{ "uniprot_canonical_ac": "A0A0G2K0S7-1", "sequence": { "header": "tr|A0A0G2K0S7-1|A0A0G2K0S7_RAT Isoform 1 of RAP1 GTPase-activating protein 2 OS=Rattus norvegicus OX=10116 GN=Rap1gap2 PE=1 SV=1 CANONICAL=A0A0G2K0S7-1", "length": 731, "sequence": "MFGRKRSVSFGGFGWIDKTMLAGLKVKKQELANSSDVTLPDRPLSPPLTAPPTMKSAEFFEMLEKMQGIKLEEQRPGPQKNKEDYIPYPSIEEVVEKGGPYPQIILPQFGGYWIEDPENVGTPTSLGSSVYEEEEEDSLSPNTFGYKLECRGEARAYRRHFLGKDHLNFYCTGSSLGNLILSIKCEEAEGIEYLRIILRSKLKTVHERIPLAGLSKLPSVPQIAKAFCDDAVGLKFNPVLYPKASQMIVSYDEHDVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDTQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQAESTGTETPSYKVSVTAREDVPAFGPPLPSPPVFQKGTEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNLHDELHTHTQVMLGMGPEEDKFENGGHGGFLESFKRAIRVRSHSMETMVGSQRKLHGGNIPGSLSGGIVHNSMEVTKTTFSPPVAAATVKNQSRSPIKRRSGLFPRLHSGSEGQGDSRTRCDSASSTPKTPDGGHSSQEIKSETSSNPSSPEICPNKEKPFIKLKENGRANISRSSSSTSSFSSTAGEGEAMEECDSGSSQPSTTSPFKQEVFVYSPSPSSESPSLGAAATPIIMSRSPTDAKSRNSPRSNLKFRFDKLSHASSSAGH" }, "uniprot_id": "A0A0G2K0S7_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "rap1 GTPase-activating protein 2 isoform X4" ], "uniprotkb": [ "RAP1 GTPase-activating protein 2" ] }, "gene": { "refseq": [ "Rap1gap2", "Garnl4" ], "uniprotkb": [ "Rap1gap2", "Garnl4" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7", "id": "A0A0G2K0S7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "RAP1 GTPase-activating protein 2." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7/publications", "id": "A0A0G2K0S7", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7#A0A0G2K0S7-1", "isoform_ac": "A0A0G2K0S7-1", "locus": { "end_pos": 61182899, "start_pos": 61361167, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000092203", "id": "ENSRNOT00000092203", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000071566", "id": "ENSRNOP00000071566", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K0S7-1|A0A0G2K0S7_RAT Isoform 1 of RAP1 GTPase-activating protein 2 OS=Rattus norvegicus OX=10116 GN=Rap1gap2 PE=1 SV=1 CANONICAL=A0A0G2K0S7-1", "length": 731, "sequence": "MFGRKRSVSFGGFGWIDKTMLAGLKVKKQELANSSDVTLPDRPLSPPLTAPPTMKSAEFFEMLEKMQGIKLEEQRPGPQKNKEDYIPYPSIEEVVEKGGPYPQIILPQFGGYWIEDPENVGTPTSLGSSVYEEEEEDSLSPNTFGYKLECRGEARAYRRHFLGKDHLNFYCTGSSLGNLILSIKCEEAEGIEYLRIILRSKLKTVHERIPLAGLSKLPSVPQIAKAFCDDAVGLKFNPVLYPKASQMIVSYDEHDVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDTQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQAESTGTETPSYKVSVTAREDVPAFGPPLPSPPVFQKGTEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNLHDELHTHTQVMLGMGPEEDKFENGGHGGFLESFKRAIRVRSHSMETMVGSQRKLHGGNIPGSLSGGIVHNSMEVTKTTFSPPVAAATVKNQSRSPIKRRSGLFPRLHSGSEGQGDSRTRCDSASSTPKTPDGGHSSQEIKSETSSNPSSPEICPNKEKPFIKLKENGRANISRSSSSTSSFSSTAGEGEAMEECDSGSSQPSTTSPFKQEVFVYSPSPSSESPSLGAAATPIIMSRSPTDAKSRNSPRSNLKFRFDKLSHASSSAGH" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7#D3ZPI4-1", "isoform_ac": "D3ZPI4-1", "locus": { "end_pos": 61186844, "start_pos": 61217973, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000065045", "id": "ENSRNOT00000065045", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000060932", "id": "ENSRNOP00000060932", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZPI4-1|A0A0G2K0S7_RAT Computationally mapped isoform of RAP1 GTPase-activating protein 2 OS=Rattus norvegicus OX=10116 GN=Rap1gap2 PE=1 SV=1 CANONICAL=A0A0G2K0S7-1", "length": 410, "sequence": "MIVSYDEHDVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDTQQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQAESTGTETPSYKVSVTAREDVPAFGPPLPSPPVFQKGTEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNLHDELHTHTQVMLGMGPEEDKFENGGHGGFLESFKRAIRVRSHSMETMVGSQRKLHGGNIPGSLSGGIVHNSMEVTKTTFSPPVAAATVKNQSRSPIKRRSGLFPRLHSGSEGQGDSRTRCDSASSTPKTPDGGHSSQEIKSETSSNPSSPEICPNKEKAASRPQPRPSSRRCLSTARPPAARAPAWGPLPRPSS" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-392517", "resource": "Reactome", "id": "R-RNO-392517", "name": "Rap1 signalling" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q5SVL6-1", "protein_name": "Rap1 GTPase-activating protein 2; Rap1GAP2; Ran-GAP domain-like protein 4.", "sequence": { "length": 