{ "uniprot_canonical_ac": "A0A0G2K261-1", "sequence": { "header": "tr|A0A0G2K261-1|A0A0G2K261_RAT Isoform 1 of Isoleucyl-tRNA synthetase 2, mitochondrial OS=Rattus norvegicus OX=10116 GN=Iars2 PE=1 SV=1 CANONICAL=A0A0G2K261-1", "length": 1011, "sequence": "MLWGLHPHGPGTAALTAAGSLWGPARFPSRLGCLGMTRRLVVRSVAGADSPQSSPKSGRYRDTVLLPQTNFPMKLLGHQQSDMELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIVNRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVNTQTLSAMEIREKARSFAQAAIEKQKSAFARWGVMADWSNCYYTFDPKYEAKQLRVFQQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNPEHVSRSVYVRFPLLKPPPTLESLTGASSPVSALVWTTQPWTVPANQAICYMPEAKYAVVKCSASGNFYILAEDKISPVASALETTFDVTATFSGVDLEGGTCSHPLIPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEEGMFTSAAGPELQNKAVLTEGTDVVIKMLQATKNVLKEESIVHSYPCDWRTKKPVLIRASKQWFVNIMDIKAHSESLKTVKFIPGAALNSMMDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIIKLVEQHGSDVWWTLPAEKLLPEEVVAQAGGPGALEYVPGQDILDIWFDSGTSWSCVLQGTEQRADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVIDPDTIISGGKDHSKEPPYGADILRWWIAESNVFTEVTIGPSVLSAARDDISKLRNTLRFLLGNLAGFNPETASVPVKNMYIIDQYMLHLIQDFATKVTDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCESETDPKRRSCQTALAEILDVLVRSFAPVLPHLAEEVFQHIPYVKEPKSVFRTGWISTSSVWKKPGLEEAVESACAMRDSFLGSIPGKNAAEYDVIIVIEPGLLFEIMEMLQAEETSSTSQLNELMMASQTTLLAQEPRERSADAIELTGTFVINLEGGDIREESSYKVIVVPTAREKCPRCWKHTAETADALCPRCAEVIGAK" }, "uniprot_id": "A0A0G2K261_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Isoleucyl-tRNA synthetase 2, mitochondrial" ] }, "gene": { "refseq": [], "uniprotkb": [ "Iars2" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "id": "A0A0G2K261", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Isoleucyl-tRNA synthetase 2, mitochondrial." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K261#A0A0G2K150-1", "isoform_ac": "A0A0G2K150-1", "locus": { "end_pos": 103239602, "start_pos": 103264906, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000085211", "id": "ENSRNOT00000085211", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000071701", "id": "ENSRNOP00000071701", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K150-1|A0A0G2K261_RAT Computationally mapped isoform of Isoleucyl-tRNA synthetase 2, mitochondrial OS=Rattus norvegicus OX=10116 GN=Iars2 PE=1 SV=1 CANONICAL=A0A0G2K261-1", "length": 730, "sequence": "MLWGLHPHGPGTAALTAAGSLWGPARFPSRLGCLGMTRRLVVRSVAGADSPQSSPKSGRYRDTVLLPQTNFPMKLLGHQQSDMELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIVNRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVNTQTLSAMEIREKARSFAQAAIEKQKSAFARWGVMADWSNCYYTFDPKYEAKQLRVFQQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNPEHVSRSVYVRFPLLKPPPTLESLTGASSPVSALVWTTQPWTVPANQAICYMPEAKYAVVKCSASGNFYILAEDKISPVASALETTFDVTATFSGVDLEGGTCSHPLIPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEEGMFTSAAGPELQNKAVLTEGTDVVIKMLQATKNLKEESIVHSYCDWRTKKPVLIRASKQWFVNIMDIKAHRKESLKTVKFIPGAALNSMMDMLDRRPYWCISRRVWGVPIPVFHHKTKSEYLVHSQTTEHIIKLVEQHGSDVWWTLPAEKLLPEEVVAQAGGPGALEYVPGQDILDIWFDSGTSWSCVLQGTEQRADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVIDPDTIISGGKDHSKEPPYGADILRWWIAESNVFTEVTIGPSVLSAARDDISKVRPAQQTL" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K261#A0A0G2K261-1", "isoform_ac": "A0A0G2K261-1", "locus": { "end_pos": 103231387, "start_pos": 103264906, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000090786", "id": "ENSRNOT00000090786", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072118", "id": "ENSRNOP00000072118", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K261-1|A0A0G2K261_RAT Isoform 1 of Isoleucyl-tRNA synthetase 2, mitochondrial OS=Rattus norvegicus OX=10116 GN=Iars2 PE=1 SV=1 CANONICAL=A0A0G2K261-1", "length": 