{ "uniprot_canonical_ac": "A0A0G2K1E2-1", "sequence": { "header": "tr|A0A0G2K1E2-1|A0A0G2K1E2_RAT Isoform 1 of Integrin subunit alpha 5 OS=Rattus norvegicus OX=10116 GN=Itga5 PE=1 SV=1 CANONICAL=A0A0G2K1E2-1", "length": 1099, "sequence": "MPPRQPTRRPGGGPSRELGKLLPALSHSPLGGLGSGSGSVAPGQGRTGAMGSWTPRSPRSPLHAVLLRWGPRRLPPLLPLLLLLWPPPLQVGGFNLDAEAPAVLSGPPGSLFGFSVEFYRPGRDGVSVLVGAPKANTSQPGVLQGGAVYVCPWGTSPIQCSTIQFDSKGSRILESSLYSEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKDPQNDPVGTCYLSTENFTRILEYAPCRSDFGSAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQISESYYPQYLINPVQGQLQTRQASSVYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTVLNGSDIHSLYNVSGEQMASYFGYAVAATDTNGDGLDDLLVGAPLLMERTADGRPQEVGRVYIYLQHPEGIEPTPSLTLTGQDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQQGVVFIFPGGPGGLNTKPSQVLQPLWAAGHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNASGKHVPNSIGFEVELQLDWQKQKGGVRRALFLASKQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPKAPMDSHGLRPVLHYQSKSRIEDKAQILLDCGEDNICVPDLQLAVYGEKKHVYLGDKNALNLTFLAQNLGEGGAYEAELRVTAPLEAEYSGLVRHPGNFSSLSCDYFAVNQSRQLVCDLGNPMKAGTSIWGGLRFTVPHLQDTKKTIQFDFQILSKNLNNSQSNMVSFPLSVEAQAQVSLNGVSKPEAVIFPVSDWNPQDQPQKEGDLGPAVHHVYELINQGPSSISQGVLEISCPQALEGQQLLYVTKVTGLNNCTSNYTPNSQGLELDPEVSPHHLQRREAPGRSSTTSGTQVLKCPEAKCFRLRCEFGPLHRQESRSLQLHFRVWAKTFLQQEYQPFSLQCEALYEALKMPYQILPRQLPQKKLQVATAVQWTKAEGSNGVPLWIIILAILFGLLLLGLLIYVLYKLGFFKRSLPYGTAMEKAQLKPPATSDA" }, "uniprot_id": "A0A0G2K1E2_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "integrin alpha-5", "integrin alpha 5 (fibronectin receptor alpha); integrin, alpha 5 (fibronectin receptor, alpha polypeptide)" ], "uniprotkb": [ "Integrin subunit alpha 5", "Integrin alpha 5 (Mapped)" ] }, "gene": { "refseq": [ "Itga5", "Itga5_retired" ], "uniprotkb": [ "Itga5", "Itga5_mapped", "rCG_50755", "Itga5_retired" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Integrin subunit alpha 5; Integrin alpha 5 (Mapped)." }, "publication": [ { "title": "Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/31331973", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "id": "NP_001101588.1", "database": "RefSeq" } ], "authors": "Takada YK, Yu J, Shimoda M, Takada Y", "date": "2019", "pmid": "31331973" }, { "title": "Integrin alpha5beta1 suppresses rBMSCs anoikis and promotes nitric oxide production.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29324307", "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "id": "NP_001101588.1", "database": "RefSeq" } ], "authors": "Chen HY, Pan L, Yang HL, Xia P, Yu WC, Tang WQ, Zhang YX, Chen SF, Xue YZ, Wang LX", "date": "2018", "pmid": "29324307" }, { "title": "The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29162887", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "id": "NP_001101588.1", "database": "RefSeq" } ], "authors": "Rogg M, Yasuda-Yamahara M, Abed A, Dinse P, Helmstadter M, Conzelmann AC, Frimmel J, Sellung D, Biniossek ML, Kretz O, Grahammer F, Schilling O, Huber TB, Schell C", "date": "2017", "pmid": "29162887" }, { "title": "Integrin alpha5beta1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28176845", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "id": "NP_001101588.1", "database": "RefSeq" } ], "authors": "Izumi Y, Wakita S, Kanbara C, Nakai T, Akaike A, Kume T", "date": "2017", "pmid": "28176845" }, { "title": "High alphav Integrin Level of Cancer Cells Is Associated with Development of Brain Metastasis in Athymic Rats.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28739685", "journal": "Anticancer research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "id": "NP_001101588.1", "database": "RefSeq" } ], "authors": "Wu YJ, Pagel MA, Muldoon LL, Fu R, Neuwelt EA", "date": "2017", "pmid": "28739685" }, { "title": "Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10022831", "journal": "The EMBO journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "id": "NP_001101588.1", "database": "RefSeq" } ], "authors": "Soldi R, Mitola S, Strasly M, Defilippi P, Tarone G, Bussolino F", "date": "1999", "pmid": "10022831" }, { "title": "Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9553049", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "id": "NP_001101588.1", "database": "RefSeq" } ], "authors": "Baudoin C, Goumans MJ, Mummery C, Sonnenberg A", "date": "1998", "pmid": "9553049" }, { "title": "Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8601592", "journal": "The