{ "uniprot_canonical_ac": "A0A0G2K2K7-1", "sequence": { "header": "tr|A0A0G2K2K7-1|A0A0G2K2K7_RAT Isoform 1 of Interleukin 18 receptor accessory protein OS=Rattus norvegicus OX=10116 GN=Il18rap PE=4 SV=1 CANONICAL=A0A0G2K2K7-1", "length": 627, "sequence": "MLCLGWVFLWFVAGEKTTGFNHSACTTKKLLWTYSARGAENFVLFCDLQELQKQDFSHRSQSSSTLGPAHQPCSGSEKDLSDVQWYMQPRSGGPLEEINRNSPHMQNKGTLRILAPQMNSIWSYICRPRSRRPQDTACCVKTVLEVKPQRNISCGSSAQDEQVLLLGSTGSIHCPSLSCQSDVRSPEMTWYKDGRLLPEYKKNPIEMEDIYDFHQGLYVCDYTQSDNVSSWTVRAVVQVRTIDEDTNVKPDILDPVTDTLDVELGKAFTLPCRVQFGFQRYSKPVIKWYVKESTQEWEISEFVEKRIQSTLKNEVIEHTVFLREVTQRDLSRKFVCFAQNSIGNTTRTIRLRKKEGVVFLYILLGMTVMLVGVLVAAALLYWHWIEVVLLCRTFKNKDETLRDKKEFDAFVSYANWSSPETEATGSLSEEHLALNLFPEVLENTYGYSLCLFERDVTPGGVYTDDIVSIIKRSRRGIFILSPRYINGPRVFELQAAVNLALVDQTLKLILIKFCSFQEPESLPYLVKKALRVLPTVTWKGLKSVHATSRFWTQIRYHMPVKNSNRFMFNWLRLIPKGFSPEKDLATQKPLGGMPNSGNSHGAQNRTPDAGNRHGAQNLLLSGHQKRC" }, "uniprot_id": "A0A0G2K2K7_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "interleukin-18 receptor accessory protein" ], "uniprotkb": [ "Interleukin 18 receptor accessory protein", "RCG22315" ] }, "gene": { "refseq": [ "Il18rap" ], "uniprotkb": [ "Il18rap", "rCG_22315" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Interleukin 18 receptor accessory protein; RCG22315." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7#A0A0G2K2K7-1", "isoform_ac": "A0A0G2K2K7-1", "locus": { "end_pos": 47233601, "start_pos": 47255649, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000077303", "id": "ENSRNOT00000077303", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072281", "id": "ENSRNOP00000072281", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K2K7-1|A0A0G2K2K7_RAT Isoform 1 of Interleukin 18 receptor accessory protein OS=Rattus norvegicus OX=10116 GN=Il18rap PE=4 SV=1 CANONICAL=A0A0G2K2K7-1", "length": 627, "sequence": "MLCLGWVFLWFVAGEKTTGFNHSACTTKKLLWTYSARGAENFVLFCDLQELQKQDFSHRSQSSSTLGPAHQPCSGSEKDLSDVQWYMQPRSGGPLEEINRNSPHMQNKGTLRILAPQMNSIWSYICRPRSRRPQDTACCVKTVLEVKPQRNISCGSSAQDEQVLLLGSTGSIHCPSLSCQSDVRSPEMTWYKDGRLLPEYKKNPIEMEDIYDFHQGLYVCDYTQSDNVSSWTVRAVVQVRTIDEDTNVKPDILDPVTDTLDVELGKAFTLPCRVQFGFQRYSKPVIKWYVKESTQEWEISEFVEKRIQSTLKNEVIEHTVFLREVTQRDLSRKFVCFAQNSIGNTTRTIRLRKKEGVVFLYILLGMTVMLVGVLVAAALLYWHWIEVVLLCRTFKNKDETLRDKKEFDAFVSYANWSSPETEATGSLSEEHLALNLFPEVLENTYGYSLCLFERDVTPGGVYTDDIVSIIKRSRRGIFILSPRYINGPRVFELQAAVNLALVDQTLKLILIKFCSFQEPESLPYLVKKALRVLPTVTWKGLKSVHATSRFWTQIRYHMPVKNSNRFMFNWLRLIPKGFSPEKDLATQKPLGGMPNSGNSHGAQNRTPDAGNRHGAQNLLLSGHQKRC" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:373540", "resource": "KEGG Pathway", "id": "rno:373540", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O95256-1", "protein_name": "Interleukin-18 receptor accessory protein; IL-18 receptor accessory protein; IL-18RAcP; IL-1R accessory protein-like; IL-1RAcPL; Accessory protein-like; AcPL; Interleukin-18 receptor beta; IL-18R-beta; IL-18Rbeta; Interleukin-1 receptor 7; IL-1R-7; IL-1R7; Interleukin-18 receptor accessory protein-like; CDw218b; CD218 antigen-like family member B.", "sequence": { "length": 599, "sequence": "MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K2K7/", "id": "A0A0G2K2K7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/2859", "id": "2859", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9Z2B1-1", "protein_name": "Interleukin-18 receptor accessory protein; IL-18 receptor accessory protein; IL-18RAcP; IL-1R accessory protein-like; IL-1RAcPL; Accessory protein-like; AcPL; Interleukin-18 receptor beta; IL-18R-beta; IL-18Rbeta; Interleukin-18 receptor accessory protein-like; CD218 antigen-like family member B.", "sequence": { "length": 614, "sequence": "MLCLGWVFLWFVAGEKTTGFNHSACATKKLLWTYSARGAENFVLFCDLQELQEQKFSHASQLSPTQSPAHKPCSGSQKDLSDVQWYMQPRSGSPLEEISRNSPHMQSEGMLHILAPQTNSIWSYICRPRIRSPQDMACCIKTVLEVKPQRNVSCGNTAQDEQVLLLGSTGSIHCPSLSCQSDVQSPEMTWYKDGRLLPEHKKNPIEMADIYVFNQGLYVCDYTQSDNVSSWTVRAVVKVRTIGKDINVKPEILDPITDTLDVELGKPLTLPCRVQFGFQRLSKPVIKWYVKESTQEWEMSVFEEKRIQSTFKNEVIERTIFLREVTQRDLSRKFVCFAQNSIGNTTRTIRLRKKEEVVFVYILLGTALMLVGVLVAAAFLYWYWIEVVLLCRTYKNKDETLGDKKEFDAFVSYSNWSSPETDAVGSLSEEHLALNLFPEVLEDTYGYRLCLLDRDVTPGGVYADDIVSIIKKSRRGIFILSPSYLNGPRVFELQAAVNLALVDQTLKLILIKFCSFQEPESLPYLVKKALRVLPTVTWKGLKSVHASSRFWTQIRYHMPVKNSNRFMFNGLRIFLKGFSPEKDLVTQKPLEGMPKSGNDHGAQNLLLYSDQKRC" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K2K7/", "id": "A0A0G2K2K7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/2859", "id": "2859", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008756243.1", "ac": "XP_008756243.1", "name": "interleukin-18 receptor accessory protein.