{ "uniprot_canonical_ac": "A0A0G2K2S5-1", "sequence": { "header": "tr|A0A0G2K2S5-1|A0A0G2K2S5_RAT Isoform 1 of Ttk protein kinase OS=Rattus norvegicus OX=10116 GN=Ttk PE=1 SV=1 CANONICAL=A0A0G2K2S5-1", "length": 863, "sequence": "MQMTGTSCSLEMEAEELIGRNLTIDSIMNKVRDIKNKINEDLTDELNSIKVCVDPTETVNQIMMVENTPENWLNFLLKLEKNSPPLNDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRLAELKAIQEPDDAHDYFQMARENCKKFAFVHVSFAQFELSQGNLKKSEQLLHKAVETGAVPLQMLETAIRNLHLQKKQLLSEEDKKSLSASTVLTAQESFSSSLGNLQSRKSSCDPKVQAAAARILYGENMPPKDAEVSHRNPLKQTNKTKRSCPFGRVPVNLLNSPDYYVKTDGSAVPQFTKRKISGSEYRDSIMPGSKSSGNDSYELRGLKPIQAIHLKDSLVSNEKSSELMSDLVTLKSKTDSSLTKLEVSEPKVRQEPEIPERRHKQWQSARKPGCGIQNSAAFAPQWHVPDVTPKADKEKCTTVEQLAFSVSKQSPPLSVPKWIDPKSVCETPSSSSLDDYMKCFKTSVVKNEFPPACPSSTPYSQLARHQQHQQQGLSTPLQNLQISGSSSMSECISVNGRIYSILKQIGSGGSSKVFQVLNEKKQINAIKYVNLEDADSQTIDSYRNEIAYLNKLQQHSDKIIRLYDYEITDRYIYMVMECGNIDLNSWLKKKKSINPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMAPEAIRDMSSSRENGKIKTKISPRSDVWSLGCILYYMTYGKTPFQHIINQVSKLHAIIDPSHEIEFPEISEKDLRDVLKCCLVRNPKERISIPELLAHPYVQIQPHPGSQMAKETTDEMKYMLGQLVCLNSPNSILKAAKTLYERYNCGESQAPSSSKTSDKKRERE" }, "uniprot_id": "A0A0G2K2S5_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "dual specificity protein kinase TTK isoform X2" ], "uniprotkb": [ "Ttk protein kinase" ] }, "gene": { "refseq": [ "Ttk", "Mps1" ], "uniprotkb": [ "Ttk", "Mps1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Ttk protein kinase." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5/publications", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5#A0A0G2K2S5-1", "isoform_ac": "A0A0G2K2S5-1", "locus": { "end_pos": 91368872, "start_pos": 91405717, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000083151", "id": "ENSRNOT00000083151", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072355", "id": "ENSRNOP00000072355", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K2S5-1|A0A0G2K2S5_RAT Isoform 1 of Ttk protein kinase OS=Rattus norvegicus OX=10116 GN=Ttk PE=1 SV=1 CANONICAL=A0A0G2K2S5-1", "length": 863, "sequence": "MQMTGTSCSLEMEAEELIGRNLTIDSIMNKVRDIKNKINEDLTDELNSIKVCVDPTETVNQIMMVENTPENWLNFLLKLEKNSPPLNDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRLAELKAIQEPDDAHDYFQMARENCKKFAFVHVSFAQFELSQGNLKKSEQLLHKAVETGAVPLQMLETAIRNLHLQKKQLLSEEDKKSLSASTVLTAQESFSSSLGNLQSRKSSCDPKVQAAAARILYGENMPPKDAEVSHRNPLKQTNKTKRSCPFGRVPVNLLNSPDYYVKTDGSAVPQFTKRKISGSEYRDSIMPGSKSSGNDSYELRGLKPIQAIHLKDSLVSNEKSSELMSDLVTLKSKTDSSLTKLEVSEPKVRQEPEIPERRHKQWQSARKPGCGIQNSAAFAPQWHVPDVTPKADKEKCTTVEQLAFSVSKQSPPLSVPKWIDPKSVCETPSSSSLDDYMKCFKTSVVKNEFPPACPSSTPYSQLARHQQHQQQGLSTPLQNLQISGSSSMSECISVNGRIYSILKQIGSGGSSKVFQVLNEKKQINAIKYVNLEDADSQTIDSYRNEIAYLNKLQQHSDKIIRLYDYEITDRYIYMVMECGNIDLNSWLKKKKSINPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMAPEAIRDMSSSRENGKIKTKISPRSDVWSLGCILYYMTYGKTPFQHIINQVSKLHAIIDPSHEIEFPEISEKDLRDVLKCCLVRNPKERISIPELLAHPYVQIQPHPGSQMAKETTDEMKYMLGQLVCLNSPNSILKAAKTLYERYNCGESQAPSSSKTSDKKRERE" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5#D4A4S7-1", "isoform_ac": "D4A4S7-1", "locus": { "end_pos": 91369627, "start_pos": 91405717, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000051612", "id": "ENSRNOT00000051612", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000042156", "id": "ENSRNOP00000042156", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4A4S7-1|A0A0G2K2S5_RAT Computationally mapped isoform of Ttk protein kinase OS=Rattus norvegicus OX=10116 GN=Ttk PE=1 SV=1 CANONICAL=A0A0G2K2S5-1", "length": 835, "sequence": "MEAEELIGRNLTIDSIMNKVRDIKNKINEDLTDELNSIKVCVDPTETVNQIMMVENTPENWLNFLLKLEKNSPPLNDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRLAELKAIQEPDDAHDYFQMARENCKKFAFVHVSFAQFELSQGNLKKSEQLLHKAVETGAVPLQMLETAIRNLHLQKKQLLSEEDKKSLSASTVLTAQESFSSSLGNLQSRKSSCDPKVQAAAARILYGENMPPKDAEVSHRNPLKQTNKTKRSCPFGRVPVNLLNSPDYYVKTDGSAVPQFTKRKISGSEYRDSIMPGSKSSGNDSYELRGLKPIQAIHLKDSLVSNEKSSELMSDLVTLKSKTDSSLTKLEEPKVRQEPEIPERRHKQWQSARKPGCGIQNSAAFAPQWHVPDVTPKADKESPPLSVPKWIDPKSVCETPSSSSLDDYMKCFKTSVVKNEFPPACPSSTPYSQLARHQQHQQQGLSTPLQNLQISGSSSMSECISVNGRIYSILKQIGSGGSSKVFQVLNEKKQINAIKYVNLEDADSQTIDSYRNEIAYLNKLQQHSDKIIRLYDYEITDRYIYMVMECGNIDLNSWLKKKKSINPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMAPEAIRDMSSSRENGKIKTKISPRSDVWSLGCILYYMTYGKTPFQHIINQVSKLHAIIDPSHEIEFPEISEKDLRDVLKCCLVRNPKERISIPELLAHPYVQIQPHPGSQMAKETTDEMKYMLGQLVCLNSPNSILKAAKTLYERYNCGESQAPSSSKTSDKKRERE" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "P33981-1", "protein_name": "Dual specificity protein kinase TTK; 2.7.12.1; Phosphotyrosine