO:0050801" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010766", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "negative regulation of sodium ion transport", "id": "GO:0010766" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090279", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "regulation of calcium ion import", "id": "GO:0090279" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010800", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "positive regulation of peptidyl-threonine phosphorylation", "id": "GO:0010800" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "negative regulation of apoptotic process", "id": "GO:0043066" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "protein localization to plasma membrane", "id": "GO:0072659" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "protein autophosphorylation", "id": "GO:0046777" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903078", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "positive regulation of protein localization to plasma membrane", "id": "GO:1903078" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090188", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "id": "A0A0G2K2Y2", "database": "UniProtKB" } ], "name": "negative regulation of pancreatic juice secretion", "id": "GO:0090188" } ], "total": 15, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 87, "annotation": "n_glycosylation_sequon", "start_pos": 85 }, { "end_pos": 390, "annotation": "n_glycosylation_sequon", "start_pos": 388 }, { "end_pos": 424, "annotation": "n_glycosylation_sequon", "start_pos": 422 }, { "end_pos": 810, "annotation": "n_glycosylation_sequon", "start_pos": 808 }, { "end_pos": 829, "annotation": "n_glycosylation_sequon", "start_pos": 827 }, { "end_pos": 846, "annotation": "n_glycosylation_sequon", "start_pos": 844 }, { "end_pos": 875, "annotation": "n_glycosylation_sequon", "start_pos": 873 }, { "end_pos": 876, "annotation": "n_glycosylation_sequon", "start_pos": 874 }, { "end_pos": 936, "annotation": "n_glycosylation_sequon", "start_pos": 934 }, { "end_pos": 1434, "annotation": "n_glycosylation_sequon", "start_pos": 1432 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008771339.1", "id": "XP_008771339.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2672351", "id": "R-RNO-2672351", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002537", "id": "ENSRNOG00000002537", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/ENNPCQH/", "id": "ENNPCQH", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "id": "IPR008271", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR024678", "id": "IPR024678", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00069", "id": "PF00069", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12202", "id": "PF12202", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/317420", "id": "317420", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1563131", "id": "1563131", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K2Y2", "disease": [], "mass": { "monoisotopic_mass": 186190.0, "chemical_mass": 186190.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2Y2", "name": "Wnk3; RGD1563131.", "locus": { "end_pos": 20454357, "start_pos": 20316893, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000002537", "id": "ENSRNOG00000002537", "database": "Ensembl Gene" } ] } } ] }