{ "uniprot_canonical_ac": "A0A0G2JZX5-1", "sequence": { "header": "tr|A0A0G2JZX5-1|A0A0G2JZX5_RAT Isoform 1 of IQ motif and Sec7 domain 2 OS=Rattus norvegicus OX=10116 GN=Iqsec2 PE=1 SV=1 CANONICAL=A0A0G2JZX5-1", "length": 949, "sequence": "MEPPWKSSRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPTSSHMGGPPAGVGLPWSQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDPVPPPSPERLPSTEPPPQGRPEFWAPAPLPPVPPPMPPGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTLARSSLEDTYGAGDGLKRGALSSSLRDLSDAGVCY" }, "uniprot_id": "A0A0G2JZX5_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "IQ motif and SEC7 domain-containing protein 2 isoform 2", "IQ motif and SEC7 domain-containing protein 2; IQ motif and Sec7 domain 2" ], "uniprotkb": [ "IQ motif and Sec7 domain 2" ] }, "gene": { "refseq": [ "Iqsec2", "RGD1562109" ], "uniprotkb": [ "Iqsec2", "RGD1562109" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5", "id": "A0A0G2JZX5", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "IQ motif and Sec7 domain 2." }, "publication": [ { "title": "Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26884337", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264315.1", "id": "NP_001264315.1", "database": "RefSeq" } ], "authors": "Elagabani MN, Brisevac D, Kintscher M, Pohle J, Kohr G, Schmitz D, Kornau HC", "date": "2016", "pmid": "26884337" }, { "title": "Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27009485", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264315.1", "id": "NP_001264315.1", "database": "RefSeq" } ], "authors": "Brown JC, Petersen A, Zhong L, Himelright ML, Murphy JA, Walikonis RS, Gerges NZ", "date": "2016", "pmid": "27009485" }, { "title": "Novel Missense Mutation A789V in IQSEC2 Underlies X-Linked Intellectual Disability in the MRX78 Family.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26793055", "journal": "Frontiers in molecular neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264315.1", "id": "NP_001264315.1", "database": "RefSeq" } ], "authors": "Kalscheuer VM, James VM, Himelright ML, Long P, Oegema R, Jensen C, Bienek M, Hu H, Haas SA, Topf M, Hoogeboom AJ, Harvey K, Walikonis R, Harvey RJ", "date": "2015", "pmid": "26793055" }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5/publications", "id": "A0A0G2JZX5", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19811534", "journal": "The European journal of neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264315.1", "id": "NP_001264315.1", "database": "RefSeq" } ], "authors": "Katsumata O, Ohara N, Tamaki H, Niimura T, Naganuma H, Watanabe M, Sakagami H", "date": "2009", "pmid": "19811534" }, { "title": "IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18164504", "journal": "Neuroscience research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264315.1", "id": "NP_001264315.1", "database": "RefSeq" } ], "authors": "Sakagami H, Sanda M, Fukaya M, Miyazaki T, Sukegawa J, Yanagisawa T, Suzuki T, Fukunaga K, Watanabe M, Kondo H", "date": "2008", "pmid": "18164504" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5#A0A0G2JZX5-1", "isoform_ac": "A0A0G2JZX5-1", "locus": { "end_pos": 22247189, "start_pos": 22292525, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000079802", "id": "ENSRNOT00000079802", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000071222", "id": "ENSRNOP00000071222", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JZX5-1|A0A0G2JZX5_RAT Isoform 1 of IQ motif and Sec7 domain 2 OS=Rattus norvegicus OX=10116 GN=Iqsec2 PE=1 SV=1 CANONICAL=A0A0G2JZX5-1", "length": 949, "sequence": "MEPPWKSSRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPTSSHMGGPPAGVGLPWSQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDPVPPPSPERLPSTEPPPQGRPEFWAPAPLPPVPPPMPPGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTLARSSLEDTYGAGDGLKRGALSSSLRDLSDAGVCY" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5#A0A0G2KAA0-1", "isoform_ac": "A0A0G2KAA0-1", "locus": { "end_pos": 22285184, "start_pos": 22286250, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000086262", "id": "ENSRNOT00000086262", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075320", "id": "ENSRNOP00000075320", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KAA0-1|A0A0G2JZX5_RAT Computationally mapped isoform of IQ motif and Sec7 domain 2 OS=Rattus norvegicus OX=10116 GN=Iqsec2 PE=1 SV=1 CANONICAL=A0A0G2JZX5-1", "length": 134, "sequence": "XIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVWALCRRKWEGDSRAAGSSANCVVCSVLGTVLQHAICMVSSKVSVPPFPSF" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:685244", "resource": "KEGG Pathway", "id": "rno:685244", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264315.1", "annotation": "Both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264315.1", "id": "NP_001264315.