1011, "sequence": "MLWGLHPHGPGTAALTAAGSLWGPARFPSRLGCLGMTRRLVVRSVAGADSPQSSPKSGRYRDTVLLPQTNFPMKLLGHQQSDMELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIVNRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVNTQTLSAMEIREKARSFAQAAIEKQKSAFARWGVMADWSNCYYTFDPKYEAKQLRVFQQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNPEHVSRSVYVRFPLLKPPPTLESLTGASSPVSALVWTTQPWTVPANQAICYMPEAKYAVVKCSASGNFYILAEDKISPVASALETTFDVTATFSGVDLEGGTCSHPLIPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEEGMFTSAAGPELQNKAVLTEGTDVVIKMLQATKNVLKEESIVHSYPCDWRTKKPVLIRASKQWFVNIMDIKAHSESLKTVKFIPGAALNSMMDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIIKLVEQHGSDVWWTLPAEKLLPEEVVAQAGGPGALEYVPGQDILDIWFDSGTSWSCVLQGTEQRADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVIDPDTIISGGKDHSKEPPYGADILRWWIAESNVFTEVTIGPSVLSAARDDISKLRNTLRFLLGNLAGFNPETASVPVKNMYIIDQYMLHLIQDFATKVTDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCESETDPKRRSCQTALAEILDVLVRSFAPVLPHLAEEVFQHIPYVKEPKSVFRTGWISTSSVWKKPGLEEAVESACAMRDSFLGSIPGKNAAEYDVIIVIEPGLLFEIMEMLQAEETSSTSQLNELMMASQTTLLAQEPRERSADAIELTGTFVINLEGGDIREESSYKVIVVPTAREKCPRCWKHTAETADALCPRCAEVIGAK" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K261#D4A8P9-1", "isoform_ac": "D4A8P9-1", "locus": { "end_pos": 103249794, "start_pos": 103264906, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000057395", "id": "ENSRNOT00000057395", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000054206", "id": "ENSRNOP00000054206", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4A8P9-1|A0A0G2K261_RAT Computationally mapped isoform of Isoleucyl-tRNA synthetase 2, mitochondrial OS=Rattus norvegicus OX=10116 GN=Iars2 PE=1 SV=3 CANONICAL=A0A0G2K261-1", "length": 557, "sequence": "MLWGLHPHGPGTAALTAAGSLWGPARFPSRLGCLGMTRRLVVRSVAGADSPQSSPKSGRYRDTVLLPQTNFPMKLLGHQQSDMELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIVNRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVNTQTLSAMEIREKARSFAQAAIEKQKSAFARWGVMADWSNCYYTFDPKYEAKQLRVFQQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNPEHVSRSVYVRFPLLKPPPTLESLTGASSPVSALVWTTQPWTVPANQAICYMPEAKYAVVKCSASGNFYILAEDKISPVASALETTFDVTATFSGVDLEGGTCSHPLIPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEEGMFTSAAGPELQNKAVLTEGTDVVIKMLQATKNLKEESIVHSYCDWRTKKPVLIRASKQWFVNIMDIKAHRKESLKTVKFIPGAALNSMMDMLDRRPYWCISRRVWGVPIPVFHHKTKRSHLINRHNLLPAMLAYSLR" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q9NSE4-1", "protein_name": "Isoleucine--tRNA ligase, mitochondrial; 6.1.1.5; Isoleucyl-tRNA synthetase; IleRS.", "sequence": { "length": 1012, "sequence": "MRWGLRPRGPGAAALATARSLWGTPRLPCSPGWQGATKRLLVRSVSGASNHQPNSNSGRYRDTVLLPQTSFPMKLLGRQQPDTELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMNGSKIHFVPGWDCHGLPIEIKVLSELGREAQNLSAMEIRKKARSFAKAAIEKQKSAFIRWGIMADWNNCYYTFDGKYEAKQLRTFYQMYDKGLVYRSYKPVFWSPSSRTALAEAELEYNPEHVSRSIYVKFPLLKPSPKLASLIDGSSPVSILVWTTQPWTIPANEAVCYMPESKYAVVKCSKSGDLYVLAADKVASVASTLETTFETISTLSGVDLENGTCSHPLIPDKASPLLPANHVTMAKGTGLVHTAPAHGMEDYGVASQHNLPMDCLVDEDGVFTDVAGPELQNKAVLEEGTDVVIKMLQTAKNLLKEEKLVHSYPYDWRTKKPVVIRASKQWFINITDIKTAAKELLKKVKFIPGSALNGMVEMMDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIVKLVEQHGSDIWWTLPPEQLLPKEVLSEVGGPDALEYVPGQDILDIWFDSGTSWSYVLPGPDQRADLYLEGKDQLGGWFQSSLLTSVAARKRAPYKTVIVHGFTLGEKGEKMSKSLGNVIHPDVVVNGGQDQSKEPPYGADVLRWWVADSNVFTEVAIGPSVLNAARDDISKLRNTLRFLLGNVADFNPETDSIPVNDMYVIDQYMLHLLQDLANKITELYKQYDFGKVVRLLRTFYTRELSNFYFSIIKDRLYCEKENDPKRRSCQTALVEILDVIVRSFAPILPHLAEEVFQHIPYIKEPKSVFRTGWISTSSIWKKPGLEEAVESACAMRDSFLGSIPGKNAAEYKVITVIEPGLLFEIIEMLQSEETSSTSQLNELMMASESTLLAQEPREMTADVIELKGKFLINLEGGDIREESSYKVIVMPTTKEKCPRCWKYTAESSDTLCPRCAEVVSGK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K261/", "id": "A0A0G2K261", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8BIJ6-1", "protein_name": "Isoleucine--tRNA ligase, mitochondrial; 6.1.1.5; Isoleucyl-tRNA synthetase; IleRS.", "sequence": { "length": 