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042007", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interleukin-18 binding", "id": "GO:0042007" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042008", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interleukin-18 receptor activity", "id": "GO:0042008" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045092", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interleukin-18 receptor complex", "id": "GO:0045092" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051092", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "positive regulation of NF-kappaB transcription factor activity", "id": "GO:0051092" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "cellular response to hydrogen peroxide", "id": "GO:0070301" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071345", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "cellular response to cytokine stimulus", "id": "GO:0071345" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035655", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interleukin-18-mediated signaling pathway", "id": "GO:0035655" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "cell population proliferation", "id": "GO:0008283" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045954", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "positive regulation of natural killer cell mediated cytotoxicity", "id": "GO:0045954" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interleukin-6 production", "id": "GO:0032635" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042119", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "neutrophil activation", "id": "GO:0042119" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032609", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interferon-gamma production", "id": "GO:0032609" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035744", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "T-helper 1 cell cytokine production", "id": "GO:0035744" } ], "total": 10, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 23, "annotation": "n_glycosylation_sequon", "start_pos": 21 }, { "end_pos": 153, "annotation": "n_glycosylation_sequon", "start_pos": 151 }, { "end_pos": 229, "annotation": "n_glycosylation_sequon", "start_pos": 227 }, { "end_pos": 346, "annotation": "n_glycosylation_sequon", "start_pos": 344 }, { "end_pos": 417, "annotation": "n_glycosylation_sequon", "start_pos": 415 }, { "end_pos": 606, "annotation": "n_glycosylation_sequon", "start_pos": 604 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008756243.1", "id": "XP_008756243.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:373540", "id": "rno:373540", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054218", "id": "ENSRNOG00000054218", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/PTVTWRG/", "id": "PTVTWRG", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "id": "IPR003599", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "id": "IPR007110", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "id": "IPR013783", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "id": "IPR036179", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013151", "id": "IPR013151", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000157", "id": "IPR000157", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035897", "id": "IPR035897", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015621", "id": "IPR015621", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041416", "id": "IPR041416", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00047", "id": "PF00047", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01582", "id": "PF01582", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF18452", "id": "PF18452", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11890", "id": "PTHR11890", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/373540", "id": "373540", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=727867", "id": "727867", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K2K7", "disease": [], "mass": { "monoisotopic_mass": 71630.0, "chemical_mass": 71630.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "name": "Il18rap; rCG_22315.", "locus": { "end_pos": 47258503, "start_pos": 47225585, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000054218", "id": "ENSRNOG00000054218", "database": "Ensembl Gene" } ] } } ] }