{
    "uniprot_canonical_ac": "A0A0G2K1Z2-1", 
    "sequence": {
        "header": "tr|A0A0G2K1Z2-1|A0A0G2K1Z2_RAT Isoform 1 of Rho GTPase-activating protein 12  OS=Rattus norvegicus OX=10116 GN=Arhgap12 PE=1 SV=1 CANONICAL=A0A0G2K1Z2-1", 
        "length": 838, 
        "sequence": "MAERSGKIASGQVYIEVEYDYEYEAKDRKIVIRQGERYLLVKKTNDDWWQVRLDENSKAFYVPAQYVKEVTRKALMPPVKQTTGLPNNSMKTTQSMHLQRSTENVNKMPELSSFGKPSSSVQGTGLIRDANQNFGSNYNSGQTLNLSLDLTHNNGKFNSDSHSPKVSSQNRTRLFGHFPGPEFLDIEKTSFSQEQSCDSAGEGSERTHQDSESGDELSSSSTEQMRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQVNGEWETHKDSSGRCYYYNRTTQERTWKPPRWARDVSTSRDFQSPGEQEPLSSEENYHSSCFSQSDSQCGSPPRGWSEELDERGHTLYTSDYTKEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDSNDKDSPTSTKLCLPENESPPTSTKHQDPGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGAAIEMASKDKSSKKNVFELKTRQGTELLIQSDNDAVINDWFKVLSSTINNQVAEADEAAEEEAPDSPGVEKQDKEKDQKELKKLRSMKGSSMDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDVDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGNIAVHTVYQNQIVELILLELSTVFGR"
    }, 
    "uniprot_id": "A0A0G2K1Z2_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "rho GTPase-activating protein 12 isoform X1"
            ], 
            "uniprotkb": [
                "Rho GTPase-activating protein 12"
            ]
        }, 
        "gene": {
            "refseq": [
                "Arhgap12"
            ], 
            "uniprotkb": [
                "Arhgap12"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2", 
                    "id": "A0A0G2K1Z2", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Rho GTPase-activating protein 12."
    }, 
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
            "journal": "Nat. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2/publications", 
                    "id": "A0A0G2K1Z2", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", 
            "date": "2012", 
            "pmid": "22673903"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2#A0A0G2K1Z2-1", 
            "isoform_ac": "A0A0G2K1Z2-1", 
            "locus": {
                "end_pos": 54300770, 
                "start_pos": 54392511, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000084919", 
                        "id": "ENSRNOT00000084919", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000072043", 
                        "id": "ENSRNOP00000072043", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2K1Z2-1|A0A0G2K1Z2_RAT Isoform 1 of Rho GTPase-activating protein 12  OS=Rattus norvegicus OX=10116 GN=Arhgap12 PE=1 SV=1 CANONICAL=A0A0G2K1Z2-1", 
                "length": 838, 
                "sequence": "MAERSGKIASGQVYIEVEYDYEYEAKDRKIVIRQGERYLLVKKTNDDWWQVRLDENSKAFYVPAQYVKEVTRKALMPPVKQTTGLPNNSMKTTQSMHLQRSTENVNKMPELSSFGKPSSSVQGTGLIRDANQNFGSNYNSGQTLNLSLDLTHNNGKFNSDSHSPKVSSQNRTRLFGHFPGPEFLDIEKTSFSQEQSCDSAGEGSERTHQDSESGDELSSSSTEQMRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQVNGEWETHKDSSGRCYYYNRTTQERTWKPPRWARDVSTSRDFQSPGEQEPLSSEENYHSSCFSQSDSQCGSPPRGWSEELDERGHTLYTSDYTKEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDSNDKDSPTSTKLCLPENESPPTSTKHQDPGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGAAIEMASKDKSSKKNVFELKTRQGTELLIQSDNDAVINDWFKVLSSTINNQVAEADEAAEEEAPDSPGVEKQDKEKDQKELKKLRSMKGSSMDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDVDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGNIAVHTVYQNQIVELILLELSTVFGR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2#D3ZDI5-1", 
            "isoform_ac": "D3ZDI5-1", 
            "locus": {
                "end_pos": 54358627, 
                "start_pos": 54392511, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000024022", 
                        "id": "ENSRNOT00000024022", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000024022", 
                        "id": "ENSRNOP00000024022", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|D3ZDI5-1|A0A0G2K1Z2_RAT Computationally mapped isoform of Rho GTPase-activating protein 12  OS=Rattus norvegicus OX=10116 GN=Arhgap12 PE=1 SV=3 CANONICAL=A0A0G2K1Z2-1", 
                "length": 494, 
                "sequence": "MNVGIPYIPVTILRKKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDSNDKDSPTSTKLCLPENESPPTSTKHQDPGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGAAIEMASKDKSSKKNVFELKTRQGTELLIQSDNDAVINDWFKVLSSTINNQVAEADEAAEEEAPDSPGVEKQDKEKDQKELKKLRSMKGSSMDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDVDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGNIAVHTVYQNQIVELILLELSTVFGR"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194840", 
            "resource": "Reactome", 
            "id": "R-RNO-194840", 
            "name": "Rho GTPase cycle"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8C0D4-1", 
            "protein_name": "Rho GTPase-activating protein 12; Rho-type GTPase-activating protein 12.", 
            "sequence": {
                "length": 838, 
                "sequence": "MAERSGKITAGQAYIEVEYDYEYDAKDRKIVIRQGERYLLVKKTNDDWWQVRPDENSKAFYVPAQYVKEVTRKALMPPVKQATGLPNNSMKTIQSMHLQRSTENVNKMPELSSFGKPSSSVQGTGLIRDANQNFGSNYNSGQTLNLSLDLTHNNGKFNSDSHSPKVSSQNRTRLFGHFPGPEFLDIEKTSFSQEQSCDSAGEGSERIQQDSESGDELSSSSTEQMRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQVNGEWETHKDSSGRCYYYNRTTQERTWKPPRWARDVSTSRDFQSPGEQEPLSSEENYHSSCFSQSDSQCGSPPRGWSEELDERGHTLYTSDYTKEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDSNDKDSPTTTKLCLPENESPPTSSKHQDPGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGAVIEMASKDKSSKKNVFELKTRQGTELLIQSDNDAVINDWFKVLSSTINNQVAEADEAAEEETPDSPGVEKHDKEKDQKELKKLRSMKGSSMDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDVDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGNIAVHTVYQNQIVELILLELSTVFGR"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/23089", 
                    "id": "23089", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q8IWW6-1", 
            "protein_name": "Rho GTPase-activating protein 12; Rho-type GTPase-activating protein 12.", 
            "sequence": {
                "length": 846, 
                "sequence": "MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSKAFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPSSSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHFPGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTRDASISKGDFQNPGDQELLSSEENYYSTSYSQSDSQCGSPPRGWSEELDERGHTLYTSDYTNEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTASSPKDQEKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFGR"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2K1Z2/", 
