{ "uniprot_canonical_ac": "A0A0G2JYU6-1", "sequence": { "header": "tr|A0A0G2JYU6-1|A0A0G2JYU6_RAT Isoform 1 of Formin-like 1 OS=Rattus norvegicus OX=10116 GN=Fmnl1 PE=1 SV=1 CANONICAL=A0A0G2JYU6-1", "length": 1101, "sequence": "MGNAAGSAEQPAGPTASPPKQPAVPKQPMPAAGELEERFTRVLNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAYIQKLKSYLDTGGVSRKVATDWMSNLGFKRRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVAYDMESTENVASGTEKNKPLEQSVEDLSKAPPSSVPKSRLTIKCPPSPRLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNVFDVGTLLEETETKNAVLEHMEELQEQVATLTERLRDTENDSMAKIAELEKQLSQARKELETLRERFSESTPMVTSRRIPEPEKVPAPTVVRPSALELKVEELEEKGLIRILRGPGDVVSIEILPGAAATPSGDDAPAPRVSTDSPSTAESVPEAASPTPPPPPPPPPPLPNLQSQQEALPSAPPLAPPLPGCAAPPPAPPLPGDLPPPPPPPPLGTDGPVPPPPPPPPGGPPDILGGQDPEIGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMNDFEEQFKTKSQGPSLDISALKGKTAHKAPTKATLIEANRAKNLAITLRKGNLGADRICEAIETYDLQTLSLDFLELLTRFLPTDYERSLIARFEKEQRPMEELSEEDRFMLRFSRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAIIAASISIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLGDVRSLQRGLELTQREFVRQDDCLVLKEFLRANSPTMDKLLADSKTAQEAYESVVEYFGENPKTTSPSMFFSLFSRFTKAYKKAEQEVEQWKKEAAADTSGREEPPAPKSPPKARRQQMDLISELKRKQLKEPLIYESDRDGAIEDIITDLRNQPYIRADTGRRSARRRPPGPPLPVTADLSL" }, "uniprot_id": "A0A0G2JYU6_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "formin-like protein 1 isoform X1" ], "uniprotkb": [ "Formin-like 1" ] }, "gene": { "refseq": [ "Fmnl1" ], "uniprotkb": [ "Fmnl1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Formin-like 1." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6/publications", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6#A0A0G2JYU6-1", "isoform_ac": "A0A0G2JYU6-1", "locus": { "end_pos": 91254240, "start_pos": 91281128, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087218", "id": "ENSRNOT00000087218", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000070794", "id": "ENSRNOP00000070794", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JYU6-1|A0A0G2JYU6_RAT Isoform 1 of Formin-like 1 OS=Rattus norvegicus OX=10116 GN=Fmnl1 PE=1 SV=1 CANONICAL=A0A0G2JYU6-1", "length": 1101, "sequence": "MGNAAGSAEQPAGPTASPPKQPAVPKQPMPAAGELEERFTRVLNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAYIQKLKSYLDTGGVSRKVATDWMSNLGFKRRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVAYDMESTENVASGTEKNKPLEQSVEDLSKAPPSSVPKSRLTIKCPPSPRLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNVFDVGTLLEETETKNAVLEHMEELQEQVATLTERLRDTENDSMAKIAELEKQLSQARKELETLRERFSESTPMVTSRRIPEPEKVPAPTVVRPSALELKVEELEEKGLIRILRGPGDVVSIEILPGAAATPSGDDAPAPRVSTDSPSTAESVPEAASPTPPPPPPPPPPLPNLQSQQEALPSAPPLAPPLPGCAAPPPAPPLPGDLPPPPPPPPLGTDGPVPPPPPPPPGGPPDILGGQDPEIGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMNDFEEQFKTKSQGPSLDISALKGKTAHKAPTKATLIEANRAKNLAITLRKGNLGADRICEAIETYDLQTLSLDFLELLTRFLPTDYERSLIARFEKEQRPMEELSEEDRFMLRFSRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAIIAASISIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLGDVRSLQRGLELTQREFVRQDDCLVLKEFLRANSPTMDKLLADSKTAQEAYESVVEYFGENPKTTSPSMFFSLFSRFTKAYKKAEQEVEQWKKEAAADTSGREEPPAPKSPPKARRQQMDLISELKRKQLKEPLIYESDRDGAIEDIITDLRNQPYIRADTGRRSARRRPPGPPLPVTADLSL" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6#D3ZAZ1-1", "isoform_ac": "D3ZAZ1-1", "locus": { "end_pos": 91254240, "start_pos": 91280808, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000065373", "id": "ENSRNOT00000065373", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000062888", "id": "ENSRNOP00000062888", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZAZ1-1|A0A0G2JYU6_RAT Computationally mapped isoform of Formin-like 1 OS=Rattus norvegicus OX=10116 GN=Fmnl1 PE=1 SV=1 CANONICAL=A0A0G2JYU6-1", "length": 1034, "sequence": "MGNAAGSAEQPAGPTASPPKQPAVPKQPMPAAGELEERFTRVLNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAYIQKLKSYLDTGGVSRKVATDWMSNLGFKRRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVAYDMESTENVASGTEKNKPLEQSVEDLSKAPPSSVPKSRLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNVFDVGTLLEETETKNAVLEHMEELQEQVATLTERLRDTENDSMAKIAELEKQLSQARKELETLRERFSESTPMVTSRRIPEPEKVPAPTVVRPSALELKVEELEEKGLIRILRGPGDVVSIEILPGAAATPSGDDAPAPRVSTDSPSTAESVPEAASPTPPPPPPPPPPLPNLQSQQEALPSAPPLAPPLPGCAAPPPAPPLPGDLPPPPPPPPLGTDGPVPPPPPPPPGGPPDILGGQDPEIGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMNDFEEQFKTKSQGPSLDISALKGKTAHKAPTKATLIEANRAKNLAITLRKGNLGADRICEAIETYDLQTLSLDFLELLTRFLPTDYERSLIARFEKEQRPMEELSEEDRFMLRFSRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAIIAASISIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLGDVRSLQRGLELTQREFVRQDDCLVLKEFLRANSPTMDKLLADSKTAQEAYESVVEYFGENPKTTSPSMFFSLFSRFTKAYKKAEQEVEQWKKEAAADTSGREEPPAPKSPPKARRQQMDLISELKRKQLKEPLIYESDRDGAIEDIITVLKTVPFTARTGKRTSRLLCEASLGEEMTL" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5663220", "resource": "Reactome", "id": "R-RNO-5663220", "name": "RHO GTPases Activate Formins" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O95466-1", "protein_name": "Formin-like protein 1; Leukocyte formin; CLL-associated antigen KW-13.", "sequence": { "length": 