1012, "sequence": "MHWGLCPRGPGAAAVAAAGSFWGPARLPSRLGCLGMTRRLVVRSVAGADSPQSSSKGGRYRDTVLLPQTSFPMKLLGRQQSDMELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVDAQSLSAMEIREKARSFAQAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNPEHVSRSIYVRFPLLRPPPKLESLTDASSPVSVLVWTTQPWTIPANQAICYMPEAKYAVVKCSASGHLYILAEDKIAPVASALETTFDVVAAFSGVDLEGGTCSHPLTPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEGGMFTDAAGPELQNKAVLKEGTDVVIKMLQATKNVLKEENIVHSYPCDWRTKTPVLIRASKQWFVNITDIKAAAKESLKTVKFIPGAALNSMTDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIIKLVEQHGSDVWWTLPAEQLLPAEVLAQAGGPGALEYAPGQDILDIWFDSGTSWSCVLQDTQQRADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTIISGGKDHSKEPPYGADILRWWIAESNVFTEVTIGPSVLSAARDDISKLRNTLRFLLGNLTGFNPETDSVPVKNMYVIDQYMLHLIQDFATKITDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCENEKDPKRRSCQTALAEILDVLVRAFAPILPHLAEEVFQHIPYVTEPKSVFRTGWINTSSIWKKPGLEEAVESACAMRDSFLGSIPGKNAAEYEVIIVIEPGLLFEIMEMLQAEETSSTSQLNELMMASQTTLLAQEPRERTAGDIELTGTFVINLEGGDIREESSYKVIVVPTAREKCPRCWKHTSETADALCPRCAEVIGAK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K261/", "id": "A0A0G2K261", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004822", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "id": "A0A0G2K261", "database": "UniProtKB" } ], "name": "isoleucine-tRNA ligase activity", "id": "GO:0004822" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002161", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "id": "A0A0G2K261", "database": "UniProtKB" } ], "name": "aminoacyl-tRNA editing activity", "id": "GO:0002161" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "id": "A0A0G2K261", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "id": "A0A0G2K261", "database": "UniProtKB" } ], "name": "tRNA binding", "id": "GO:0000049" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "id": "A0A0G2K261", "database": "UniProtKB" } ], "name": "mitochondrion", "id": "GO:0005739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "id": "A0A0G2K261", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006428", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "id": "A0A0G2K261", "database": "UniProtKB" } ], "name": "isoleucyl-tRNA aminoacylation", "id": "GO:0006428" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "id": "A0A0G2K261", "database": "UniProtKB" } ], "name": "mitochondrial translation", "id": "GO:0032543" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002368", "id": "ENSRNOG00000002368", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/HLGTAWN/", "id": "HLGTAWN", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07960", "id": "cd07960", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002301", "id": "IPR002301", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009008", "id": "IPR009008", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002300", "id": "IPR002300", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "id": "IPR014729", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009080", "id": "IPR009080", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001412", "id": "IPR001412", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013155", "id": "IPR013155", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023585", "id": "IPR023585", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033708", "id": "IPR033708", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00133", "id": "PF00133", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08264", "id": "PF08264", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311857", "id": "1311857", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K261", "disease": [], "mass": { "monoisotopic_mass": 112677.0, "chemical_mass": 112677.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "name": "Iars2.", "locus": { "end_pos": 103231387, "start_pos": 103264906, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000002368", "id": "ENSRNOG00000002368", "database": "Ensembl Gene" } ] } } ] }