Journal of cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "id": "NP_001101588.1", "database": "RefSeq" } ], "authors": "Wada J, Kumar A, Liu Z, Ruoslahti E, Reichardt L, Marvaldi J, Kanwar YS", "date": "1996", "pmid": "8601592" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2#A0A0G2K1E2-1", "isoform_ac": "A0A0G2K1E2-1", "locus": { "end_pos": 144971419, "start_pos": 144993529, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087748", "id": "ENSRNOT00000087748", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000071805", "id": "ENSRNOP00000071805", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K1E2-1|A0A0G2K1E2_RAT Isoform 1 of Integrin subunit alpha 5 OS=Rattus norvegicus OX=10116 GN=Itga5 PE=1 SV=1 CANONICAL=A0A0G2K1E2-1", "length": 1099, "sequence": "MPPRQPTRRPGGGPSRELGKLLPALSHSPLGGLGSGSGSVAPGQGRTGAMGSWTPRSPRSPLHAVLLRWGPRRLPPLLPLLLLLWPPPLQVGGFNLDAEAPAVLSGPPGSLFGFSVEFYRPGRDGVSVLVGAPKANTSQPGVLQGGAVYVCPWGTSPIQCSTIQFDSKGSRILESSLYSEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKDPQNDPVGTCYLSTENFTRILEYAPCRSDFGSAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQISESYYPQYLINPVQGQLQTRQASSVYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTVLNGSDIHSLYNVSGEQMASYFGYAVAATDTNGDGLDDLLVGAPLLMERTADGRPQEVGRVYIYLQHPEGIEPTPSLTLTGQDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQQGVVFIFPGGPGGLNTKPSQVLQPLWAAGHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNASGKHVPNSIGFEVELQLDWQKQKGGVRRALFLASKQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPKAPMDSHGLRPVLHYQSKSRIEDKAQILLDCGEDNICVPDLQLAVYGEKKHVYLGDKNALNLTFLAQNLGEGGAYEAELRVTAPLEAEYSGLVRHPGNFSSLSCDYFAVNQSRQLVCDLGNPMKAGTSIWGGLRFTVPHLQDTKKTIQFDFQILSKNLNNSQSNMVSFPLSVEAQAQVSLNGVSKPEAVIFPVSDWNPQDQPQKEGDLGPAVHHVYELINQGPSSISQGVLEISCPQALEGQQLLYVTKVTGLNNCTSNYTPNSQGLELDPEVSPHHLQRREAPGRSSTTSGTQVLKCPEAKCFRLRCEFGPLHRQESRSLQLHFRVWAKTFLQQEYQPFSLQCEALYEALKMPYQILPRQLPQKKLQVATAVQWTKAEGSNGVPLWIIILAILFGLLLLGLLIYVLYKLGFFKRSLPYGTAMEKAQLKPPATSDA" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:315346", "resource": "KEGG Pathway", "id": "rno:315346", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1566977", "resource": "Reactome", "id": "R-RNO-1566977", "name": "Fibronectin matrix formation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-202733", "resource": "Reactome", "id": "R-RNO-202733", "name": "Cell surface interactions at the vascular wall" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1566948", "resource": "Reactome", "id": "R-RNO-1566948", "name": "Elastic fibre formation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-216083", "resource": "Reactome", "id": "R-RNO-216083", "name": "Integrin cell surface interactions" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-445144", "resource": "Reactome", "id": "R-RNO-445144", "name": "Signal transduction by L1" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "annotation": "Transduction of rat bone marrow mesenchymal stem cells with ITGA5B1 lentivirus could prevent cell anoikis and increase nitric oxide production.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "id": "NP_001101588.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "annotation": "Alpha 5 integrin promotes brain metastases in cancer cells and may mediate early steps in the metastatic cascade, such as adhesion to brain vasculature. Targeting alphav integrin with intetumumab could provide clinical benefit in treating cancer patients who develop metastases.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "id": "NP_001101588.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "annotation": "These results indicate that integrin alpha5beta1 expression on dopaminergic neurons plays an important role in the dopaminergic neurite outgrowth on striatal neurons. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "id": "NP_001101588.