712, "sequence": "MLAGLKVKKQELANSSDVTLPDRPLSPPLTAPPTMKSAEFFEMLEKMQGIKLEEQRPGPQKNKDDYIPYPSIDEVVEKGGPYPLIILPQFGGYWIEDPENVGTPTSLGSSVYEEEEEDSLSPNTFGYKLECRGEARAYRRHFLGKDHLNFYCTGSSLGNLILSIKCEEAEGMEYLRIILRSKLKTVHERIPLAGLSKLPSVPQIAKAFCDDAVGLKFNPVLYPKASQMIVSYDEHDVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDTQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQADNPGTETPSYKVSVTAREDVPAFGPPLPSPPVFQKGAEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNLHDELHTHTQVMLGMGPEEDKFENGGHGGFLESFKRAIRVRSHSMETMVGSQRKLHGGNLPGSLSGGIVHNSMEVTKTTFSPPVAAATAKNQSRSPIKRRSGLFPRLHSGSEGQGDSRTRCDSASSTPKTPDGGHSSQEIKSETSSNPSSPEICPNKEKPFIKLKENGRANISRSSSSTSSFSSTAGEGEAMEECDSGSSQPSTTSPFKQEVFAYSPSPSSESPSLGAAATPIIMSRSPTDAKSRNSPRSNLKFRFDKLSHASSSAGH" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K0S7/", "id": "A0A0G2K0S7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/56695", "id": "56695", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q684P5-1", "protein_name": "Rap1 GTPase-activating protein 2; Rap1GAP2; Ran-GAP domain-like protein 4.", "sequence": { "length": 730, "sequence": "MFGRKRSVSFGGFGWIDKTMLASLKVKKQELANSSDATLPDRPLSPPLTAPPTMKSSEFFEMLEKMQGIKLEEQKPGPQKNKDDYIPYPSIDEVVEKGGPYPQVILPQFGGYWIEDPENVGTPTSLGSSICEEEEEDNLSPNTFGYKLECKGEARAYRRHFLGKDHLNFYCTGSSLGNLILSVKCEEAEGIEYLRVILRSKLKTVHERIPLAGLSKLPSVPQIAKAFCDDAVGLRFNPVLYPKASQMIVSYDEHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNLHDELHAHTQAMLGLGPEEDKFENGGHGGFLESFKRAIRVRSHSMETMVGGQKKSHSGGIPGSLSGGISHNSMEVTKTTFSPPVVAATVKNQSRSPIKRRSGLFPRLHTGSEGQGDSRARCDSTSSTPKTPDGGHSSQEIKSETSSNPSSPEICPNKEKPFMKLKENGRAISRSSSSTSSVSSTAGEGEAMEEGDSGGSQPSTTSPFKQEVFVYSPSPSSESPSLGAAATPIIMSRSPTDAKSRNSPRSNLKFRFDKLSHASSGAGH" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/56695", "id": "56695", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452780.1", "ac": "XP_017452780.1", "name": "rap1 GTPase-activating protein 2 isoform X4.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7", "id": "A0A0G2K0S7", "database": "UniProtKB" } ], "name": "GTPase activator activity", "id": "GO:0005096" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7", "id": "A0A0G2K0S7", "database": "UniProtKB" } ], "name": "centrosome", "id": "GO:0005813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7", "id": "A0A0G2K0S7", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7", "id": "A0A0G2K0S7", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7", "id": "A0A0G2K0S7", "database": "UniProtKB" } ], "name": "nuclear membrane", "id": "GO:0031965" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7", "id": "A0A0G2K0S7", "database": "UniProtKB" } ], "name": "neuron projection", "id": "GO:0043005" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051056", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7", "id": "A0A0G2K0S7", "database": "UniProtKB" } ], "name": "regulation of small GTPase mediated signal transduction", "id": "GO:0051056" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010977", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7", "id": "A0A0G2K0S7", "database": "UniProtKB" } ], "name": "negative regulation of neuron projection development", "id": "GO:0010977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008361", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7", "id": "A0A0G2K0S7", "database": "UniProtKB" } ], "name": "regulation of cell size", "id": "GO:0008361" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 35, "annotation": "n_glycosylation_sequon", "start_pos": 33 }, { "end_pos": 259, "annotation": "n_glycosylation_sequon", "start_pos": 257 }, { "end_pos": 556, "annotation": "n_glycosylation_sequon", "start_pos": 554 }, { "end_pos": 636, "annotation": "n_glycosylation_sequon", "start_pos": 634 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452780.1", "id": "XP_017452780.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-392517", "id": "R-RNO-392517", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002652", "id": "ENSRNOG00000002652", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/HDELHGH/", "id": "HDELHGH", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000331", "id": "IPR000331", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035974", "id": "IPR035974", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF02145", "id": "PF02145", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/303298", "id": "303298", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304590", "id": "1304590", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2K0S7", "disease": [], "mass": { "monoisotopic_mass": 80514.0, "chemical_mass": 80514.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K0S7", "name": "Rap1gap2; Garnl4.", "locus": { "end_pos": 61177936, "start_pos": 61361250, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000002652", "id": "ENSRNOG00000002652", "database": "Ensembl Gene" } ] } } ] }