1100, "sequence": "MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKPLEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGPSRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVIKTVPFTARTGKRTSRLLCEASLGEEMPL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JYU6/", "id": "A0A0G2JYU6", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9JL26-1", "protein_name": "Formin-like protein 1; Formin-related protein.", "sequence": { "length": 1094, "sequence": "MGNAAGSAEQPAGPTASPPKQPAVPKQPMPAAGELEERFTRVLNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAYIQKLKSYLDTGGVSRKVASDWMSNLGFKRRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVAYDMESTDSVASGAEKSKPLDQSVEDLSKAPPSSVPKSRLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKSPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLMEYFRHEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNVFDVGTLLEETETKNAVLEHMEELQEQVATLTERLRDTENDSMAKIAELEKQLSQARKELETLRERFSESTPMGTSRRIPEPEKVPVPTVVRPSALELKVEELEEKGLIRILRGPGDVVSIEILPGAAATPSGDDAQAPRVSTDSPSTAESIPEAASPPPPPPPPPPPLPNLQSQQEAPPSAPPLAPPLPGCAEPPPAPPLPGDLPPPPPPPPLGTDGPVPPPPPPPPGGPPDILGGQGPDIGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMNDFEEHFKTKSQGPCLDISALKGKASQKAPTKTILIEANRAKNLAITLRKGNLGADRICQAIETYDLQTLSLDFLELLTRFLPTDYERSLIARFEKEQRPMEELSEEDRFMLRFSRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLGDVRSLQRGLELTQREFVRQDDCLVLKEFLRANSPTMDKLLADSKTAQEAYESVVEYFGENPKTTSPSMFFSLFSRFTKAYKKAEQEVEQWKKEAAADTSGREEPPTPKSPPKARRQQMDLISELKRKQQKEPLIYESDRDGAIEDIITDLRNQPYIRADTGRRSARRRPPGPPLPVTTDLAL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/135620", "id": "135620", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2JYU6/", "id": "A0A0G2JYU6", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006247560.1", "ac": "XP_006247560.1", "name": "formin-like protein 1 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032794", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "GTPase activating protein binding", "id": "GO:0032794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "actin filament binding", "id": "GO:0051015" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048365", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "Rac GTPase binding", "id": "GO:0048365" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005522", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "profilin binding", "id": "GO:0005522" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "phagocytic vesicle", "id": "GO:0045335" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "regulation of cell shape", "id": "GO:0008360" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030866", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "cortical actin cytoskeleton organization", "id": "GO:0030866" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006929", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "substrate-dependent cell migration", "id": "GO:0006929" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051014", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "id": "A0A0G2JYU6", "database": "UniProtKB" } ], "name": "actin filament severing", "id": "GO:0051014" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 427, "annotation": "n_glycosylation_sequon", "start_pos": 425 }, { "end_pos": 853, "annotation": "n_glycosylation_sequon", "start_pos": 851 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006247560.1", "id": "XP_006247560.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5663220", "id": "R-RNO-5663220", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000003207", "id": "ENSRNOG00000003207", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/MDSTDNG/", "id": "MDSTDNG", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR010472", "id": "IPR010472", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014767", "id": "IPR014767", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014768", "id": "IPR014768", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR010473", "id": "IPR010473", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027657", "id": "IPR027657", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015425", "id": "IPR015425", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042201", "id": "IPR042201", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF06367", "id": "PF06367", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF06371", "id": "PF06371", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF02181", "id": "PF02181", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45857:SF2", "id": "PTHR45857:SF2", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/287746", "id": "287746", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311042", "id": "1311042", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JYU6", "disease": [], "mass": { "monoisotopic_mass": 122807.0, "chemical_mass": 122807.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JYU6", "name": "Fmnl1.", "locus": { "end_pos": 91281418, "start_pos": 91254058, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000003207", "id": "ENSRNOG00000003207", "database": "Ensembl Gene" } ] } } ] }