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P08648-1", "protein_name": "Integrin alpha-5; VLA-5; CD49 antigen-like family member E; Integrin alpha-F; Fibronectin receptor subunit alpha.", "sequence": { "length": 1049, "sequence": "MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLSTDNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQIAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQEVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSIGFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVFGEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDYFAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVVSFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRSSASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAVYKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYILYKLGFFKRSLPYGTAMEKAQLKPPATSDA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K1E2/", "id": "A0A0G2K1E2", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/20508", "id": "20508", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "P11688-1", "protein_name": "Integrin alpha-5; VLA-5; CD49 antigen-like family member E; Integrin alpha-F; Fibronectin receptor subunit alpha.", "sequence": { "length": 1053, "sequence": "MGSWTPRSPRSPLHAVLLRWGPRRLPPLLPLLLLLWPPPLQVGGFNLDAEAPAVLSGPPGSLFGFSVEFYRPGRDGVSVLVGAPKANTSQPGVLQGGAVYVCPWGTSPIQCTTIQFDSKGSRILESSLYSAKGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKDPQNDPVGTCYLSTENFTRILEYAPCRSDFGSAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQISESYYPEYLINPVQGQLQTRQASSVYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTVLNGSDIHSLYNVSGEQMASYFGYAVAATDTNGDGLDDLLVGAPLLMERTADGRPQEVGRVYIYLQRPAGIDPTPTLTLTGQDEFSRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQQGVVFIFPGGPGGLSTKPSQVLQPLWAAGRTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNASGKHVPNSIGFEVELQLDWQKQKGGVRRALFLTSKQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPKAPMDSHGLRPVLHYQSKSRIEDKAQILLDCGEDNICVPDLQLDVYGEKKHVYLGDKNALNLTFHAQNLGEGGAYEAELRVTAPLEAEYSGLVRHPGNFSSLSCDYFAVNQSRQLVCDLGNPMKAGTSLWGGLRFTVPHLQDTKKTIQFDFQILSKNLNNSQSNVVSFPLSVEAQAQVSLNGVSKPEAVIFPVSDWNPQDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQQLLYVTKVTGLSNCTSNYTPNSQGLELDPETSPHHLQKREAPGRSSTASGTQVLKCPEAKCFRLRCEFGPLHRQESRSLQLHFRVWAKTFLQREYQPFSLQCEAVYEALKMPYQILPRQLPQKKLQVATAVQWTKAEGSNGVPLWIIILAILFGLLLLGLLIYVLYKLGFFKRSLPYGTAMEKAQLKPPATSDA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K1E2/", "id": "A0A0G2K1E2", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/20508", "id": "20508", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101588.1", "ac": "NP_001101588.1", "name": "integrin alpha-5; integrin alpha 5 (fibronectin receptor alpha); integrin, alpha 5 (fibronectin receptor, alpha polypeptide).", "summary": "alpha subunit that interacts with beta 1 subunit to form a fibronectin receptor [RGD, Feb 2006]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "integrin binding", "id": "GO:0005178" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "cell adhesion molecule binding", "id": "GO:0050839" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005154", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "epidermal growth factor receptor binding", "id": "GO:0005154" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "signaling receptor activity", "id": "GO:0038023" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008305", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "integrin complex", "id": "GO:0008305" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "cell-cell junction", "id": "GO:0005911" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "focal adhesion", "id": "GO:0005925" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "synapse", "id": "GO:0045202" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "external side of plasma membrane", "id": "GO:0009897" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle", "id": "GO:0031410" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "ruffle membrane", "id": "GO:0032587" } ], "total": 12, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "cell adhesion", "id": "GO:0007155" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "integrin-mediated signaling pathway", "id": "GO:0007229" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "positive regulation of cell migration", "id": "GO:0030335" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "female pregnancy", "id": "GO:0007565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010811", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "positive regulation of cell-substrate adhesion", "id": "GO:0010811" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903672", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K1E2", "id": "A0A0G2K1E2", "database": "UniProtKB" } ], "name": "positive regulation of sprouting angiogenesis", "id": "GO:1903672" }, { "url": 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