{
    "uniprot_canonical_ac": "A0A0G2K048-1", 
    "sequence": {
        "header": "tr|A0A0G2K048-1|A0A0G2K048_RAT Isoform 1 of Deltex E3 ubiquitin ligase 4  OS=Rattus norvegicus OX=10116 GN=Dtx4 PE=4 SV=1 CANONICAL=A0A0G2K048-1", 
        "length": 513, 
        "sequence": "MEVGITIQHAYEKQHPWIDLTSIGFSYIIDFSTMGQINRQTQRQRRVRRRLDLIYPMVTGTVPKAQSWPVSPGPATPSPAPPCSCPQCVLVMSVKAAVVHGSTGPLHPPAARKNIAPSGVGKLPQPPGPGAKPLDTTGTIRGPGKTAPSQVIRRQVSNTPAGVTVGSPASPQGSNRKTGRVALTTLNRSNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSKCGHIYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSQEKD"
    }, 
    "uniprot_id": "A0A0G2K048_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "Deltex E3 ubiquitin ligase 4"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "Dtx4"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K048", 
                    "id": "A0A0G2K048", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Deltex E3 ubiquitin ligase 4."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048#A0A0G2K048-1", 
            "isoform_ac": "A0A0G2K048-1", 
            "locus": {
                "end_pos": 228733185, 
                "start_pos": 228755674, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000083283", 
                        "id": "ENSRNOT00000083283", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000071301", 
                        "id": "ENSRNOP00000071301", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2K048-1|A0A0G2K048_RAT Isoform 1 of Deltex E3 ubiquitin ligase 4  OS=Rattus norvegicus OX=10116 GN=Dtx4 PE=4 SV=1 CANONICAL=A0A0G2K048-1", 
                "length": 513, 
                "sequence": "MEVGITIQHAYEKQHPWIDLTSIGFSYIIDFSTMGQINRQTQRQRRVRRRLDLIYPMVTGTVPKAQSWPVSPGPATPSPAPPCSCPQCVLVMSVKAAVVHGSTGPLHPPAARKNIAPSGVGKLPQPPGPGAKPLDTTGTIRGPGKTAPSQVIRRQVSNTPAGVTVGSPASPQGSNRKTGRVALTTLNRSNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSKCGHIYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSQEKD"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048#Q6TXG2-1", 
            "isoform_ac": "Q6TXG2-1", 
            "locus": {
                "end_pos": 228733185, 
                "start_pos": 228753422, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000028626", 
                        "id": "ENSRNOT00000028626", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000028626", 
                        "id": "ENSRNOP00000028626", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|Q6TXG2-1|A0A0G2K048_RAT Computationally mapped isoform of Deltex E3 ubiquitin ligase 4  OS=Rattus norvegicus OX=10116 GN=Dtx4 PE=4 SV=1 CANONICAL=A0A0G2K048-1", 
                "length": 321, 
                "sequence": "MMMMVMMMMVVVVWVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSKCGHIYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSQEKD"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2122948", 
            "resource": "Reactome", 
            "id": "R-RNO-2122948", 
            "name": "Activated NOTCH1 Transmits Signal to the Nucleus"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3134975", 
            "resource": "Reactome", 
            "id": "R-RNO-3134975", 
            "name": "Regulation of innate immune responses to cytosolic DNA"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3270619", 
            "resource": "Reactome", 
            "id": "R-RNO-3270619", 
            "name": "IRF3-mediated induction of type I IFN"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9Y2E6-1", 
            "protein_name": "E3 ubiquitin-protein ligase DTX4; 2.3.2.27; Protein deltex-4; Deltex4; RING finger protein 155; RING-type E3 ubiquitin transferase DTX4.", 
            "sequence": {
                "length": 619, 
                "sequence": "MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2K048/", 
                    "id": "A0A0G2K048", 
                    "database": "OMA"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q6PDK8-1", 
            "protein_name": "E3 ubiquitin-protein ligase DTX4; 2.3.2.27; Protein deltex-4; Deltex4; RING-type E3 ubiquitin transferase DTX4.", 
            "sequence": {
                "length": 616, 
                "sequence": "MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQYAYEKQHPWIDLTSIGFSYIIDFSTMGQINRQTQRQRRVRRRLDLIYPMVTGTMPKTQSWPVSPGPATSSPAPPCSCPQCVLVMSVKAAVVHGGTGPPAVRKNMALSGVGKLPQPPGPGAKPLDTTGTIRGPGKTAPSQVIRRQVSNAPAGATVGSPASPQGSNRKTGRVALATLNRSNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHIYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSHEKD"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2K048/", 
                    "id": "A0A0G2K048", 
                    "database": "OMA"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K048", 
                                "id": "A0A0G2K048", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "zinc ion binding", 
                        "id": "GO:0008270"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K048", 
                                "id": "A0A0G2K048", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Notch signaling pathway", 
                        "id": "GO:0007219"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K048", 
                                "id": "A0A0G2K048", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein ubiquitination", 
                        "id": "GO:0016567"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 189, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 187
        }, 
        {
            "end_pos": 218, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 216
        }, 
        {
            "end_pos": 270, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 268
        }, 
        {
            "end_pos": 481, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 479
        }
    ], 
    "crossref": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2122948", 
            "id": "R-RNO-2122948", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3134975", 
            "id": "R-RNO-3134975", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3270619", 
            "id": "R-RNO-3270619", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000021086", 
            "id": "ENSRNOG00000021086", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/EKQHPWV/", 
            "id": "EKQHPWV", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09633", 
            "id": "cd09633", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", 
            "id": "IPR001841", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", 
            "id": "IPR013083", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004170", 
            "id": "IPR004170", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037197", 
            "id": "IPR037197", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018123", 
            "id": "IPR018123", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018957", 
            "id": "IPR018957", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039396", 
            "id": "IPR039396", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039398", 
            "id": "IPR039398", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039399", 
            "id": "IPR039399", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF02825", 
            "id": "PF02825", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00097", 
            "id": "PF00097", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF18102", 
            "id": "PF18102", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12622", 
            "id": "PTHR12622", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311767", 
            "id": "1311767", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0G2K048", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 55135.0, 
        "chemical_mass": 55135.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048", 
            "name": "Dtx4.", 
            "locus": {
                "end_pos": 228732985, 
                "start_pos": 228755866, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000021086", 
                        "id": "ENSRNOG00000021086", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}