                    "id": "A0A0G2K1Z2", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/23089", 
                    "id": "23089", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254073.1", 
        "ac": "XP_006254073.1", 
        "name": "rho GTPase-activating protein 12 isoform X1.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2", 
                                "id": "A0A0G2K1Z2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "GTPase activator activity", 
                        "id": "GO:0005096"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2", 
                                "id": "A0A0G2K1Z2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001891", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2", 
                                "id": "A0A0G2K1Z2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phagocytic cup", 
                        "id": "GO:0001891"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043087", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2", 
                                "id": "A0A0G2K1Z2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of GTPase activity", 
                        "id": "GO:0043087"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006911", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2", 
                                "id": "A0A0G2K1Z2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phagocytosis, engulfment", 
                        "id": "GO:0006911"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2", 
                                "id": "A0A0G2K1Z2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "actin filament organization", 
                        "id": "GO:0007015"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2", 
                                "id": "A0A0G2K1Z2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "signal transduction", 
                        "id": "GO:0007165"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051058", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2", 
                                "id": "A0A0G2K1Z2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of small GTPase mediated signal transduction", 
                        "id": "GO:0051058"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002011", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2", 
                                "id": "A0A0G2K1Z2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "morphogenesis of an epithelial sheet", 
                        "id": "GO:0002011"
                    }
                ], 
                "total": 6, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 89, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 87
        }, 
        {
            "end_pos": 147, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 145
        }, 
        {
            "end_pos": 172, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 170
        }, 
        {
            "end_pos": 285, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 283
        }, 
        {
            "end_pos": 391, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 389
        }, 
        {
            "end_pos": 444, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 442
        }, 
        {
            "end_pos": 465, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 463
        }, 
        {
            "end_pos": 508, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 506
        }, 
        {
            "end_pos": 660, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 658
        }, 
        {
            "end_pos": 710, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 708
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254073.1", 
            "id": "XP_006254073.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194840", 
            "id": "R-RNO-194840", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017791", 
            "id": "ENSRNOG00000017791", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/FPCPEFL/", 
            "id": "FPCPEFL", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", 
            "id": "cd00201", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12070", 
            "id": "cd12070", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", 
            "id": "IPR000198", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", 
            "id": "IPR001452", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", 
            "id": "IPR001849", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", 
            "id": "IPR008936", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", 
            "id": "IPR011993", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", 
            "id": "IPR036028", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", 
            "id": "IPR001202", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", 
            "id": "IPR036020", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035491", 
            "id": "IPR035491", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00169", 
            "id": "PF00169", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00620", 
            "id": "PF00620", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF14604", 
            "id": "PF14604", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00397", 
            "id": "PF00397", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/307016", 
            "id": "307016", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310017", 
            "id": "1310017", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0G2K1Z2", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 95344.0, 
        "chemical_mass": 95344.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K1Z2", 
            "name": "Arhgap12.", 
            "locus": {
                "end_pos": 54394634, 
                "start_pos": 54280851, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000017791", 
                        "id": "ENSRNOG00000017791", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}