{ "uniprot_canonical_ac": "A0A0G2K283-1", "sequence": { "header": "tr|A0A0G2K283-1|A0A0G2K283_RAT Isoform 1 of DEAH-box helicase 8 OS=Rattus norvegicus OX=10116 GN=Dhx8 PE=1 SV=1 CANONICAL=A0A0G2K283-1", "length": 1242, "sequence": "MAVAVATAGVLMGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEEDVKVAVDVLKELEALMPSAAGQEKQRDTEHRDRTKKKKRSRSRDRDRDRDRDRDRDRDRDRDKDRERDRDRERDRERDRDRDHKRRHRSRSRSHSRTRERAKGKSRYRSRSRSQSPFKDRKDREKYGERNLDRWRDKHVDRPPPEEPAIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEPLYNRYEEPNAWRISRAFRRR" }, "uniprot_id": "A0A0G2K283_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "ATP-dependent RNA helicase DHX8 isoform X1" ], "uniprotkb": [ "DEAH-box helicase 8", "DEAH (Asp-Glu-Ala-His) box polypeptide 8" ] }, "gene": { "refseq": [ "Dhx8", "LRRGT00035" ], "uniprotkb": [ "Dhx8", "rCG_33588", "LRRGT00035" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283", "id": "A0A0G2K283", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "DEAH-box helicase 8; DEAH (Asp-Glu-Ala-His) box polypeptide 8." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283/publications", "id": "A0A0G2K283", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283#A0A0G2K283-1", "isoform_ac": "A0A0G2K283-1", "locus": { "end_pos": 89646195, "start_pos": 89682000, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000086892", "id": "ENSRNOT00000086892", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072141", "id": "ENSRNOP00000072141", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K283-1|A0A0G2K283_RAT Isoform 1 of DEAH-box helicase 8 OS=Rattus norvegicus OX=10116 GN=Dhx8 PE=1 SV=1 CANONICAL=A0A0G2K283-1", "length": 1242, "sequence": "MAVAVATAGVLMGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEEDVKVAVDVLKELEALMPSAAGQEKQRDTEHRDRTKKKKRSRSRDRDRDRDRDRDRDRDRDRDKDRERDRDRERDRERDRDRDHKRRHRSRSRSHSRTRERAKGKSRYRSRSRSQSPFKDRKDREKYGERNLDRWRDKHVDRPPPEEPAIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEPLYNRYEEPNAWRISRAFRRR" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K283#Q6TXG4-1", "isoform_ac": "Q6TXG4-1", "locus": { "end_pos": 89646195, "start_pos": 89683443, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000048140", "id": "ENSRNOT00000048140", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000043050", "id": "ENSRNOP00000043050", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q6TXG4-1|A0A0G2K283_RAT Computationally mapped isoform of DEAH-box helicase 8 OS=Rattus norvegicus OX=10116 GN=Dhx8 PE=1 SV=1 CANONICAL=A0A0G2K283-1", "length": 1210, "sequence": "MAVAVATAGVLMGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTTMLDEEDVKVAVDVLKELEALMPSAAGQEKQRDTEHRDRTKKKKRSRSRDRDRDRDRDRDRDRDRDRDKDRERDRDRERDRERDRDRDHKRRHRSRSRSHSRTRERAKGKSRYRSRSRSQSPFKDRKDREKYGERNLDRWRDKHVDRPPPEEPAIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEPLYNRGEGMRVLYTELRSWKAQDCWTNYGCTYRYSFRLLPES" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "A2A4P0-1", "protein_name": "ATP-dependent RNA helicase DHX8; 3.6.4.13; DEAH box protein 8.", "sequence": { "length": 1244, "sequence": "MAVAVAAAGVLMGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLRELFPVLCQPDNPSARTMLDEEDVKVAVDVLKELEALMPSAAGQEKQRDPEHRDRTKKKKRSRSRDRDRDRDRDRDRDRDRDRDRDKDRERDRDRERDRERDRERDHKRRHRSRSRSHSRTRERTKGKSRYRSRSRSQSPFKDRKDREKYGERNLDRWRDKHVDRPPPEEPAIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEPLYNRYEEPNAWRISRAFRRR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/3628", "id": "3628", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "F5H658-1", "protein_name": "ATP-dependent RNA helicase DHX8.", "sequence": { "length": 1181, "sequence": "MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPECPKHFLPVVAVAVSLEQCLSKFEDLNKELGLVTC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/3628", "id": "3628", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006247348.1", "ac": "XP_006247348.1", "name": "ATP-dependent RNA helicase DHX8 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283", "id": "A0A0G2K283", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283", "id": "A0A0G2K283", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283", "id": "A0A0G2K283", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283", "id": "A0A0G2K283", "database": "UniProtKB" } ], "name": "helicase activity", "id": "GO:0004386" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283", "id": "A0A0G2K283", "database": "UniProtKB" } ], "name": "catalytic step 2 spliceosome", "id": "GO:0071013" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283", "id": "A0A0G2K283", "database": "UniProtKB" } ], "name": "nuclear body", "id": "GO:0016604" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071007", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283", "id": "A0A0G2K283", "database": "UniProtKB" } ], "name": "U2-type catalytic step 2 spliceosome", "id": "GO:0071007" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000390", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283", "id": "A0A0G2K283", "database": "UniProtKB" } ], "name": "spliceosomal complex disassembly", "id": "GO:0000390" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 62, "annotation": "n_glycosylation_sequon", "start_pos": 60 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006247348.1", "id": "XP_006247348.1", "database": "RefSeq" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020772", "id": "ENSRNOG00000020772", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/RIQKAIC/", "id": "RIQKAIC", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "id": "IPR012340", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "id": "IPR001650", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "id": "IPR014001", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002464", "id": "IPR002464", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003029", "id": "IPR003029", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011709", "id": "IPR011709", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007502", "id": "IPR007502", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR022967", "id": "IPR022967", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00271", "id": "PF00271", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF07717", "id": "PF07717", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00575", "id": "PF00575", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF04408", "id": "PF04408", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/287727", "id": "287727", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310723", "id": "1310723", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K283", "disease": [], "mass": { "monoisotopic_mass": 142291.0, "chemical_mass": 142291.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K283", "name": "Dhx8; rCG_33588; LRRGT00035.", "locus": { "end_pos": 89683446, "start_pos": 89645973, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000020772", "id": "ENSRNOG00000020772", "database": "Ensembl Gene" } ] } } ] }