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q5JU85-2", "protein_name": "IQ motif and SEC7 domain-containing protein 2.", "sequence": { "length": 1488, "sequence": "MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRDLREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNREGAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/19407", "id": "19407", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q5DU25-1", "protein_name": "IQ motif and SEC7 domain-containing protein 2.", "sequence": { "length": 1478, "sequence": "MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRDLREESQLHRGELHRDPLGARDSPGRESQYQNLRETQFHHRELRESQFHQASRDVGYPNRDGAYQNREAIYRDKEREASYQLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGQRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRNVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPTSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDPVPPPSPERLPSTEPPPQGRPEFWAPAPLPPVPPPMPPGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTLARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPPLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/19407", "id": "19407", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264315.1", "ac": "NP_001264315.1", "name": "IQ motif and SEC7 domain-containing protein 2 isoform 2; IQ motif and SEC7 domain-containing protein 2; IQ motif and Sec7 domain 2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005086", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5", "id": "A0A0G2JZX5", "database": "UniProtKB" } ], "name": "ARF guanyl-nucleotide exchange factor activity", "id": "GO:0005086" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5", "id": "A0A0G2JZX5", "database": "UniProtKB" } ], "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051968", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5", "id": "A0A0G2JZX5", "database": "UniProtKB" } ], "name": "positive regulation of synaptic transmission, glutamatergic", "id": "GO:0051968" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5", "id": "A0A0G2JZX5", "database": "UniProtKB" } ], "name": "actin cytoskeleton organization", "id": "GO:0030036" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900454", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5", "id": "A0A0G2JZX5", "database": "UniProtKB" } ], "name": "positive regulation of long-term synaptic depression", "id": "GO:1900454" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098696", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5", "id": "A0A0G2JZX5", "database": "UniProtKB" } ], "name": "regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "id": "GO:0098696" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032012", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5", "id": "A0A0G2JZX5", "database": "UniProtKB" } ], "name": "regulation of ARF protein signal transduction", "id": "GO:0032012" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 493, "annotation": "n_glycosylation_sequon", "start_pos": 491 }, { "end_pos": 503, "annotation": "n_glycosylation_sequon", "start_pos": 501 }, { "end_pos": 507, "annotation": "n_glycosylation_sequon", "start_pos": 505 }, { "end_pos": 902, "annotation": "n_glycosylation_sequon", "start_pos": 900 }, { "end_pos": 914, "annotation": "n_glycosylation_sequon", "start_pos": 912 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264315.1", "id": "NP_001264315.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:685244", "id": "rno:685244", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000058975", "id": "ENSRNOG00000058975", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/LDSTIEX/", "id": "LDSTIEX", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13318", "id": "cd13318", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00171", "id": "cd00171", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033742", "id": "IPR033742", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "id": "IPR000048", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "id": "IPR001849", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000904", "id": "IPR000904", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023394", "id": "IPR023394", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035999", "id": "IPR035999", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF16453", "id": "PF16453", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01369", "id": "PF01369", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/685244", "id": "685244", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1596452", "id": "1596452", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JZX5", "disease": [], "mass": { "monoisotopic_mass": 105189.0, "chemical_mass": 105189.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZX5", "name": "Iqsec2; RGD1562109.", "locus": { "end_pos": 22294402, "start_pos": 22212132, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000058975", "id": "ENSRNOG00000058975", "database": "Ensembl Gene" } ] } } ] }