{ "uniprot_canonical_ac": "A0A0G2JZC4-1", "sequence": { "header": "tr|A0A0G2JZC4-1|A0A0G2JZC4_RAT Isoform 1 of Semaphorin 6D OS=Rattus norvegicus OX=10116 GN=Sema6d PE=1 SV=1 CANONICAL=A0A0G2JZC4-1", "length": 1069, "sequence": "MRFFLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLAGGYEQDTEYGNTAHLGDCHESLPTSTTPDYKIFGGPTSDMEVPSSSVTTVASSPEITSKVIDTWRPKLTSSRKFVVQDDPNTSDFTDTISGVRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSDKAHGHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY" }, "uniprot_id": "A0A0G2JZC4_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Semaphorin 6D" ] }, "gene": { "refseq": [], "uniprotkb": [ "Sema6d" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Semaphorin 6D." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4/publications", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4#A0A0G2JZC4-1", "isoform_ac": "A0A0G2JZC4-1", "locus": { "end_pos": 116943346, "start_pos": 116955636, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000090802", "id": "ENSRNOT00000090802", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000070994", "id": "ENSRNOP00000070994", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JZC4-1|A0A0G2JZC4_RAT Isoform 1 of Semaphorin 6D OS=Rattus norvegicus OX=10116 GN=Sema6d PE=1 SV=1 CANONICAL=A0A0G2JZC4-1", "length": 1069, "sequence": "MRFFLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLAGGYEQDTEYGNTAHLGDCHESLPTSTTPDYKIFGGPTSDMEVPSSSVTTVASSPEITSKVIDTWRPKLTSSRKFVVQDDPNTSDFTDTISGVRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSDKAHGHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4#D3ZDA2-1", "isoform_ac": "D3ZDA2-1", "locus": { "end_pos": 116943346, "start_pos": 116955636, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000066101", "id": "ENSRNOT00000066101", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000062577", "id": "ENSRNOP00000062577", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZDA2-1|A0A0G2JZC4_RAT Computationally mapped isoform of Semaphorin 6D OS=Rattus norvegicus OX=10116 GN=Sema6d PE=1 SV=1 CANONICAL=A0A0G2JZC4-1", "length": 990, "sequence": "MRFFLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLLLTEDFFAFHNHSAGGYEQDTEYGNTAHLGDCHGVRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSDKAHGHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416700", "resource": "Reactome", "id": "R-RNO-416700", "name": "Other semaphorin interactions" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8NFY4-1", "protein_name": "Semaphorin-6D.", "sequence": { "length": 1073, "sequence": "MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JZC4/", "id": "A0A0G2JZC4", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030215", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "semaphorin receptor binding", "id": "GO:0030215" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045499", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "chemorepellent activity", "id": "GO:0045499" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "integral component of plasma membrane", "id": "GO:0005887" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "positive regulation of cell migration", "id": "GO:0030335" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071526", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "semaphorin-plexin signaling pathway", "id": "GO:0071526" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "neural crest cell migration", "id": "GO:0001755" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050919", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "negative chemotaxis", "id": "GO:0050919" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048843", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "negative regulation of axon extension involved in axon guidance", "id": "GO:0048843" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014912", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "negative regulation of smooth muscle cell migration", "id": "GO:0014912" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021591", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "ventricular system development", "id": "GO:0021591" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014911", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4", "database": "UniProtKB" } ], "name": "positive regulation of smooth muscle cell migration", "id": "GO:0014911" } ], "total": 8, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 53, "annotation": "n_glycosylation_sequon", "start_pos": 51 }, { "end_pos": 285, "annotation": "n_glycosylation_sequon", "start_pos": 283 }, { "end_pos": 437, "annotation": "n_glycosylation_sequon", "start_pos": 435 }, { "end_pos": 463, "annotation": "n_glycosylation_sequon", "start_pos": 461 }, { "end_pos": 633, "annotation": "n_glycosylation_sequon", "start_pos": 631 }, { "end_pos": 830, "annotation": "n_glycosylation_sequon", "start_pos": 828 }, { "end_pos": 836, "annotation": "n_glycosylation_sequon", "start_pos": 834 }, { "end_pos": 965, "annotation": "n_glycosylation_sequon", "start_pos": 963 }, { "end_pos": 1032, "annotation": "n_glycosylation_sequon", "start_pos": 1030 } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416700", "id": "R-RNO-416700", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004812", "id": "ENSRNOG00000004812", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/SCKKACI/", "id": "SCKKACI", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "id": "IPR002165", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027231", "id": "IPR027231", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352", "id": "IPR036352", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627", "id": "IPR001627", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01437", "id": "PF01437", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01403", "id": "PF01403", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036", "id": "PTHR11036", "database": "PANTHER" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310910", "id": "1310910", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JZC4", "disease": [], "mass": { "monoisotopic_mass": 119488.0, "chemical_mass": 119488.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "name": "Sema6d.", "locus": { "end_pos": 116958050, "start_pos": 116899878, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000004812", "id": "ENSRNOG00000004812", "database": "Ensembl Gene" } ] } } ] }