{ "uniprot_canonical_ac": "A0A0G2JZ01-1", "sequence": { "header": "tr|A0A0G2JZ01-1|A0A0G2JZ01_RAT Isoform 1 of Eyes absent homolog OS=Rattus norvegicus OX=10116 GN=Eya3 PE=1 SV=1 CANONICAL=A0A0G2JZ01-1", "length": 607, "sequence": "MTPRKNFSGFLKTVCEDRRDLQSSHISVCKETAVLMEEEQDLPERPVKKAKMQEPGEQTLSQVNNPDTSDQKPETASLASNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFGALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIPASSTNASLISTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDTENTALAATTYQTEKPGAMGPAPATQRLPSDSSTSPPLSQTTPNKDADDQARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL" }, "uniprot_id": "A0A0G2JZ01_RAT", "enzyme_annotation": [ { "ec": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "ec": "3.1.3.48", "activity": "" } ], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Eyes absent homolog", "3.1.3.48" ] }, "gene": { "refseq": [], "uniprotkb": [ "Eya3" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Eyes absent homolog; 3.1.3.48." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01#A0A0G2JZ01-1", "isoform_ac": "A0A0G2JZ01-1", "locus": { "end_pos": 150787139, "start_pos": 150911621, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000082945", "id": "ENSRNOT00000082945", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000070857", "id": "ENSRNOP00000070857", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JZ01-1|A0A0G2JZ01_RAT Isoform 1 of Eyes absent homolog OS=Rattus norvegicus OX=10116 GN=Eya3 PE=1 SV=1 CANONICAL=A0A0G2JZ01-1", "length": 607, "sequence": "MTPRKNFSGFLKTVCEDRRDLQSSHISVCKETAVLMEEEQDLPERPVKKAKMQEPGEQTLSQVNNPDTSDQKPETASLASNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFGALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIPASSTNASLISTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDTENTALAATTYQTEKPGAMGPAPATQRLPSDSSTSPPLSQTTPNKDADDQARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01#D3ZHX6-1", "isoform_ac": "D3ZHX6-1", "locus": { "end_pos": 150855177, "start_pos": 150911621, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000056170", "id": "ENSRNOT00000056170", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000053016", "id": "ENSRNOP00000053016", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZHX6-1|A0A0G2JZ01_RAT Computationally mapped isoform of Eyes absent homolog OS=Rattus norvegicus OX=10116 GN=Eya3 PE=1 SV=1 CANONICAL=A0A0G2JZ01-1", "length": 510, "sequence": "MQEPGEQTLSQVNNPDTSDQKPETASLASNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFASSTNASLISTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDTENTALAATTYQTEKPGAMGPAPATQRLPSDSSTSPPLSQTTPNKDADDQARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5693565", "resource": "Reactome", "id": "R-RNO-5693565", "name": "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q99504-1", "protein_name": "Eyes absent homolog 3; 3.1.3.48.", "sequence": { "length": 573, "sequence": "MEEEQDLPEQPVKKAKMQESGEQTISQVSNPDVSDQKPETSSLASNLPMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETAYPGQTQYQTLQQTQPYAVYPQATQTYGLPPFGALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIQASSTNASLISTSSTIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAESTTLAATTYQSEKPSVMAPAPAAQRLSSGDPSTSPSLSQTTPSKDTDDQSRKNMTSKNRGKRKADATSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JZ01/", "id": "A0A0G2JZ01", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "P97480-1", "protein_name": "Eyes absent homolog 3; 3.1.3.48.", "sequence": { "length": 510, "sequence": "MQEPREQTLSQVNNPDASDEKPETSSLASNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFASSTNASLIPTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAETTTLAATTYQTEKPSAMVPAPATQRLPSDSSASPPLSQTTPNKDADDQARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCANVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JZ01/", "id": "A0A0G2JZ01", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "protein tyrosine phosphatase activity", "id": "GO:0004725" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "centrosome", "id": "GO:0005813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "transcription factor complex", "id": "GO:0005667" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045739", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "positive regulation of DNA repair", "id": "GO:0045739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048856", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "anatomical structure development", "id": "GO:0048856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001240", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand", "id": "GO:2001240" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016576", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "histone dephosphorylation", "id": "GO:0016576" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007275", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "multicellular organism development", "id": "GO:0007275" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "double-strand break repair", "id": "GO:0006302" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010212", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "name": "response to ionizing radiation", "id": "GO:0010212" } ], "total": 7, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 8, "annotation": "n_glycosylation_sequon", "start_pos": 6 }, { "end_pos": 83, "annotation": "n_glycosylation_sequon", "start_pos": 81 }, { "end_pos": 208, "annotation": "n_glycosylation_sequon", "start_pos": 206 }, { "end_pos": 317, "annotation": "n_glycosylation_sequon", "start_pos": 315 }, { "end_pos": 418, "annotation": "n_glycosylation_sequon", "start_pos": 416 } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5693565", "id": "R-RNO-5693565", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010396", "id": "ENSRNOG00000010396", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/NYNFSTD/", "id": "NYNFSTD", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02601", "id": "cd02601", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006545", "id": "IPR006545", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028472", "id": "IPR028472", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR038102", "id": "IPR038102", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028479", "id": "IPR028479", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042577", "id": "IPR042577", "database": "InterPro" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10190", "id": "PTHR10190", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10190:SF5", "id": "PTHR10190:SF5", "database": "PANTHER" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309932", "id": "1309932", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JZ01", "disease": [], "mass": { "monoisotopic_mass": 66569.0, "chemical_mass": 66569.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "name": "Eya3.", "locus": { "end_pos": 150913757, "start_pos": 150787043, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000010396", "id": "ENSRNOG00000010396", "database": "Ensembl Gene" } ] } } ] }