{ "uniprot_canonical_ac": "A0A0G2JWZ1-1", "sequence": { "header": "tr|A0A0G2JWZ1-1|A0A0G2JWZ1_RAT Isoform 1 of Rho-related BTB domain-containing 1 OS=Rattus norvegicus OX=10116 GN=Rhobtb1 PE=4 SV=1 CANONICAL=A0A0G2JWZ1-1", "length": 696, "sequence": "MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSISLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSTGTSDAACLLDNPLCADVLFILHDQEHIFAHRIYLATSSSKFYDLFLMECEDSPGWSGGAGEEVPCRDFQGRTQSLGAAEEGQEGSQRTPQADPGASSGQDLLESLASQTDASVSEAHALTGWSKGFVSMHREVRVNPISKRVGPVTVVRLDSSMQSGPFRTLLRFLYSGQLDEKEKDLLGLAQMAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFTLDDGAISAHKPLLICSCEWMAAMFGGSFVESTNSEVHLPNINKMSMQAVLEYLYTKQLSPNLDLDPLELIALATRFACTSHMWSLCKQHAVQELTKAAVSGVSIDGEVLSYLELAQFHNANQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDLALNKHHSRRKWCFWHPSPAVA" }, "uniprot_id": "A0A0G2JWZ1_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Rho-related BTB domain-containing 1" ] }, "gene": { "refseq": [], "uniprotkb": [ "Rhobtb1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Rho-related BTB domain-containing 1." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1#A0A0G2JWZ1-1", "isoform_ac": "A0A0G2JWZ1-1", "locus": { "end_pos": 20640688, "start_pos": 20680675, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087085", "id": "ENSRNOT00000087085", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000070070", "id": "ENSRNOP00000070070", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JWZ1-1|A0A0G2JWZ1_RAT Isoform 1 of Rho-related BTB domain-containing 1 OS=Rattus norvegicus OX=10116 GN=Rhobtb1 PE=4 SV=1 CANONICAL=A0A0G2JWZ1-1", "length": 696, "sequence": "MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSISLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSTGTSDAACLLDNPLCADVLFILHDQEHIFAHRIYLATSSSKFYDLFLMECEDSPGWSGGAGEEVPCRDFQGRTQSLGAAEEGQEGSQRTPQADPGASSGQDLLESLASQTDASVSEAHALTGWSKGFVSMHREVRVNPISKRVGPVTVVRLDSSMQSGPFRTLLRFLYSGQLDEKEKDLLGLAQMAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFTLDDGAISAHKPLLICSCEWMAAMFGGSFVESTNSEVHLPNINKMSMQAVLEYLYTKQLSPNLDLDPLELIALATRFACTSHMWSLCKQHAVQELTKAAVSGVSIDGEVLSYLELAQFHNANQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDLALNKHHSRRKWCFWHPSPAVA" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1#D3ZD37-1", "isoform_ac": "D3ZD37-1", "locus": { "end_pos": 20640688, "start_pos": 20680675, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000000784", "id": "ENSRNOT00000000784", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000000784", "id": "ENSRNOP00000000784", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZD37-1|A0A0G2JWZ1_RAT Computationally mapped isoform of Rho-related BTB domain-containing 1 OS=Rattus norvegicus OX=10116 GN=Rhobtb1 PE=4 SV=2 CANONICAL=A0A0G2JWZ1-1", "length": 694, "sequence": "MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSISLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSTGTSDAACLLDNPLCADVLFILHDQEHIFAHRIYLATSSSKFYDLFLMECEDSPGWSGGAGEEVPCRDFQGRTQSLGAAEEGQEGSQRTPQADPGASSGQDLLESLASQTDASVSEAHALTGWSKGFVSMHREVRVNPISKRVGPVTVVRLDSSMQSGPFRTLLRFLYSGQLDEKEKDLLGLAQMAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFTLDDGAISAHKPLLICSCEWMAAMFGGSFVESTNSEVHLPNINKMSMQAVLEYLYTKQLSPNLDLDPLELIALATRFWPPLVPLVEQHAVQELTKAAVSGVSIDGEVLSYLELAQFHNANQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDLALNKHHSRRKWCFWHPSPAVA" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194840", "resource": "Reactome", "id": "R-RNO-194840", "name": "Rho GTPase cycle" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O94844-1", "protein_name": "Rho-related BTB domain-containing protein 1.", "sequence": { "length": 696, "sequence": "MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKSMWYPEIKHFCPRTPVILVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGLPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMGTNEAACLLDNPLCADVLFILQDQEHIFAHRIYLATSSSKFYDLFLMECEESPNGSEGACEKEKQSRDFQGRILSVDPEEEREEGPPRIPQADQWKSSNKSLVEALGLEAEGAVPETQTLTGWSKGFIGMHREMQVNPISKRMGPMTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFKLDDGAISAHKPLLICSCEWMAAMFGGSFVESANSEVYLPNINKISMQAVLDYLYTKQLSPNLDLDPLELIALANRFCLPHLVALAEQHAVQELTKAATSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHRSRRKWCFWNSSPAVA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JWZ1/", "id": "A0A0G2JWZ1", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "GTPase activity", "id": "GO:0003924" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "GTP binding", "id": "GO:0005525" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "cell cortex", "id": "GO:0005938" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032153", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "cell division site", "id": "GO:0032153" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "actin filament organization", "id": "GO:0007015" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "regulation of actin cytoskeleton organization", "id": "GO:0032956" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051017", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "actin filament bundle assembly", "id": "GO:0051017" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007266", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "Rho protein signal transduction", "id": "GO:0007266" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "regulation of cell migration", "id": "GO:0030334" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "regulation of cell shape", "id": "GO:0008360" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030950", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "id": "A0A0G2JWZ1", "database": "UniProtKB" } ], "name": "establishment or maintenance of actin cytoskeleton polarity", "id": "GO:0030950" } ], "total": 7, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 39, "annotation": "n_glycosylation_sequon", "start_pos": 37 } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194840", "id": "R-RNO-194840", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000000633", "id": "ENSRNOG00000000633", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/WMSAMFG/", "id": "WMSAMFG", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "id": "IPR001806", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "id": "IPR000210", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "id": "IPR011333", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "id": "IPR005225", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003578", "id": "IPR003578", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00071", "id": "PF00071", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00651", "id": "PF00651", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306871", "id": "1306871", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JWZ1", "disease": [], "mass": { "monoisotopic_mass": 78939.0, "chemical_mass": 78939.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ1", "name": "Rhobtb1.", "locus": { "end_pos": 20638579, "start_pos": 20713128, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000000633", "id": "ENSRNOG00000000633", "database": "Ensembl Gene" } ] } } ] }