{
    "uniprot_canonical_ac": "A0A0G2JYL3-1", 
    "sequence": {
        "header": "tr|A0A0G2JYL3-1|A0A0G2JYL3_RAT Isoform 1 of Rho guanine nucleotide exchange factor 3  OS=Rattus norvegicus OX=10116 GN=Arhgef3 PE=4 SV=1 CANONICAL=A0A0G2JYL3-1", 
        "length": 551, 
        "sequence": "MNQCIYRGMEEHKERPKRPRQNNFSMFPSPKAWNFRGRKRKQSAQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKTTPLKRFSQTLQRSISFRNESRPDILAPRAWSRNATSSSTKRRDSKLWSETFDVCVSQVLTAKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSESLSQSPGTENRELRGETKLEQMDQSDSESDCSMDTSEVSLECERMEQTDASCANSRPEENV"
    }, 
    "uniprot_id": "A0A0G2JYL3_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "rho guanine nucleotide exchange factor 3 isoform X2"
            ], 
            "uniprotkb": [
                "Rho guanine nucleotide exchange factor 3"
            ]
        }, 
        "gene": {
            "refseq": [
                "Arhgef3"
            ], 
            "uniprotkb": [
                "Arhgef3"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JYL3", 
                    "id": "A0A0G2JYL3", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Rho guanine nucleotide exchange factor 3."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYL3#A0A0G2JYL3-1", 
            "isoform_ac": "A0A0G2JYL3-1", 
            "locus": {
                "end_pos": 2780017, 
                "start_pos": 3024836, 
                "chromosome": "16", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000087873", 
                        "id": "ENSRNOT00000087873", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000070700", 
                        "id": "ENSRNOP00000070700", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2JYL3-1|A0A0G2JYL3_RAT Isoform 1 of Rho guanine nucleotide exchange factor 3  OS=Rattus norvegicus OX=10116 GN=Arhgef3 PE=4 SV=1 CANONICAL=A0A0G2JYL3-1", 
                "length": 551, 
                "sequence": "MNQCIYRGMEEHKERPKRPRQNNFSMFPSPKAWNFRGRKRKQSAQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKTTPLKRFSQTLQRSISFRNESRPDILAPRAWSRNATSSSTKRRDSKLWSETFDVCVSQVLTAKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSESLSQSPGTENRELRGETKLEQMDQSDSESDCSMDTSEVSLECERMEQTDASCANSRPEENV"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYL3#D4A1J1-1", 
            "isoform_ac": "D4A1J1-1", 
            "locus": {
                "end_pos": 2958404, 
                "start_pos": 3024836, 
                "chromosome": "16", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000019511", 
                        "id": "ENSRNOT00000019511", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000019511", 
                        "id": "ENSRNOP00000019511", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|D4A1J1-1|A0A0G2JYL3_RAT Computationally mapped isoform of Rho guanine nucleotide exchange factor 3  OS=Rattus norvegicus OX=10116 GN=Arhgef3 PE=4 SV=1 CANONICAL=A0A0G2JYL3-1", 
                "length": 524, 
                "sequence": "MVAKDYPFYLTVKRANCSLEAPLGSGVAKDEEPSNKRVKPLSRVTSLANLIPPVKTTPLKRFSQTLQRSISFRNESRPDILAPRAWSRNATSSSTKRRDSKLWSETFDVCVSQVLTAKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSESLSQSPGTENRELRGETKLEQMDQSDSESDCSMDTSEVSLECERMEQTDASCANSRPEENV"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194840", 
            "resource": "Reactome", 
            "id": "R-RNO-194840", 
            "name": "Rho GTPase cycle"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193648", 
            "resource": "Reactome", 
            "id": "R-RNO-193648", 
            "name": "NRAGE signals death through JNK"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416482", 
            "resource": "Reactome", 
            "id": "R-RNO-416482", 
            "name": "G alpha (12/13) signalling events"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q91X46-1", 
            "protein_name": "Rho guanine nucleotide exchange factor 3.", 
            "sequence": {
                "length": 524, 
                "sequence": "MVAKDYPFYLTVKRANCSLEAPLGSGVAKDEEPSNKRVKPLSRVTSLANLIPPVKTTPLKRFSQTLQRSISFRSESRPDILAPRAWSRNATSSSTKRRDSKLWSETFDVCVNQVLTAKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERVKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSEGLVQGPGTENREPQGETKLEQMDQSDSESDCSMDTSEVSLECERMEQTDASCANSRPEESV"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/41329", 
                    "id": "41329", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q9NR81-1", 
            "protein_name": "Rho guanine nucleotide exchange factor 3; Exchange factor found in platelets and leukemic and neuronal tissues; XPLN.", 
            "sequence": {
                "length": 526, 
                "sequence": "MVAKDYPFYLTVKRANCSLELPPASGPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/41329", 
                    "id": "41329", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006252636.1", 
        "ac": "XP_006252636.1", 
        "name": "rho guanine nucleotide exchange factor 3 isoform X2.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005089", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYL3", 
                                "id": "A0A0G2JYL3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Rho guanyl-nucleotide exchange factor activity", 
                        "id": "GO:0005089"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYL3", 
                                "id": "A0A0G2JYL3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intracellular signal transduction", 
                        "id": "GO:0035556"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035023", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYL3", 
                                "id": "A0A0G2JYL3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of Rho protein signal transduction", 
                        "id": "GO:0035023"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 25, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 23
        }, 
        {
            "end_pos": 103, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 101
        }, 
        {
            "end_pos": 118, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 116
        }, 
        {
            "end_pos": 448, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 446
        }, 
        {
            "end_pos": 460, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 458
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006252636.1", 
            "id": "XP_006252636.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194840", 
            "id": "R-RNO-194840", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193648", 
            "id": "R-RNO-193648", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416482", 
            "id": "R-RNO-416482", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000014363", 
            "id": "ENSRNOG00000014363", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/WTYLDVP/", 
            "id": "WTYLDVP", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", 
            "id": "cd00160", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", 
            "id": "IPR001849", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", 
            "id": "IPR011993", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", 
            "id": "IPR000219", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001331", 
            "id": "IPR001331", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", 
            "id": "IPR035899", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00621", 
            "id": "PF00621", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/290541", 
            "id": "290541", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310672", 
            "id": "1310672", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0G2JYL3", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 63172.0, 
        "chemical_mass": 63172.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYL3", 
            "name": "Arhgef3.", 
            "locus": {
                "end_pos": 3026760, 
                "start_pos": 2743823, 
                "chromosome": "16", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000014363", 
                        "id": "ENSRNOG00000014363", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}