picked threonine-protein kinase; PYT.", "sequence": { "length": 857, "sequence": "MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K2S5/", "id": "A0A0G2K2S5", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/2489", "id": "2489", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006243523.1", "ac": "XP_006243523.1", "name": "dual specificity protein kinase TTK isoform X2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "protein serine/threonine kinase activity", "id": "GO:0004674" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004712", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "protein serine/threonine/tyrosine kinase activity", "id": "GO:0004712" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "protein homodimerization activity", "id": "GO:0042803" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043515", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "kinetochore binding", "id": "GO:0043515" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "spindle", "id": "GO:0005819" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "kinetochore", "id": "GO:0000776" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033316", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "meiotic spindle assembly checkpoint", "id": "GO:0033316" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "chromosome segregation", "id": "GO:0007059" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007094", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "mitotic spindle assembly checkpoint", "id": "GO:0007094" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018105", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "peptidyl-serine phosphorylation", "id": "GO:0018105" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034501", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "protein localization to kinetochore", "id": "GO:0034501" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016321", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "female meiosis chromosome segregation", "id": "GO:0016321" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "protein localization to meiotic spindle midzone", "id": "GO:1903096" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018108", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "peptidyl-tyrosine phosphorylation", "id": "GO:0018108" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "protein autophosphorylation", "id": "GO:0046777" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018107", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "peptidyl-threonine phosphorylation", "id": "GO:0018107" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051304", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "id": "A0A0G2K2S5", "database": "UniProtKB" } ], "name": "chromosome separation", "id": "GO:0051304" } ], "total": 11, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 23, "annotation": "n_glycosylation_sequon", "start_pos": 21 }, { "end_pos": 115, "annotation": "n_glycosylation_sequon", "start_pos": 113 }, { "end_pos": 272, "annotation": "n_glycosylation_sequon", "start_pos": 270 }, { "end_pos": 328, "annotation": "n_glycosylation_sequon", "start_pos": 326 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006243523.1", "id": "XP_006243523.1", "database": "RefSeq" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000029055", "id": "ENSRNOG00000029055", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/KSECINQ/", "id": "KSECINQ", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027084", "id": "IPR027084", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "id": "IPR011990", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "id": "IPR008271", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00069", "id": "PF00069", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22974:SF21", "id": "PTHR22974:SF21", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/315852", "id": "315852", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305558", "id": "1305558", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K2S5", "disease": [], "mass": { "monoisotopic_mass": 97348.0, "chemical_mass": 97348.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "name": "Ttk; Mps1.", "locus": { "end_pos": 91405993, "start_pos": 91368111, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000029055", "id": "ENSRNOG00000029055", "database": "Ensembl Gene" } ] } } ] }